Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease.

abstract：:In eukaryotes, mitochondria are critical for cellular bioenergetics and mediating apoptosis. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. However, the role of PGC-1alpha in neuronal a...

journal_title：Journal of neuroscience research

authors： Liang J,Yang Y,Zhu X,Wang X,Chen R

更新日期：2010-07-01 00:00:00

abstract：:Cranial idiopathic acute peripheral facial nerve paralysis (Bell palsy) has been used as a model disease in the present study mainly to investigate trophic capacity of serum components. The ability to induce sprouting from chick embryo dorsal root ganglia was used as the bioassay for trophic activity. Sera from normal...

journal_title：Journal of neuroscience research

authors： Aviel A,Schwartz M

更新日期：1983-01-01 00:00:00

abstract：:Subarachnoid hemorrhage (SAH) by a rupture of cerebral aneurysms remains the most devastating cerebrovascular disease. Early brain injury (EBI) is increasingly recognized to be the primary determinant for poor outcomes, and also considered to cause delayed cerebral ischemia (DCI) after SAH. Both clinical and experimen...

journal_title：Journal of neuroscience research

authors： Suzuki H,Fujimoto M,Kawakita F,Liu L,Nakatsuka Y,Nakano F,Nishikawa H,Okada T,Kanamaru H,Imanaka-Yoshida K,Yoshida T,Shiba M

更新日期：2020-01-01 00:00:00

abstract：:Within the parenchyma of the CNS, the endothelium of all vessels is surrounded by a layer of cells, pericytes in capillaries and periendothelial or intima smooth muscle cells in other vessels. The origin of these cell types, their relationship, and their role are unclear. However, it has been recently shown that genet...

journal_title：Journal of neuroscience research

authors： Alliot F,Rutin J,Leenen PJ,Pessac B

更新日期：1999-11-01 00:00:00

abstract：:Cultures of rat C6 rat glioma cells exhibit a diminished response to isoproterenol and forskolin after being treated with phorbol 12,13-dibutyrate (PDbU). An IC50 for PDbU of 38 +/- 5 nM and 62 +/- 8 nM was observed in the isoproterenol and forskolin response, respectively. Similarly, C6 cultures exhibited a diminishe...

journal_title：Journal of neuroscience research

authors： Bressler JP,Tinsely P

更新日期：1990-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)-mediated innate immunity against viral infections. We examined whether human neuronal cells (primary human neurons, NT2-N and CHP-212 cells) express TLRs and mount type I IFN-mediated innate immunity against herpes si...

journal_title：Journal of neuroscience research

authors： Zhou Y,Ye L,Wan Q,Zhou L,Wang X,Li J,Hu S,Zhou D,Ho W

更新日期：2009-10-01 00:00:00

abstract：:Microglia are prominently involved in neural degenerative diseases of the CNS and the retina. In this study, we determined the activation and phagocytotic function of different subtypes of retinal microglial cells at 1 week and 1 month following optic axotomy. Fluorescent DiI crystals were placed at the stumps of the ...

journal_title：Journal of neuroscience research

authors： Zhang C,Tso MO

更新日期：2003-09-15 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection in its human host often results in progressive dementia and encephalopathy in adults and children, respectively. The mechanisms underlying virus-induced neurocognitive dysfunction are not fully understood. However, several studies strongly suggest that secretory vi...

journal_title：Journal of neuroscience research

authors： Dong J,Xiong H

更新日期：2006-02-15 00:00:00

abstract：:Only a few proteins are known to be exclusively expressed in central nervous system (CNS) myelin. A novel surface membrane protein expressed only in CNS myelin and oligodendrocytes of higher vertebrates has been identified by a monoclonal antibody. This CNS myelin/oligodendrocyte-specific protein, MOSP, has a molecula...

journal_title：Journal of neuroscience research

authors： Dyer CA,Hickey WF,Geisert EE Jr

更新日期：1991-04-01 00:00:00

abstract：:Microarray analyses demonstrated that a variety of genes was affected by treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor (PEDF). The genes for neurotrophins, glial cell-derived neurotrophic factor (GDNF), and their receptors were regulated differentially in i...

