Enzyme replacement therapy attenuates disease progression in a canine model of late-infantile neuronal ceroid lipofuscinosis (CLN2 disease).

abstract：:The concentration of myelin basic protein (MBP) mRNA in primary cultures of cells dissociated from embryonic mouse cerebra and grown in the presence of varying amounts of thyroid hormone was measured using a 32P-labeled cDNA probe and a dot-blot procedure. The cDNA probe contained 1.85 kilobases of the gene for MBP. T...

journal_title：Journal of neuroscience research

authors： Shanker G,Campagnoni AT,Pieringer RA

更新日期：1987-01-01 00:00:00

abstract：:Rapsyn is a key molecule involved in the formation of postsynaptic specializations at the neuromuscular junction, in its absence there are both pre- and post-synaptic deficits including failure to cluster acetylcholine receptors. Recently we have documented increases in both nerve-muscle branching and numbers of moton...

journal_title：Journal of neuroscience research

authors： Bartlett SE,Banks GB,Reynolds AJ,Waters MJ,Hendry IA,Noakes PG

更新日期：2001-06-15 00:00:00

abstract：:The induction of heat-shock protein 70 (hsp70) mRNA in the hyperthermic rabbit brain has been examined previously by using Northern blotting and in situ hybridization procedures that measure steady-state levels of mRNA, which may be influenced by transcript stability and transcription rate. In the present investigatio...

journal_title：Journal of neuroscience research

authors： D'Souza CA,Rush SJ,Brown IR

更新日期：1998-06-01 00:00:00

abstract：:The types of cells contacted by growth cones were examined in chick-quail and vice versa chimeras. Simultaneously, the presence of nonspecific cholinesterase (nChE) was monitored in developing peripheral nerves of these embryos. In all the chimeras studied, the growth cones were in contact with both Schwann cell proge...

journal_title：Journal of neuroscience research

authors： Haninec P,Dubový P

更新日期：1992-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Progressive and systemic loss of motor neurons with gliosis in the central nervous system (CNS) is a neuropathological hallmark of ALS. Chondroitin sulfate proteoglycans (CSPGs) are the major components of the extracellular matrix of the mammali...

journal_title：Journal of neuroscience research

authors： Shijo T,Warita H,Suzuki N,Kitajima Y,Ikeda K,Akiyama T,Ono H,Mitsuzawa S,Nishiyama A,Izumi R,Aoki M

更新日期：2018-02-01 00:00:00

abstract：:The effects of blinding with or without pineal ablation on brain monoamine levels were studied in male rats. Brain dopamine (DA), norepinephrine (NE), epinephrine (E), and serotonin (5-HT) were measured by radioenzymatic assays. Four weeks following pinealectomy, E levels were significantly enhanced in the frontal cor...

journal_title：Journal of neuroscience research

authors： Niles LP,Brown GM,Mishra RK

更新日期：1983-01-01 00:00:00

abstract：:Astroglial participation in the regional differences of vulnerability to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-induced neurodegeneration was investigated in the rat hippocampus and medial septum using L-alpha-aminoadipate (alpha-AA) as a specific astroglial toxin. alpha-AA was microinjected i...

journal_title：Journal of neuroscience research

authors： Rodríguez MJ,Martínez-Sánchez M,Bernal F,Mahy N

更新日期：2004-08-01 00:00:00

abstract：:This experiment was directed toward determining the relative effectiveness of discrete and diffuse pain stimuli in influencing perception and behavior. Shocks to the footpads were used to activate the discrete pain pathways and shocks to the upper canine teeth to activate the diffuse pain pathways. In the first phase ...

journal_title：Journal of neuroscience research

authors： Anderson KV,Pearl GS,Honeycutt C

更新日期：1976-01-01 00:00:00

abstract：:Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an endogenous ligand for the NOP receptor, ample evidence has revealed unique functional profiles of the N/OFQ-NOP receptor system. NOP receptors are expressed in key neural substrates involved in pain and reward modulation. In nonhuma...

journal_title：Journal of neuroscience research

authors： Kiguchi N,Ding H,Ko MC

更新日期：2020-04-07 00:00:00

abstract：:Recent advances in human induced pluripotent stem cells (hiPSCs) offer new possibilities for biomedical research and clinical applications. Differentiated neurons from hiPSCs are expected to be useful for developing novel methods of treatment for various neurological diseases. However, the detailed process of function...

