Abstract:
:Regional estimates of type I and type II vestibular hair cells (HC) and supporting cell (SC) numbers were obtained from the horizontal crista ampullaris by using design-based stereology in human. Cristae were microdissected from temporal bones obtained post-mortem (N=16, age range 26-98 years). Three groups were made according to age: group 1, n=5, ages between 26 and 67 years, average age 51 years; group 2, n=4, average age 84 years; and group 3, n=7, average age 94 years. For group 1, the average total HC number was 8,005+/-214, corresponding to 4,119+/-107 type I HC, 3,886+/-117 type II HC, and 10,274+/-224 SC. The type I:type II HC ratio was 1.06+/-0.01, and HC density was 0.80 cells/100 microm2. For group 2, the average total HC number was 7,074+/-489, corresponding to 3,733+/-212 type I HC, 3,341+/-314 type II HC, and 9,321+/-858 SC. The type I:II HC ratio was 1.12+/-0.06, and HC density was 0.75 cells/100 microm2. For group 3, the average HC number was 6,009+/-327, corresponding to 3,380+/-223 type I HC, 2,628+/-235 type II HC, and 10,185+/-182 SC. The type I:II HC ratio was 1.34+/-0.10, and HC density was 0.63 cells/100 microm2. A significant decline in type I, type II, and total HC number and density was found in groups 2 and 3, with individuals exceeding the average human life span.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Lopez I,Ishiyama G,Tang Y,Tokita J,Baloh RW,Ishiyama Adoi
10.1002/jnr.20652keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
421-31issue
3eissn
0360-4012issn
1097-4547journal_volume
82pub_type
杂志文章abstract::Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of Parkinson's disease (PD). Neurogenesis, the generation of new neurons, persists throughout the mammalian life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of P...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23677
更新日期:2016-01-01 00:00:00
abstract::In its severe form, X-linked adrenoleukodystrophy (ALD) is a lethal neurologic disease of children, characterized by progressive cerebral demyelination and adrenal insufficiency. Associated with a biochemical defect of peroxisomal beta-oxidation, very long-chain fatty acids (VLCFA) build up in tissues that have a high...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19971201)50:5<829::AID-JNR
更新日期:1997-12-01 00:00:00
abstract::To study the potential role of Alzheimer precursor protein A4 (APP) and beta-amyloid (A/beta) on aging motor neuron survival, expression of APP, A/beta, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury. Approximately 45% in number of total aged spi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10667
更新日期:2003-08-15 00:00:00
abstract::The actions of endogenous opioids and nociceptin/orphanin FQ are mediated by four homologous G protein-coupled receptors that constitute the opioid receptor family. However, little is known about opioid systems in cyclostomes (living jawless fish) and how opioid systems might have evolved from invertebrates. Here, we ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24682
更新日期:2020-08-23 00:00:00
abstract::Oligodendrocyte responses in vitro to platelet-derived growth factor (PDGF) include proliferation, survival, migration, and changes in cell morphology and molecular expression. Studies of mixed glial cultures established that astrocytes secrete PDGF; thus astrocytes are considered to be key regulators of oligodendrocy...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960701)45:1<28::AID-JNR3
更新日期:1996-07-01 00:00:00
abstract::DBA/2J mice are one of several animal strains used for experimental models of both intraocular hypertension and glaucoma. This study investigates the relationship between endoplasmic reticulum (ER) stress and optic nerve degeneration in DBA/2J mice. Intraocular pressure (IOP) was measured in DBA/2J mice between the ag...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23630
更新日期:2015-11-01 00:00:00
abstract::Glutamate-induced neurotoxicity consequent to N-methyl-D-aspartic acid (NMDA) and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propionic acid (AMPA) receptor activation underlies the pathogenesis of a wide range of central nervous system disorders, including brain ischemia. Prevention of ischemia/reperfusion (I/R)-ind...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22151
更新日期:2009-12-01 00:00:00
abstract::Neurotrophic factors regulate the developmental survival and differentiation of specific neuronal populations. Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the nerve growth factor (NGF) protein family, also known as the neurotrophins. Insights into the different roles of neurotroph...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340602
更新日期:1993-04-15 00:00:00
abstract::To examine the role of platelet-derived growth factor (PDGF) in the in vivo regulation of Schwann cell proliferation, steady-state levels of mRNAs encoding PDGF A and B chains, and PDGF alpha and beta receptors were measured in immature and adult rat sciatic nerves and in cultured rat Schwann cells. PDGF B chain and P...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310206
更新日期:1992-02-01 00:00:00
abstract::The rate and direction of neurite growth have been shown in a number of studies to be determined by the distribution of adhesive sites on the growth cone. Recent evidence showing that the application of extrinsic electric fields can redistribute membrane molecules and alter both the rate and direction of neurite growt...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490130118
更新日期:1985-01-01 00:00:00
abstract::The effects of phorbol 12-tetradecanoyl-13-acetate (TPA) and dibutyryl cAMP on the glutamate transport present in chick Bergmann glial cell (BGC) cultures were examined. TPA produced a significant decrease in [3H]-D-aspartate uptake, while dibutyryl cAMP treatment elicited a slight reduction in the transport. This eff...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19971115)50:4<585::AID-JNR
更新日期:1997-11-15 00:00:00
abstract::Relationships among different intensities of electroshock treatment (EST), EEG-recordable primary after discharge (PAD), and beta-adrenergic binding in various brain regions were investigated in adult rats. Different intensities of EST (1-2, 6-8, 20-30 mamp) were applied through ear-clip electrodes for 7 consecutive d...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490070306
