Bax phosphorylation association with nucleus and oligomerization after neonatal hypoxia-ischemia.

abstract：:Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift ...

journal_title：Journal of neuroscience research

authors： Wahl P,Nielsen B,Krogsgaard-Larsen P,Hansen JJ,Schousboe A,Miledi R

更新日期：1992-11-01 00:00:00

abstract：:The transplantation of dopaminergic (DA) progenitors derived from pluripotent stem cells improves the behavior of Parkinson's disease model animals. However, the survival of DA progenitors is low, and the final yield of DA neurons is only approximately 0.3%-2% the number of transplanted cells. Zonisamide (ZNS) increas...

journal_title：Journal of neuroscience research

authors： Miyawaki Y,Samata B,Kikuchi T,Nishimura K,Takahashi J

更新日期：2020-08-01 00:00:00

abstract：:In the rat brain, a heteromeric association between adenosine A(1) and purinergic P2Y(1) receptors has been demonstrated. It is suggested that this association plays an important role in the control of purine-mediated responses during pathophysiological conditions. Recently, we have demonstrated that these receptors c...

journal_title：Journal of neuroscience research

authors： Tonazzini I,Trincavelli ML,Montali M,Martini C

更新日期：2008-10-01 00:00:00

abstract：:Amyloid beta-peptide (A beta) likely causes functional alterations in neurons well prior to their death. Nuclear factor-kappaB (NF-kappaB), a transcription factor that is known to play important roles in cell survival and apoptosis, has been shown to be modulated by A beta in neurons and glia, but the mechanism is unk...

journal_title：Journal of neuroscience research

authors： Kawamoto EM,Lepsch LB,Boaventura MF,Munhoz CD,Lima LS,Yshii LM,Avellar MC,Curi R,Mattson MP,Scavone C

更新日期：2008-03-01 00:00:00

abstract：:Neural precursor cells, including neural stem and progenitor cells, in the subventricular zone (SVZ) are the main targets for cytomegalovirus (CMV) infection in developing brains. The neural precursor cells in the SVZ of the adult brain have been reported to respond by proliferating after infusion with epidermal growt...

journal_title：Journal of neuroscience research

authors： Han GP,Li L,Kosugi I,Kawasaki H,Tsuchida T,Miura K,Tsutsui Y

更新日期：2007-10-01 00:00:00

abstract：:Neuronal progenitors in the adult hippocampus continually proliferate and differentiate to the neuronal lineage, and ischemic insult promotes hippocampal neurogenesis. However, newborn neurons show a progressive reduction in numbers during the initial few weeks, therefore, enhanced survival of newborn neurons seems to...

journal_title：Journal of neuroscience research

authors： Sasaki T,Kitagawa K,Yagita Y,Sugiura S,Omura-Matsuoka E,Tanaka S,Matsushita K,Okano H,Tsujimoto Y,Hori M

更新日期：2006-11-01 00:00:00

abstract：:We here reconsider current theories of neural ensembles in the context of recent discoveries about neuronal dendritic physiology. The key physiological observation is that the dendritic plateau potential produces sustained depolarization of the cell body (amplitude 10-20 mV, duration 200-500 ms). Our central hypothesi...

journal_title：Journal of neuroscience research

authors： Antic SD,Hines M,Lytton WW

更新日期：2018-09-01 00:00:00

abstract：:The brain is both central in orchestrating the response to stress, and, a very sensitive target when such response is not controlled. In fact, stress has long been associated with the onset and/or exacerbation of several neuropsychiatric disorders such as anxiety, depression, and drug addiction. The hippocampus is a k...

journal_title：Journal of neuroscience research

authors： Alviña K,Jodeiri Farshbaf M,Mondal AK

更新日期：2021-01-01 00:00:00

abstract：:The actions of endogenous opioids and nociceptin/orphanin FQ are mediated by four homologous G protein-coupled receptors that constitute the opioid receptor family. However, little is known about opioid systems in cyclostomes (living jawless fish) and how opioid systems might have evolved from invertebrates. Here, we ...

journal_title：Journal of neuroscience research

authors： Huang AY,Taylor AMW,Ghogha A,Pribadi M,Wang Q,Kim TSJ,Cahill CM,Coppola G,Evans CJ

更新日期：2020-08-23 00:00:00

abstract：:A link between aluminum (Al) exposure and age-related neurological disorders has long been proposed. Although the exact mechanism by which the metal may influence disease processes is unknown, there is evidence that exposure to Al causes an increase in both oxidative stress and inflammatory events. These processes hav...

