Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases.

abstract：:Lithium, the most prevalent treatment for manic-depressive illness, might have a neuroprotective effect after brain injury. In culture, lithium can exert neurotoxic effects associated with reduction in polyamine synthesis but neuroprotective effects as cultured neurons mature. Cumulative evidence suggests that lithium...

journal_title：Journal of neuroscience research

authors： Gilad GM,Gilad VH

更新日期：2007-02-15 00:00:00

abstract：:The neural cell adhesion molecule L1 is a multidomain protein that plays important roles in cell adhesion, migration, and neurite outgrowth. It can interact with itself by a self-binding, i.e., homophilic adhesion mechanism (Kadmon et al.: J Cell Biol 110: 193-208, 1990a). To determine the domains of L1 involved in ho...

journal_title：Journal of neuroscience research

authors： Holm J,Appel F,Schachner M

更新日期：1995-09-01 00:00:00

abstract：:The analysis of proteins in damaged myelin is crucial to clarify the mechanisms of dysmyelination and demyelination. In the present study, proteomic analysis of myelin using a modified two-dimensional electrophoresis (2-DE) method was carried out to obtain a better understanding of myelin biology. Although standard 2-...

journal_title：Journal of neuroscience research

authors： Yamaguchi Y,Miyagi Y,Baba H

更新日期：2008-03-01 00:00:00

abstract：:We investigated the role of kainate (KA) receptor activation and desensitization in inducing the increase in the intracellular free Ca(2+) concentration ([Ca(2+)](i)) in individual cultured rat hippocampal neurons. The rat hippocampal neurons in the cultures were shown to express kainate receptor subunits, KA2 and Glu...

journal_title：Journal of neuroscience research

authors： Silva AP,Malva JO,Ambrósio AF,Salgado AJ,Carvalho AP,Carvalho CM

更新日期：2001-09-01 00:00:00

abstract：:The interaction of bovine white matter proteolipid apoproteins with sodium dodecyl sulfate (SDS) was studied. Equilibrium dialysis binding measurements show that the apoprotein binds approximately 1.5 gm SDS per gram protein at high ionic strength (gamma/2 = 0.17). At low ionic strength (gamma/2 = 0.01) the protein bi...

journal_title：Journal of neuroscience research

authors： Sakura JD

更新日期：1981-01-01 00:00:00

abstract：:Traumatic brain injuries (TBIs) pose a massive burden of disease and continue to be a leading cause of morbidity and mortality throughout the world. A major obstacle in developing effective treatments is the lack of comprehensive understanding of the underlying mechanisms that mediate tissue damage and recovery after ...

journal_title：Journal of neuroscience research

authors： Bogoslovsky T,Bernstock JD,Bull G,Gouty S,Cox BM,Hallenbeck JM,Maric D

更新日期：2018-04-01 00:00:00

abstract：:Here we show that rabbit Müller cell differentiation from radial glial progenitor cells is accompanied by a decreasing capability to respond to specific stimuli (depolarization and extracellular adenosine 5'-triphosphate [ATP]) with an elevation of intracellular calcium. Intracellular free calcium was recorded in reti...

journal_title：Journal of neuroscience research

authors： Uckermann O,Grosche J,Reichenbach A,Bringmann A

更新日期：2002-10-15 00:00:00

abstract：:The effects of cations on the spontaneous and potassium-stimulated taurine release from mouse cerebral cortex slices were assessed with an emphasis on the as yet unestablished calcium dependence of the stimulated release. Spontaneous and stimulated GABA release was analyzed for comparison. A depolarizing concentration...

journal_title：Journal of neuroscience research

authors： Oja SS,Kontro P

更新日期：1987-01-01 00:00:00

abstract：:The 14-3-3 proteins exist predominantly in the brain and may play regulatory roles in cellular processes of growth, differentiation, survival, and apoptosis. The biological functions, however, of the various 14-3-3 isoforms (beta, epsilon, eta, gamma, and zeta) in the brain remain unclear. We have reported previously ...

journal_title：Journal of neuroscience research

authors： Chen XQ,Liu S,Qin LY,Wang CR,Fung YW,Yu AC

更新日期：2005-01-01 00:00:00

abstract：:Biology of GnRH neurons is critically dependent on extracellular Ca(2+) (Ca(2+) (o)). We evaluated differences in gene expression patterns with low and high Ca(2+) (o) in an immortalized GnRH neuron line, GT1-7 cells. Mouse global oligonucleotide microarray was used to evaluate transcriptional differences among the ge...

