Nitric oxide synthase/nicotinamide adenine dinucleotide phosphate-diaphorase in the brainstem trigeminal nuclei after transection of the masseteric nerve in rats.

abstract：:In Alzheimer's disease, Aβ deposits are considered the initial cardinal events that induce tauopathy secondarily. However, the relationship between Aβ amyloidosis and tauopathy has not been determined in detail. We produced double transgenic mice, 2×TgTau(+/-) APP(+/-) , by mating Tg2576 mice that exhibit Aβ amyloidos...

journal_title：Journal of neuroscience research

authors： Seino Y,Kawarabayashi T,Wakasaya Y,Watanabe M,Takamura A,Yamamoto-Watanabe Y,Kurata T,Abe K,Ikeda M,Westaway D,Murakami T,Hyslop PS,Matsubara E,Shoji M

更新日期：2010-12-01 00:00:00

abstract：:The cholinergic neurons of the basal forebrain (CNBF) are the major source of cholinergic innervation of the cortex and hippocampus. In Alzheimer's disease and aged brain, there are severe losses of cholinergic neurons in the nucleus basalis of Meynert, leading to a reduction of cortical cholinergic activity which cor...

journal_title：Journal of neuroscience research

authors： Wörtwein G,Yu J,Toliver-Kinsky T,Perez-Polo JR

更新日期：1998-05-01 00:00:00

abstract：:Fast-scan cyclic voltammetry (FSCV) is an established method for measuring dopamine (DA) levels in the brain in real time. However, it is difficult to discriminate DA from other monoamines such as serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). We report a novel DA-specific biosensor consisting of a car...

journal_title：Journal of neuroscience research

authors： Ishida A,Imamura A,Ueda Y,Shimizu T,Marumoto R,Jung CG,Hida H

更新日期：2018-05-01 00:00:00

abstract：:Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin. HO1 is a stress-inducible protein that protects cells against oxidative injury, ...

journal_title：Journal of neuroscience research

authors： Kitamura Y,Ishida Y,Takata K,Mizutani H,Kakimura J,Inden M,Nakata J,Taniguchi T,Tsukahara T,Akaike A,Shimohama S

更新日期：2003-02-15 00:00:00

abstract：:CD200, a type I transmembrane glycoprotein, can interact with its receptor CD200R, which plays an inhibitory role in the activation of microglia-the resident macrophages of the central nervous system. In this study, the rat C6 glioma cell line (C6-1) that was previously characterized with high in vivo tumorigenicity w...

journal_title：Journal of neuroscience research

authors： Wang CY,Hsieh YT,Fang KM,Yang CS,Tzeng SF

更新日期：2016-12-01 00:00:00

abstract：:Molecular mechanisms which underlie the heat shock response have commonly been analyzed using tissue culture systems, with less investigation of the intact mammal. In tissue culture, a temperature elevation of 5 degrees C is required to activate mammalian heat shock transcription factor 1 (HSF1) to the DNA-binding for...

journal_title：Journal of neuroscience research

authors： Brown IR,Rush SJ

更新日期：1996-04-01 00:00:00

abstract：:The presence of glycosaminoglycans (GAG) has been histochemically demonstrated in the CNS of various mammalian species. They have been related with some nerve functions as neurotransmitters storage and synaptic transmission. In the present paper, the histochemical properties of nerve cell cytoplasmic GAG were studied ...

journal_title：Journal of neuroscience research

authors： Alvarado MV,Castejón HV

更新日期：1984-01-01 00:00:00

abstract：:Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue-derived mesenchymal stem cells (ADMSCs) were intrave...

journal_title：Journal of neuroscience research

authors： Park D,Yang G,Bae DK,Lee SH,Yang YH,Kyung J,Kim D,Choi EK,Choi KC,Kim SU,Kang SK,Ra JC,Kim YB

更新日期：2013-05-01 00:00:00

abstract：:Gap junctions (GJs) are widely distributed in brains across the animal kingdom. To visualize the GJ- coupled networks of two major mechanosensory neurons in the ganglia of medicinal leeches, we injected these cells with the GJ-permeable tracer Neurobiotin. When diffusion time was limited to only 30 min, tracer couplin...

