Mu-type calcium-activated neutral protease in the rat peripheral nerve.

abstract：:As a neurotransmitter and neuromodulator, serotonin (5-HT) influences neuronal outgrowth in the nervous systems of several species. In PC12 cells, 5-HT is known to have neuritogenic effects, although the signal transduction pathway responsible for these effects is not understood. In this study, we hypothesized that a ...

journal_title：Journal of neuroscience research

authors： Homma K,Kitamura Y,Ogawa H,Oka K

更新日期：2006-08-01 00:00:00

abstract：:In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...

journal_title：Journal of neuroscience research

authors： Becker CG,Becker T

更新日期：2007-09-01 00:00:00

abstract：:Germinal matrix (GM) vasculature is selectively vulnerable to hemorrhage in premature infants during the first 48 hr of life. This is attributed to rapid angiogenesis of this brain region, resulting in formation of nascent vessels that show a paucity of pericytes and immaturity of extracellular matrix. Integrins are k...

journal_title：Journal of neuroscience research

authors： Dummula K,Vinukonda G,Xu H,Hu F,Zia MT,Braun A,Shi Q,Wolk J,Ballabh P

更新日期：2010-05-01 00:00:00

abstract：:Hyperglycemia and acidosis are the key factors in diabetic complications. It has been shown that acute or chronic diabetes alters serotonin levels in brain. However, the mechanism of hyperglycemia- or acidosis-induced changes in serotonin levels remains poorly understood. Because Ca2+-dependent protein kinases play a ...

journal_title：Journal of neuroscience research

authors： Ramakrishnan R,Prabhakaran K,Jayakumar AR,Gunasekaran P,Sheeladevi R,Suthanthirarajan N

更新日期：2005-05-15 00:00:00

abstract：:In vertebrates and invertebrates, dopamine signaling modulates a wide variety of physical and behavioral functions and exerts these effects through heterotrimeric G proteins. The soil nematode Caenorhabditis elegans has been used to model dopamine signaling and reacts reproducibly to alterations in dopamine levels thr...

journal_title：Journal of neuroscience research

authors： Felton CM,Johnson CM

更新日期：2011-10-01 00:00:00

abstract：:5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria. We have demonstrated recently that 5-hydroxyoxindole is an endogenous compound in blood and tissues of mammals, including humans. To date, 5-hydroxyoxindole's role...

journal_title：Journal of neuroscience research

authors： Crumeyrolle-Arias M,Tournaire MC,Rabot S,Malpaux B,Thiéry JC

更新日期：2008-01-01 00:00:00

abstract：:High-affinity uptake, potassium-stimulated release and receptor binding of gamma-aminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetate-malate (IAM). Such treatments produce a selective damage of the inner retinal layers (MSG) or of the photoreceptor...

journal_title：Journal of neuroscience research

authors： Salceda R,Pasantes-Morales H

更新日期：1982-01-01 00:00:00

abstract：:Injury to areas of the central nervous system can alter neurotrophin levels, which may influence postlesion neuronal survival and plasticity. To determine if sensorineural hearing loss induces such changes, we used an enzyme-linked immunosorbent assay (ELISA) to measure neurotrophin-3 (NT-3) and brain-derived neurotro...

journal_title：Journal of neuroscience research

authors： Suneja SK,Yan L,Potashner SJ

更新日期：2005-05-01 00:00:00

abstract：:Iron deficiency and chronic mild carbon monoxide (CO) exposure are nutritional and environmental problems that can be experienced simultaneously. We examined the effects of chronic mild CO exposure and iron availability on auditory development in the rat. We propose that chronic mild CO exposure creates an oxidative s...

journal_title：Journal of neuroscience research

authors： Webber DS,Lopez I,Korsak RA,Hirota S,Acuna D,Edmond J

更新日期：2005-06-01 00:00:00

abstract：:The expression of GABAB receptors in cultured mouse cerebellar granule cells was investigated in binding experiments using [3H](S,R)-baclofen as well as in functional assessment of the ability of (R)-baclofen to interact with depolarization (15-40 mM KCl) coupled changes in intracellular Ca2+ homeostasis and neurotran...

