Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis.

abstract：:The balance of bone morphogenic protein (BMP), transforming growth factor-β (TGFβ)/activin/nodal, and Wnt signals regulates the early lineage segregation of human embryonic stem cells (ESCs). Here we demonstrate that a combination of small-molecule inhibitors of BMP (Dorsomorphin) and TGFβ/activin/nodal (SB431542) sig...

journal_title：Journal of neuroscience research

authors： Morizane A,Doi D,Kikuchi T,Nishimura K,Takahashi J

更新日期：2011-02-01 00:00:00

abstract：:Human P0 is the main myelin glycoprotein of the peripheral nervous system. It can bind six different glycans, all linked to Asn(93) , the unique glycosylation site. Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn(36) , MOG at Asn(31) ), bind only one glycan. The MAG has 10 glycosylation...

journal_title：Journal of neuroscience research

authors： Sedzik J,Jastrzebski JP,Grandis M

更新日期：2015-01-01 00:00:00

abstract：:Anorexia nervosa (AN) is a severe and complex psychiatric disorder characterized by intense fear about weight gain and finalized to food-related control behaviors. Growing interest has been demonstrated about neurobiological processes subtend to AN physiopathology. The present review aimed to collect neurostructural a...

journal_title：Journal of neuroscience research

authors： Alfano V,Mele G,Cotugno A,Longarzo M

更新日期：2020-11-01 00:00:00

abstract：:A coordinated up-regulation in the expression of all three neurofilament (NF) proteins occurs during postnatal development in the rat (Schlaepfer and Bruce, J Neurosci Res [in press], 1990a). In the present study, sciatic nerves were transected in neonatal rats in order to determine the effects of axotomy on the postn...

journal_title：Journal of neuroscience research

authors： Schwartz ML,Shneidman PS,Bruce J,Schlaepfer WW

更新日期：1990-10-01 00:00:00

abstract：:HEPES inhibited the taurine uptake in glial cells. A different kind of inhibition was observed when HEPES was present in the culture medium or in the incubation medium used for the taurine-uptake measurement. As an example of a possible interference of HEPES in pharmacological experiments, we have studied the effect o...

journal_title：Journal of neuroscience research

authors： Lleu PL,Rebel G

更新日期：1989-05-01 00:00:00

abstract：:Although they likely involve activation of N-methyl-D-aspartate (NMDA) receptors, the mechanisms giving rise to perinatal hypoxic-ischemic-induced damages remained unclear. The purpose of the present study was to investigate in vivo the mechanisms regulating the glutamate-induced release of toxic hydroxyl radicals (.O...

journal_title：Journal of neuroscience research

authors： Cambonie G,Laplanche L,Kamenka JM,Barbanel G

更新日期：2000-10-01 00:00:00

abstract：:Several neurological diseases involve focal injury of specific brain structures. Poisons of the electron transport chain complexes (ETCC) can also produce selective injury of brain structures when given systemically and have been implicated in the development of neurological disease. Why ETCC poisons damage particular...

journal_title：Journal of neuroscience research

authors： Fern R

更新日期：2003-03-15 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating condition characterized by disruption of axonal connections, failure of axonal regeneration, and loss of motor and sensory function. The therapeutic promise of neural stem cells has been focused on cell replacement, but many obstacles remain in obtaining neuronal integration f...

journal_title：Journal of neuroscience research

authors： Bonner JF,Blesch A,Neuhuber B,Fischer I

更新日期：2010-05-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FG...

journal_title：Journal of neuroscience research

authors： Tourbah A,Baron-Van Evercooren A,Oliver L,Raulais D,Jeanny JC,Gumpel M

更新日期：1992-09-01 00:00:00

abstract：:There are a considerable number of studies concerning the behavioral effects of physical exercise on the epileptic brain; however, the intracellular signaling mechanisms involved remain unclear. We investigated the effects of aerobic exercise on hippocampal levels of brain-derived neurotrophic factor (BDNF), expressio...

journal_title：Journal of neuroscience research

authors： de Almeida AA,Gomes da Silva S,Lopim GM,Vannucci Campos D,Fernandes J,Cabral FR,Arida RM

更新日期：2018-05-01 00:00:00

abstract：:Six different types of spectral responses were recorded from horizontal cells under mesopic conditions in perfused retina, isolated from the dark-adapted mojarra (Eugerres plumieri). They were tentatively termed photopic Lr-, Lg1-, Lg2-, Lb-, and C-type, and scotopic L-type. The Lr-, Lg-, and Lb-type responses showed ...