journal_title：Journal of neuroscience research

authors： Yabe T,Herbert JT,Takanohashi A,Schwartz JP

更新日期：2004-09-01 00:00:00

abstract：:Anorexia nervosa (AN) is a severe and complex psychiatric disorder characterized by intense fear about weight gain and finalized to food-related control behaviors. Growing interest has been demonstrated about neurobiological processes subtend to AN physiopathology. The present review aimed to collect neurostructural a...

journal_title：Journal of neuroscience research

authors： Alfano V,Mele G,Cotugno A,Longarzo M

更新日期：2020-11-01 00:00:00

abstract：:The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury-based model of neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive deficits are associated with a functional reorganization of the medial prefrontal cortex (mPFC). Here, we have employed an adapted model of C...

journal_title：Journal of neuroscience research

authors： Medeiros P,de Freitas RL,Boccella S,Iannotta M,Belardo C,Mazzitelli M,Romano R,De Gregorio D,Coimbra NC,Palazzo E,Maione S

更新日期：2020-02-01 00:00:00

abstract：:Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to investigate whether L-Asp and NMDA inhibit histamine-stimula...

journal_title：Journal of neuroscience research

authors： Tsai LH,Lee YJ,Wu JY

更新日期：2004-09-01 00:00:00

abstract：:Metabolic abnormalities found in epileptogenic tissue provide considerable evidence of brain hypometabolism, while major risk factors for acquired epilepsy all share brain hypometabolism as one common outcome, suggesting that a breakdown of brain energy homeostasis may actually precede epileptogenesis. However, a caus...

journal_title：Journal of neuroscience research

authors： Samokhina E,Popova I,Malkov A,Ivanov AI,Papadia D,Osypov A,Molchanov M,Paskevich S,Fisahn A,Zilberter M,Zilberter Y

更新日期：2017-11-01 00:00:00

abstract：:We have developed an animal model of learning and memory impairment associated with activation of microglia in the mouse brain. Injection of lipopolysaccharide into the CA1 region of the mouse hippocampus resulted in an increased production of inflammatory cytokines, such as interleukin-1β. Immunostaining for interleu...

journal_title：Journal of neuroscience research

authors： Tanaka S,Kondo H,Kanda K,Ashino T,Nakamachi T,Sekikawa K,Iwakura Y,Shioda S,Numazawa S,Yoshida T

更新日期：2011-04-01 00:00:00

abstract：:Brain injury and neuroinflammation are pathophysiologic contributors to acute and chronic neurologic disorders, which are progressive diseases not fully understood. Mammalian metallothioneins I and II (MT-I&II) have significant neuroprotective functions, but the precise mechanisms underlying these effects are still un...

journal_title：Journal of neuroscience research

authors： Penkowa M,Tio L,Giralt M,Quintana A,Molinero A,Atrian S,Vasák M,Hidalgo J

更新日期：2006-05-01 00:00:00

abstract：:In this report, we address the molecular mechanisms that regulate axonal growth by focusing on the gene for one of the major axonal cytoskeletal proteins, T alpha1 alpha-tubulin. During the developmental growth of sympathetic neurons, transcription of a beta-galactosidase transgene driven by the T alpha1 promoter (T a...

journal_title：Journal of neuroscience research

authors： Wu W,Gloster A,Miller FD

更新日期：1997-06-01 00:00:00

abstract：:Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H NMR experiments, originate undesired resonances i...

journal_title：Journal of neuroscience research

authors： Lei H,Duarte JM,Mlynarik V,Python A,Gruetter R

更新日期：2010-02-01 00:00:00

abstract：:The effects of extracellular acidification on the synaptic function and neuronal excitability were investigated on the hippocampal CA1 neurons. A decrease of extracellular pH from 7.4 to 6.7 did not alter either the resting membrane potential or the neuronal membrane input resistance. Extracellularly recorded field ex...

journal_title：Journal of neuroscience research

authors： Hsu KS,Liang YC,Huang CC

更新日期：2000-11-01 00:00:00

abstract：:The effects of cations on the spontaneous and potassium-stimulated taurine release from mouse cerebral cortex slices were assessed with an emphasis on the as yet unestablished calcium dependence of the stimulated release. Spontaneous and stimulated GABA release was analyzed for comparison. A depolarizing concentration...

