Abstract：
:Integrins comprise a large family of cell adhesion molecules that mediate interactions between the extracellular environment and the cytoplasm. During the last decade, analysis of the expression and function of these molecules has revealed that integrins regulate many aspects of cell behavior including cell death, proliferation, migration, and differentiation. Within the central nervous system (CNS), most of the early studies focused on the role of integrins in mediating adhesive and migratory events in two distinct processes: neural development and CNS inflammation. Interestingly, recent analysis of transgenic mice has provided some surprising results regarding the role of integrins in neural development. Furthermore, a large body of evidence now supports the idea that in addition to these well-described functions, integrins play multiple roles in the CNS, both during development and in the adult in areas as diverse as synaptogenesis, activation of microglia, and stabilization of the endothelium and blood-brain barrier. Many excellent reviews have addressed the contribution of integrins in mediating leukocyte extravasation during CNS inflammation. This review will focus on recently emerging evidence of novel and diverse roles of integrins and their ligands in the CNS during development and in the adult, in health and disease.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Milner R,Campbell ILdoi
10.1002/jnr.10321keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
286-91issue
3eissn
0360-4012issn
1097-4547journal_volume
69pub_type
杂志文章,评审abstract：:Although reactive oxygen species (ROS) have been implicated in ischemic preconditioning (IPC)-induced neuronal protection, several key questions concerning ROS remain to be elucidated. The purpose of this study is to obtain direct evidence for the formation of specific ROS species generated by IPC, and to determine th...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20402
更新日期：2005-03-15 00:00:00
abstract：:Structural microtubule-associated proteins (MAPs) interact with microtubules to regulate the various dynamic stages of microtubules. The purpose of this study was to measure the impact of myc-tagged MAP1a fragments on microtubule dynamic phases in vivo. Cells from an epithelial kidney cell line (LLCPK1) that had been ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21920
更新日期：2009-04-01 00:00:00
abstract：:The metabolism of glutamate, the most likely neurotransmitter of vestibular ganglion cells, includes synthesis from glutamine by the enzyme glutaminase. We used microdissection combined with a fluorometric assay to measure glutaminase activity in the vestibular nerve root and nuclei of rats with unilateral vestibular ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20179
更新日期：2004-08-15 00:00:00
abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21984
更新日期：2009-11-15 00:00:00
abstract：:We have studied the effect of induced glial fibrillary acidic protein (GFAP) on motility, cell morphology, and proliferation of two originally GFAP-negative human glioma cell lines. Glioma cell lines U-1242 MG and U-251 MG sp subclone 3A were transfected with a vector system that allows for an inducible GFAP expressio...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(20000415)60:2<245::AID-JNR
更新日期：2000-04-15 00:00:00
abstract：:Two clones encoding human glial fibrillary acidic protein (GFAP) were isolated from a human astrocytoma cDNA library. The clones pHGFAP1 and pHGFAP2 were selected by the combined use of differential colony hybridization and hybridization-selection technique with polyclonal anti GFAP antiserum. The longer one, pHGFAP1,...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490200204
更新日期：1988-01-01 00:00:00
abstract：:Sulfoglucuronosyl paragloboside (SGPG) is a member of the sulfated glucuronic acid-containing glycolipid (SGGL) family found primarily in peripheral nerves. These glycolipids contain the HNK-1 carbohydrate epitope and are recognized by monoclonal IgM from patients with chronic demyelinating neuropathy and paraproteine...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19960615)44:6<586::AID-JNR
更新日期：1996-06-15 00:00:00
abstract：:Hippocalcin is a Ca2+-binding protein that is expressed mainly in pyramidal nerve cells of the hippocampus. However, its functions and mechanism in the brain remain unclear. To elucidate the role of hippocalcin, we used a conditionally immortalized hippocampal cell line (H19-7) and showed that bFGF treatment increased...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21602
更新日期：2008-05-15 00:00:00
abstract：:Astrocyte activation is an important feature in many disorders of the central nervous system, including chronic pain conditions. Activation of astrocytes is characterized by a change in morphology, including hypertrophy and increased size of processes, proliferation, and an increased production of proinflammatory medi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23144
更新日期：2013-02-01 00:00:00
abstract：:Amyloid plaques, found in characteristically large numbers in specific brain areas of Alzheimer's disease (AD) and Down's Syndrome (DS) patients, are composed of a 41-43 amino acid peptide, A4, derived from a transmembrane glycoprotein, amyloid precursor protein (APP). In transformed cells APP has been shown to be cle...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490290115
更新日期：1991-05-01 00:00:00
abstract：:Statins are potent cholesterol biosynthesis inhibitors that exert protective effects in humans and in experimental models of stroke. The mechanisms involved in these protective actions are not completely understood. This study evaluates whether atorvastatin (ATV) treatment affects the GluN1 and GluN2B subunits of the ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23426
更新日期：2014-11-01 00:00:00
abstract：:Soluble amyloid beta protein (Abeta) oligomers have been considered recently to be responsible for the cognitive dysfunction that sets in prior to senile plaque formation in the Alzheimer's disease (AD) brain. By using the newly prepared antibody against oligomer Abeta, rather than fibrillar or monomer Abeta, we obser...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20952
更新日期：2006-08-15 00:00:00
abstract：:Inhibitors of differentiation (Id) play an essential role in the neurogenesis of the central nervous system. However, the expression and function of Id in the development of cochlear sensory epithelial cells have yet to be elucidated. In this study, we demonstrate the Id1 gene was expressed in the rapidly growing otoc...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21133