journal_title：Journal of neuroscience research

authors： Campbell A,Becaria A,Lahiri DK,Sharman K,Bondy SC

更新日期：2004-02-15 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of unknown etiology. Both genetic-susceptibility and environment exposures, including vitamin D deficiency, Epstein-Barr viral and Herpesvirus (HHV-6) infections are strongly implicated in the activation of T cells and MS-pathogenesis. Despite precis...

journal_title：Journal of neuroscience research

authors： Tiwari S,Lapierre J,Ojha CR,Martins K,Parira T,Dutta RK,Caobi A,Garbinski L,Ceyhan Y,Esteban-Lopez M,El-Hage N

更新日期：2018-12-01 00:00:00

abstract：:The recent recognition that the p75 neurotrophin receptor, p75((NTR)), can induce apoptotic signals has contributed to the perception that it acts primarily as a death receptor. Although the molecular mechanisms of p75(NTR) signaling remain to be fully characterized, many of the currently identified pathways activated...

journal_title：Journal of neuroscience research

authors： Dobrowsky RT,Carter BD

更新日期：2000-08-01 00:00:00

abstract：:The effects of hyposmotic conditions on taurine uptake and release were studied in mice cultured cerebellar granule cells. The effect of DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonate) and of the divalent cations Mg++ and Mn++ on the hyposmolarity-induced changes in these parameters was investigated. Mg++ (20 mM...

journal_title：Journal of neuroscience research

authors： Schousboe A,Sánchez Olea R,Morán J,Pasantes-Morales H

更新日期：1991-12-01 00:00:00

abstract：:Efficient functioning of maintenance and repair processes seem to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, under control of several genes termed vitagenes. These include members of the heat shock protein system,...

journal_title：Journal of neuroscience research

authors： Calabrese V,Ravagna A,Colombrita C,Scapagnini G,Guagliano E,Calvani M,Butterfield DA,Giuffrida Stella AM

更新日期：2005-02-15 00:00:00

abstract：:The effects of exogenous GM1 and GD1a on S20Y murine neuroblastoma cells were assessed by monitoring morphology, tumorigenicity, mitotic index, and plating efficiency. S20Y cells were seeded at a density equivalent to 5 X 10(4) cells per 35-mm tissue culture dish; 38-42 hr after seeding (preconfluent stage) the cells ...

journal_title：Journal of neuroscience research

authors： Carine K,Schengrund CL

更新日期：1984-01-01 00:00:00

abstract：:Larval acetylcholinesterase (acetylcholine acetylhydrolase) EC 3.1.3.7 of the trematode Schistosoma mansoni was characterized and purified by affinity chromatography. The enzyme was solubilized from sonicated cercarial tissue and showed a Km value of 1.83 mM and a Vmax value of 102 U/mg protein. It was characterized a...

journal_title：Journal of neuroscience research

authors： Goldlust A,Arnon R,Silman I,Tarrab-Hazdai R

更新日期：1986-01-01 00:00:00

abstract：:Accumulation of beta-amyloid protein (Abeta) in the brain is a hallmark of Alzheimer's disease (AD), and Abeta-mediated pathogenesis could result from increased production of Abeta or insufficient Abeta clearance by microglia, astrocytes, or the vascular system. Cell-surface receptors, such as scavenger receptors, mig...

journal_title：Journal of neuroscience research

authors： Nakamura K,Ohya W,Funakoshi H,Sakaguchi G,Kato A,Takeda M,Kudo T,Nakamura T

更新日期：2006-09-01 00:00:00

abstract：:Astroglial participation in the regional differences of vulnerability to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-induced neurodegeneration was investigated in the rat hippocampus and medial septum using L-alpha-aminoadipate (alpha-AA) as a specific astroglial toxin. alpha-AA was microinjected i...

journal_title：Journal of neuroscience research

authors： Rodríguez MJ,Martínez-Sánchez M,Bernal F,Mahy N

更新日期：2004-08-01 00:00:00

abstract：:The medial prefrontal cortex (mPFC) is critical for selecting and shaping complex behavioral responses. In rodent models of neuropathic pain there is evidence for both structural and functional changes in the mPFC. Brain derived neurotrophic factor (BDNF) plays a critical role in the normal functioning of the mPFC. It...

