Abstract:
:The brain is both central in orchestrating the response to stress, and, a very sensitive target when such response is not controlled. In fact, stress has long been associated with the onset and/or exacerbation of several neuropsychiatric disorders such as anxiety, depression, and drug addiction. The hippocampus is a key brain region involved in the response to stress, not only due to its anatomical connections with the hypothalamic-pituitary-adrenal axis but also as a major target of stress mediators. The hippocampal dentate gyrus (DG)-CA3 circuit, composed of DG granule cells axons (mossy fibers) synapsing onto CA3 pyramidal cells, plays an essential role in memory encoding and retrieval, functions that are vulnerable to stress. Although naturally excitatory, this circuit is under the inhibitory control of GABAergic interneurons that maintain the excitation/inhibition balance. One subgroup of such interneurons produces neuropeptide Y (NPY), which has emerged as a promising endogenous stress "resilience molecule" due to its anxiolytic and anti-epileptic properties. Here we examine existing evidence that reveals a potential role for hilar NPY+ interneurons in mediating stress-induced changes in hippocampal function. We will focus specifically on rodent models of early life stress (ELS), defined as adverse conditions during the early postnatal period that can have profound consequences for neurodevelopment. Collectively, these findings suggest that the long-lasting effects of ELS might stem from the loss of GABAergic NPY+ cells, which then can lead to reduced inhibition in the DG-CA3 pathway. Such change might then lead to hyperexcitability and concomitant hippocampal-dependent behavioral deficits.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Alviña K,Jodeiri Farshbaf M,Mondal AKdoi
10.1002/jnr.24614subject
Has Abstractpub_date
2021-01-01 00:00:00pages
57-66issue
1eissn
0360-4012issn
1097-4547journal_volume
99pub_type
杂志文章,评审abstract::The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490190311
更新日期:1988-03-01 00:00:00
abstract::To study the influence of cell surface-associated molecules on intercellular communication, C6 glioma cells were cultured both on plastic and on substrata of paraformaldehyde-fixed B104 neuroblastoma cells. By then comparing the phenotypic expression of these "cocultured" C6 cells with cells cultured on tissue culture...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490070403
更新日期:1982-01-01 00:00:00
abstract::The extracellular matrix surrounds different neuronal compartments in the mature nervous system. In a variety of vertebrates, most brain regions are loaded with a distinct type of extracellular matrix around the somatodendritic part of neurons, termed perineuronal nets. The present study reports that chondrotin sulfat...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22761
更新日期:2012-02-01 00:00:00
abstract::The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390506
更新日期:1994-12-01 00:00:00
abstract::The activation of cellular inflammatory response is tightly linked to induced production of reactive oxygen species (ROS) and nitric oxide (NO), which in turn have been identified as important regulators of cellular iron metabolism. In the present study, we have used the microglia cell line BV-2 and the neuroblastoma ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21005
更新日期:2006-10-01 00:00:00
abstract::Interleukin-1beta has been demonstrated in neurons of the rat hypothalamus, including cells of the magnocellular neurosecretory system and tuberoinfundibular system (Lechan et al., [1990] Brain Res. 514:135-140). Despite its potential importance to regulation of neuroendocrine function, however, neither the specific c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000515)60:4<478::AID-JNR
更新日期:2000-05-15 00:00:00
abstract::The interleukin (IL)-15-dependent immune responses of murine microglia were strongly affected by low concentrations of the ganglioside GD3. The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20777
更新日期:2006-04-01 00:00:00
abstract::Intact synaptosomes prepared from 28-day-old rat brains were incubated with CMP-N-acetyl-(14C) neuraminic acid in Krebs-Henseleit buffer in an atmosphere of 95% O2: 5% CO2, at 37 degrees C. The activity of CMP-NANA:ganglioside sialosyltransferase using endogenous acceptors was 0.84 pmoles NANA transferred/mg synaptoso...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180312
更新日期:1987-01-01 00:00:00
abstract::Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22407
更新日期:2010-08-15 00:00:00
abstract::We investigated by (13)C nuclear magnetic resonance (NMR) the mechanisms underlying Li(+) effects on glutamatergic and GABAergic neurotransmission systems in the adult rat brain and in primary cultures of cortical neurons and astrocytes during the metabolism of (1-(13)C) glucose or (2-(13)C) acetate. Adult male rats r...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21900
更新日期:2009-03-01 00:00:00
abstract::Although increased neurogenesis has been described in rodent models of focal traumatic brain injury (TBI), the neurogenic response occurring after diffuse TBI uncomplicated by focal injury has not been examined to date, despite the pervasiveness of this distinct type of brain injury in the TBI patient population. Here...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22635
更新日期:2011-07-01 00:00:00
abstract::Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC zeta activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC zeta. Inhibit...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990201)55:3<293::AID-JNR
更新日期:1999-02-01 00:00:00
abstract::The medial prefrontal cortex (mPFC) is critical for selecting and shaping complex behavioral responses. In rodent models of neuropathic pain there is evidence for both structural and functional changes in the mPFC. Brain derived neurotrophic factor (BDNF) plays a critical role in the normal functioning of the mPFC. It...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24095
更新日期:2017-12-01 00:00:00
abstract::The number of older people who are suffering from memory impairment is increasing among populations throughout the world. Alzheimer's disease (AD) affects about 5% of people over 65 years old. The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage in the early stages of AD. ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23319