journal_title：Journal of neuroscience research

authors： Oja SS,Kontro P

更新日期：1987-01-01 00:00:00

abstract：:The type 1 metabotropic glutamate receptor (mGluR1) plays an import role in the synaptic physiology and development of cerebellar Purkinje neurons. mGluR1 expression occurs early in the developmental program of Purkinje neurons, at an age that precedes expression of the dendritic structure. Few studies have investigat...

journal_title：Journal of neuroscience research

authors： Netzeband JG,Gruol DL

更新日期：2008-02-01 00:00:00

abstract：:Nerve growth factor (NGF) has been purified from the guinea pig prostate using a modification of the Bocchini-Angeletti method for isolating 2.5S NGF from mouse submaxillary glands. As with the mouse preparation, guinea pig prostate NGF appears to migrate as a high molecular weight entity at physiological pH. Followin...

journal_title：Journal of neuroscience research

authors： Rubin JS,Bradshaw RA

更新日期：1981-01-01 00:00:00

abstract：:To scale up human neural stem/progenitor cell (NSPC) cultures for clinical use, we need to know how long these cells can live ex vivo without losing their ability to proliferate and differentiate; thus, a convenient method is needed to estimate the proliferative activity of human NSPCs grown in neurosphere cultures, a...

journal_title：Journal of neuroscience research

authors： Kanemura Y,Mori H,Kobayashi S,Islam O,Kodama E,Yamamoto A,Nakanishi Y,Arita N,Yamasaki M,Okano H,Hara M,Miyake J

更新日期：2002-09-15 00:00:00

abstract：:Previous studies from our laboratory suggest that Alzheimer's disease sera contain a repertoire of antibodies to the heavy neurofilament subunit (NF-H) and that a subpopulation of these antibodies bind specifically to epitopes highly enriched in NF-H isolated from the purely cholinergic electromotor neurons of Torpedo...

journal_title：Journal of neuroscience research

authors： Faigon M,Hadas E,Alroy G,Chapman J,Auerbach JM,Michaelson DM

更新日期：1991-08-01 00:00:00

abstract：:This investigation explores the central nervous system protein-synthetic responses to hemisection of the spinal cord. Adult male rats hemisected at mid T2 were given intravenous injections of 14C-leucine at 0.7, 30, or 70 days postoperative. Four hours later the T1, T2, T3, and C6 segments of the spinal cord and right...

journal_title：Journal of neuroscience research

authors： Luttge WG,Mannis MJ,Bernstein JJ

更新日期：1975-01-01 00:00:00

abstract：:The discharge behavior of neurons depends on a variable expression and sorting pattern of voltage-dependent potassium (Kv) channels that changes during development. The rodent retina represents a neuronal network whose main functions develop after birth. To obtain information about neuronal maturation we analyzed the ...

journal_title：Journal of neuroscience research

authors： Höltje M,Brunk I,Grosse J,Beyer E,Veh RW,Bergmann M,Grosse G,Ahnert-Hilger G

更新日期：2007-01-01 00:00:00

abstract：:The concept of the neurovascular unit emphasizes that common signals and substrates underlie the physiology and pathophysiology of neuronal and endothelial compartments in brain. Recent data suggest that activation of the integrin-associated protein CD47 promotes neuronal cell death. Is it possible that CD47 may also ...

journal_title：Journal of neuroscience research

authors： Xing C,Lee S,Kim WJ,Wang H,Yang YG,Ning M,Wang X,Lo EH

更新日期：2009-08-15 00:00:00

abstract：:We have performed proteomic analysis in the cerebrospinal fluid in an animal model of Parkinson's disease induced by axotomy of the medial forebrain bundle. In this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in the substantia nigra and a loss...

journal_title：Journal of neuroscience research

authors： Rite I,Argüelles S,Venero JL,García-Rodriguez S,Ayala A,Cano J,Machado A

更新日期：2007-12-01 00:00:00

abstract：:Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC zeta activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC zeta. Inhibit...

journal_title：Journal of neuroscience research

authors： Wang YM,Seibenhener ML,Vandenplas ML,Wooten MW

更新日期：1999-02-01 00:00:00

abstract：:Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disord...

journal_title：Journal of neuroscience research

authors： Hermanto Y,Maki T,Takagi Y,Miyamoto S,Takahashi J

更新日期：2019-07-01 00:00:00