Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neurons.

abstract：:The postmortem stability of brain RNA was measured in rat and human samples for up to 48 hr. Whole rat brains, cooled at a rate approximating that of human brains awaiting autopsy, were collected at intervals from 0 to 48 hr after death and frozen. These samples were compared with freshly obtained, unfrozen rat brains...

journal_title：Journal of neuroscience research

authors： Johnson SA,Morgan DG,Finch CE

更新日期：1986-01-01 00:00:00

abstract：:The cellular localization of calpain is important in understanding the roles that calpain may play in physiological function. We, therefore, examined calpain expression, activity, and immunofluorescent localization in primary cultures of rat oligodendrocytes. The mRNA expression of m-calpain was 64.8% (P = 0.0033) and...

journal_title：Journal of neuroscience research

authors： Ray SK,Neuberger TJ,Deadwyler G,Wilford G,DeVries GH,Banik NL

更新日期：2002-11-15 00:00:00

abstract：:The neuronal intermediate filaments include not only the neurofilament triplet proteins but also peripherin and alpha-internexin. To determine whether neurite outgrowth is enhanced by alpha-internexin, the cDNA of rat alpha-internexin tagged with enhanced green fluorescent protein (EGFP) was transfected into a rat adr...

journal_title：Journal of neuroscience research

authors： Chien CL,Liu TC,Ho CL,Lu KS

更新日期：2005-06-01 00:00:00

abstract：:The neurotrophins are important for their long-term effects on the survival and differentiation of many types of neurons during development. They also appear to protect mature neurons from injury caused by nutrient or oxygen deprivation. More recently, the neurotrophins have been implicated in such short-term processe...

journal_title：Journal of neuroscience research

authors： Jiang H,Guroff G

更新日期：1997-11-01 00:00:00

abstract：:The effects of ischemia (removal of oxygen and glucose for 4 h) and anoxia (removal of oxygen alone) on astrocytes were studied in dissociated cultures of E14 spinal cord containing both neurons and astrocytes. In addition, a group of cultures was treated with a low Na+, low Ca2+, and high K+ medium during the 4-h isc...

journal_title：Journal of neuroscience research

authors： Goldberg WJ,Connor JR,Bernstein JJ

更新日期：1987-01-01 00:00:00

abstract：:N-cadherin and beta-catenin are involved in cell adhesion and cell cycle in tumor cells and neural crest. Both are expressed at key stages of Schwann cell (SC) development, but little is known about their function in the SC lineage. We studied the role of these molecules in adult rat derived SC-embryonic dorsal root g...

journal_title：Journal of neuroscience research

authors： Gess B,Halfter H,Kleffner I,Monje P,Athauda G,Wood PM,Young P,Wanner IB

更新日期：2008-03-01 00:00:00

abstract：:Male and female rodents respond differently to acute stress. We tested our hypothesis that this sex difference is based on differences in stress sensitivity of forebrain areas, by determining possible effects of a single acute psychogenic stressor (1-hr restraint stress) on neuronal gene expression (c-Fos and FosB imm...

journal_title：Journal of neuroscience research

authors： Sterrenburg L,Gaszner B,Boerrigter J,Santbergen L,Bramini M,Roubos EW,Peeters BW,Kozicz T

更新日期：2012-01-01 00:00:00

abstract：:CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 differen...

journal_title：Journal of neuroscience research

authors： Ungaro C,Mazzei R,Conforti FL,Sprovieri T,Servillo P,Liguori M,Citrigno L,Gabriele AL,Magariello A,Patitucci A,Muglia M,Quattrone A

更新日期：2009-04-01 00:00:00

abstract：:We have studied the effect of induced glial fibrillary acidic protein (GFAP) on motility, cell morphology, and proliferation of two originally GFAP-negative human glioma cell lines. Glioma cell lines U-1242 MG and U-251 MG sp subclone 3A were transfected with a vector system that allows for an inducible GFAP expressio...

journal_title：Journal of neuroscience research

authors： Elobeid A,Bongcam-Rudloff E,Westermark B,Nistér M

更新日期：2000-04-15 00:00:00

abstract：:Metabolite levels in cerebrospinal fluid from patients with Parkinson disease or Huntington chorea were compared with the levels in healthy controls using proton magnetic resonance spectroscopy. No significant differences were found for any metabolite measured in cerebrospinal fluid from patients with Parkinson diseas...

