Sex, ADHD symptoms, and CHRNA5 genotype influence reaction time but not response inhibition.

abstract：:The effects of the environmental contaminants methylmercury (MeHg) and inorganic mercury (HgCl(2)) on cell viability, intracellular calcium concentration ([Ca(2+)](i)), and reactive oxygen species (ROS) generation were studied in rat cerebellar granule neuron cultures using fluorescent methods. MeHg exhibited an LC(50...

journal_title：Journal of neuroscience research

authors： Gassó S,Cristòfol RM,Selema G,Rosa R,Rodríguez-Farré E,Sanfeliu C

更新日期：2001-10-01 00:00:00

abstract：:The effects of cations on the spontaneous and potassium-stimulated taurine release from mouse cerebral cortex slices were assessed with an emphasis on the as yet unestablished calcium dependence of the stimulated release. Spontaneous and stimulated GABA release was analyzed for comparison. A depolarizing concentration...

journal_title：Journal of neuroscience research

authors： Oja SS,Kontro P

更新日期：1987-01-01 00:00:00

abstract：:Cortical or total brain cultures of microglia are commonly used as a model to study the inflammatory processes in Parkinson's disease. Here we characterize microglia cultures from rat ventral midbrain and evaluate their response to zymosan A. We used specific markers of microglia and evaluated the morphology, the phag...

journal_title：Journal of neuroscience research

authors： Cristóvão AC,Saavedra A,Fonseca CP,Campos F,Duarte EP,Baltazar G

更新日期：2010-02-15 00:00:00

abstract：:Tau microtubule-associated proteins are believed to play a role in regulation of the growth of neuronal processes. In order to study the function of tau protein in vivo, we examined the inhibition of tau expression in PC12 cells by exposing the cells to tau antisense oligodeoxynucleotides. A specific retraction of neu...

journal_title：Journal of neuroscience research

authors： Hanemaaijer R,Ginzburg I

更新日期：1991-09-01 00:00:00

abstract：:The role of the transcription factor AP-1 in regulating D2 receptor transcriptional activity was investigated in D2 receptor expressing neuroblastoma cells, NB41A3, and in non-D2 receptor expressing CHO cells. Deletion of a region containing the putative AP-1 binding site resulted in a significant reduction in the act...

journal_title：Journal of neuroscience research

authors： Wang J,Miller JC,Friedhoff AJ

更新日期：1997-10-01 00:00:00

abstract：:To promote neurite elongation, nerve growth cones must adhere to other surfaces. A complex of integral membrane glycoproteins mediates cell binding to the extracellular glycoproteins fibronectin and laminin (Horwitz et al., J Cell Biol 101:2134-2144, 1985). The receptor complex, named integrin, binds to fibronectin by...

journal_title：Journal of neuroscience research

authors： Letourneau PC,Pech IV,Rogers SL,Palm SL,McCarthy JB,Furcht LT

更新日期：1988-10-01 00:00:00

abstract：:In order to study the voltage-dependent ion channels in microglia, and their possible modulation by pro-inflammatory substances like lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) we employed the patch-clamp technique on purified rat microglial cell subcultures grown for 1 - 5 days in control condition or a...

journal_title：Journal of neuroscience research

authors： Visentin S,Agresti C,Patrizio M,Levi G

更新日期：1995-11-01 00:00:00

abstract：:Enriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis...

journal_title：Journal of neuroscience research

authors： Lee YB,Nagai A,Kim SU

更新日期：2002-07-01 00:00:00

abstract：:Understanding the pathway for amyloid percursor protein (APP) catabolism has become an important line of investigation. APP is a ubiquitous membrane bound protein that is rapidly cleaved at the membrane, yielding a secreted protein identical to protease nexin II and an internalized 11.5 kDa 100 residue C terminal deri...

journal_title：Journal of neuroscience research

authors： Wolozin B,Bacic M,Merrill MJ,Lesch KP,Chen C,Lebovics RS,Sunderland T

更新日期：1992-09-01 00:00:00

abstract：:Extracts of bovine heart, rat heart, and rat skeletal muscle were chromatographically separated and the fractions tested for their ability to maintain the survival of dissociated sympathetic, parasympathetic, and sensory neurones. Bovine heart contained at least five, rat heart at least six, and rat skeletal muscle at...