journal_title：Journal of neuroscience research

authors： Ohara Y,Koganezawa N,Yamazaki H,Roppongi RT,Sato K,Sekino Y,Shirao T

更新日期：2015-12-01 00:00:00

abstract：:Cranial idiopathic acute peripheral facial nerve paralysis (Bell palsy) has been used as a model disease in the present study mainly to investigate trophic capacity of serum components. The ability to induce sprouting from chick embryo dorsal root ganglia was used as the bioassay for trophic activity. Sera from normal...

journal_title：Journal of neuroscience research

authors： Aviel A,Schwartz M

更新日期：1983-01-01 00:00:00

abstract：:We report a study of the characterization of voltage-activated potassium (K+) currents in retinal ON bipolar cells in zebrafish. At single-channels levels, the open probability of the K+ channels increased when the membrane potential was increased. The maximal open proportion was 0.76+/-0.05 under our testing conditio...

journal_title：Journal of neuroscience research

authors： Yu CJ,Li L

更新日期：2005-11-01 00:00:00

abstract：:Previous studies have shown that PC12 cells overexpressing beta/A4 amyloid peptide display altered morphology characterized by pronounced membrane ruffling and extensive intercellular appositions. Having observed other cell types in which these features accompany increased connexin43 (Cx43) production and gap junction...

journal_title：Journal of neuroscience research

authors： Nagy JI,Hossain MZ,Hertzberg EL,Marotta CA

更新日期：1996-04-15 00:00:00

abstract：:N-cadherin and beta-catenin are involved in cell adhesion and cell cycle in tumor cells and neural crest. Both are expressed at key stages of Schwann cell (SC) development, but little is known about their function in the SC lineage. We studied the role of these molecules in adult rat derived SC-embryonic dorsal root g...

journal_title：Journal of neuroscience research

authors： Gess B,Halfter H,Kleffner I,Monje P,Athauda G,Wood PM,Young P,Wanner IB

更新日期：2008-03-01 00:00:00

abstract：:Mitochondria are power organelles generating biochemical energy, ATP, in the cell. Mitochondria play a variety of roles, including integrating extracellular signals and executing critical intracellular events, such as neuronal cell survival and death. Increasing evidence suggests that a cross-talk mechanism between mi...

journal_title：Journal of neuroscience research

authors： Lee J,Sharma S,Kim J,Ferrante RJ,Ryu H

更新日期：2008-04-01 00:00:00

abstract：:Studies have shown that individuals with both a history of traumatic brain injury and inheritance of apolipoprotein E-4 (ApoE4) allele are associated with a poor neurologic outcome and an increased risk for Alzheimer's disease. We assessed the hypothesis that thrombin released during brain injury causes an increase in...

journal_title：Journal of neuroscience research

authors： Mhatre M,Hensley K,Nguyen A,Grammas P

更新日期：2006-08-01 00:00:00

abstract：:To further our understanding of the functions of the major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), and other myelin proteins, such as 2'3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin-associated glycoprotein (MAG), bovine brain myelin was extracted with Triton X-100, and p...

journal_title：Journal of neuroscience research

authors： Arvanitis DN,Yang W,Boggs JM

更新日期：2002-10-01 00:00:00

abstract：:The striatum plays an important role in learning, selecting, and executing actions. As a major input hub of the basal ganglia, it receives and processes a diverse array of signals related to sensory, motor, and cognitive information. Aberrant neural activity in this area is implicated in a wide variety of neurological...

journal_title：Journal of neuroscience research

authors： Lee K,Masmanidis SC

更新日期：2019-12-01 00:00:00

abstract：:Only a few proteins are known to be exclusively expressed in central nervous system (CNS) myelin. A novel surface membrane protein expressed only in CNS myelin and oligodendrocytes of higher vertebrates has been identified by a monoclonal antibody. This CNS myelin/oligodendrocyte-specific protein, MOSP, has a molecula...

journal_title：Journal of neuroscience research

authors： Dyer CA,Hickey WF,Geisert EE Jr

更新日期：1991-04-01 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating condition characterized by disruption of axonal connections, failure of axonal regeneration, and loss of motor and sensory function. The therapeutic promise of neural stem cells has been focused on cell replacement, but many obstacles remain in obtaining neuronal integration f...