journal_title：Journal of neuroscience research

authors： Gårseth M,Sonnewald U,White LR,Rød M,Zwart JA,Nygaard O,Aasly J

更新日期：2000-06-15 00:00:00

abstract：:Relationships among different intensities of electroshock treatment (EST), EEG-recordable primary after discharge (PAD), and beta-adrenergic binding in various brain regions were investigated in adult rats. Different intensities of EST (1-2, 6-8, 20-30 mamp) were applied through ear-clip electrodes for 7 consecutive d...

journal_title：Journal of neuroscience research

authors： Perumal AS,Barkai AI

更新日期：1982-01-01 00:00:00

abstract：:The mitochondrial permeability transition (mPT) has been implicated in both excitotoxic and apoptotic neuronal cell death, despite the fact that it has not been previously identified in neurons. To study the mPT in hippocampal neurons, cultures were loaded with the mitochondrial dye JC-1 and observed with confocal and...

journal_title：Journal of neuroscience research

authors： Dubinsky JM,Levi Y

更新日期：1998-09-15 00:00:00

abstract：:The exposure of SY5Y neuroblastoma cells to high concentrations of glucose, fructose, or galactose is an experimental model commonly used for in vitro evaluation of typical neuronal alterations observed in diabetes mellitus. In the present study, we observed that 2 weeks of exposure to high carbohydrate concentrations...

journal_title：Journal of neuroscience research

authors： Di Giulio AM,Lesma E,Germani E,Gorio A

更新日期：1999-09-01 00:00:00

abstract：:The companion study showed that acoustic overstimulation of adult chinchillas, with a noise level sufficient to damage the cochlea, led to cytological changes and degeneration of synaptic endings in the cochlear nucleus within 1-16 weeks. In the present study, the same stimulus was used to study the long-term effects ...

journal_title：Journal of neuroscience research

authors： Kim JJ,Gross J,Potashner SJ,Morest DK

更新日期：2004-09-15 00:00:00

abstract：:Highly malignant neuroblastoma tumors generally have defects in differentiation and apoptotic pathways. For a better understanding of these events, we use a murine neuroblastoma cell line (NBP2) that terminally differentiates into mature neurons in response to elevated levels of cAMP. Because one of the main downstrea...

journal_title：Journal of neuroscience research

authors： Andreatta CP,Nahreini P,Hanson AJ,Prasad KN

更新日期：2004-11-15 00:00:00

abstract：:Previous animal studies have linked white matter damage to certain schizophrenia-like behaviors in cuprizone (CPZ)-exposed mouse. Mitochondrial dysfunction, oxidative stress, neuroinflammation, and oligodendrocyte loss coexist in the brain of such mice. The aim of this study was to examine effects of the antioxidant N...

journal_title：Journal of neuroscience research

authors： Zhang L,Xu S,Huang Q,Xu H

更新日期：2018-05-01 00:00:00

abstract：:Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...

journal_title：Journal of neuroscience research

authors： Lärkfors L,Strömberg I,Ebendal T,Olson L

更新日期：1987-01-01 00:00:00

abstract：:The inner ear of humans and experimental animals demonstrate an abundance of glucocorticoid receptors (GR). Glucocorticoids (GC) are widely used to treat different hearing disorders; yet the mechanisms of GC action on the inner ear are unknown. We demonstrate how GR can directly modulate hearing sensitivity in respons...

journal_title：Journal of neuroscience research

authors： Tahera Y,Meltser I,Johansson P,Bian Z,Stierna P,Hansson AC,Canlon B

更新日期：2006-05-01 00:00:00

abstract：:Dissociated embryonic rat ventral mesencephalon containing the developing A8-A10 dopamine (DA) neurons was cultured alone or in the presence of a 10 mm segment of adult rat sciatic nerve that had been explanted and maintained in separate culture for 72 hours prior to introduction to mesencephalic cultures. Nerve segme...

journal_title：Journal of neuroscience research

authors： Collier TJ,Sladek CD,Gallagher MJ,Gereau RW 4th,Springer JE

更新日期：1990-11-01 00:00:00

abstract：:High-affinity uptake, potassium-stimulated release and receptor binding of gamma-aminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetate-malate (IAM). Such treatments produce a selective damage of the inner retinal layers (MSG) or of the photoreceptor...

