Abstract:
:The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calculated. The results show that in TMO-treated animals the time to the onset of convulsions, the time to the onset of NADH oxidation-reduction cycles, and the survival time were significantly longer than in the control group. The effect of TMO on the EEG shows that the tonic phase of the convulsive activity was almost completely abolished.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Mayevsky Adoi
10.1002/jnr.490010205subject
Has Abstractpub_date
1975-01-01 00:00:00pages
131-42issue
2eissn
0360-4012issn
1097-4547journal_volume
1pub_type
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