journal_title：Journal of neuroscience research

authors： Negishi K,Salas R,Parthe V,Drujan BD

更新日期：1988-01-01 00:00:00

abstract：:Inhibitory luminopsins (iLMO2) integrate opto- and chemo-genetic approaches and allow for cell-type specific inhibition of neuronal activity. When exposed to a Renilla luciferase substrate, Coelenterazine (CTZ), iLMO2 generates bioluminescence-mediated activation of its amino-terminal halorhodopsin, resulting in neuro...

journal_title：Journal of neuroscience research

authors： Jaiswal PB,Tung JK,Gross RE,English AW

更新日期：2020-03-01 00:00:00

abstract：:The hippocampus is an important brain region involved in memory and learning. Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B (TrkB), and phospho-p44/p42 mitogen-activated protein kinase (MAPK) are known to contribute to hippocampal memory/learning. The present study aimed to clarify the effects o...

journal_title：Journal of neuroscience research

authors： Ogawa T,Okihara H,Kokai S,Abe Y,Karin Harumi UK,Makiguchi M,Kato C,Yabushita T,Michikawa M,Ono T

更新日期：2018-06-01 00:00:00

abstract：:Cell transplantation offers a potential new treatment for stroke. Animal studies using models that produce ischemic damage in both the striatum and the frontal cortex have shown beneficial effects when hNT cells (postmitotic immature neurons) were transplanted into the ischemic striatum. In this study, we investigated...

journal_title：Journal of neuroscience research

authors： Bliss TM,Kelly S,Shah AK,Foo WC,Kohli P,Stokes C,Sun GH,Ma M,Masel J,Kleppner SR,Schallert T,Palmer T,Steinberg GK

更新日期：2006-05-01 00:00:00

abstract：:Intrinsic mechanisms that guide damaged axons to regenerate following spinal cord injury remain poorly understood. Manipulation of posttranslational modifications of key proteins in mature neurons could reinvigorate growth machinery after injury. One such modification is acetylation, a reversible process controlled by...

journal_title：Journal of neuroscience research

authors： Lin S,Nazif K,Smith A,Baas PW,Smith GM

更新日期：2015-08-01 00:00:00

abstract：:Increase of intracellular [Ca(2+)] evoked by action potentials in a cell can induce long-term synaptic plasticity even without concomitant presynaptic stimulation. We used optical recording of the fluorescence of a Ca(2+)-indicator Oregon Green to investigate whether differences in results obtained with modifications ...

journal_title：Journal of neuroscience research

authors： Balaban P,Chistiakova M,Malyshev A,Volgushev M

更新日期：2004-05-15 00:00:00

abstract：:Neural precursor cells, including neural stem and progenitor cells, in the subventricular zone (SVZ) are the main targets for cytomegalovirus (CMV) infection in developing brains. The neural precursor cells in the SVZ of the adult brain have been reported to respond by proliferating after infusion with epidermal growt...

journal_title：Journal of neuroscience research

authors： Han GP,Li L,Kosugi I,Kawasaki H,Tsuchida T,Miura K,Tsutsui Y

更新日期：2007-10-01 00:00:00

abstract：:As a neurotransmitter and neuromodulator, serotonin (5-HT) influences neuronal outgrowth in the nervous systems of several species. In PC12 cells, 5-HT is known to have neuritogenic effects, although the signal transduction pathway responsible for these effects is not understood. In this study, we hypothesized that a ...

journal_title：Journal of neuroscience research

authors： Homma K,Kitamura Y,Ogawa H,Oka K

更新日期：2006-08-01 00:00:00

abstract：:Hippocalcin is a Ca2+-binding protein that is expressed mainly in pyramidal nerve cells of the hippocampus. However, its functions and mechanism in the brain remain unclear. To elucidate the role of hippocalcin, we used a conditionally immortalized hippocampal cell line (H19-7) and showed that bFGF treatment increased...

journal_title：Journal of neuroscience research

authors： Oh DY,Cho JH,Park SY,Kim YS,Yoon YJ,Yoon SH,Chung KC,Lee KS,Han JS

更新日期：2008-05-15 00:00:00

abstract：:The two inbred strains of mice C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) mice have been shown to differ significantly in their preference for alcohol (EtOH). We have previously demonstrated the differences in the density and the affinity of cannabinoid (CB1) receptors in the brains of the two inbred C5...

journal_title：Journal of neuroscience research

authors： Basavarajappa BS,Hungund BL

更新日期：2001-05-15 00:00:00

abstract：:Encephalitogenic T cells from Lewis rats use a restricted T cell receptor (TCR) gene combination, Vbeta8.2 and Valpha2. The oral administration of myelin basic protein (MBP) to Lewis rats prior to encephalitogenic challenge results in a marked inhibition of clinical neurologic signs of encephalitis, reduced central ne...