journal_title：Journal of neuroscience research

authors： Salceda R,Pasantes-Morales H

更新日期：1982-01-01 00:00:00

abstract：:This study demonstrates the ability of proteasome inhibitors (lactacystin, MG 115, MG 132) adenosine diphosphate to induce a time- and dose-dependent increase in poly-ADP-ribosylation (PAR) in the neural PC6 cell line, a subclone of PC12 cells. Elevated levels of PAR contribute to the toxicity associated with impaired...

journal_title：Journal of neuroscience research

authors： Keller JN,Markesbery WR

更新日期：2000-08-15 00:00:00

abstract：:T cell receptor (TCR) transgenic mice have been used extensively to study T cell development in vivo. Such studies have demonstrated high levels of expression of the TCR transgenes. Although a number of human T cell receptors appear to play a role in the development of autoimmune diseases, in vitro studies have proven...

journal_title：Journal of neuroscience research

authors： Baker AM,Wang Y,Richert JR

更新日期：1996-08-15 00:00:00

abstract：:Zinc is an endogenous N-methyl-D-aspartate (NMDA) receptor blocker. It is possible that zinc-mediated modification of hippocampal CA1 long-term potentiation (LTP) is linked to the expression of NMDA receptor subunits, which varies with postnatal development. In the present study, the effect of ZnCl(2) and CaEDTA, a me...

journal_title：Journal of neuroscience research

authors： Takeda A,Itagaki K,Ando M,Oku N

更新日期：2012-03-01 00:00:00

abstract：:Bioassays of factors promoting nerve growth in embryonic ganglia are described. Chick embryo extract evokes fiber outgrowth in both sympathetic and ciliary ganglia explanted into a collagen gel. The response is not suppressed by antibodies directed against mouse nerve growth factor (NGF). Chick embryo extract also sup...

journal_title：Journal of neuroscience research

authors： Ebendal T,Hedlund KO,Norrgren G

更新日期：1982-01-01 00:00:00

abstract：:Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in young adults and children in the developed world, occurring in over 1.7 million persons and resulting in 50,000 deaths in the United States alone. The Centers for Disease Control and Prevention estimate that between 3.2 and 5.3 million ...

journal_title：Journal of neuroscience research

authors： Sulhan S,Lyon KA,Shapiro LA,Huang JH

更新日期：2020-01-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that also possesses neurotrophic and antiapoptotic properties. G-CSF has been reported to decrease amyloid burden significantly, promote hippocampal neurogenesis, and improve spatial learning in a mouse model of Alzheimer's disease. To understan...

journal_title：Journal of neuroscience research

authors： Song S,Wang X,Sava V,Weeber EJ,Sanchez-Ramos J

更新日期：2014-08-01 00:00:00

abstract：:Amyloid plaques, found in characteristically large numbers in specific brain areas of Alzheimer's disease (AD) and Down's Syndrome (DS) patients, are composed of a 41-43 amino acid peptide, A4, derived from a transmembrane glycoprotein, amyloid precursor protein (APP). In transformed cells APP has been shown to be cle...

journal_title：Journal of neuroscience research

authors： Baskin F,Rosenberg RN,Greenberg BD

更新日期：1991-05-01 00:00:00

abstract：:Recently we demonstrated that a member of the neuregulin-1 (NRG-1) family of growth factors is a mitogen and survival factor for olfactory ensheathing cells (OECs). OECs are specialized glial cells within the olfactory system that are believed to play a role in the continual nerve re-growth of this tissue. OECs share ...

journal_title：Journal of neuroscience research

authors： Thompson RJ,Roberts B,Alexander CL,Williams SK,Barnett SC

更新日期：2000-07-15 00:00:00

abstract：:Studies using Aplysia californica have demonstrated that transcription after nerve injury occurs during a rapid, transient first phase and a delayed, prolonged second phase. Although the second phase is especially important for regeneration, the mRNAs produced during this phase have not been identified. We characteriz...

journal_title：Journal of neuroscience research

authors： Colby GP,Sung YJ,Ambron RT

更新日期：2005-11-15 00:00:00

abstract：:We have demonstrated recently that atypical antipsychotics possess neuroprotective actions in H2O2-mediated and serum-withdrawal models of cell death. In the present study, we compared the ability of atypical and typical antipsychotics to protect against an insult mediated by Abeta(25-35), an apoptogenic fragment of t...

journal_title：Journal of neuroscience research

authors： Wei Z,Mousseau DD,Richardson JS,Dyck LE,Li XM

更新日期：2003-12-15 00:00:00