Activation of ryanodine receptors is required for PKA-mediated downregulation of A-type K+ channels in rat hippocampal neurons.

abstract：:The ED1 monoclonal antibody recognizes an antigen in lysosomal membranes of phagocytes. The expression of this antigen in cells increases during phagocytic activity. Here we describe the expression of ED1-immunoreactivity during the various stages of both acute (monophasic) and chronic relapsing experimental autoimmun...

journal_title：Journal of neuroscience research

authors： Bauer J,Sminia T,Wouterlood FG,Dijkstra CD

更新日期：1994-07-01 00:00:00

abstract：:The cholinergic neurons of the basal forebrain (CNBF) are the major source of cholinergic innervation of the cortex and hippocampus. In Alzheimer's disease and aged brain, there are severe losses of cholinergic neurons in the nucleus basalis of Meynert, leading to a reduction of cortical cholinergic activity which cor...

journal_title：Journal of neuroscience research

authors： Wörtwein G,Yu J,Toliver-Kinsky T,Perez-Polo JR

更新日期：1998-05-01 00:00:00

abstract：:Superior cervical ganglion (SCG) cells from neonatal rats underwent apoptosis upon treatment with colchicine, a microtubule-disrupting agent. Western blotting and activity measurements showed that caspase-3 was indeed activated, but its peptide inhibitor (Ac-DEVD-CHO) neither suppressed nuclear fragmentation nor rescu...

journal_title：Journal of neuroscience research

authors： Mitsui C,Sakai K,Ninomiya T,Koike T

更新日期：2001-11-15 00:00:00

abstract：:Numerical synaptic density and synaptic vesicle density in rat frontal cortex were examined by electron microscopy as a function of age. The density of axospinous synapses, a major population of synapses, was found to peak at age 1 month, and to gradually decrease with aging. The synaptic vesicle density in axospinous...

journal_title：Journal of neuroscience research

authors： Nakamura H,Kobayashi S,Ohashi Y,Ando S

更新日期：1999-05-01 00:00:00

abstract：:Immature and mature rat astroglia in culture were assayed for glutamine synthetase (GS) activity after a single exposure to the epileptogen FeCl2. Cells were cultured with both standard and elevated extracellular potassium or glutamate (Glu) concentrations. FeCl2 reduced GS activity below control levels, whereas high ...

journal_title：Journal of neuroscience research

authors： Tiffany-Castiglioni E,Roberts JA,Sheeler-Gough LV

更新日期：1989-12-01 00:00:00

abstract：:Membrane compaction and adhesion at the major dense line (cytoplasmic apposition) of myelin, particularly in the central nervous system (CNS), is typically attributed to myelin basic protein (MBP). To explore the role of MBP in myelin membrane adhesion, we attempted to reconstitute the major dense line of myelin from ...

journal_title：Journal of neuroscience research

authors： Riccio P,Fasano A,Borenshtein N,Bleve-Zacheo T,Kirschner DA

更新日期：2000-02-15 00:00:00

abstract：:The potassium-induced stimulation of oxygen consumption in brain slices has a threshold value of 15-20 mM potassium, and it reaches its maximum at 35-50 mM. Although this phenomenon now has been known for almost 50 years, its physiological role remains undetermined. One reason for this may be that the high concentrati...

journal_title：Journal of neuroscience research

authors： Hertz L,Kjeldsen CS

更新日期：1985-01-01 00:00:00

abstract：:The first synapse in the olfactory pathway mediates a significant transfer of information given the restricted association of specific olfactory receptor neurons with specific glomeruli in the olfactory bulb. To understand better how this connection is made and what the functional capacities of the participating cells...

journal_title：Journal of neuroscience research

authors： Josephson EM,Yilma S,Vodyanoy V,Morrison EE

更新日期：2004-03-01 00:00:00

abstract：:Catecholamine-producing cell types are generated from specified neuronal lineages during vertebrate development. The catecholaminergic phenotype is also expressed transiently in some cell types in non-catecholaminergic tissues, including the sensory ganglia, enteric ganglia, and ventral portions of the neural tube dur...

journal_title：Journal of neuroscience research

authors： Matsushita N,Kobayashi K,Miyazaki J,Kobayashi K

更新日期：2004-10-01 00:00:00

abstract：:Neural precursor cells (NPCs) critically regulate brain morphogenesis and recent studies have revealed an unexpectedly high frequency of NPC chromosomal abnormalities and apoptosis in the developing brain. We have shown previously that the apoptotic response of NPCs to genotoxic agents is dependent on p53 and caspase-...

journal_title：Journal of neuroscience research

authors： D'Sa C,Klocke BJ,Cecconi F,Lindsten T,Thompson CB,Korsmeyer SJ,Flavell RA,Roth KA

更新日期：2003-11-01 00:00:00

abstract：:Spinal cord injury (SCI) triggers chronic intraspinal inflammation consisting of activated resident and infiltrating immune cells (especially microglia/macrophages). The environmental factors contributing to this protracted inflammation are not well understood; however, myelin lipid debris is a hallmark of SCI. Myelin...

journal_title：Journal of neuroscience research

authors： Kopper TJ,Gensel JC

更新日期：2018-06-01 00:00:00

abstract：:Finding inhibitors of the first step of the amyloid cascade, A beta (42) generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, beta-and gamma-secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes were not identified. U...

