Interleukin-1beta immunoreactivity in identified neurons of the rat magnocellular neurosecretory system: evidence for activity-dependent release.

abstract：:NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and...

journal_title：Journal of neuroscience research

authors： Kong X,Yuan Z,Cheng J

更新日期：2017-08-01 00:00:00

abstract：:Increase of intracellular [Ca(2+)] evoked by action potentials in a cell can induce long-term synaptic plasticity even without concomitant presynaptic stimulation. We used optical recording of the fluorescence of a Ca(2+)-indicator Oregon Green to investigate whether differences in results obtained with modifications ...

journal_title：Journal of neuroscience research

authors： Balaban P,Chistiakova M,Malyshev A,Volgushev M

更新日期：2004-05-15 00:00:00

abstract：:Cultures of dissociated hypothalamic cells taken from rat fetuses of 19 days of gestation were studied using time-lapse recording and sequential microphotography from 1 to 5 days in vitro (DIV) and at 7 and 21 DIV. Cultures were seeded with cells taken from fetuses grouped by sex or sexually mixed; experimental cultur...

journal_title：Journal of neuroscience research

authors： Díaz H,Lorenzo A,Carrer HF,Cáceres A

更新日期：1992-10-01 00:00:00

abstract：:It has been postulated that cellular glutamate is released into the extracellular fluid when the energy supply of the brain is compromised (i.e., anoxia or oxygen/glucose deprivation), and there the amino acid triggers the so-called excitotoxic cascade, causing neuronal death. Several mechanisms for this release have ...

journal_title：Journal of neuroscience research

authors： Martín ME,Muñoz FM,Dickinson DA,Forman HJ,Martín del Río R,Salinas M,Fando JL

更新日期：2005-10-01 00:00:00

abstract：:Perinatal hypoxia is a major cause of neurodevelopmental deficits. Neuronal migration patterns are particularly sensitive to perinatal hypoxia/ischemia and are associated with the clinical deficits. The rat model of hypoxia/ischemia at P7 mimics that of perinatal injury in humans. Before assessing the effects of postn...

journal_title：Journal of neuroscience research

authors： Bockhorst KH,Narayana PA,Liu R,Ahobila-Vijjula P,Ramu J,Kamel M,Wosik J,Bockhorst T,Hahn K,Hasan KM,Perez-Polo JR

更新日期：2008-05-15 00:00:00

abstract：:The non-receptor protein tyrosine kinase Fyn, which is a member of the Src family of kinases, has been shown to be essential for normal myelination and has been suggested to play a role in oligodendrocyte development. However, oligodendrocyte development has not been studied directly in cells lacking Fyn. Additionally...

journal_title：Journal of neuroscience research

authors： Sperber BR,McMorris FA

更新日期：2001-02-15 00:00:00

abstract：:Glutamate is an important regulator of dendrite development; however, during cerebral ischemia, massive glutamate release can lead to neurodegeneration and death. An early consequence of glutamate excitotoxicity is dendrite injury, which often precedes cell death. We examined the effect of glutamate on dendrite growth...

journal_title：Journal of neuroscience research

authors： Monnerie H,Shashidhara S,Le Roux PD

更新日期：2003-12-01 00:00:00

abstract：:Transplanting neural stem cells (NSC) to the damaged brain has been regarded as a potential treatment for neurodegenerative diseases such as Alzheimer's disease (AD), a condition characterized by memory loss. We hypothesized that transplantation of NSC into the hippocampal regions of APP + PS1 transgenic (Tg) mice, a ...

journal_title：Journal of neuroscience research

authors： Zhang W,Wang GM,Wang PJ,Zhang Q,Sha SH

更新日期：2014-02-01 00:00:00

abstract：:Protein kinase C (PKC) and its potential role in myelin gene expression were investigated in primary cultured rat oligodendrocytes. The major myelin genes were expressed in a developmentally coordinated manner in cultured oligodendrocytes. PKC activity in these cells was similarly regulated with differential expressio...

journal_title：Journal of neuroscience research

authors： Asotra K,Macklin WB

更新日期：1993-04-01 00:00:00

abstract：:Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an endogenous ligand for the NOP receptor, ample evidence has revealed unique functional profiles of the N/OFQ-NOP receptor system. NOP receptors are expressed in key neural substrates involved in pain and reward modulation. In nonhuma...