更新日期:1982-01-01 00:00:00
abstract::Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be a critical step leading to axonal degeneration. Kinesin and microtubules (MT) were evaluated as molecular sites of action using...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19961001)46:1<7::AID-JNR2>
更新日期:1996-10-01 00:00:00
abstract::Oxidative stress results in protein oxidation and is implicated in cerebral disease, such as Parkinson's disease, Alzheimer's disease, and ischemic stroke. Sulfiredoxin-1 (Srxn1) is an endogenous antioxidant protein that has neuroprotective effects. The mechanisms of Srxn1 in oxidative stress have not been well studie...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23218
更新日期:2013-06-01 00:00:00
abstract::Increased serum level of homocysteine, a sulfur-containing amino acid, is considered a risk factor in vascular disorders and in dementias. The effect of homocysteine and metabolically related compounds on brain production of kynurenic acid (KYNA), an endogenous antagonist of glutamate ionotropic receptors, was studied...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20359
更新日期:2005-02-01 00:00:00
abstract::Although protein kinase Cdk5-p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21438
更新日期:2007-11-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Progressive and systemic loss of motor neurons with gliosis in the central nervous system (CNS) is a neuropathological hallmark of ALS. Chondroitin sulfate proteoglycans (CSPGs) are the major components of the extracellular matrix of the mammali...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24127
更新日期:2018-02-01 00:00:00
abstract::Although serotonin regulates synthesis of the neurotrophic factor S-100 beta by astrocytes, its ability to affect nerve growth factor (NGF) synthesis has never been examined. We report here that there is a correlation between the effect of serotonin on cyclic adenosine monophosphate (cAMP) content and on NGF content i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1074
更新日期:2001-05-01 00:00:00
abstract::Although the thalamus is not considered primarily as a limbic structure, abundant evidence indicates the essential role of the thalamus as a modulator of limbic functions indirectly through the amygdala. The amygdala is a central component of the limbic system and serves an essential role in modulating the core proces...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24235
更新日期:2018-07-01 00:00:00
abstract::Recently we demonstrated that a member of the neuregulin-1 (NRG-1) family of growth factors is a mitogen and survival factor for olfactory ensheathing cells (OECs). OECs are specialized glial cells within the olfactory system that are believed to play a role in the continual nerve re-growth of this tissue. OECs share ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20000715)61:2<172::AID-JNR8>3.0.
更新日期:2000-07-15 00:00:00
abstract::Zinc concentration and (65)Zn uptake in the brain of rats fed zinc-deficient diet for 12 weeks were examined, based on a previous finding of the impairment of learning behavior by the zinc deprivation. Zinc concentrations in the brain, except for the hippocampal formation, did not decrease significantly in zinc-defici...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20010301)63:5<447::AID-JNR1040>3
更新日期:2001-03-01 00:00:00
abstract::Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24312
更新日期:2020-07-01 00:00:00
abstract::Zinc is an endogenous N-methyl-D-aspartate (NMDA) receptor blocker. It is possible that zinc-mediated modification of hippocampal CA1 long-term potentiation (LTP) is linked to the expression of NMDA receptor subunits, which varies with postnatal development. In the present study, the effect of ZnCl(2) and CaEDTA, a me...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22787
更新日期:2012-03-01 00:00:00
abstract::We generated a new cell line, N38, by conditionally immortalizing mouse oligodendrocytes (OLs) at early stages of maturation. The morphology and marker expression pattern suggest N38 cells are similar to immature OLs. N38 cells were sensitive to changes in serum concentrations, and forcing the cells to differentiate i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20001101)62:3<319::AID-JNR1>3.0.
更新日期:2000-11-01 00:00:00
abstract::There is evidence that zinc may be involved in the pathogenesis of Parkinson's disease by an apoptotic pathway. However, the mechanisms underlying zinc-induced apoptosis are unknown. Previous studies showed that 6-hydroxydopamine (6-OHDA)-enhanced potassium channels are involved in apoptosis of dopaminergic neurons. O...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21854
更新日期:2009-02-01 00:00:00
abstract::We suggest that a dysregulation of energy metabolism in the brain of genetic absence epilepsy rats from Strasbourg (GAERS) could create a specific cerebral environment that would favor the expression of spike-and-wave discharges (SWD) in the thalamocortical loop, largely dependent on glutamatergic and gamma-aminobutyr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10086
更新日期:2001-12-01 00:00:00
abstract::Trophic factors, such as the neurotrophins, CNTF, and GDNF, represent unique families of proteins that are essential for the development of the vertebrate nervous system. Surprisingly, there is little evidence to date that these proteins exist in Drosophila melanogaster and Caenorhabditis elegans, even though other po...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than ma...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23784
更新日期:2017-01-02 00:00:00
abstract::The present experiments tested the hypothesis that one of the critical mechanisms underlying genetically defined aggressiveness involves brain serotonin 5-HT1A receptors. 5-HT1A receptor density, the receptor mRNA expression in brain structures, and functional correlates for 5-HT1A receptors identified as 8-OH-DPAT-in...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20456
更新日期:2005-04-15 00:00:00
abstract::Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder of the central nervous system (CNS) caused by a wide variety of mutations affecting proteolipid protein 1 (PLP1). We assessed the effects of PLP1 mutations on water diffusion in CNS white matter by using diffusion tensor imaging. Twelve patients with different...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23458
更新日期:2014-12-01 00:00:00