更新日期:2014-04-01 00:00:00
abstract::Amyotrophic lateral sclerosis is an age-related neurological disease, characterized by neurofilament (NF) accumulation in primary axons followed by degeneration of motor neurons. To elucidate age-related factors that might lead to pathological NF accumulation, NFs were compared between young and aged rats. Electron mi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-10-15 00:00:00
abstract::Parallel corticostriatonigral circuits have been proposed that separately process motor, cognitive, and emotional-motivational information. Functional integration requires that interactions exist between neurons participating in these circuits. This makes it imperative to study the complex anatomical substrate underly...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24242
更新日期:2018-09-01 00:00:00
abstract::Using morphological, immunocytochemical, and functional parameters we have previously shown that highly purified adult rat microglial cells undergo a process of "activation" when cultured in a serum-containing medium in the absence of added proinflammatory substances or other factors (Slepko and Levi: Glia 16:241-246,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(sici)1097-4547(19970801)49:3<292::aid-jnr
更新日期:1997-08-01 00:00:00
abstract::Although it has been well established that the drug efflux pump P-glycoprotein (P-gp) protects the brain against the entry of cytotoxic drugs, its real in situ localization, i.e., at brain capillary endothelial cells or on astrocyte foot processes, is still controversial. The aim of this study was to compare the expre...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000601)60:5<594::AID-JNR
更新日期:2000-06-01 00:00:00
abstract::New neurons are continuously generated throughout life in the subgranular zone in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles. With the aid of new methodologies, significant progress has been made in the characterization of endogenous stem cells (ependymal ce...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23480
更新日期:2015-03-01 00:00:00
abstract::Calpains and cathepsins are two families of proteases that play an important role in ischemic cell death. In this study, we investigated the effect of E64d, a mu-calpain and cathepsin B inhibitor, in the prevention of neuronal and endothelial apoptotic cell death after focal cerebral ischemia in rats. Rats underwent 2...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20977
更新日期:2006-09-01 00:00:00
abstract::Axonal injury is often characterized by axonal transport defects and abnormal accumulation of intra-axonal components. Nitric oxide (NO) has a key role in mediating inflammatory axonopathy in many neurodegenerative diseases, but little is known about how nitrosative/oxidative stress affects axonal transport or whether...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23556
更新日期:2015-06-01 00:00:00
abstract::The expression of different muscarinic receptor subtypes was analyzed in immature Schwann cells obtained from sciatic nerve of 2-day neonatal rats. By using RT-PCR analysis, we demonstrated the presence of M1, M2, M3, and M4 receptor subtypes in cultured Schwann cells, with M2 displaying the highest expression levels....
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20874
更新日期:2006-07-01 00:00:00
abstract::Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Glioma cells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21757
更新日期:2008-11-01 00:00:00
abstract::Identification of behavioral loci through complex trait mapping remains a widely employed approach but suffers from poor gene localization and low replicability. Genome-tagged mice (GTMs) are overlapping sets of congenic strains spanning the whole genome and offer the possibilities of superior mapping power and reprod...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10765
更新日期:2003-11-15 00:00:00
abstract::Cytomegalovirus (CMV) is a major cause of congenital brain disease, and its neuropathogenesis may be related to viral infection of rapidly dividing, susceptible neural precursor cells (NPCs). In the present study, we evaluated the susceptibility of human fetal brain-derived NPCs (nestin(+), A2B5(+), CD133(+)) to infec...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20682
更新日期:2005-12-15 00:00:00
abstract::A growing body of evidence suggests that neurotrophins (NTs) play a critical role in synaptic plasticity and other activity dependent processes in the CNS. Release of these growth factors by neurons and neuroendocrine cells was recently shown to occur via the regulated secretory pathway, representing a possible mechan...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980215)51:4<463::AID-JNR
更新日期:1998-02-15 00:00:00
abstract::We studied the postischemic alterations of second messenger and receptor systems focusing on the strionigral pathway in order to clarify the mechanism of the delayed neuronal changes in remote areas of the rat brain after transient focal ischemia. Chronological changes of [3H]forskolin and [3H]SCH 23390 binding sites ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330315
更新日期:1992-11-01 00:00:00
abstract::Spinocerebellar ataxia type 1 (SCA1) is a devastating neurodegenerative disorder in which an abnormally expanded polyglutamine tract is inserted into causative ataxin-1 proteins. We have previously shown that SCA1 knockin (SCA1-KI) mice over 6 months of age exhibit a degeneration of motor neuron axons and their encasi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23698
更新日期:2016-03-01 00:00:00
abstract::This Review describes the current status of poststroke epilepsy (PSE) with an emphasis on poststroke epileptogenesis modeling for testing new therapeutic agents. Stroke is a leading cause of epilepsy in an aging population. Late-onset "epileptic" seizures have been reported in up to 30% cases after stroke. Nevertheles...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23836
更新日期:2017-04-01 00:00:00
abstract::Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein ex...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24275
更新日期:2018-10-01 00:00:00