更新日期：2007-02-15 00:00:00
abstract：:Although the expression of hepatocyte growth factor (HGF) and its receptor, proto-oncogene c-met, has been demonstrated in the central nervous system (CNS), the function of HGF in the CNS was not fully understood. In the present studies, we determined the effects of HGF on neuronal development in neocortical explant a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19960301)43:5<554::AID-JNR
更新日期：1996-03-01 00:00:00
abstract：:We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490320409
更新日期：1992-08-01 00:00:00
abstract：:In a military setting, traumatic brain injury (TBI) is frequently caused by blast waves that can trigger a series of neuronal biochemical changes. Although many animal models have been used to study the effects of primary blast waves, elucidating the mechanisms of damage in a whole-animal model is extremely complex. I...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23594
更新日期：2015-09-01 00:00:00
abstract：:Nerve growth factor (NGF) is a protein essential for the survival and normal function of sympathetic neurons. Two-site immunoassays have been developed over the past decade in several laboratories and used to estimate its endogenous concentrations in a variety of effector tissues. However, levels appear restricted to ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19961201)46:5<581::AID-JNR
更新日期：1996-12-01 00:00:00
abstract：:Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC zeta activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC zeta. Inhibit...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990201)55:3<293::AID-JNR
更新日期：1999-02-01 00:00:00
abstract：:Previous studies have shown that treating rat cortical neurons in primary culture with apolipoprotein E (apoE) peptide increased cytoplasmic Ca2+ by 2 mechanisms: 1) an influx of extracellular Ca2+ resulting from the activation of a cell surface Ca2+ channel; and 2) release of Ca2+ from internal Ca2+ stores via a G-pr...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980301)51:5<658::AID-JNR
更新日期：1998-03-01 00:00:00
abstract：:In a number of pathological states of the brain, the activation of the inducible nitric oxide synthase (iNOS) plays a major role. Interleukin (IL)-1beta is believed to be an essential factor in the induction of iNOS. However, little is known about the cascade of events culminating in iNOS expression in vivo. To identi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：:Using a canine model of classical late-infantile neuronal ceroid lipofuscinosis (CLN2 disease), a study was conducted to evaluate the potential pharmacological activity of recombinant human tripeptidyl peptidase-1 (rhTPP1) enzyme replacement therapy administered directly to the cerebrospinal fluid (CSF). CLN2 disease ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23423
更新日期：2014-11-01 00:00:00
abstract：:Oxidative mechanisms of injury are important in many neurological disorders. Developing oligodendrocytes (pre-OLs) are particularly sensitive to oxidative stress-mediated injury. We previously demonstrated a novel function of phylloquinone (vitamin K(1)) and menaquinone 4 (MK-4; a major form of vitamin K2) in protecti...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22029
更新日期：2009-07-01 00:00:00
abstract：:Brain cathepsin D, purified by affinity chromatography on Sepharose pepstatin columns, was incubated with synthetic peptides corresponding to the susceptible regions of the myelin basic protein encompassing the two Phe-Phe bonds. One peptide, Leu-Gly-Arg-Phe-Phe-Gly-Gly, was cleaved by cathepsin D at the Phe-Phe bond ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490050306
更新日期：1980-01-01 00:00:00
abstract：:In this Mini-Review we present a new hypothesis in support of the neurodegenerative theory as a mechanism for the pathogenesis of multiple sclerosis (MS). The pathogenesis of MS results from changes in two distinct CNS compartments. These are the "myelin" and "nonmyelin" compartments. The myelin compartment is where p...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.20420
更新日期：2005-05-01 00:00:00
abstract：:We describe here the presence of ubiquitin and its conjugation system in the rat retina. Retinal homogenates and supernatants conjugate [125I]human ubiquitin with either endogenous or exogenous proteins. The conjugating activity is relatively stable over time, requires ATP, and has a pH optimum of approximately 8. The...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490300220
更新日期：1991-10-01 00:00:00
abstract：:Our previous work indicated that in E14 embryonic rat spinal cord cultures ciliary neuronotrophic factor (CNTF) exerted (1) a survival-promoting effect on motor neurons and on a large population of unidentified neurons, and (2) a regulatory role on the expression of ChAT and low affinity NGF receptor (LNGFR) in a popu...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490300314
更新日期：1991-11-01 00:00:00
abstract：:The effects of treatment with a high dose of nandrolone or testosterone on nerve growth factor (NGF) levels and NGF low-affinity receptor (p75-NGFr) distribution in the brain were analyzed. Nandrolone, subcutaneously injected in rats for several weeks, caused an increase of NGF levels in the hippocampus and septum and...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(sici)1097-4547(19970115)47:2<198::aid-jnr
更新日期：1997-01-15 00:00:00
abstract：:Neuronal degeneration has been shown to be involved in various neurological disorders. Growth/trophic factors and their receptors are known to be important for the regeneration and survival of neurons. We report here the molecular cloning of a receptor-like protein tyrosine kinase, bsk, (for brain specific kinase). Bs...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490370117
更新日期：1994-01-01 00:00:00
abstract：:The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10285
更新日期：2002-07-15 00:00:00
abstract：:Monoclonal 2C3 specific to β-amyloid (Aβ) oligomers (AβOs) enabled us to test our hypothesis that the alteration of lipoprotein-Aβ interaction in the central nervous system (CNS) initiates and/or accelerates the cascade favoring Aβ assembly. Immunoprecipitation of frontal cortex employing 2C3 unequivocally detected so...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22615
更新日期：2011-06-01 00:00:00