journal_title：Journal of neuroscience research

authors： Kardos J,Elster L,Damgaard I,Krogsgaard-Larsen P,Schousboe A

更新日期：1994-12-15 00:00:00

abstract：:Nociceptive neuronal activation in subcortical regions has not been well investigated in functional magnetic resonance imaging (fMRI) studies. The present report aimed to use the blood oxygenation level-dependent (BOLD) fMRI technique to map nociceptive responses in both subcortical and cortical regions by employing a...

journal_title：Journal of neuroscience research

authors： Shih YY,Chen YY,Chen CC,Chen JC,Chang C,Jaw FS

更新日期：2008-06-01 00:00:00

abstract：:Recent studies suggest that heterotypic cell-cell interactions influence gliogenesis in the developing rat central nervous system. CNS neuron-derived factors have been hypothesized to exist, and several have been identified and partially characterized which affect the number of oligodendrocytes in vitro. In order to s...

journal_title：Journal of neuroscience research

authors： Bottenstein JE,Hunter SF,Seidel M

更新日期：1988-07-01 00:00:00

abstract：:In eukaryotes, mitochondria are critical for cellular bioenergetics and mediating apoptosis. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. However, the role of PGC-1alpha in neuronal a...

journal_title：Journal of neuroscience research

authors： Liang J,Yang Y,Zhu X,Wang X,Chen R

更新日期：2010-07-01 00:00:00

abstract：:The minimal requirements for the regeneration of optic nerve fibers in vitro were established in a serum-free retinal explant preparation. This serum-free preparation was developed as a prerequisite for testing the growth-promoting activity of tissue extracts prepared from the primary target of regenerating fibers. Ex...

journal_title：Journal of neuroscience research

authors： Johnson JE,Turner JE

更新日期：1982-01-01 00:00:00

abstract：:Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...

journal_title：Journal of neuroscience research

authors： Mioduszewska B,Jaworski J,Szklarczyk AW,Klejman A,Kaczmarek L

更新日期：2008-01-01 00:00:00

abstract：:Despite the accumulating data on the molecular and cell biological characteristics of neural stem/progenitor cells, their electrophysiological properties are not well understood. In the present work, changes in the membrane properties and current profiles were investigated in the course of in vitro-induced neuron form...

journal_title：Journal of neuroscience research

authors： Jelitai M,Anderová M,Chvátal A,Madarász E

更新日期：2007-06-01 00:00:00

abstract：:Several recently discovered lines of evidence support the involvement of myelin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested for reactivity to cl...

journal_title：Journal of neuroscience research

authors： Chou YK,Henderikx P,Vainiene M,Whitham R,Bourdette D,Chou CH,Hashim G,Offner H,Vandenbark AA

更新日期：1991-02-01 00:00:00

abstract：:It has been postulated that the pathogenesis of Parkinson's disease (PD) is associated with mitochondrial dysfunction. Rotenone, an inhibitor of mitochondrial complex I, provides models of PD both in vivo and in vitro. We investigated the neuroprotective effect of D-beta-hydroxybutyrate (bHB), a ketone body, against r...

journal_title：Journal of neuroscience research

authors： Imamura K,Takeshima T,Kashiwaya Y,Nakaso K,Nakashima K

更新日期：2006-11-01 00:00:00

abstract：:Alcohol-related events have been proposed to be under neurochemical control. For example, the concentration of methionine enkephalin (Met-enkephalin) in brain has been inversely correlated with ethanol consumption in alcohol-preferring and alcohol-nonpreferring mice. The concentrations of Met-enkephalin are controlled...

journal_title：Journal of neuroscience research

authors： Plotkin SR,Banks WA,Waguespack PJ,Kastin AJ

更新日期：1997-05-01 00:00:00

abstract：:Despite a large body of literature on the nociceptin (NC) opioid system in pain modulation, the mechanism of action of NC remains largely unexplored. Here, we investigated the role and mode of action of the spinal NC system in inflammatory pain. Preemptive intrathecal administration of NC attenuated thermal hyperalges...

journal_title：Journal of neuroscience research

authors： Chen Y,Sommer C

更新日期：2007-05-15 00:00:00

abstract：:Oxidative stress, neuroinflammation, and excitotoxicity are frequently considered distinct but common hallmarks of several neurological disorders, including Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and Alzheimer's disease. Although neuron degeneration and death are the ultimate consequen...