journal_title：Journal of neuroscience research

authors： Bandyopadhyay S,Jeong KH,Hansen JT,Vassilev PM,Brown EM,Chattopadhyay N

更新日期：2007-03-01 00:00:00

abstract：:The periglomerular cells (PG) of the olfactory bulb (OB) are involved in the primary processing and the refinement of sensory information from the olfactory epithelium. The neurochemical composition of these neurons has been studied in depth in many species, and over the last decades such studies have focused mainly o...

journal_title：Journal of neuroscience research

authors： Baltanás FC,Curto GG,Gómez C,Díaz D,Murias AR,Crespo C,Erdelyi F,Szabó G,Alonso JR,Weruaga E

更新日期：2011-01-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) acts as a potent survival factor for many neuronal populations, including spinal motoneurons, indicating the therapeutic promise of GDNF for neurological disorders. Injury to spinal cord (SCI) triggers processes destructive to ascending sensory and descending motor co...

journal_title：Journal of neuroscience research

authors： Cheng H,Wu JP,Tzeng SF

更新日期：2002-08-01 00:00:00

abstract：:Macrophages play critical roles in both degenerative and regenerative processes following peripheral nerve injury. These include phagocytosis of debris, stimulation of Schwann cell dedifferentiation and proliferation, and salvage of myelin lipids for reutilization during regeneration. To better define the role of macr...

journal_title：Journal of neuroscience research

authors： Venezie RD,Toews AD,Morell P

更新日期：1995-01-01 00:00:00

abstract：:The concentration of myelin basic protein (MBP) mRNA in primary cultures of cells dissociated from embryonic mouse cerebra and grown in the presence of varying amounts of thyroid hormone was measured using a 32P-labeled cDNA probe and a dot-blot procedure. The cDNA probe contained 1.85 kilobases of the gene for MBP. T...

journal_title：Journal of neuroscience research

authors： Shanker G,Campagnoni AT,Pieringer RA

更新日期：1987-01-01 00:00:00

abstract：:There is growing evidence on the existence of endogenous ouabain-like factors that modulate Na+, K(+)-ATPase activity. In this laboratory, two soluble subfractions (peaks I and II) were previously separated from rat cerebral cortex, which had opposite effects on Na+, K(+)-ATPase activity. Peak I stimulated and peak II...

journal_title：Journal of neuroscience research

authors： Antonelli M,Casillas T,Rodríguez de Lores Arnaiz G

更新日期：1991-03-01 00:00:00

abstract：:Regional estimates of type I and type II vestibular hair cells (HC) and supporting cell (SC) numbers were obtained from the horizontal crista ampullaris by using design-based stereology in human. Cristae were microdissected from temporal bones obtained post-mortem (N=16, age range 26-98 years). Three groups were made ...

journal_title：Journal of neuroscience research

authors： Lopez I,Ishiyama G,Tang Y,Tokita J,Baloh RW,Ishiyama A

更新日期：2005-11-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) are known to be synthesized in the central nervous system (CNS) and to act on CNS cells in vitro, but less is known about their synthesis, expression, and role in vivo. In this work, using specific anti-acidic fibroblast growth factor (aFGF) antibodies, we have shown for the first time...

journal_title：Journal of neuroscience research

authors： Tourbah A,Oliver L,Jeanny JC,Gumpel M

更新日期：1991-08-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is a common occurrence in preterm and low-birth-weight infants, and the incidence of low-birth-weight and preterm births is increasing. Characterization of brain injury after HI is of critical importance in developing new treatments that more accurately target the injury. After severe HI...

journal_title：Journal of neuroscience research

authors： Infante SK,Oberhauser AF,Perez-Polo JR

更新日期：2013-09-01 00:00:00

abstract：:We reported previously that stem cell factor (SCF) is produced mainly by neurons and that its receptor (c-kitR), encoded by the protooncogene c-kit, is expressed in microglia, suggesting that SCF/c-kitR signaling may be involved in neuron-microglia interactions. We now report that SCF supports microglial survival in c...

journal_title：Journal of neuroscience research

authors： Zhang SC,Fedoroff S

更新日期：1998-07-01 00:00:00

abstract：:The ErbB family, ErbB1 (also known as the epidermal growth factor receptor EGFR), ErbB2, ErbB3, and ErbB4 comprise a group of receptor tyrosine kinases that interact with ligands from the epidermal growth factor (EGF) superfamily, subsequently dimerize, catalytically activate each other by cross-phosphorylation, and t...