journal_title：Journal of neuroscience research

authors： Segura OM,Abdulnoor L,Hua VV,Solano MJ,Macagno ER,Baker MW

更新日期：2020-06-01 00:00:00

abstract：:Highly malignant neuroblastoma tumors generally have defects in differentiation and apoptotic pathways. For a better understanding of these events, we use a murine neuroblastoma cell line (NBP2) that terminally differentiates into mature neurons in response to elevated levels of cAMP. Because one of the main downstrea...

journal_title：Journal of neuroscience research

authors： Andreatta CP,Nahreini P,Hanson AJ,Prasad KN

更新日期：2004-11-15 00:00:00

abstract：:Although proteins belonging to the sHSP superfamily are diverse in sequence and size, most share characteristic features, including 1) a small molecular mass of 12-43 kDa, 2) a conserved alpha-crystallin domain of 80-100 residues, 3) formation of large oligomers, 4) a dynamic quaternary structure, and 5) induction by ...

journal_title：Journal of neuroscience research

authors： Hu Z,Yang B,Lu W,Zhou W,Zeng L,Li T,Wang X

更新日期：2008-08-01 00:00:00

abstract：:Molecular cloning has introduced an unexpected, large diversity of neurotransmitter hetero- oligomeric receptors. Extensive research on the molecular structure of the γ-aminobutyric acid receptor (GABAR) has been of great significance for understanding how the nervous system works in both vertebrates and invertebrates...

journal_title：Journal of neuroscience research

authors： Jiménez-Vázquez EN,Díaz-Velásquez CE,Uribe RM,Arias JM,García U

更新日期：2016-02-01 00:00:00

abstract：:The N-methyl-D-aspartate receptor (NMDAR) is a major neurotransmitter receptor in the central nervous system (CNS), with functional roles in learning, memory, and sensation. Several mechanisms potentiate NMDARs, and NMDAR hyperexcitability plays pathophysiological roles in many conditions, such as neurodegenerative di...

journal_title：Journal of neuroscience research

authors： Mattar PA,Holmes KD,Dekaban GA

更新日期：2003-12-01 00:00:00

abstract：:Preterm birth and associated brain injury are the primary cause of cerebral palsy and developmental disabilities and are among the most serious global health issues that modern society faces. Current therapy for infants suffering from premature brain injury is still mainly supportive, and there are no effective treatm...

journal_title：Journal of neuroscience research

authors： Peng X,Song J,Li B,Zhu C,Wang X

更新日期：2020-05-01 00:00:00

abstract：:The molecular pathways underlying the neuroprotective effects of preconditioning are promising, potentially drugable targets to promote cell survival. However, these pathways are complex and are not yet fully understood. In this study we have established a paradigm of hypoxic preconditioning based on a chick embryo mo...

journal_title：Journal of neuroscience research

authors： Giusti S,Fiszer de Plazas S

更新日期：2012-02-01 00:00:00

abstract：:An angiotensin 2 type 1 receptor blocker, olmesartan, and a calcium channel blocker, azelnidipine, possess not only an antihypertensive effect but also an antioxidative effect and other beneficial effects. In the present study, we examined the efficacy of olmesartan and azelnidipine monotherapy (2 mg/kg or 10 mg/kg ea...

journal_title：Journal of neuroscience research

authors： Omote Y,Deguchi K,Kono S,Liu W,Kurata T,Hishikawa N,Yamashita T,Ikeda Y,Abe K

更新日期：2014-10-01 00:00:00

abstract：:Fibroblast growth factor 2 (FGF2) exhibits pleiotropic functions during embryogenesis. In neural development, both pro- and antineurogenic activities of FGF2 have been described in the differentiation of neuronal progenitors into postmitotic neurons. We used cultured neural stem cells (NSCs) derived from rat embryonic...

journal_title：Journal of neuroscience research

authors： Tsai RY,Kim S

更新日期：2005-10-15 00:00:00

abstract：:Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...

journal_title：Journal of neuroscience research

authors： Zhou F,Qu L,Lv K,Chen H,Liu J,Liu X,Li Y,Sun X

更新日期：2011-11-01 00:00:00

abstract：:In eukaryotes, mitochondria are critical for cellular bioenergetics and mediating apoptosis. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. However, the role of PGC-1alpha in neuronal a...

journal_title：Journal of neuroscience research

authors： Liang J,Yang Y,Zhu X,Wang X,Chen R

更新日期：2010-07-01 00:00:00

abstract：:Hemin, the oxidized form of heme, is released from hemoglobin after CNS hemorrhage and may contribute to injury to surrounding tissue. The heme oxygenase (HO) enzymes catalyze the breakdown of hemin to biliverdin, carbon monoxide, and ferric iron. Although HO-2, the isoform expressed predominantly in neurons, accelera...