journal_title：Journal of neuroscience research

authors： Tilleux S,Hermans E

更新日期：2007-08-01 00:00:00

abstract：:In the embryonic and postnatal rat retina a cell surface antigen that is detected by monoclonal antibody JONES is distributed in a dorsoventral gradient. Biochemical analysis has determined that the antigen is a modified ganglioside, 9-O-acetyl GD3. In the present study, the distributions of 9-O-acetyl GD3 and its pos...

journal_title：Journal of neuroscience research

authors： Sparrow JR,Barnstable CJ

更新日期：1988-10-01 00:00:00

abstract：:The mammalian genome contains both constitutively expressed and heat-shock-inducible members of the hsp70 gene family. Riboprobes derived from members of these two classes of heat shock genes were utilized in Northern blot studies to analyze brain mRNA isolated from control rabbits and rats and from animals subjected ...

journal_title：Journal of neuroscience research

authors： Brown IR,Rush SJ

更新日期：1990-01-01 00:00:00

abstract：:Cerebrospinal fluid was collected from the lateral ventricles and cisternal space from beagle dogs under light pentobarbital anesthesia. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglyco-sulfate (MOPEG-SO4) levels in the liquor taken from these two regions were evaluated,...

journal_title：Journal of neuroscience research

authors： Bareggi SR,Stabenau JR,Shaskan EG,Becker RE,Roberts M

更新日期：1975-01-01 00:00:00

abstract：:Antibody-producing hybridoma cells specifically bind to microgram quantities of antigen molecules adsorbed onto the surface of plastic microtiter plates. The binding of hybridoma cells to nonantigen is optimally below 5%, similar binding of non-antibody-producing cells is 4-7%, compared to the binding of the hybridoma...

journal_title：Journal of neuroscience research

authors： Najbauer J,Tigyi GJ,Nemeth P

更新日期：1986-01-01 00:00:00

abstract：:The development of cells of the oligodendroglial lineage, from immature progenitor to myelinating cells, occurs largely in a neuronal environment, yet little is known about specific interactions between these 2 cell types. We have tested the effects of medium conditioned by cultures of rat cerebral cortical neurons (C...

journal_title：Journal of neuroscience research

authors： Hardy R,Reynolds R

更新日期：1993-04-01 00:00:00

abstract：:Light microscopic anterograde tracing studies indicate that neurons in the central nucleus of the amygdala (CNA) project to a region of the dorsal pontine tegmentum ventral to the superior cerebellar peduncle which contains noradrenergic dendrites of the nucleus locus coeruleus (LC). However, it has not been establish...

journal_title：Journal of neuroscience research

authors： Van Bockstaele EJ,Chan J,Pickel VM

更新日期：1996-08-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, has been implicated in the pathogenesis of several disorders and injuries in the central nervous system (CNS). Unlike IGF-I, which promotes CNS growth, TNF-alpha causes brain growth retardation and neural damage. Recently TNF-alpha has been shown to ...

journal_title：Journal of neuroscience research

authors： Ye P,Price W,Kassiotis G,Kollias G,D'Ercole AJ

更新日期：2003-03-01 00:00:00

abstract：:P-glycoprotein (P-gp), a drug efflux pump, is known to alter the bioavailability of antiretroviral drugs at several sites, including the brain. We have previously shown that human immunodeficiency virus-1 (HIV-1) glycoprotein 120 (gp120) induces proinflammatory cytokine secretion and decreases P-gp functional expressi...

journal_title：Journal of neuroscience research

authors： Ashraf T,Ronaldson PT,Persidsky Y,Bendayan R

更新日期：2011-11-01 00:00:00

abstract：:Gangliosides, sialic acid-containing glycosphingolipids, are ubiquitously expressed in all eukaryotic cells and are localized primarily in the plasma membrane. For a rat pheochromocytoma cell line, PC12, which has been used frequently as a model for investigating events leading to neuronal differentiation, it is gener...

journal_title：Journal of neuroscience research

authors： Yanagisawa M,Ariga T,Yu RK

更新日期：2006-11-01 00:00:00