Abstract:
:The location of glyoxylate-complex molecules has been investigated in several areas of the rat cerebral cortex using the immunohistochemical peroxidase-antiperoxidase (PAP) method. Antibodies against glyoxylate-complex molecules have been developed in the rabbit after immunization with a glyoxylate-bovine serum albumin conjugate. Observations carried out with the light microscope demonstrated positive immunostaining at the membrane level of scattered neurons located in all cortical areas, mainly in cortical layer IV. The striate areas (17, 18, 18a) had both the greatest number of immunopositive neurons and the most intense ones. At the electron microscopic level, it was observed that in the striate areas an immunopositive reaction was located mainly in the periphery of synaptic vesicles of some nerve endings, and in both pre- and postsynaptic membranes of these synaptic structures. The presence of glyoxylic acid and glyoxylate-complex molecules in such areas leads us to suggest that these substances could play an important role in selected synaptic contacts in which some pyramidal and non-pyramidal neurons are involved.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Martínez-Rodríguez R,Alonso MJ,De Miguel E,Gómez de Segura I,Gómez-Aguado F,Picazo A,Corcuera MT,Alvarez MI,Toledano Adoi
10.1002/(SICI)1097-4547(19980115)51:2<268::AID-JNRsubject
Has Abstractpub_date
1998-01-15 00:00:00pages
268-74issue
2eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19980115)51:2<268::AID-JNRjournal_volume
51pub_type
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