Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro.

abstract：:The rationale for designing and synthesizing 24 different peptide analogs and subpeptides of residues 69-84 of guinea pig myelin basic protein is presented. The encephalitogenic potential of 19 of these peptides in Lewis rats is also given. ...

journal_title：Journal of neuroscience research

authors： Hashim GA,Day ED

更新日期：1987-01-01 00:00:00

abstract：:The mast cell, an immunocompetent cell that contributes to neurogenic inflammation in a variety of tissues, including synovium, is found in close proximity to peripheral terminals of unmyelinated primary afferents and sympathetic postganglionic nerve terminals. In this study we evaluated the hypothesis that the densit...

journal_title：Journal of neuroscience research

authors： Levine JD,Coderre TJ,Covinsky K,Basbaum AI

更新日期：1990-07-01 00:00:00

abstract：:Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder of the central nervous system (CNS) caused by a wide variety of mutations affecting proteolipid protein 1 (PLP1). We assessed the effects of PLP1 mutations on water diffusion in CNS white matter by using diffusion tensor imaging. Twelve patients with different...

journal_title：Journal of neuroscience research

authors： Laukka JJ,Makki MI,Lafleur T,Stanley J,Kamholz J,Garbern JY

更新日期：2014-12-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) coactivates a number of transcription factors critical for mitochondrial biogenesis. Previously, we found that the expression of PGC-1alpha is governed by neuronal activity, but the signaling mechanism is poorly understood. The present st...

journal_title：Journal of neuroscience research

authors： Liang HL,Dhar SS,Wong-Riley MT

更新日期：2010-02-15 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and it has multi-functional effects in a variety of cells in various organs. HGF stimulates DNA synthesis and promotes cell migration and morphogenesis in several cell types including the olfactory system. To characterize the potential mitogeni...

journal_title：Journal of neuroscience research

authors： Yan H,Nie X,Kocsis JD

更新日期：2001-11-15 00:00:00

abstract：:We have determined the localization of Cav1.2 (L-Type) Ca2+ channels in the cells and nerve fibers in molars of normal or injured rats. We observed high levels of immunostaining of L-type Ca2+ channels in odontoblast cell bodies and their processes, in fibroblast cell bodies and in Schwann cells. Many Cav1.2-containin...

journal_title：Journal of neuroscience research

authors： Westenbroek RE,Anderson NL,Byers MR

更新日期：2004-02-01 00:00:00

abstract：:Neurogenesis of heterotopic gray matter in the brain of the microcephalic mouse prenatally exposed to X-rays at embryonic day 13 (E13) was studied immunohistochemically. Bromodeoxyuridine (BrdU) as a marker to label the migrating position of neuroblasts generated at various embryonic stages showed that no "inside-out"...

journal_title：Journal of neuroscience research

authors： Sun XZ,Takahashi S,Fukui Y,Hisano S,Kubota Y,Sato H,Inouye M

更新日期：2001-12-15 00:00:00

abstract：:Cortical or total brain cultures of microglia are commonly used as a model to study the inflammatory processes in Parkinson's disease. Here we characterize microglia cultures from rat ventral midbrain and evaluate their response to zymosan A. We used specific markers of microglia and evaluated the morphology, the phag...

journal_title：Journal of neuroscience research

authors： Cristóvão AC,Saavedra A,Fonseca CP,Campos F,Duarte EP,Baltazar G

更新日期：2010-02-15 00:00:00

abstract：:The induction of heat-shock protein 70 (hsp70) mRNA in the hyperthermic rabbit brain has been examined previously by using Northern blotting and in situ hybridization procedures that measure steady-state levels of mRNA, which may be influenced by transcript stability and transcription rate. In the present investigatio...

journal_title：Journal of neuroscience research

authors： D'Souza CA,Rush SJ,Brown IR

更新日期：1998-06-01 00:00:00

abstract：:Acetylcholinesterase (AChE) molecular forms were studied in normal (NM) and in dystrophic (DM) 129B6F1/J mouse muscle. Successive extractions of the tissue with saline and saline-Triton X-100 buffers yielded two soluble fractions, S1 and S2. Forty percent of the AChE in NM was measured in S1 and 60% in S2, and 65% and...

journal_title：Journal of neuroscience research

authors： Cabezas-Herrera J,Campoy FJ,Vidal CJ

更新日期：1994-08-01 00:00:00

abstract：:The existence of endogenous neural progenitor cells (NPCs) in the adult spinal cord (sc) provides the potential for tailored repair therapies after spinal cord injury (SCI). This study investigates the impact of inflammatory mediators on properties of NPC cultures derived from adult rats after SCI. The Infinite Horizo...