journal_title：Journal of neuroscience research

authors： Goldman-Brezinski S,Brezinski K,Zhang XM,Gienapp I,Cox K,Heber-Katz E,Whitacre C

更新日期：1998-01-01 00:00:00

abstract：:Forty-seven rats were cannulated permanently in either the globus pallidus or neostriatum and subsequently injected with carbachol, scopolamine, or carbachol plus scopolamine. The injection of carbachol (1 mug) into the globus pallidus produced transient hyperkinetic phasic dyskinesias (84%) followed in some cases by ...

journal_title：Journal of neuroscience research

authors： Springer P,Dill RE

更新日期：1975-01-01 00:00:00

abstract：:The transport kinetics of the excitatory sulphur-containing amino acid (SAA) transmitter candidates, L-cysteine sulphinate (L-CSA), L-cysteate (L-CA), L-homocysteine sulphinate (L-HCSA), and L-homocysteate (L-HCA), together with their plasma membrane carrier specificity, was studied in cerebrocortical synaptosome frac...

journal_title：Journal of neuroscience research

authors： Grieve A,Butcher SP,Griffiths R

更新日期：1992-05-01 00:00:00

abstract：:In the non-amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is cleaved within the amyloid-beta domain by alpha-secretase precluding deposition of intact amyloid-beta peptide. The large ectodomain released from the cell surface by the action of alpha-secretase has several neuroprotective propertie...

journal_title：Journal of neuroscience research

authors： Allinson TM,Parkin ET,Turner AJ,Hooper NM

更新日期：2003-11-01 00:00:00

abstract：:Cultures of dissociated hypothalamic cells taken from rat fetuses of 19 days of gestation were studied using time-lapse recording and sequential microphotography from 1 to 5 days in vitro (DIV) and at 7 and 21 DIV. Cultures were seeded with cells taken from fetuses grouped by sex or sexually mixed; experimental cultur...

journal_title：Journal of neuroscience research

authors： Díaz H,Lorenzo A,Carrer HF,Cáceres A

更新日期：1992-10-01 00:00:00

abstract：:Neurogenesis of heterotopic gray matter in the brain of the microcephalic mouse prenatally exposed to X-rays at embryonic day 13 (E13) was studied immunohistochemically. Bromodeoxyuridine (BrdU) as a marker to label the migrating position of neuroblasts generated at various embryonic stages showed that no "inside-out"...

journal_title：Journal of neuroscience research

authors： Sun XZ,Takahashi S,Fukui Y,Hisano S,Kubota Y,Sato H,Inouye M

更新日期：2001-12-15 00:00:00

abstract：:The effects of the nematocyst venom of the sea anemone Bunodosoma cangicum on depolarization-activated currents were studies in opener crayfish muscle fibers and in cultured bovine chromaffin cells. The venom selectively and reversibly blocked the Ca(2+)-dependent K+ current (IK(Ca)) present in crayfish muscle in a do...

journal_title：Journal of neuroscience research

authors： Araque A,Urbano FJ,Cerveñansky C,Gandía L,Buño W

更新日期：1995-11-01 00:00:00

abstract：:The cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) signal through a receptor complex formed between two transmembrane proteins, gp130 and LIFRbeta. In addition, CNTF also uses a ligand-binding component which is anchored to the cell membrane. In the case of cardiotrophin-1 (CT-1), LI...

journal_title：Journal of neuroscience research

authors： Arce V,Garces A,de Bovis B,Filippi P,Henderson C,Pettmann B,deLapeyrière O

更新日期：1999-01-01 00:00:00

abstract：:gammadelta T cells represent a small subpopulation of T cells expressing a restricted repertoire of T-cell receptors and, unlike alphabeta T cells, function more as cells of the innate immune system. These cells are found in skin and mucosal sites as well as secondary lymphoid tissues and frequently act as first line ...

journal_title：Journal of neuroscience research

authors： Wohler JE,Smith SS,Barnum SR

更新日期：2010-01-01 00:00:00

abstract：:A morphogenic role of neurotransmitters during cellular differentiation in vitro has been demonstrated in recent years. Using in situ hybridization, we confirm the presence of the D1 receptor at E16 and show additionally that the transcript is relatively widespread and present in both proliferative and differentiating...

journal_title：Journal of neuroscience research

authors： Reinoso BS,Undie AS,Levitt P

更新日期：1996-02-15 00:00:00