journal_title：Journal of neuroscience research

authors： Fox IJ,Kornblum HI

更新日期：2005-03-01 00:00:00

abstract：:Cerebrospinal fluid was collected from the lateral ventricles and cisternal space from beagle dogs under light pentobarbital anesthesia. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglyco-sulfate (MOPEG-SO4) levels in the liquor taken from these two regions were evaluated,...

journal_title：Journal of neuroscience research

authors： Bareggi SR,Stabenau JR,Shaskan EG,Becker RE,Roberts M

更新日期：1975-01-01 00:00:00

abstract：:The regeneration of transected mouse sciatic nerves using semipermeable acrylic copolymer tubes to enclose both stumps has been qualitatively assessed from 1 to 30 weeks post-operative. Quantitative morphometric analysis of electron micrograph montages of complete transverse sections of the segment regenerated between...

journal_title：Journal of neuroscience research

authors： Uzman BG,Villegas GM

更新日期：1983-01-01 00:00:00

abstract：:Anoxia during delivery is a complication that can disturb infant brain development leading to various types of neurological disorders. Our studies have shown that increased body temperature of newborn rats of both sexes intensifies the postanoxic oxidative stress and prevents triggering the endogenous adaptive respons...

journal_title：Journal of neuroscience research

authors： Kletkiewicz H,Maliszewska J,Jaworski K,Jermacz Ł,Smoliński DJ,Rogalska J

更新日期：2019-10-01 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of unknown etiology. Both genetic-susceptibility and environment exposures, including vitamin D deficiency, Epstein-Barr viral and Herpesvirus (HHV-6) infections are strongly implicated in the activation of T cells and MS-pathogenesis. Despite precis...

journal_title：Journal of neuroscience research

authors： Tiwari S,Lapierre J,Ojha CR,Martins K,Parira T,Dutta RK,Caobi A,Garbinski L,Ceyhan Y,Esteban-Lopez M,El-Hage N

更新日期：2018-12-01 00:00:00

abstract：:To further our understanding of the functions of the major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), and other myelin proteins, such as 2'3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin-associated glycoprotein (MAG), bovine brain myelin was extracted with Triton X-100, and p...

journal_title：Journal of neuroscience research

authors： Arvanitis DN,Yang W,Boggs JM

更新日期：2002-10-01 00:00:00

abstract：:This Review describes some in vitro approaches used to investigate the mechanisms involved in Krabbe's disease, with particular regard to the cellular systems employed to study processes of inflammation, apoptosis, and angiogenesis. The aim was to update the knowledge on the results obtained from in vitro models of th...

journal_title：Journal of neuroscience research

authors： Avola R,Graziano AC,Pannuzzo G,Alvares E,Cardile V

更新日期：2016-11-01 00:00:00

abstract：:The turmeric derivative curcumin protects against cerebral ischemic injury. We previously demonstrated that curcumin activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor involved in both neuroprotective and anti-inflammatory signaling pathways. This study tested wheth...

journal_title：Journal of neuroscience research

authors： Liu ZJ,Liu HQ,Xiao C,Fan HZ,Huang Q,Liu YH,Wang Y

更新日期：2014-11-01 00:00:00

abstract：:Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...

journal_title：Journal of neuroscience research

authors： Zeng Z,Yuan X,Liu G,Zeng X,Zeng X,Ng H,Chen H,Jiang T,Akasaki Y,Kessey K,Black KL,Yu JS

更新日期：2007-02-01 00:00:00

abstract：:The cell line PC12, derived from a rat pheochromocytoma, has served as a model for studies on the mechanism of action of nerve growth factor, as well as for the exploration of neuronal differentiation in general. When treated with nanomolar concentrations of nerve growth factor, these neoplastic chromaffin-like cells ...

journal_title：Journal of neuroscience research

authors： Simpson DL,Dickens G,Doll S,Koizumi S,Tocco M,Okuda O,Oshima M,Rudkin BB,Brightman M,Guroff G

更新日期：1991-04-01 00:00:00

abstract：:Persephin (PSP) is the most recently discovered member of the GDNF family of neurotrophic factors. We have used an RT-PCR approach to start addressing the putative functional significance of PSP by determining sites of its synthesis in the neonatal rat brain. Generally, two transcripts were found. Sequence analysis of...

journal_title：Journal of neuroscience research

authors： Jaszai J,Farkas L,Galter D,Reuss B,Strelau J,Unsicker K,Krieglstein K

更新日期：1998-08-15 00:00:00