journal_title：Journal of neuroscience research

authors： Knerlich-Lukoschus F,Krossa S,Krause J,Mehdorn HM,Scheidig A,Held-Feindt J

更新日期：2015-04-01 00:00:00

abstract：:Neurotrophic factors regulate the developmental survival and differentiation of specific neuronal populations. Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the nerve growth factor (NGF) protein family, also known as the neurotrophins. Insights into the different roles of neurotroph...

journal_title：Journal of neuroscience research

authors： Escandón E,Burton LE,Szönyi E,Nikolics K

更新日期：1993-04-15 00:00:00

abstract：:The effects of cations on the spontaneous and potassium-stimulated taurine release from mouse cerebral cortex slices were assessed with an emphasis on the as yet unestablished calcium dependence of the stimulated release. Spontaneous and stimulated GABA release was analyzed for comparison. A depolarizing concentration...

journal_title：Journal of neuroscience research

authors： Oja SS,Kontro P

更新日期：1987-01-01 00:00:00

abstract：:The combination of nerve growth factor (NGF) and phorbol 12-myristate 13-acetate (PMA) rapidly induced the locomotion of PC12 cells by sequentially stimulating lamellar spreading, ruffling with pinocytosis, and polarization by retraction from the substratum. During migration, cells acquired long processes as a result ...

journal_title：Journal of neuroscience research

authors： Altun-Gultekin ZF,Wagner JA

更新日期：1996-05-15 00:00:00

abstract：:The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calcu...

journal_title：Journal of neuroscience research

authors： Mayevsky A

更新日期：1975-01-01 00:00:00

abstract：:Oligodendrocytes have a high rate of synthetic activity and produce vast amounts of myelin. The membrane production requires specific sorting and transport processes and structural support. In culture, oligodendrocytes extend flat membranous sheets containing an extensive cytoskeletal network of microtubules (MTs) and...

journal_title：Journal of neuroscience research

authors： Richter-Landsberg C

更新日期：2000-01-01 00:00:00

abstract：:Although they likely involve activation of N-methyl-D-aspartate (NMDA) receptors, the mechanisms giving rise to perinatal hypoxic-ischemic-induced damages remained unclear. The purpose of the present study was to investigate in vivo the mechanisms regulating the glutamate-induced release of toxic hydroxyl radicals (.O...

journal_title：Journal of neuroscience research

authors： Cambonie G,Laplanche L,Kamenka JM,Barbanel G

更新日期：2000-10-01 00:00:00

abstract：:In culture, cerebellar granule neurons die of apoptosis in serum-free media containing a physiologic level of K(+) but survive in a depolarizing concentration of K(+) or when insulin-like growth factor 1 (IGF-1) is added. Both Akt/PKB activation and caspase-3 inhibition were implicated as the underlying neuroprotectiv...

journal_title：Journal of neuroscience research

authors： Zhong J,Deng J,Huang S,Yang X,Lee WH

更新日期：2004-03-15 00:00:00

abstract：:This study was undertaken in order to establish the presence of pluripotential neuroblasts in the developing chick CNS. This has been suggested by our previous observations that expression of emerging neuronal phenotypes in the chick embryo CNS is affected by exposure to neurotrophic substances (i.e., GHRH, SRIF, NGF,...

journal_title：Journal of neuroscience research

authors： Kentroti S,Vernadakis A

更新日期：1995-08-01 00:00:00

abstract：:Production of hydrogen peroxide as a by-product of the breakdown of catecholamines by the enzyme monoamine oxidase (MAO) has been hypothesized to contribute to the increased proclivity of dopaminergic neurons for oxidative injury. We established clonal dopaminergic PC12 cell lines which have elevated MAO activity leve...

journal_title：Journal of neuroscience research

authors： Wei Q,Yeung M,Jurma OP,Andersen JK

更新日期：1996-12-15 00:00:00

abstract：:We have previously shown that myelin-associated glycoprotein (MAG) inhibits neurite growth from a neuronal cell line. In this study we show that 60% of axonal growth cones of postnatal day 1 hippocampal neurons collapsed when they encountered polystyrene beads coated with recombinant MAG (rMAG). Such collapse was not ...

