Abstract:
:Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration of leptin, at 10 days after stroke onset, on neurogenesis and angiogenesis after stroke. Sabra mice underwent photothrombotic stroke and were treated with vehicle or leptin given either as a single dose or in triple dosing, 10 days later. Newborn cells were labeled with bromodeoxyuridine. Functional outcome was studied with the neurological severity score for 90 days poststroke, and the brains were then evaluated via immunohistochemistry. Final infarct volumes did not differ between the groups. Exogenous leptin led to significant increments in the number of proliferating BrdU(+) cells in the subventricular zone and in the cortex abutting the lesion (2.5-fold and 1.4-fold, respectively). There were significant increments in the number of newborn neurons and glia (4- and 3.4-fold, respectively) in leptin-treated animals. Leptin also significantly increased the number of blood vessels in the perilesioned cortex. However, animals treated with leptin failed to demonstrate significantly better functional states. In conclusion, leptin induces neurogenesis and angiogenesis even when given late after stroke but does not lead to better functional outcome in this delayed-treatment paradigm. These results suggest that the main beneficial effects of leptin after stroke are associated with its early neuroprotective role rather than with its proneurogenic or proangiogenic effects.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Avraham Y,Dayan M,Lassri V,Vorobiev L,Davidi N,Chernoguz D,Berry E,Leker RRdoi
10.1002/jnr.23147subject
Has Abstractpub_date
2013-02-01 00:00:00pages
187-95issue
2eissn
0360-4012issn
1097-4547journal_volume
91pub_type
杂志文章abstract::We have previously shown that Na+, K(+)-ATPase activity in hypothalamus is increased after administration of an acute dose of desipramine, a noradrenaline uptake inhibitor (Viola et al., Cell Molec Neurobiol 9:263-271, 1989). In this report the same treatment (10 mg per kg) was applied to evaluate 3H-ouabain binding i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(sici)1097-4547(19970101)47:1<77::aid-jnr8
更新日期:1997-01-01 00:00:00
abstract::To identify and characterize the lineage potential of rat neural retina progenitor cells (NRPCs) in vitro and engrafted into rats with retinal degeneration, NRPCs were isolated from neural retinas of embryonic day 17 Long Evans rats and cultured in serum-free or serum-containing media with fibroblast growth factor 2 a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10320
更新日期:2002-08-15 00:00:00
abstract::Anoxia during delivery is a complication that can disturb infant brain development leading to various types of neurological disorders. Our studies have shown that increased body temperature of newborn rats of both sexes intensifies the postanoxic oxidative stress and prevents triggering the endogenous adaptive respons...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24486
更新日期:2019-10-01 00:00:00
abstract::The increase in myelin basic protein (MBP) synthesis observed in brain aggregate cultures supplemented with macrophages is reflected in elevated supernatant protein levels of the key promoters of oligodendrocyte proliferation, fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-AA (PDGF-AA), during t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10837
更新日期:2003-12-15 00:00:00
abstract::Rapsyn is a protein that interacts with the cytoplasmic face of the nicotinic acetylcholine receptors (AChR) to cluster them within postsynaptic membrane of muscle. Here we show that intracellular AChRs are also affected by rapsyn. When rapsyn was co-transfected with AChR into QT-6 fibroblasts, (125)I-alpha-bungarotox...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000415)60:2<155::AID-JNR
更新日期:2000-04-15 00:00:00
abstract::Rho-GTPase has been implicated in the apoptosis of many cell types, including neurons, but the mechanism by which it acts is not fully understood. Here, we investigate the roles of Rho and ROCK in apoptosis during transplantation of embryonic stem cell-derived neural precursor cells. We find that dissociation of neura...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21502
更新日期:2008-02-01 00:00:00
abstract::Acoustic overstimulation causes apoptotic cell death in the cochlea. This death process is mediated, in part, by the mitochondrial signaling pathway involving Bcl-2 family proteins. Myeloid cell leukemia sequence 1 (Mcl-l) is an antiapoptotic member of the Bcl-2 family. Its involvement in noise-induced hair cell death...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22333
更新日期:2010-06-01 00:00:00
abstract::The extracellular matrix surrounds different neuronal compartments in the mature nervous system. In a variety of vertebrates, most brain regions are loaded with a distinct type of extracellular matrix around the somatodendritic part of neurons, termed perineuronal nets. The present study reports that chondrotin sulfat...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22761
更新日期:2012-02-01 00:00:00
abstract::The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calcu...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490010205
更新日期:1975-01-01 00:00:00
abstract::Although the thalamus is not considered primarily as a limbic structure, abundant evidence indicates the essential role of the thalamus as a modulator of limbic functions indirectly through the amygdala. The amygdala is a central component of the limbic system and serves an essential role in modulating the core proces...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24235
更新日期:2018-07-01 00:00:00
abstract::Metallothionein (MT) belongs to a family of metal-binding cysteine-rich proteins comprising several structurally related proteins implicated in tissue protection and regeneration after injuries and functioning as antiapoptotic antioxidants in neurological disorders. This has been demonstrated in animals receiving MT t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22118
更新日期:2009-10-01 00:00:00
abstract::Apoptosis is a form of cell death historically defined by morphological and biochemical changes that occur in the cell body and nucleus. However, in contrast to nonneuronal cells in which apoptosis has been most intensively studied, neurons exhibit elaborate morphologies with synaptic connections often located at site...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-01 00:00:00