journal_title：Journal of neuroscience research

authors： Kiguchi N,Ding H,Ko MC

更新日期：2020-04-07 00:00:00

abstract：:The objective of the present investigation was to answer the following question: Does the visual cortex affect the neuronal firing of retinal ganglion cells in the rat? To test this hypothesis, the visual cortex was inactivated by a reversible cryoblockade. Action potentials of a ganglion cell were recorded from its a...

journal_title：Journal of neuroscience research

authors： Molotchnikoff S,Tremblay F

更新日期：1983-01-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 causes neuronal cell death; however, the molecular mechanisms of the neurotoxic effect remain largely unresolved. It has been suggested that gp120 evokes cell death by inducing the release of neurotoxins, including glutamate. The objective of this work...

journal_title：Journal of neuroscience research

authors： Bachis A,Mocchetti I

更新日期：2004-01-01 00:00:00

abstract：:The thyroid hormones triiodothyronine (T3) and L-thyroxine appear to enhance regeneration in the peripheral and central nervous system (CNS). The following experiments examine possible metabolic substrates for the action of T3 on the adult rat CNS after spinal hemisection. The protein incorporation of (3H)lysine after...

journal_title：Journal of neuroscience research

authors： Wells MR,Lofton SA,Bernstein JJ

更新日期：1981-01-01 00:00:00

abstract：:Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...

journal_title：Journal of neuroscience research

authors： Mioduszewska B,Jaworski J,Szklarczyk AW,Klejman A,Kaczmarek L

更新日期：2008-01-01 00:00:00

abstract：:Precursor cells of the adult mouse subventricular zone (SVZ) are mobilized and recruited by a lysolecithin (LPC)-induced demyelination of the corpus callosum. Because age decreases the proliferation of the SVZ neural precursors as well as the potential for myelin repair of the adult central nervous system, we have com...

journal_title：Journal of neuroscience research

authors： Decker L,Picard-Riera N,Lachapelle F,Baron-Van Evercooren A

更新日期：2002-09-15 00:00:00

abstract：:Thymocyte differentiation antigen-1 (Thy-1) is a cell surface glycoprotein found on T cells and neurons and is involved in cell-to-cell interactions. In addition, Thy-1 knockouts (KO) are a potential mouse model of restless legs syndrome (RLS) based on clinical observations and the role of dopamine in the disease. In ...

journal_title：Journal of neuroscience research

authors： Carkaci-Salli N,Battula S,Wang X,Connor JR,Vrana KE

更新日期：2012-08-01 00:00:00

abstract：:5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria. We have demonstrated recently that 5-hydroxyoxindole is an endogenous compound in blood and tissues of mammals, including humans. To date, 5-hydroxyoxindole's role...

journal_title：Journal of neuroscience research

authors： Crumeyrolle-Arias M,Tournaire MC,Rabot S,Malpaux B,Thiéry JC

更新日期：2008-01-01 00:00:00

abstract：:We have performed proteomic analysis in the cerebrospinal fluid in an animal model of Parkinson's disease induced by axotomy of the medial forebrain bundle. In this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in the substantia nigra and a loss...

journal_title：Journal of neuroscience research

authors： Rite I,Argüelles S,Venero JL,García-Rodriguez S,Ayala A,Cano J,Machado A

更新日期：2007-12-01 00:00:00

abstract：:Target ablation by olfactory bulbectomy synchronizes the degenerative cell death of olfactory receptor neurons (ORNs), infiltration of macrophages, and proliferation of progenitor cells, leading to neurogenesis, ORN replacement, and regeneration of the sensory epithelium. Although macrophages participate in the degene...

journal_title：Journal of neuroscience research

authors： Getchell TV,Subhedar NK,Shah DS,Hackley G,Partin JV,Sen G,Getchell ML

更新日期：2002-12-15 00:00:00

abstract：:The location of glyoxylate-complex molecules has been investigated in several areas of the rat cerebral cortex using the immunohistochemical peroxidase-antiperoxidase (PAP) method. Antibodies against glyoxylate-complex molecules have been developed in the rabbit after immunization with a glyoxylate-bovine serum albumi...

journal_title：Journal of neuroscience research

authors： Martínez-Rodríguez R,Alonso MJ,De Miguel E,Gómez de Segura I,Gómez-Aguado F,Picazo A,Corcuera MT,Alvarez MI,Toledano A

