An antisense construct reduces N-methyl-D-aspartate receptor 2A expression and receptor-mediated excitotoxicity as determined by a novel flow cytometric approach.

abstract：:The neuroblastoma, N1E-115, was grown for 9 days after subcultivation. The development of acetylcholinestrase (AChE), choline acetyltransferase (CAT), QNB-binding, choline uptake, and acetylcholine release was measured on days 1, 3, 6, and 9. In parallel experiments the irreversible AChE inhibitor soman was added to n...

journal_title：Journal of neuroscience research

authors： Kumar U,Sellström A

更新日期：1990-09-01 00:00:00

abstract：:During late postnatal development, mice with the autosomal recessive wobbler mutation (wr/wr) develop motoneuron degeneration associated with astrogliosis in the spinal cord. In vitro, primary wobbler astrocytes are also affected, exhibiting abnormal cell-cell contacts. To characterize further the wobbler disease, we ...

journal_title：Journal of neuroscience research

authors： Aït-Ikhlef A,Hantaz-Ambroise D,Henderson CE,Rieger F

更新日期：2000-01-01 00:00:00

abstract：:Brain edema accounts for significant morbidity and mortality in many neurologic conditions such as head trauma, stroke, meningitis, and brain tumor. The water channel aquaporin-4 (AQP4) has been found to be an important determinant of brain water accumulation and clearance of excess brain water. We report the developm...

journal_title：Journal of neuroscience research

authors： Thiagarajah JR,Papadopoulos MC,Verkman AS

更新日期：2005-04-15 00:00:00

abstract：:The limited availability and potential to culture primary human brain cells means that there is still a need for cell lines that reliably model human neurons and glial cells. The human-derived NTera2/D1 (NT2) cell line is a promising tool from which both neuronal (NT2N) and astrocytic (NT2A) cells can be derived in vi...

journal_title：Journal of neuroscience research

authors： Goodfellow CE,Graham SE,Dragunow M,Glass M

更新日期：2011-10-01 00:00:00

abstract：:Neuroanatomical studies suggest that neuronal atrophy and destruction occur over the course of many years in neurodegenerative conditions such as schizophrenia and Alzheimer's disease. In schizophrenia, early intervention with atypical neuroleptics such as olanzapine has been shown to prevent development of some of th...

journal_title：Journal of neuroscience research

authors： Wei Z,Bai O,Richardson JS,Mousseau DD,Li XM

更新日期：2003-08-01 00:00:00

abstract：:Diabetes and obesity are characterized by hyperlipidemia and represent risk factors for premature neurological disorders. Diabetic/obese animals have impaired adult neurogenesis. We hypothesize that lipotoxicity leading to neurogenesis impairment plays a role in the development of neurological complications. If so, no...

journal_title：Journal of neuroscience research

authors： Mansouri S,Ortsäter H,Pintor Gallego O,Darsalia V,Sjöholm A,Patrone C

更新日期：2012-04-01 00:00:00

abstract：:Previously, we reported that chelation of intracellular zinc with N, N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN)-induced macromolecule synthesis-dependent apoptosis of cultured cortical neurons. According to the current theory of apoptosis, release of mitochondrial cytochrome C into the cytosol is required...

journal_title：Journal of neuroscience research

authors： Ahn YH,Koh JY,Hong SH

更新日期：2000-09-01 00:00:00

abstract：:Although they likely involve activation of N-methyl-D-aspartate (NMDA) receptors, the mechanisms giving rise to perinatal hypoxic-ischemic-induced damages remained unclear. The purpose of the present study was to investigate in vivo the mechanisms regulating the glutamate-induced release of toxic hydroxyl radicals (.O...

journal_title：Journal of neuroscience research

authors： Cambonie G,Laplanche L,Kamenka JM,Barbanel G

更新日期：2000-10-01 00:00:00

abstract：:We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of ...

journal_title：Journal of neuroscience research

authors： Martin D,Schoenen J,Delrée P,Gilson V,Rogister B,Leprince P,Stevenaert A,Moonen G