journal_title：Journal of neuroscience research

authors： Bonner JF,Blesch A,Neuhuber B,Fischer I

更新日期：2010-05-01 00:00:00

abstract：:Comparisons were made of whole cell voltage clamp recordings from cultures of normal Schwann cells (SC) from three human subjects and from three neurofibrosarcoma cell lines. The whole cell K+ (K) currents of normal and tumor cells could be divided into three types based on voltage activation range, pharmacology, and ...

journal_title：Journal of neuroscience research

authors： Fieber LA

更新日期：1998-11-15 00:00:00

abstract：:We generated a new cell line, N38, by conditionally immortalizing mouse oligodendrocytes (OLs) at early stages of maturation. The morphology and marker expression pattern suggest N38 cells are similar to immature OLs. N38 cells were sensitive to changes in serum concentrations, and forcing the cells to differentiate i...

journal_title：Journal of neuroscience research

authors： Bongarzone ER,Byravan S,Givogri MI,Schonmann V,Campagnoni AT

更新日期：2000-11-01 00:00:00

abstract：:The demyelinative potential of the cytokines interleukin-1 alpha (IL-1 alpha), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) has been investigated in myelinating aggregate brain cell cultures. Treatment of myelinated cultures with these cytokines resulted in a reduction in myelin basic prot...

journal_title：Journal of neuroscience research

authors： Loughlin AJ,Honegger P,Woodroofe MN,Comte V,Matthieu JM,Cuzner ML

更新日期：1994-04-01 00:00:00

abstract：:Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis...

journal_title：Journal of neuroscience research

authors： Kane DJ,Ord T,Anton R,Bredesen DE

更新日期：1995-02-01 00:00:00

abstract：:People showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signaling, and show differences between both sexes. We ex...

journal_title：Journal of neuroscience research

authors： Schote AB,A L Sayk C,Pabst K,Meier JK,Frings C,Meyer J

更新日期：2019-02-01 00:00:00

abstract：:During late postnatal development, mice with the autosomal recessive wobbler mutation (wr/wr) develop motoneuron degeneration associated with astrogliosis in the spinal cord. In vitro, primary wobbler astrocytes are also affected, exhibiting abnormal cell-cell contacts. To characterize further the wobbler disease, we ...

journal_title：Journal of neuroscience research

authors： Aït-Ikhlef A,Hantaz-Ambroise D,Henderson CE,Rieger F

更新日期：2000-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)-mediated innate immunity against viral infections. We examined whether human neuronal cells (primary human neurons, NT2-N and CHP-212 cells) express TLRs and mount type I IFN-mediated innate immunity against herpes si...

journal_title：Journal of neuroscience research

authors： Zhou Y,Ye L,Wan Q,Zhou L,Wang X,Li J,Hu S,Zhou D,Ho W

更新日期：2009-10-01 00:00:00

abstract：:Acetylcholinesterase (AChE) molecular forms were studied in normal (NM) and in dystrophic (DM) 129B6F1/J mouse muscle. Successive extractions of the tissue with saline and saline-Triton X-100 buffers yielded two soluble fractions, S1 and S2. Forty percent of the AChE in NM was measured in S1 and 60% in S2, and 65% and...

journal_title：Journal of neuroscience research

authors： Cabezas-Herrera J,Campoy FJ,Vidal CJ

更新日期：1994-08-01 00:00:00

abstract：:Cerebrospinal fluid was collected from the lateral ventricles and cisternal space from beagle dogs under light pentobarbital anesthesia. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglyco-sulfate (MOPEG-SO4) levels in the liquor taken from these two regions were evaluated,...

journal_title：Journal of neuroscience research

authors： Bareggi SR,Stabenau JR,Shaskan EG,Becker RE,Roberts M

更新日期：1975-01-01 00:00:00

abstract：:Fractionation of muscle microsomes rich in sarcoplasmic reticulum (SR) by isopicnic centrifugation yielded three types of membranes. Heavy (HM), intermediate (IM), and light membranes (LM), with isopicnic points of 38, 33, and 25% w/w sucrose, were rich in terminal cisternae/triads, longitudinal SR, and T-tubules, res...

journal_title：Journal of neuroscience research

authors： Campoy FJ,Cabezas-Herrera J,Vidal CJ

更新日期：1992-12-01 00:00:00