journal_title：Journal of neuroscience research

authors： Chen-Roetling J,Benvenisti-Zarom L,Regan RF

更新日期：2005-12-15 00:00:00

abstract：:Growth hormone (GH) appears to play a major role in a reciprocal axis that has been postulated between the thymus and pituitary glands. Our previous studies showed that thymic structure, as well as T-cell proliferation and IL-2 synthesis, could be restored in aged female Wistar-Furth rats by the implantation of GH3 pi...

journal_title：Journal of neuroscience research

authors： Davila DR,Brief S,Simon J,Hammer RE,Brinster RL,Kelley KW

更新日期：1987-01-01 00:00:00

abstract：:Recent advances in human induced pluripotent stem cells (hiPSCs) offer new possibilities for biomedical research and clinical applications. Differentiated neurons from hiPSCs are expected to be useful for developing novel methods of treatment for various neurological diseases. However, the detailed process of function...

journal_title：Journal of neuroscience research

authors： Ohara Y,Koganezawa N,Yamazaki H,Roppongi RT,Sato K,Sekino Y,Shirao T

更新日期：2015-12-01 00:00:00

abstract：:Previously we reported results of an incubation experiment with neurofilaments that supported the existence of a mu-type of Ca2+-activated neutral protease in the rat peripheral nerve; it was active with microM order Ca2+ (mu-CANP). This time, we partially purified the mu-CANP from a crude CANP fraction of rat periphe...

journal_title：Journal of neuroscience research

authors： Kamakura K,Ishiura S,Sugita H

更新日期：1986-01-01 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:Only a few proteins are known to be exclusively expressed in central nervous system (CNS) myelin. A novel surface membrane protein expressed only in CNS myelin and oligodendrocytes of higher vertebrates has been identified by a monoclonal antibody. This CNS myelin/oligodendrocyte-specific protein, MOSP, has a molecula...

journal_title：Journal of neuroscience research

authors： Dyer CA,Hickey WF,Geisert EE Jr

更新日期：1991-04-01 00:00:00

abstract：:The amygdala contributes to the generation and propagation of epileptiform activity in temporal lobe epilepsy (TLE). Ictal symptoms such as fear, dreamy states (déjà vu, memory flashbacks, experiential hallucinations), epigastric auras, or sympathetic outflow with cardiovascular changes are often linked to a seizure f...

journal_title：Journal of neuroscience research

authors： Yilmazer-Hanke D,O'Loughlin E,McDermott K

更新日期：2016-06-01 00:00:00

abstract：:Polyglutamine (polyQ) aggregate bodies are a hallmark of dentatorubral-pallidoluysian atrophy and related neurodegenerative disorders, although the relationship between aggregate body formation and cell death is not clear. We analyzed the kinetics of polyQ aggregate formation and the time intervals for cell death, tra...

journal_title：Journal of neuroscience research

authors： Toyoshima I,Sugawara M,Kato K,Wada C,Shimohata T,Koide R,Onodera O,Tsuji S

更新日期：2002-05-15 00:00:00

abstract：:Neurogenesis of heterotopic gray matter in the brain of the microcephalic mouse prenatally exposed to X-rays at embryonic day 13 (E13) was studied immunohistochemically. Bromodeoxyuridine (BrdU) as a marker to label the migrating position of neuroblasts generated at various embryonic stages showed that no "inside-out"...

journal_title：Journal of neuroscience research

authors： Sun XZ,Takahashi S,Fukui Y,Hisano S,Kubota Y,Sato H,Inouye M

更新日期：2001-12-15 00:00:00

abstract：:Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression...

journal_title：Journal of neuroscience research

authors： Bränn E,Fransson E,White RA,Papadopoulos FC,Edvinsson Å,Kamali-Moghaddam M,Cunningham JL,Sundström-Poromaa I,Skalkidou A

更新日期：2020-07-01 00:00:00

abstract：:Two fundamental questions about neuron cell culture were addressed. Can one serum-free medium that was developed for optimum growth of hippocampal neurons support the growth of neurons from other regions of the brain? Is the region specific state of differentiation maintained in culture? To answer these questions, we ...

journal_title：Journal of neuroscience research

authors： Brewer GJ

更新日期：1995-12-01 00:00:00