更新日期：1992-08-01 00:00:00

abstract：:The effects of phorbol 12-tetradecanoyl-13-acetate (TPA) and dibutyryl cAMP on the glutamate transport present in chick Bergmann glial cell (BGC) cultures were examined. TPA produced a significant decrease in [3H]-D-aspartate uptake, while dibutyryl cAMP treatment elicited a slight reduction in the transport. This eff...

journal_title：Journal of neuroscience research

authors： González MI,Ortega A

更新日期：1997-11-15 00:00:00

abstract：:Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin. HO1 is a stress-inducible protein that protects cells against oxidative injury, ...

journal_title：Journal of neuroscience research

authors： Kitamura Y,Ishida Y,Takata K,Mizutani H,Kakimura J,Inden M,Nakata J,Taniguchi T,Tsukahara T,Akaike A,Shimohama S

更新日期：2003-02-15 00:00:00

abstract：:Glutamine synthetase (GS) activity was used as a marker to examine differences in astrocyte development in mice selectively bred for ethanol sensitivity: long sleep (LS), short sleep (SS), mild ethanol withdrawal (MEW), severe ethanol withdrawal (SEW) and control ethanol withdrawal (CEW). We found that 1) GS activity ...

journal_title：Journal of neuroscience research

authors： Sakellaridis N,Mangoura D,Masserrano JM,Detsis V,Leoni CJ,Deitrich R,Vernadakis A

更新日期：1989-11-01 00:00:00

abstract：:The galactolipids galactocerebroside and sulfatide have been implicated in oligodendrocyte (OL) development and myelin formation. Much of the early evidence for myelin galactolipid function has been derived from antibody and chemical perturbation of OLs in vitro. To determine the role of these lipids in vivo, we previ...

journal_title：Journal of neuroscience research

authors： Shroff SM,Pomicter AD,Chow WN,Fox MA,Colello RJ,Henderson SC,Dupree JL

更新日期：2009-11-15 00:00:00

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:We have previously shown that myelin-associated glycoprotein (MAG) inhibits neurite growth from a neuronal cell line. In this study we show that 60% of axonal growth cones of postnatal day 1 hippocampal neurons collapsed when they encountered polystyrene beads coated with recombinant MAG (rMAG). Such collapse was not ...

journal_title：Journal of neuroscience research

authors： Li M,Shibata A,Li C,Braun PE,McKerracher L,Roder J,Kater SB,David S

更新日期：1996-11-15 00:00:00

abstract：:The inward-rectifier K(+) channel Kir4.1 is responsible for maintaining cochlear homeostasis and restoring neural excitability. The large-conductance calcium-activated K(+) channel (BK(Ca)) plays a key role in phase locking signals in the mammalian inner ear. To evaluate the influence of mitochondrial dysfunction on t...

journal_title：Journal of neuroscience research

authors： Zou J,Zhang Y,Yin S,Wu H,Pyykkö I

更新日期：2009-01-01 00:00:00

abstract：:Monocarboxylate transporters (MCTs) are involved in the uptake and release of lactate, pyruvate, and ketone bodies. Studies of their distribution at both the mRNA and protein levels have highlighted the specific expression of MCT1, MCT2, and more recently MCT4 in the central nervous system. MCT1 was found strongly exp...

journal_title：Journal of neuroscience research

authors： Pellerin L,Bergersen LH,Halestrap AP,Pierre K

更新日期：2005-01-01 00:00:00

abstract：:The large, medium-sized, and small neurons of the dorsal root ganglion (DRG) have different functions in the processing of various senses. Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN) contribute greatly to neuronal excitability. In the present study, which used whole-cell patch clamp techniques ...

journal_title：Journal of neuroscience research

authors： Tu H,Deng L,Sun Q,Yao L,Han JS,Wan Y

更新日期：2004-06-01 00:00:00

abstract：:In this study, the responses of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) activities were quantitatively analyzed at different times in both ipsilateral and contralateral sides of trigeminal nuclei, after unilateral trigeminal muscle nerve transection, i...

journal_title：Journal of neuroscience research

authors： Varathan V,Shigenaga Y,Takemura M

更新日期：2001-11-01 00:00:00

abstract：:Evidence indicates that the ubiquitin-proteasome system and the endoplasmic retculum (ER) quality-control system work in concert to ensure that proteins are correctly folded in the ER and that misfolded proteins are retrotransported to the cytosol for degradation by proteasomes. Dysfunction of either system results in...

