Alterations of central nervous system protein synthesis in response to spinal cord hemisection.

abstract：:Glial cell line-derived neurotrophic factor (GDNF) acts as a potent survival factor for many neuronal populations, including spinal motoneurons, indicating the therapeutic promise of GDNF for neurological disorders. Injury to spinal cord (SCI) triggers processes destructive to ascending sensory and descending motor co...

journal_title：Journal of neuroscience research

authors： Cheng H,Wu JP,Tzeng SF

更新日期：2002-08-01 00:00:00

abstract：:The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...

journal_title：Journal of neuroscience research

authors： Yeh YY

更新日期：1988-03-01 00:00:00

abstract：:In the non-amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is cleaved within the amyloid-beta domain by alpha-secretase precluding deposition of intact amyloid-beta peptide. The large ectodomain released from the cell surface by the action of alpha-secretase has several neuroprotective propertie...

journal_title：Journal of neuroscience research

authors： Allinson TM,Parkin ET,Turner AJ,Hooper NM

更新日期：2003-11-01 00:00:00

abstract：:Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue-derived mesenchymal stem cells (ADMSCs) were intrave...

journal_title：Journal of neuroscience research

authors： Park D,Yang G,Bae DK,Lee SH,Yang YH,Kyung J,Kim D,Choi EK,Choi KC,Kim SU,Kang SK,Ra JC,Kim YB

更新日期：2013-05-01 00:00:00

abstract：:Synaptic vesicles were isolated from adult bovine cortical gray matter by differential centrifugation and membrane filtration of a hypoosmotically lysed crude mitochondrial fraction. Vesicle preparations were analyzed for purity by electron microscopy and enzyme assays. Polyacrylamide gel electrophoresis of SDS-solubi...

journal_title：Journal of neuroscience research

authors： Richter-Landsberg C,Neuhoff V,Waehneldt TV

更新日期：1977-01-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is a common occurrence in preterm and low-birth-weight infants, and the incidence of low-birth-weight and preterm births is increasing. Characterization of brain injury after HI is of critical importance in developing new treatments that more accurately target the injury. After severe HI...

journal_title：Journal of neuroscience research

authors： Infante SK,Oberhauser AF,Perez-Polo JR

更新日期：2013-09-01 00:00:00

abstract：:We studied the electrophysiological, hemodynamic, and cytomorphological consequences of microhemorrhagic brain injury induced by a nanoscale iron injection. Of particular interest were the etiology, development, and treatment of epilepsy associated with this injury. We developed an animal model of chronic epilepsy usi...

journal_title：Journal of neuroscience research

authors： Jo A,Heo C,Schwartz TH,Suh M

更新日期：2014-03-01 00:00:00

abstract：:We here reconsider current theories of neural ensembles in the context of recent discoveries about neuronal dendritic physiology. The key physiological observation is that the dendritic plateau potential produces sustained depolarization of the cell body (amplitude 10-20 mV, duration 200-500 ms). Our central hypothesi...

journal_title：Journal of neuroscience research

authors： Antic SD,Hines M,Lytton WW

更新日期：2018-09-01 00:00:00

abstract：:The effects of blinding with or without pineal ablation on brain monoamine levels were studied in male rats. Brain dopamine (DA), norepinephrine (NE), epinephrine (E), and serotonin (5-HT) were measured by radioenzymatic assays. Four weeks following pinealectomy, E levels were significantly enhanced in the frontal cor...

journal_title：Journal of neuroscience research

authors： Niles LP,Brown GM,Mishra RK

更新日期：1983-01-01 00:00:00

abstract：:We have studied the characteristics of pH(i) regulation at different stages of rat oligodendrocyte differentiation in primary culture. pH(i) was measured at 37 degrees C using the pH-sensitive fluorescent probe BCECF. In immature oligodendrocyte progenitor (OLP), three distinct ionic mechanisms were involved in pH(i) ...

journal_title：Journal of neuroscience research

authors： Boussouf A,Gaillard S

更新日期：2000-03-15 00:00:00

abstract：:Six different types of spectral responses were recorded from horizontal cells under mesopic conditions in perfused retina, isolated from the dark-adapted mojarra (Eugerres plumieri). They were tentatively termed photopic Lr-, Lg1-, Lg2-, Lb-, and C-type, and scotopic L-type. The Lr-, Lg-, and Lb-type responses showed ...