abstract::P-glycoprotein (P-gp), a drug efflux pump, is known to alter the bioavailability of antiretroviral drugs at several sites, including the brain. We have previously shown that human immunodeficiency virus-1 (HIV-1) glycoprotein 120 (gp120) induces proinflammatory cytokine secretion and decreases P-gp functional expressi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22720
更新日期:2011-11-01 00:00:00
abstract::The companion study showed that acoustic overstimulation of adult chinchillas, with a noise level sufficient to damage the cochlea, led to cytological changes and degeneration of synaptic endings in the cochlear nucleus within 1-16 weeks. In the present study, the same stimulus was used to study the long-term effects ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20212
更新日期:2004-09-15 00:00:00
abstract::Even though ischemic stroke is among the leading causes of death worldwide, the pathogenic mechanisms underlying ischemia reperfusion (I/R) brain injury remain unclear. Gasdermin D (GSDMD), as an important factor of pyroptotic death execution downstream of caspase-11 (noncanonical inflammasome) and caspase-1 (canonica...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24385
更新日期:2019-06-01 00:00:00
abstract::The influence of a concentrated extract of soluble substances from the sciatic nerve upon the acetylcholine receptor (AChR) content in the soleus muscle of adult rats was examined by in vivo infusions. Internal and membrane-inserted AChR were quantitated by the specific binding of 125I-alpha-bungarotoxin (a-BuTX). Int...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490160307
更新日期:1986-01-01 00:00:00
abstract::Raf kinases are downstream effectors of Ras and upstream activators of the MEK-ERK cascade. Ras and MEK-ERK signaling play roles in learning and memory (L&M) and neural plasticity, but the roles of Raf kinases in L&M and plasticity are unclear. Among Raf isoforms, B-raf is preferentially expressed in the brain. To det...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20703
更新日期:2006-01-01 00:00:00
abstract::Experiments were conducted to determine whether the intensity of cyclic light exposure to the retina over a long period of time affects retinoid-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE). Albino rats were maintained from weaning on diets either containing (+A) or lacking (-A) retinyl...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990701)57:1<106::AID-JNR
更新日期:1999-07-01 00:00:00
abstract::Although protein kinase Cdk5-p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21438
更新日期:2007-11-01 00:00:00
abstract::Six different types of spectral responses were recorded from horizontal cells under mesopic conditions in perfused retina, isolated from the dark-adapted mojarra (Eugerres plumieri). They were tentatively termed photopic Lr-, Lg1-, Lg2-, Lb-, and C-type, and scotopic L-type. The Lr-, Lg-, and Lb-type responses showed ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200214
更新日期:1988-01-01 00:00:00
abstract::Encephalitogenic T cells from Lewis rats use a restricted T cell receptor (TCR) gene combination, Vbeta8.2 and Valpha2. The oral administration of myelin basic protein (MBP) to Lewis rats prior to encephalitogenic challenge results in a marked inhibition of clinical neurologic signs of encephalitis, reduced central ne...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980101)51:1<67::AID-JNR7
更新日期:1998-01-01 00:00:00
abstract::Dihydropteridine reductase was purified approximately 1,700-fold from human outdated blood platelets. Two forms of the enzyme, A and B, were resolved. They have the same Km values for 2-amino-6,7,-dimethyl-4-hydroxydihydropteridine (46 microM vs 49 microM), but the A form has a Km for NADH that is two times higher tha...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490060205
更新日期:1981-01-01 00:00:00
abstract::This essay discusses the directional movements of metazoan tissue cells generally, with special emphasis on neurons, in an attempt to show that the directional movements of all share fundamental similarities. ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490130102
更新日期:1985-01-01 00:00:00
abstract::Subarachnoid hemorrhage (SAH) by a rupture of cerebral aneurysms remains the most devastating cerebrovascular disease. Early brain injury (EBI) is increasingly recognized to be the primary determinant for poor outcomes, and also considered to cause delayed cerebral ischemia (DCI) after SAH. Both clinical and experimen...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24330
更新日期:2020-01-01 00:00:00
abstract::Experiments were conducted with the aid of intracellular microelectrodes to study physiological properties of neuropile glial cells in the central nervous system of the medicinal leech. The results showed significant contributions of both K+ and Cl- ions to the membrane potential. The transmitter substance 5-hydroxytr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490070108
更新日期:1982-01-01 00:00:00
abstract::Our previous results support the idea that CREB (cyclic AMP-response element binding protein) may be a mediator of neuroligand and growth factor signals that, coupled to different signal transduction pathways, play different roles at specific stages of oligodendrocyte development. In the early stages, when cells are i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1195
更新日期:2001-10-01 00:00:00
abstract::The inflammatory response initiated after spinal cord injury (SCI) is characterized by the accumulation of macrophages at the impact site. Monocyte chemoattractant protein-1 (MCP-1) is a strong candidate for mediating chemotaxis of monocytes to the injured nervous system. To help in defining the role of MCP-1 in infla...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10269
更新日期:2002-06-15 00:00:00
abstract::Charcot-Marie-Tooth neuropathy type 1A (CMT 1 A) is the most common inherited neuropathy in humans and is mostly caused by a 1.5-Mb tandem duplication of chromosome 17 comprising the gene for the peripheral myelin protein 22-kDa (PMP 22). Although there are numerous studies on the functional role of PMP 22, the mechan...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20601
更新日期:2005-09-15 00:00:00
abstract::The p53 tumor suppressor gene, which is considered the guardian of the genome, encodes a phosphoprotein, which is a sequence-specific transcriptional activator or repressor of target genes. The role of p53 in developmental processes has not been studied extensively, although its expression appears to undergo temporal ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990515)56:4<427::AID-JNR
更新日期:1999-05-15 00:00:00
abstract::Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21984
更新日期:2009-11-15 00:00:00