Abstract:
:Increase of intracellular [Ca(2+)] evoked by action potentials in a cell can induce long-term synaptic plasticity even without concomitant presynaptic stimulation. We used optical recording of the fluorescence of a Ca(2+)-indicator Oregon Green to investigate whether differences in results obtained with modifications of that purely postsynaptic induction protocol could be due to differential Ca(2+) influx. We compared changes of the somatic [Ca(2+)] in layer II-III pyramidal cells in slices of rat visual cortex evoked by bursts of depolarization pulses and long depolarizing steps. During weak depolarizations, the Ca(2+) influx was proportional to the amplitude and duration of the depolarization. With suprathreshold depolarizations, the Ca(2+) influx was proportional to the number of action potentials. Because the burst depolarizations evoked more spikes than did the long duration steps, this burst protocol led to a larger Ca(2+) influx. With all stimulation protocols, the spike-induced Ca(2+) influx was reduced during blockade of N-methyl-D-aspartate (NMDA) receptors. Differences in intracellular [Ca(2+)] increases thus may be one reason for differential effects of purely postsynaptic challenges on synaptic transmission.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Balaban P,Chistiakova M,Malyshev A,Volgushev Mdoi
10.1002/jnr.20104keywords:
subject
Has Abstractpub_date
2004-05-15 00:00:00pages
481-7issue
4eissn
0360-4012issn
1097-4547journal_volume
76pub_type
杂志文章abstract::Monitoring pathology/regeneration in experimental models of de-/remyelination requires an accurate measure not only of functional changes but also of the amount of myelin. We tested whether X-ray diffraction (XRD), which measures periodicity in unfixed myelin, can assess the structural integrity of myelin in fixed tis...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22241
更新日期:2010-03-01 00:00:00
abstract::N-cadherin and beta-catenin are involved in cell adhesion and cell cycle in tumor cells and neural crest. Both are expressed at key stages of Schwann cell (SC) development, but little is known about their function in the SC lineage. We studied the role of these molecules in adult rat derived SC-embryonic dorsal root g...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21528
更新日期:2008-03-01 00:00:00
abstract::People showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signaling, and show differences between both sexes. We ex...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24342
更新日期:2019-02-01 00:00:00
abstract::To determine whether one or more opioid receptor types might be preferentially involved in gliogenesis, primary mixed glial cultures derived from mouse cerebra were continuously treated with varying concentrations of opioid agonists selective for mu (mu), i.e., DAGO ([D-Ala2, MePhe4, Gly(ol)5]enkephalin), delta (delta...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490290415
更新日期:1991-08-01 00:00:00
abstract::The ability of altered environmental conditions to modulate some properties of synaptosomes has been studied. Incubation conditions used included the presence of methyl mercury or an organochlorine insecticide: chlordecone. Other adverse chemical conditions during incubation were the absence of calcium salts from the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250211
更新日期:1990-02-01 00:00:00
abstract::During surgical intervention in medically refractory temporal lobe epilepsy (TLE) patients, diagnosed with either mesial temporal lobe sclerosis (MTS)- or tumor (T)-associated TLE, biopsies were taken from the anterior temporal neocortex and the hippocampal region. Synaptosomes, isolated from these biopsies were used ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000601)60:5<686::AID-JNR
更新日期:2000-06-01 00:00:00
abstract::The minimal requirements for the regeneration of optic nerve fibers in vitro were established in a serum-free retinal explant preparation. This serum-free preparation was developed as a prerequisite for testing the growth-promoting activity of tissue extracts prepared from the primary target of regenerating fibers. Ex...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490080221
更新日期:1982-01-01 00:00:00
abstract::The induction of an inflammatory response and release of cytokines such as TNF may be involved in the age-related etiology of Alzheimer disease (AD). In the brain, microglia have been shown to produce a wide variety of immune mediators, including the pro-inflammatory cytokine tumor necrosis factor (TNF). We hypothesiz...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1097
更新日期:2001-06-01 00:00:00
abstract::The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury-based model of neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive deficits are associated with a functional reorganization of the medial prefrontal cortex (mPFC). Here, we have employed an adapted model of C...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24501
更新日期:2020-02-01 00:00:00
abstract::Transection of the hindlimb dorsal column fibers leads to a partial deafferentation of the neurons of the nucleus gracilis, the first relay of the ascending dorsal column-medial lemniscal (DC-ML) neural network. In response to the deafferentation, a synaptic renewal cycle is initiated and the neurons of the nucleus gr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400409
更新日期:1995-03-01 00:00:00
abstract::Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be a critical step leading to axonal degeneration. Kinesin and microtubules (MT) were evaluated as molecular sites of action using...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19961001)46:1<7::AID-JNR2>
更新日期:1996-10-01 00:00:00
abstract::In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410110
更新日期:1995-05-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is an extensively studied protein that is evolutionarily conserved and widely distributed in the brain of vertebrates. It acts via its cognate receptors TrkB and p75NTR and plays a central role in the developmental neurogenesis, neuronal survival, proliferation, differentiation...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24536
更新日期:2020-05-01 00:00:00