journal_title：Journal of neuroscience research

authors： Kuang XL,Liu F,Chen H,Li Y,Liu Y,Xiao J,Shan G,Li M,Snider BJ,Qu J,Barger SW,Wu S

更新日期：2014-10-01 00:00:00

abstract：:In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...

journal_title：Journal of neuroscience research

authors： Becker CG,Becker T

更新日期：2007-09-01 00:00:00

abstract：:Although it has been well established that the drug efflux pump P-glycoprotein (P-gp) protects the brain against the entry of cytotoxic drugs, its real in situ localization, i.e., at brain capillary endothelial cells or on astrocyte foot processes, is still controversial. The aim of this study was to compare the expre...

journal_title：Journal of neuroscience research

authors： Declèves X,Regina A,Laplanche JL,Roux F,Boval B,Launay JM,Scherrmann JM

更新日期：2000-06-01 00:00:00

abstract：:Intracranial atherosclerosis (ICAS) is the most common etiology of ischemic stroke with the highest rate of stroke recurrence. Little is currently known of the association of circulating inflammation-regulatory microRNAs (miRNAs) with ICAS. In this review, we briefly discuss that ICAS is characterized as a dynamic and...

journal_title：Journal of neuroscience research

authors： Li J,Li K,Chen X

更新日期：2019-10-01 00:00:00

abstract：:Molecular cloning has introduced an unexpected, large diversity of neurotransmitter hetero- oligomeric receptors. Extensive research on the molecular structure of the γ-aminobutyric acid receptor (GABAR) has been of great significance for understanding how the nervous system works in both vertebrates and invertebrates...

journal_title：Journal of neuroscience research

authors： Jiménez-Vázquez EN,Díaz-Velásquez CE,Uribe RM,Arias JM,García U

更新日期：2016-02-01 00:00:00

abstract：:Microglia are prominently involved in neural degenerative diseases of the CNS and the retina. In this study, we determined the activation and phagocytotic function of different subtypes of retinal microglial cells at 1 week and 1 month following optic axotomy. Fluorescent DiI crystals were placed at the stumps of the ...

journal_title：Journal of neuroscience research

authors： Zhang C,Tso MO

更新日期：2003-09-15 00:00:00

abstract：:Neural precursor cells, including neural stem and progenitor cells, in the subventricular zone (SVZ) are the main targets for cytomegalovirus (CMV) infection in developing brains. The neural precursor cells in the SVZ of the adult brain have been reported to respond by proliferating after infusion with epidermal growt...

journal_title：Journal of neuroscience research

authors： Han GP,Li L,Kosugi I,Kawasaki H,Tsuchida T,Miura K,Tsutsui Y

更新日期：2007-10-01 00:00:00

abstract：:Spinal cord injury (SCI) triggers chronic intraspinal inflammation consisting of activated resident and infiltrating immune cells (especially microglia/macrophages). The environmental factors contributing to this protracted inflammation are not well understood; however, myelin lipid debris is a hallmark of SCI. Myelin...

journal_title：Journal of neuroscience research

authors： Kopper TJ,Gensel JC

更新日期：2018-06-01 00:00:00

abstract：:Integrins comprise a large family of cell adhesion molecules that mediate interactions between the extracellular environment and the cytoplasm. During the last decade, analysis of the expression and function of these molecules has revealed that integrins regulate many aspects of cell behavior including cell death, pro...

journal_title：Journal of neuroscience research

authors： Milner R,Campbell IL

更新日期：2002-08-01 00:00:00

abstract：:The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...

journal_title：Journal of neuroscience research

authors： Yeh YY

更新日期：1988-03-01 00:00:00

abstract：:Astrocytes are glial cells that are distributed throughout the central nervous system in an arrangement optimal for chemical and physical interaction with neuronal synapses and brain blood supply vessels. Neurotransmission modulates astrocytic excitability by activating an array of cell surface receptors and transport...

journal_title：Journal of neuroscience research

authors： Acosta C,Anderson HD,Anderson CM

更新日期：2017-12-01 00:00:00