Abstract：
:The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of dentate gyrus size. At postnatal day 10 (P10), granule cell numbers were not significantly different in IGF1 null and littermate wildtype (WT) dentate gyri. The subgranular zone cell population, however, was relatively increased, and the granule cell layer population relatively decreased in the IGF1 null dentate gyrus. By P50, total dentate cell numbers were decreased by 20% (P = 0.01) in the IGF1 null mouse, although IGF1 null subgranular zone progenitor cells remained relatively increased compared with WT (38%, P < 0.05). IGF1 null dentate cell proliferation, assessed by thymidine analogue incorporation, was actually increased at P10 (33%, P < 0.05) and P50 (167%, P = 0.001). Dentate granule cell death, assessed by the appearance of pycnotic cells and DNA fragmentation, was also significantly increased in the IGF1 null dentate (61%, P < 0.05 and 101%, P = 0.03). These data suggest that endogenous IGF1 serves an important role in dentate granule cell survival during the course of postnatal brain development. In addition, this work suggests the potential of a compensatory mechanism promoting increased dentate cell proliferation in the face of impaired cell survival during postnatal neurogenesis. J. Neurosci. Res. 64:341-347, 2001. Published 2001 Wiley-Liss, Inc.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Cheng CM,Cohen M,Tseng V,Bondy CAdoi
10.1002/jnr.1084keywords:
subject
Has Abstractpub_date
2001-05-15 00:00:00pages
341-7issue
4eissn
0360-4012issn
1097-4547journal_volume
64pub_type
杂志文章abstract：:Using a solution-hybridization assay and specific oligonucleotidic probes, we have studied IGF-I and insulin receptor mRNAs in the rat central nervous system during development. The expression of mRNAs was maximal at embryonic day 15 and 20 for IGF-I receptors, and at embryonic day 20 and the day of birth for insulin ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490280212
更新日期：1991-02-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease caused by the selective death of motor neurons. Between 5% and 10% of ALS patients have a genetically inherited form of the disease known as familial ALS (FALS), and approximately 20% of FALS patients have mutations in the SOD1 gene. Although the m...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21902
更新日期：2009-03-01 00:00:00
abstract：:The Oct-2 transcription factor has a predominantly inhibitory effect on gene expression in neuronal cell lines. This factor and its corresponding mRNA have previously been shown to be elevated in adult rat dorsal root ganglion (DRG) neurons chronically exposed to nerve growth factor (NGF). Here we show that the Oct-2 ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490400205
更新日期：1995-02-01 00:00:00
abstract：:In 2000, a landmark case report described the concurrent restoration of consciousness and thalamo-frontal connectivity after severe brain injury (Laureys et al., ). Being a single case however, this study could not disambiguate whether the result was specific to the restoration of consciousness per se as opposed to th...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24115
更新日期：2018-04-01 00:00:00
abstract：:In an effort to identify genes involved in neuronal differentiation, we have used representational difference analysis (RDA) to clone cDNAs that are preferentially induced by nerve growth factor (NGF) vs. epidermal growth factor (EGF) in PC12 pheochromocytoma cells. We now report the cloning of a previously unknown pr...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1058
更新日期：2001-04-15 00:00:00
abstract：:Bovine cerebrum, including the corpus callosum, and a human oligodendroglioma were investigated by an immunohistochemical technique to determine the distribution of 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNP). Also, three human oligodendrogliomas (ODG) were characterized by an immunoblot procedure to identify a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490130309
更新日期：1985-01-01 00:00:00
abstract：:Astrogliosis and microglial reactions are correlated with the formation of scar tissue and synapse loss. 4-hydroxy-tempo (TEMPOL) is a reactive oxygen species scavenger with proven neuroprotective efficacy in experimental models of traumatic injury and cerebral ischemia. TEMPOL has not, however, been applied following...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24365
更新日期：2019-04-01 00:00:00
abstract：:Integrins comprise a large family of cell adhesion molecules that mediate interactions between the extracellular environment and the cytoplasm. During the last decade, analysis of the expression and function of these molecules has revealed that integrins regulate many aspects of cell behavior including cell death, pro...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.10321
更新日期：2002-08-01 00:00:00
abstract：:Electrical activity shapes development of the nervous system, presumably in part by regulating gene expression. A set of regulatory genes, immediate early genes (IEGs), which are responsive to a number of extrinsic cellular stimuli have been proposed to play a role in coupling such activity to gene expression. Using a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490350502
更新日期：1993-08-01 00:00:00
abstract：:The mammalian genome contains both constitutively expressed and heat-shock-inducible members of the hsp70 gene family. Riboprobes derived from members of these two classes of heat shock genes were utilized in Northern blot studies to analyze brain mRNA isolated from control rabbits and rats and from animals subjected ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490250103
更新日期：1990-01-01 00:00:00
abstract：:Structural microtubule-associated proteins (MAPs) interact with microtubules to regulate the various dynamic stages of microtubules. The purpose of this study was to measure the impact of myc-tagged MAP1a fragments on microtubule dynamic phases in vivo. Cells from an epithelial kidney cell line (LLCPK1) that had been ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21920
更新日期：2009-04-01 00:00:00
abstract：:A cholinergically disrupted laboratory animal has been produced by administration of the cholinotoxin ethylcholine aziridinium mustard (AF64A), which produced a dysfunction in the cholinergic forebrain system. After AF64A treatment, a reduction of choline acetyl transferase (ChAT) activity was measured in the hippocam...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990115)55:2<178::AID-JNR
更新日期：1999-01-15 00:00:00
abstract：:The role of the plasmin-generating system, a serum component, in the development of dissociated embryonic chick spinal cord cells in culture was studied. Studies were performed in a defined system where the cells were maintained in a serum-free medium. Under these conditions the cells produce plasminogen activator. It...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490080237