abstract::Noise exposure is one of the most common causes of hearing loss. Recent studies found that noise exposure-induced cochlear damage may change the excitability and tonotopic organization of the central auditory system (CAS). This plasticity was suspected to be related to tinnitus and hyperacusis. However, how cochlear d...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23152
更新日期:2013-02-01 00:00:00
abstract::A-type K+ channels (IA channels) contribute to learning and memory mechanisms by regulating neuronal excitabilities in the CNS, and their expression level is targeted by Ca2+ influx via synaptic NMDA receptors (NMDARs) during long-term potentiation (LTP). However, it is not clear how local synaptic Ca2+ changes induce...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24076
更新日期:2017-12-01 00:00:00
abstract::As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non-invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provides novel experimenta...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24514
更新日期:2019-08-16 00:00:00
abstract::The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20245
更新日期:2004-10-15 00:00:00
abstract::Metabolism of amyloid-beta peptide (A beta) is closely associated with the pathology and etiology of Alzheimer's disease (AD). Neprilysin is the only rate-limiting catabolic peptidase proven by means of reverse genetics to participate in A beta metabolism in vivo. The aim of the present study is to assess whether poss...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10390
更新日期:2002-11-01 00:00:00
abstract::Little is known about the structural neural substrates that may contribute to sex differences in risk-taking propensity (RTP). A close association between risk-seeking behavior and the emotional-regulation network led us to hypothesize that the sex differences in RTP would be associated with sex differences in brain m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24504
更新日期:2020-02-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) infection in its human host often results in progressive dementia and encephalopathy in adults and children, respectively. The mechanisms underlying virus-induced neurocognitive dysfunction are not fully understood. However, several studies strongly suggest that secretory vi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20745
更新日期:2006-02-15 00:00:00
abstract::Nitric oxide (NO) is produced by the enzyme nitric oxide synthase (NOS) and has been implicated in inter- and intracellular communication in the nervous system. The present study was undertaken to assess the effects of sodium nitroprusside (SNP) and hydroxylamine (HOA), NO donors, on a dopamine (DA)-induced K+ current...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19971101)50:3<450::AID-JNR
更新日期:1997-11-01 00:00:00
abstract::The effects of the human immunodeficiency virus type 1 envelope protein gp120 on the release of GABA elicited by N-methyl-D-aspartate (NMDA) from rat hippocampal neurons in primary culture has been investigated. NMDA (1-300 microM) increased in a concentration-dependent manner (EC50 =37.9+/-12 microM) the release of [...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19970915)49:6<732::AID-JNR
更新日期:1997-09-15 00:00:00
abstract::Inhibitory luminopsins (iLMO2) integrate opto- and chemo-genetic approaches and allow for cell-type specific inhibition of neuronal activity. When exposed to a Renilla luciferase substrate, Coelenterazine (CTZ), iLMO2 generates bioluminescence-mediated activation of its amino-terminal halorhodopsin, resulting in neuro...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24109
更新日期:2020-03-01 00:00:00
abstract::Recently we demonstrated that a member of the neuregulin-1 (NRG-1) family of growth factors is a mitogen and survival factor for olfactory ensheathing cells (OECs). OECs are specialized glial cells within the olfactory system that are believed to play a role in the continual nerve re-growth of this tissue. OECs share ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20000715)61:2<172::AID-JNR8>3.0.
更新日期:2000-07-15 00:00:00
abstract::Restless Legs Syndrome (RLS) is a disorder of sensation with a prevalence of around 2-5% of the population. Relevant to understanding the possible pathophysiological mechanism is the fact that RLS is extremely responsive to dopaminergic agents. A second issue is that iron deficiency states may precipitate RLS in as mu...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/1097-4547(20001201)62:5<623::AID-JNR1>3.0.
更新日期:2000-12-01 00:00:00
abstract::Withdrawal of serum from cell cultures constitutes a useful model for the study of mechanisms involved in the regulation of Akt function in vitro. However, there have been several reports of changes in Akt activity that are not fully explained by the current model of phosphatidylinositol 3'-kinase (PI3K)/Akt signaling...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21516
更新日期:2008-02-15 00:00:00
abstract::We used intracellular recording to investigate the functional interaction between protein kinase C (PKC) and protein kinase A (PKA) signal transduction cascades in the control of transmitter release in the neuromuscular synapses from adult rats. Our results indicate that: 1) PKA and PKC are independently involved in a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21885
更新日期:2009-02-15 00:00:00
abstract::Rapsyn is a key molecule involved in the formation of postsynaptic specializations at the neuromuscular junction, in its absence there are both pre- and post-synaptic deficits including failure to cluster acetylcholine receptors. Recently we have documented increases in both nerve-muscle branching and numbers of moton...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1109
更新日期:2001-06-15 00:00:00
abstract::Muscle spindles are sensory receptors composed of specialized muscle fibers, known as intrafusal muscle fibers, along with the endings of sensory neuron axons that innervate these muscle fibers. Formation of muscle spindles requires neuregulin1 (NRG1), which is released by sensory axons, activating ErbB receptors in m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23293
更新日期:2014-02-01 00:00:00
abstract::Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21784
更新日期:2008-11-15 00:00:00