journal_title：Journal of neuroscience research

authors： Bonyhady RE,Hendry IA,Hill CE,Watters DJ

更新日期：1985-01-01 00:00:00

abstract：:The Dale's law postulates that a neuron releases the same neurotransmitter from all its branches. In the case of multiple neurotransmitters it would require all transmitters to be released from all branches. The retinal cholinergic amacrine cells contain and release gamma-aminobutyric (GABA) and, therefore, if GABA an...

journal_title：Journal of neuroscience research

authors： Duarte CB,Santos PF,Carvalho AP

更新日期：1999-11-15 00:00:00

abstract：:The neuronal intermediate filaments include not only the neurofilament triplet proteins but also peripherin and alpha-internexin. To determine whether neurite outgrowth is enhanced by alpha-internexin, the cDNA of rat alpha-internexin tagged with enhanced green fluorescent protein (EGFP) was transfected into a rat adr...

journal_title：Journal of neuroscience research

authors： Chien CL,Liu TC,Ho CL,Lu KS

更新日期：2005-06-01 00:00:00

abstract：:Neurons in culture rely on the supply of exogenous cysteine for their glutathione synthesis. After application of cysteine to neuron-rich primary cultures, the glutathione content was doubled after a 4-hr incubation. The dipeptide cysteinylglycine (CysGly) was able to substitute for cysteine as exogenous glutathione p...

journal_title：Journal of neuroscience research

authors： Dringen R,Gutterer JM,Gros C,Hirrlinger J

更新日期：2001-12-01 00:00:00

abstract：:Fetal low brain oxygenation may be an outcome of maternal complications during pregnancy and is associated with increased risk of cerebral palsy and periventricular leukomalacia in newborns. One treatment used for prevention of fetal brain damage is maternal treatment with MgSO(4). Although this treatment is indicated...

journal_title：Journal of neuroscience research

authors： Golan H,Kashtuzki I,Hallak M,Sorokin Y,Huleihel M

更新日期：2004-11-01 00:00:00

abstract：:This paper describes a novel technique to identify and study neurons that express specific mRNAs. The method is called Live FISH because it is like fluorescent in situ hybridization (FISH) but can be applied to living tissues. In Live FISH, molecular beacons, which fluoresce only in the presence of the complementary m...

journal_title：Journal of neuroscience research

authors： Simon B,Sandhu M,Myhr KL

更新日期：2010-01-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated ion channels (HCN) are key determinants of CNS functions. Here we describe an increase in hyperpolarization-activated current (I(h)) at the beginning of whole-cell recordings in rat layer 5 cortical neurons. For a closer investigation of this I(h) increase, we overex...

journal_title：Journal of neuroscience research

authors： Battefeld A,Bierwirth C,Li YC,Barthel L,Velmans T,Strauss U

更新日期：2010-11-01 00:00:00

abstract：:Protein kinase C (PKC) and its potential role in myelin gene expression were investigated in primary cultured rat oligodendrocytes. The major myelin genes were expressed in a developmentally coordinated manner in cultured oligodendrocytes. PKC activity in these cells was similarly regulated with differential expressio...

journal_title：Journal of neuroscience research

authors： Asotra K,Macklin WB

更新日期：1993-04-01 00:00:00

abstract：:Autonomic neuropathy in several neurodegenerative disorders results from disturbance in physiological functions of different cell types in the central and peripheral nervous systems. For a clearer understanding of the etiology and pathogenesis of the autonomic disorders it is necessary to create animal models in which...

journal_title：Journal of neuroscience research

authors： Sawada H,Nishii K,Suzuki T,Hasegawa K,Hata T,Nagatsu I,Kreitman RJ,Pastan I,Nagatsu T,Kobayashi K

更新日期：1998-01-15 00:00:00

abstract：:Elk is a member of the eph family of receptor-like tyrosine kinases. Although its function is unknown, elk is postulated to play a role in nervous system development. Using Northern analysis, we examined the developmental regulation of RNAs encoding elk, and several ligands for the eph family of RTKs, the LERKs. Expre...

journal_title：Journal of neuroscience research

authors： Carpenter MK,Shilling H,VandenBos T,Beckmann MP,Cerretti DP,Kott JN,Westrum LE,Davison BL,Fletcher FA

更新日期：1995-10-01 00:00:00

abstract：:A growing body of evidence suggests that neurotrophins (NTs) play a critical role in synaptic plasticity and other activity dependent processes in the CNS. Release of these growth factors by neurons and neuroendocrine cells was recently shown to occur via the regulated secretory pathway, representing a possible mechan...