更新日期：1982-01-01 00:00:00
abstract：:In chronic demyelinating lesions of the central nervous system, insufficient generation of oligodendrocytes (OLs) is not due to a lack of oligodendrocyte precursor cells (OPCs), because the accumulation of OPCs and premyelinating OLs can be observed within these lesions. Here we sought to identify the basis for the fa...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23153
更新日期：2013-02-01 00:00:00
abstract：:Highly malignant neuroblastoma tumors generally have defects in differentiation and apoptotic pathways. For a better understanding of these events, we use a murine neuroblastoma cell line (NBP2) that terminally differentiates into mature neurons in response to elevated levels of cAMP. Because one of the main downstrea...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20304
更新日期：2004-11-15 00:00:00
abstract：:Male gerbils (Meriones unguiculatus) were bred and reared either grouped under enriched environmental conditions or isolated under impoverished environmental conditions. The objective of the present study was to examine the influence of social environment on structural and functional ontogeny of the medial prefrontal ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980415)52:2<201::AID-JNR
更新日期：1998-04-15 00:00:00
abstract：:During surgical intervention in medically refractory temporal lobe epilepsy (TLE) patients, diagnosed with either mesial temporal lobe sclerosis (MTS)- or tumor (T)-associated TLE, biopsies were taken from the anterior temporal neocortex and the hippocampal region. Synaptosomes, isolated from these biopsies were used ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(20000601)60:5<686::AID-JNR
更新日期：2000-06-01 00:00:00
abstract：:Mounting evidence has demonstrated that the microenvironment of stem/progenitor cells plays an important role in their proliferation and commitment to their fate. However, it remains unclear how all elements, such as astrocytes, microglia, extracellular matrix molecules, soluble factors, and their cross-talk interacti...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21454
更新日期：2008-01-01 00:00:00
abstract：:Using a canine model of classical late-infantile neuronal ceroid lipofuscinosis (CLN2 disease), a study was conducted to evaluate the potential pharmacological activity of recombinant human tripeptidyl peptidase-1 (rhTPP1) enzyme replacement therapy administered directly to the cerebrospinal fluid (CSF). CLN2 disease ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23423
更新日期：2014-11-01 00:00:00
abstract：:Despite a large body of literature on the nociceptin (NC) opioid system in pain modulation, the mechanism of action of NC remains largely unexplored. Here, we investigated the role and mode of action of the spinal NC system in inflammatory pain. Preemptive intrathecal administration of NC attenuated thermal hyperalges...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21272
更新日期：2007-05-15 00:00:00
abstract：:The two inbred strains of mice C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) mice have been shown to differ significantly in their preference for alcohol (EtOH). We have previously demonstrated the differences in the density and the affinity of cannabinoid (CB1) receptors in the brains of the two inbred C5...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1094
更新日期：2001-05-15 00:00:00
abstract：:We have performed proteomic analysis in the cerebrospinal fluid in an animal model of Parkinson's disease induced by axotomy of the medial forebrain bundle. In this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in the substantia nigra and a loss...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21452
更新日期：2007-12-01 00:00:00
abstract：:Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that also possesses neurotrophic and antiapoptotic properties. G-CSF has been reported to decrease amyloid burden significantly, promote hippocampal neurogenesis, and improve spatial learning in a mouse model of Alzheimer's disease. To understan...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23378
更新日期：2014-08-01 00:00:00
abstract：:Neuroepithelial b2T cells were derived from the hindbrain and the spinal cord of mouse transgenic embryos, which expressed SV40 T antigen under the control of a Hoxb2 enhancer. Strikingly, b2T cell lines of either origin exhibit a very similar gene expression pattern, including markers of the hindbrain and the spinal ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10716
更新日期：2003-09-15 00:00:00
abstract：:Cerebrospinal fluid was collected from the lateral ventricles and cisternal space from beagle dogs under light pentobarbital anesthesia. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglyco-sulfate (MOPEG-SO4) levels in the liquor taken from these two regions were evaluated,...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490010513
更新日期：1975-01-01 00:00:00
abstract：:TCP and its derivative gacyclidine (+/- GK11) are high-affinity non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors (NMDARs) and as such exhibit significant neuroprotective properties. These compounds also bind with a low affinity to binding sites whose pharmacological profiles are different from that...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10203
更新日期：2002-05-01 00:00:00
abstract：:Although alterations in adenylate cyclase (AC) activity and somatostatin (SRIF) receptor density have been reported in Alzheimer's disease, the effects of amyloid beta-peptide (Abeta) on these parameters in the hippocampus are unknown. Our aim was to investigate whether the peptide fragment Abeta(25-35) can affect the...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21115
更新日期：2007-02-01 00:00:00
abstract：:The existence of endogenous neural progenitor cells (NPCs) in the adult spinal cord (sc) provides the potential for tailored repair therapies after spinal cord injury (SCI). This study investigates the impact of inflammatory mediators on properties of NPC cultures derived from adult rats after SCI. The Infinite Horizo...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23527
更新日期：2015-04-01 00:00:00
abstract：:Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.24417
更新日期：2019-12-01 00:00:00
abstract：:Chloride efflux is known to be involved in the progression of apoptosis in various cell types. We have recently shown that the volume-sensitive outwardly rectifying (VSOR) anion channel serves as the pathway for apoptotic chloride efflux in some cells. In the present study, we tested the neuroprotective effects of dru...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21279
更新日期：2007-05-15 00:00:00