更新日期：1998-01-15 00:00:00

abstract：:Cranial idiopathic acute peripheral facial nerve paralysis (Bell palsy) has been used as a model disease in the present study mainly to investigate trophic capacity of serum components. The ability to induce sprouting from chick embryo dorsal root ganglia was used as the bioassay for trophic activity. Sera from normal...

journal_title：Journal of neuroscience research

authors： Aviel A,Schwartz M

更新日期：1983-01-01 00:00:00

abstract：:The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...

journal_title：Journal of neuroscience research

authors： Avale ME,Nemirovsky SI,Raisman-Vozari R,Rubinstein M

更新日期：2004-10-15 00:00:00

abstract：:Production of hydrogen peroxide as a by-product of the breakdown of catecholamines by the enzyme monoamine oxidase (MAO) has been hypothesized to contribute to the increased proclivity of dopaminergic neurons for oxidative injury. We established clonal dopaminergic PC12 cell lines which have elevated MAO activity leve...

journal_title：Journal of neuroscience research

authors： Wei Q,Yeung M,Jurma OP,Andersen JK

更新日期：1996-12-15 00:00:00

abstract：:Highly malignant neuroblastoma tumors generally have defects in differentiation and apoptotic pathways. For a better understanding of these events, we use a murine neuroblastoma cell line (NBP2) that terminally differentiates into mature neurons in response to elevated levels of cAMP. Because one of the main downstrea...

journal_title：Journal of neuroscience research

authors： Andreatta CP,Nahreini P,Hanson AJ,Prasad KN

更新日期：2004-11-15 00:00:00

abstract：:The large, medium-sized, and small neurons of the dorsal root ganglion (DRG) have different functions in the processing of various senses. Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN) contribute greatly to neuronal excitability. In the present study, which used whole-cell patch clamp techniques ...

journal_title：Journal of neuroscience research

authors： Tu H,Deng L,Sun Q,Yao L,Han JS,Wan Y

更新日期：2004-06-01 00:00:00

abstract：:The periglomerular cells (PG) of the olfactory bulb (OB) are involved in the primary processing and the refinement of sensory information from the olfactory epithelium. The neurochemical composition of these neurons has been studied in depth in many species, and over the last decades such studies have focused mainly o...

journal_title：Journal of neuroscience research

authors： Baltanás FC,Curto GG,Gómez C,Díaz D,Murias AR,Crespo C,Erdelyi F,Szabó G,Alonso JR,Weruaga E

更新日期：2011-01-01 00:00:00

abstract：:In Alzheimer's disease, Aβ deposits are considered the initial cardinal events that induce tauopathy secondarily. However, the relationship between Aβ amyloidosis and tauopathy has not been determined in detail. We produced double transgenic mice, 2×TgTau(+/-) APP(+/-) , by mating Tg2576 mice that exhibit Aβ amyloidos...

journal_title：Journal of neuroscience research

authors： Seino Y,Kawarabayashi T,Wakasaya Y,Watanabe M,Takamura A,Yamamoto-Watanabe Y,Kurata T,Abe K,Ikeda M,Westaway D,Murakami T,Hyslop PS,Matsubara E,Shoji M

更新日期：2010-12-01 00:00:00

abstract：:Monoclonal antibody J1-31 (MAb J1-31, isotype IgG 2b) was raised against crude homogenate of brain tissue from a multiple sclerosis (MS) patient (autopsy sample; Malhotra et al.: Microbios Letters 26:151-157, 1984). In human brain, MAb J1-31 recognizes an intracellular protein antigen (J1-31 antigen), which bands at a...

journal_title：Journal of neuroscience research

authors： Malhotra SK,Predy R,Johnson ES,Singh R,Leeuw K

更新日期：1989-01-01 00:00:00

abstract：:Although protein kinase Cdk5-p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult ...

journal_title：Journal of neuroscience research

authors： Sato K,Zhu YS,Saito T,Yotsumoto K,Asada A,Hasegawa M,Hisanaga S

更新日期：2007-11-01 00:00:00

abstract：:Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration of leptin, at 10 days after stroke onset, on neurogenesis and angiogenesis after stroke....

journal_title：Journal of neuroscience research

authors： Avraham Y,Dayan M,Lassri V,Vorobiev L,Davidi N,Chernoguz D,Berry E,Leker RR

更新日期：2013-02-01 00:00:00