journal_title：Journal of neuroscience research

authors： Möller JC,Krüttgen A,Heymach JV Jr,Ghori N,Shooter EM

更新日期：1998-02-15 00:00:00

abstract：:Perceptually similar stimuli, despite not being consciously distinguishable, may result in distinct cortical brain activations. Hypothesizing that perceptually similar tastes are discriminable by electroencephalography (EEG), we recorded 22 human participants' response to equally intense sweet-tasting stimuli: caloric...

journal_title：Journal of neuroscience research

authors： Andersen CA,Kring ML,Andersen RH,Larsen ON,Kjaer TW,Kidmose U,Møller S,Kidmose P

更新日期：2019-03-01 00:00:00

abstract：:Withdrawal of serum from cell cultures constitutes a useful model for the study of mechanisms involved in the regulation of Akt function in vitro. However, there have been several reports of changes in Akt activity that are not fully explained by the current model of phosphatidylinositol 3'-kinase (PI3K)/Akt signaling...

journal_title：Journal of neuroscience research

authors： Sephton CF,Mousseau DD

更新日期：2008-02-15 00:00:00

abstract：:Previous studies from our laboratory suggest that Alzheimer's disease sera contain a repertoire of antibodies to the heavy neurofilament subunit (NF-H) and that a subpopulation of these antibodies bind specifically to epitopes highly enriched in NF-H isolated from the purely cholinergic electromotor neurons of Torpedo...

journal_title：Journal of neuroscience research

authors： Faigon M,Hadas E,Alroy G,Chapman J,Auerbach JM,Michaelson DM

更新日期：1991-08-01 00:00:00

abstract：:Monoclonal 2C3 specific to β-amyloid (Aβ) oligomers (AβOs) enabled us to test our hypothesis that the alteration of lipoprotein-Aβ interaction in the central nervous system (CNS) initiates and/or accelerates the cascade favoring Aβ assembly. Immunoprecipitation of frontal cortex employing 2C3 unequivocally detected so...

journal_title：Journal of neuroscience research

authors： Takamura A,Kawarabayashi T,Yokoseki T,Shibata M,Morishima-Kawashima M,Saito Y,Murayama S,Ihara Y,Abe K,Shoji M,Michikawa M,Matsubara E

更新日期：2011-06-01 00:00:00

abstract：:We investigated the ability of human bone marrow stromal cell (hBMSC) treatment to reduce axonal loss in experimental autoimmune encephalomyelitis (EAE) mice. EAE was induced in SJL/J mice by injection with proteolipid protein (PLP). Mice were injected intravenously with hBMSCs or PBS on the day of clinical onset, and...

journal_title：Journal of neuroscience research

authors： Zhang J,Li Y,Lu M,Cui Y,Chen J,Noffsinger L,Elias SB,Chopp M

更新日期：2006-08-15 00:00:00

abstract：:The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR-alpha agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE), the animal model ...

journal_title：Journal of neuroscience research

authors： Xu J,Storer PD,Chavis JA,Racke MK,Drew PD

更新日期：2005-08-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2), a key enzyme in prostanoid biosynthesis, may represent an important therapeutic target in Alzheimer's disease (AD). In the present study, we explored the regulation of COX-2 in the hippocampal formation in sporadic AD. Using semiquantitative immunocytochemical techniques, we found that in AD ...

journal_title：Journal of neuroscience research

authors： Ho L,Pieroni C,Winger D,Purohit DP,Aisen PS,Pasinetti GM

更新日期：1999-08-01 00:00:00

abstract：:The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...

journal_title：Journal of neuroscience research

authors： Li W,Maeda Y,Ming X,Cook S,Chapin J,Husar W,Dowling P

更新日期：2002-07-15 00:00:00

abstract：:The companion study showed that acoustic overstimulation of adult chinchillas, with a noise level sufficient to damage the cochlea, led to cytological changes and degeneration of synaptic endings in the cochlear nucleus within 1-16 weeks. In the present study, the same stimulus was used to study the long-term effects ...

journal_title：Journal of neuroscience research

authors： Kim JJ,Gross J,Potashner SJ,Morest DK

更新日期：2004-09-15 00:00:00

abstract：:Traumatic injury to the adult central nervous system (CNS) results in a rapid response from resident astrocytes, a process often referred to as reactive astrogliosis or glial scarring. The robust formation of the glial scar and its associated extracellular matrix (ECM) molecules have been suggested to interfere with a...

journal_title：Journal of neuroscience research

authors： McGraw J,Hiebert GW,Steeves JD

更新日期：2001-01-15 00:00:00