journal_title：Journal of neuroscience research

authors： Kang JWM,Keay KA,Mor D

更新日期：2017-12-01 00:00:00

abstract：:Multiple neurodegenerative disorders are associated with altered mitochondrial bioenergetics. Although mitochondrial O(2) consumption is frequently measured in isolated mitochondria, isolated synaptic nerve terminals (synaptosomes), or cultured cells, the absence of mature brain circuitry is a remaining limitation. He...

journal_title：Journal of neuroscience research

authors： Schuh RA,Clerc P,Hwang H,Mehrabian Z,Bittman K,Chen H,Polster BM

更新日期：2011-12-01 00:00:00

abstract：:Traditionally, the sources of guidance cues for dendritic outgrowth are mainly associated with external bodies (A) rather than with the same neuron from which dendrites originate (B). To quantify the relationship between factors A and B as determinants of the adult dendritic shape, the morphology of 83 intracellularly...

journal_title：Journal of neuroscience research

authors： Samsonovich AV,Ascoli GA

更新日期：2003-01-15 00:00:00

abstract：:The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...

journal_title：Journal of neuroscience research

authors： Cheng CM,Cohen M,Tseng V,Bondy CA

更新日期：2001-05-15 00:00:00

abstract：:Localization of acetylcholine receptors (AChRs) to the postsynaptic region of muscle is mediated in part by transcriptional mechanisms, because the genes encoding AChR subunits are transcribed selectively in synaptic myofiber nuclei. Neuregulin-1 (NRG-1) is a synaptic signal and induces transcription of AChRs in muscl...

journal_title：Journal of neuroscience research

authors： Herndon CA,Fromm L

更新日期：2008-04-01 00:00:00

abstract：:The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA bindi...

journal_title：Journal of neuroscience research

authors： Zang J,Lu D,Xu A

更新日期：2020-01-01 00:00:00

abstract：:Inhibitors of differentiation (Id) play an essential role in the neurogenesis of the central nervous system. However, the expression and function of Id in the development of cochlear sensory epithelial cells have yet to be elucidated. In this study, we demonstrate the Id1 gene was expressed in the rapidly growing otoc...

journal_title：Journal of neuroscience research

authors： Ozeki M,Hamajima Y,Feng L,Ondrey FG,Schlentz E,Lin J

更新日期：2007-02-15 00:00:00

abstract：:Chloride efflux is known to be involved in the progression of apoptosis in various cell types. We have recently shown that the volume-sensitive outwardly rectifying (VSOR) anion channel serves as the pathway for apoptotic chloride efflux in some cells. In the present study, we tested the neuroprotective effects of dru...

journal_title：Journal of neuroscience research

authors： Inoue H,Ohtaki H,Nakamachi T,Shioda S,Okada Y

更新日期：2007-05-15 00:00:00

abstract：:Although upregulation of ryanodine receptor (RyR)-1 and -2 is mediated through the activation of dopamine D1 receptors (D1DRs) in the development of psychostimulant-induced place preference, little is known about how such increased expressions of RyRs are negatively regulated. This study investigated negative regulato...

journal_title：Journal of neuroscience research

authors： Kurokawa K,Mizuno K,Ohkuma S

更新日期：2012-08-01 00:00:00

abstract：:The use of progesterone following brain injury has a controversial history. On one hand, some lab-based models have showed progesterone as being neuroprotective, but on the other, clinical trials have showed quite the opposite. One of many complaints that arose from this discrepancy was the lack of a diverse pool of a...

journal_title：Journal of neuroscience research

authors： Blackshear K,Giessner S,Hayden JP,Duncan KA

更新日期：2018-04-01 00:00:00

abstract：:Cranial idiopathic acute peripheral facial nerve paralysis (Bell palsy) has been used as a model disease in the present study mainly to investigate trophic capacity of serum components. The ability to induce sprouting from chick embryo dorsal root ganglia was used as the bioassay for trophic activity. Sera from normal...

journal_title：Journal of neuroscience research

authors： Aviel A,Schwartz M

更新日期：1983-01-01 00:00:00

abstract：:The extension of filopodia from growth cones of regenerating neurites from rat superior cervical ganglion neurons in tissue culture was studied. Cultures were grown on a thin layer of fibrous collagen and maintained in a medium containing serum and nerve growth factor. Time-lapse cinematography and computer-assisted m...

journal_title：Journal of neuroscience research

authors： Argiro V,Bunge MB,Johnson MI

更新日期：1985-01-01 00:00:00