Abstract:
:Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FGF (aFGF) expression and CNS cell changes occurring after a chemically induced demyelinating lesion. In a first early period, aFGF immunostaining was shown to decrease around the demyelinated area. A dramatic increase was then observed and was accompanied by an increase of cell density around and inside the lesion. This was correlated with the beginning of remyelination. Late after demyelination, while remyelination was still in progress, aFGF immunostaining of the lesion and unlesioned spinal cord were comparable. A role of aFGF in remyelination is proposed.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Tourbah A,Baron-Van Evercooren A,Oliver L,Raulais D,Jeanny JC,Gumpel Mdoi
10.1002/jnr.490330107keywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
47-59issue
1eissn
0360-4012issn
1097-4547journal_volume
33pub_type
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