journal_title：Journal of neuroscience research

authors： Negishi K,Salas R,Parthe V,Drujan BD

更新日期：1988-01-01 00:00:00

abstract：:Living organotypic cocultures of rat thalamic and cortical explants were used to examine the effects of blocking action potential activity on the morphological development of axons in the mammalian neocortex. Studies in vivo have suggested that blocking sodium channel-dependent activity influences the growth character...

journal_title：Journal of neuroscience research

authors： Wilkemeyer MF,Angelides KJ

更新日期：1996-03-15 00:00:00

abstract：:Neural precursor cells (NPCs) critically regulate brain morphogenesis and recent studies have revealed an unexpectedly high frequency of NPC chromosomal abnormalities and apoptosis in the developing brain. We have shown previously that the apoptotic response of NPCs to genotoxic agents is dependent on p53 and caspase-...

journal_title：Journal of neuroscience research

authors： D'Sa C,Klocke BJ,Cecconi F,Lindsten T,Thompson CB,Korsmeyer SJ,Flavell RA,Roth KA

更新日期：2003-11-01 00:00:00

abstract：:The role of intracellular proteases (e.g., calpains and caspases) in the pathophysiology of neuronal cell death has been extensively investigated. More recently, accumulating data have suggested that extracellular proteolysis also plays a critical role. The two major systems that modify the extracellular matrix in bra...

journal_title：Journal of neuroscience research

authors： Lo EH,Wang X,Cuzner ML

更新日期：2002-07-01 00:00:00

abstract：:Persephin (PSP) is the most recently discovered member of the GDNF family of neurotrophic factors. We have used an RT-PCR approach to start addressing the putative functional significance of PSP by determining sites of its synthesis in the neonatal rat brain. Generally, two transcripts were found. Sequence analysis of...

journal_title：Journal of neuroscience research

authors： Jaszai J,Farkas L,Galter D,Reuss B,Strelau J,Unsicker K,Krieglstein K

更新日期：1998-08-15 00:00:00

abstract：:Axotomy of peripheral nerves in neonatal rats induces motoneuron death that can be delayed but not arrested by the application of several neurotrophic factors (NFs) or adenoviral vectors carrying genes for NFs. We tested whether an adenoviral vector carrying the gene for glial cell-line-derived neurotrophic factor (Ad...

journal_title：Journal of neuroscience research

authors： Baumgartner BJ,Shine HD

更新日期：1998-12-15 00:00:00

abstract：:Oxidative mechanisms of injury are important in many neurological disorders. Developing oligodendrocytes (pre-OLs) are particularly sensitive to oxidative stress-mediated injury. We previously demonstrated a novel function of phylloquinone (vitamin K(1)) and menaquinone 4 (MK-4; a major form of vitamin K2) in protecti...

journal_title：Journal of neuroscience research

authors： Li J,Wang H,Rosenberg PA

更新日期：2009-07-01 00:00:00

abstract：:Neuronal progenitors in the adult hippocampus continually proliferate and differentiate to the neuronal lineage, and ischemic insult promotes hippocampal neurogenesis. However, newborn neurons show a progressive reduction in numbers during the initial few weeks, therefore, enhanced survival of newborn neurons seems to...

journal_title：Journal of neuroscience research

authors： Sasaki T,Kitagawa K,Yagita Y,Sugiura S,Omura-Matsuoka E,Tanaka S,Matsushita K,Okano H,Tsujimoto Y,Hori M

更新日期：2006-11-01 00:00:00

abstract：:We investigated the ability of human bone marrow stromal cell (hBMSC) treatment to reduce axonal loss in experimental autoimmune encephalomyelitis (EAE) mice. EAE was induced in SJL/J mice by injection with proteolipid protein (PLP). Mice were injected intravenously with hBMSCs or PBS on the day of clinical onset, and...

journal_title：Journal of neuroscience research

authors： Zhang J,Li Y,Lu M,Cui Y,Chen J,Noffsinger L,Elias SB,Chopp M

更新日期：2006-08-15 00:00:00

abstract：:Glial cell-line derived neurotrophic factor (GDNF) is the most potent trophic factor for motoneuron survival and neuromuscular junction formation. GDNF is upregulated in injured or denervated skeletal muscle and returns to normal levels following reinnervation. However, the mechanism by which GDNF is regulated in dene...