journal_title：Journal of neuroscience research

authors： Li M,Shibata A,Li C,Braun PE,McKerracher L,Roder J,Kater SB,David S

更新日期：1996-11-15 00:00:00

abstract：:The mechanisms by which polyglutamine expansion causes common features of neuronal death remain unclear. Here we describe an approach for delivering polyglutamine expansions directly into cultured sympathetic neurons. Glutamine (Q) residues (n = 10, 22, 30) were conjugated with a peptide possessing translocation prope...

journal_title：Journal of neuroscience research

authors： Suzuki M,Koike T

更新日期：2005-05-15 00:00:00

abstract：:Previous studies have shown that the mechanical wounding of 3-week-old cultured rat astrocytes results in cell proliferation and hypertrophy resembling astrocyte responses to a brain injury in vivo. We now report the effects of basic fibroblast growth factor (bFGF) and an anti-bFGF antibody on astrocyte morphology, pr...

journal_title：Journal of neuroscience research

authors： Hou YJ,Yu AC,Garcia JM,Aotaki-Keen A,Lee YL,Eng LF,Hjelmeland LJ,Menon VK

更新日期：1995-02-15 00:00:00

abstract：:Utilizing a specific polyclonal antibody against a peptide unique for brain-derived neurotrophic factor (BDNF), we investigated the regional and temporal profiles of immunoreactivity of the BDNF protein in the rat hippocampus after transient forebrain ischemia. The pattern of immunoreactivity for the BDNF receptor (Tr...

journal_title：Journal of neuroscience research

authors： Yamasaki Y,Shigeno T,Furukawa Y,Furukawa S

更新日期：1998-08-01 00:00:00

abstract：:We used cDNA arrays to investigate molecular aspects of the differentiation of an immortalized line of oligodendroglial progenitors, and of immunopan-purified primary cultures of oligodendroglial progenitors, to immature oligodendroglia. Developmental regulation of the proteolipid and 2-hydroxyacylsphingosine 1-galact...

journal_title：Journal of neuroscience research

authors： Scarlato M,Beesley J,Pleasure D

更新日期：2000-02-01 00:00:00

abstract：:Primary brain tumors, particularly glioblastomas (GB), remain a challenge for oncology. An element of the malignant brain tumors' aggressive behavior is the fact that GB are among the most densely vascularized tumors. To determine some of the molecular regulations occuring at the brain tumor endothelium level during t...

journal_title：Journal of neuroscience research

authors： Régina A,Jodoin J,Khoueir P,Rolland Y,Berthelet F,Moumdjian R,Fenart L,Cecchelli R,Demeule M,Béliveau R

更新日期：2004-01-15 00:00:00

abstract：:Studies have shown that individuals with both a history of traumatic brain injury and inheritance of apolipoprotein E-4 (ApoE4) allele are associated with a poor neurologic outcome and an increased risk for Alzheimer's disease. We assessed the hypothesis that thrombin released during brain injury causes an increase in...

journal_title：Journal of neuroscience research

authors： Mhatre M,Hensley K,Nguyen A,Grammas P

更新日期：2006-08-01 00:00:00

abstract：:Isatin (indole-2,3-dione) is an endogenous indole that has a distinct and discontinuous distribution in the brain and in other mammalian tissues and body fluids. Its output is increased under conditions of stress and anxiety. Its biological targets remain poorly characterized, although [(3)H]isatin binding sites have ...

journal_title：Journal of neuroscience research

authors： Crumeyrolle-Arias M,Buneeva O,Zgoda V,Kopylov A,Cardona A,Tournaire MC,Pozdnev V,Glover V,Medvedev A

更新日期：2009-09-01 00:00:00

abstract：:Primary cultures of cerebral glia derived from neonatal rat brain were utilized to determine 1) the developmental changes of dolichol-linked oligosaccharide and N-linked glycoprotein biosyntheses, 2) the enzymatic correlates of these developmental changes, and 3) the temporal relations between the biosyntheses of doli...

journal_title：Journal of neuroscience research

authors： Ishii S,Volpe JJ

更新日期：1988-08-01 00:00:00

abstract：:Several neuronal and non-neuronal cell lines express a Ca(2+)-dependent mechanism of transmitter release that can be demonstrated after loading the cells with acetylcholine during culture. In contrast, a particular cell line, the neuroblastoma N18TG-2, was found to be deficient for release. We transfected N18TG-2 cell...

journal_title：Journal of neuroscience research

authors： Falk-Vairant J,Meunier FM,Lesbats B,Corrèges P,Eder-Colli L,Salem N,Synguelakis M,Dunant Y,Israël M

更新日期：1996-08-01 00:00:00