journal_title：Journal of neuroscience research

authors： Rosa E,Cha J,Bain JR,Fahnestock M

更新日期：2015-03-01 00:00:00

abstract：:People showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signaling, and show differences between both sexes. We ex...

journal_title：Journal of neuroscience research

authors： Schote AB,A L Sayk C,Pabst K,Meier JK,Frings C,Meyer J

更新日期：2019-02-01 00:00:00

abstract：:In its severe form, X-linked adrenoleukodystrophy (ALD) is a lethal neurologic disease of children, characterized by progressive cerebral demyelination and adrenal insufficiency. Associated with a biochemical defect of peroxisomal beta-oxidation, very long-chain fatty acids (VLCFA) build up in tissues that have a high...

journal_title：Journal of neuroscience research

authors： Forss-Petter S,Werner H,Berger J,Lassmann H,Molzer B,Schwab MH,Bernheimer H,Zimmermann F,Nave KA

更新日期：1997-12-01 00:00:00

abstract：:This experiment was directed toward determining the relative effectiveness of discrete and diffuse pain stimuli in influencing perception and behavior. Shocks to the footpads were used to activate the discrete pain pathways and shocks to the upper canine teeth to activate the diffuse pain pathways. In the first phase ...

journal_title：Journal of neuroscience research

authors： Anderson KV,Pearl GS,Honeycutt C

更新日期：1976-01-01 00:00:00

abstract：:Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...

journal_title：Journal of neuroscience research

authors： Kuo TY,Hong CJ,Chien HL,Hsueh YP

更新日期：2010-08-15 00:00:00

abstract：:Little is known about the structural neural substrates that may contribute to sex differences in risk-taking propensity (RTP). A close association between risk-seeking behavior and the emotional-regulation network led us to hypothesize that the sex differences in RTP would be associated with sex differences in brain m...

journal_title：Journal of neuroscience research

authors： Bajaj S,Killgore WDS

更新日期：2020-02-01 00:00:00

abstract：:The tissue- and cell-specific expression of three neutral glycosphingolipids, gangliotetraosylceramide (GA1), gangliopentaosylceramide (GalNAc-GA1), and the novel 3-O-acetyl-sphingosine-series glycolipid (FMC-5), were examined with monospecific polyclonal antibodies. Immunohistochemical studies of rodent brain cross-s...

journal_title：Journal of neuroscience research

authors： Dasgupta S,Bhat NR,Spicer SS,Hogan EL,Furuya S,Hirabayashi Y

更新日期：2007-10-01 00:00:00

abstract：:The transport kinetics of the excitatory sulphur-containing amino acid (SAA) transmitter candidates, L-cysteine sulphinate (L-CSA), L-cysteate (L-CA), L-homocysteine sulphinate (L-HCSA), and L-homocysteate (L-HCA), together with their plasma membrane carrier specificity, was studied in cerebrocortical synaptosome frac...

journal_title：Journal of neuroscience research

authors： Grieve A,Butcher SP,Griffiths R

更新日期：1992-05-01 00:00:00

abstract：:The distribution of phosphofructokinase (PFK) in gray and white matter regions of the rat nervous system was evaluated. Determinations of PFK activity revealed that cell body enriched regions (sensorimotor cortex) had a significantly higher level of activity than axonal regions (sciatic nerve, dorsal roots, and optic ...

journal_title：Journal of neuroscience research

authors： Oblinger MM,Foe LG,Kwiatkowska D,Kemp RG

更新日期：1988-09-01 00:00:00

abstract：:Mutations in the beta-amyloid precursor protein (APP) gene cause familial Alzheimer's disease (AD). Although amyloid beta peptide (Abeta) is the principal constituent of senile plaques in AD, other cleavage products of APP are also implicated in playing a role in the pathogenesis of AD. C-terminal fragments of APP (AP...

journal_title：Journal of neuroscience research

authors： Lee JP,Chang KA,Kim HS,Kim SS,Jeong SJ,Suh YH

更新日期：2000-05-15 00:00:00

abstract：:The neuronal intermediate filaments include not only the neurofilament triplet proteins but also peripherin and alpha-internexin. To determine whether neurite outgrowth is enhanced by alpha-internexin, the cDNA of rat alpha-internexin tagged with enhanced green fluorescent protein (EGFP) was transfected into a rat adr...

journal_title：Journal of neuroscience research

authors： Chien CL,Liu TC,Ho CL,Lu KS

更新日期：2005-06-01 00:00:00