journal_title：Journal of neuroscience research

authors： Citron M

更新日期：2002-11-01 00:00:00

abstract：:The neuroblastoma, N1E-115, was grown for 9 days after subcultivation. The development of acetylcholinestrase (AChE), choline acetyltransferase (CAT), QNB-binding, choline uptake, and acetylcholine release was measured on days 1, 3, 6, and 9. In parallel experiments the irreversible AChE inhibitor soman was added to n...

journal_title：Journal of neuroscience research

authors： Kumar U,Sellström A

更新日期：1990-09-01 00:00:00

abstract：:The mitochondrial permeability transition (mPT) has been implicated in both excitotoxic and apoptotic neuronal cell death, despite the fact that it has not been previously identified in neurons. To study the mPT in hippocampal neurons, cultures were loaded with the mitochondrial dye JC-1 and observed with confocal and...

journal_title：Journal of neuroscience research

authors： Dubinsky JM,Levi Y

更新日期：1998-09-15 00:00:00

abstract：:L-deprenyl protects neurons in a number of in vivo and in vitro models and it has been postulated that it ameliorates some neurodegenerative disorders. Superoxide dismutase (SOD) is one of the enzymes responsible for the inactivation of oxygen free radicals, and one of the mechanisms of the effect of L-deprenyl is tho...

journal_title：Journal of neuroscience research

authors： Li XM,Juorio AV,Qi J,Boulton AA

更新日期：1998-07-15 00:00:00

abstract：:Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue-derived mesenchymal stem cells (ADMSCs) were intrave...

journal_title：Journal of neuroscience research

authors： Park D,Yang G,Bae DK,Lee SH,Yang YH,Kyung J,Kim D,Choi EK,Choi KC,Kim SU,Kang SK,Ra JC,Kim YB

更新日期：2013-05-01 00:00:00

abstract：:The contribution of glucose carbon to the biosynthesis of cholesterol and phospholipids in distinct brain regions was studied quantitatively in the adult male rat. Rates of flow of glucose carbon into the lipids in vivo were calculated from two measurements: the curve representing the decrease in plasma 14C-glucose wi...

journal_title：Journal of neuroscience research

authors： Barkai AI

更新日期：1981-01-01 00:00:00

abstract：:Adenosine signalling has an important role in cochlear protection from oxidative stress. In most tissues, intracellular adenosine kinase (ADK) is the primary route of adenosine metabolism and the key regulator of intracellular and extracellular adenosine levels. The present study provides the first evidence for ADK di...

journal_title：Journal of neuroscience research

authors： Vlajkovic SM,Guo CX,Dharmawardana N,Wong AC,Boison D,Housley GD,Thorne PR

更新日期：2010-09-01 00:00:00

abstract：:The mutant hypogonadal (hpg) mouse lacks a functioning gene for the neurohormone gonadotropin releasing hormone (GnRH). Previous studies from our laboratory had indicated that the initiation and maintenance of reproductive function in these mice could be brought about by the implantation of normal fetal grafts into ad...

journal_title：Journal of neuroscience research

authors： Silverman RC,Gibson MJ,Silverman AJ

更新日期：1992-01-01 00:00:00

abstract：:Ionotropic glutamate receptors, N-methyl-d-aspartate receptors (NMDARs) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs), are densely distributed in the mammalian brain and actively regulate a variety of cellular activities. Expression and function of these receptors are also under a tig...

journal_title：Journal of neuroscience research

authors： Wang JQ,Liu X,Zhang G,Parelkar NK,Arora A,Haines M,Fibuch EE,Mao L

更新日期：2006-12-01 00:00:00

abstract：:The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...

journal_title：Journal of neuroscience research

authors： Bensouilah M,Denizot JP

更新日期：1994-12-01 00:00:00

abstract：:Microtubule-associated protein (MAP)1B-heterozygous (MAP1B+/-) mice are deficient in the expression of MAP1B in the hippocampus, cerebellum, and olfactory cortex. Although MAP1B+/- mice showed half the normal levels of MAP1B protein, they had no measurable amounts of phosphorylated MAP1B. High-frequency theta burst st...

journal_title：Journal of neuroscience research

authors： Zervas M,Opitz T,Edelmann W,Wainer B,Kucherlapati R,Stanton PK

更新日期：2005-10-01 00:00:00

abstract：:The effects of hyposmotic conditions on taurine uptake and release were studied in mice cultured cerebellar granule cells. The effect of DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonate) and of the divalent cations Mg++ and Mn++ on the hyposmolarity-induced changes in these parameters was investigated. Mg++ (20 mM...

journal_title：Journal of neuroscience research

authors： Schousboe A,Sánchez Olea R,Morán J,Pasantes-Morales H

更新日期：1991-12-01 00:00:00

abstract：:Retinal microglia play an important role as resident immunocompetent and phagocytic cells in the event of injury and disease. Retinal microglia and microglia precursor transplantation show a rescue effect in ischemic retina and retinal degeneration. However, studies of retinal microglia have been hampered by the diffi...

journal_title：Journal of neuroscience research

authors： Jiang XS,Ni YQ,Liu TJ,Zhang M,Jiang R,Xu GZ

更新日期：2014-04-01 00:00:00

abstract：:Clusterin (apolipoprotein J) is a highly conserved, multifunctional, vertebrate glycoprotein. Several isoforms of clusterin have been described including the predominant secreted isoform (sCLU) and several nuclear isoforms (nCLU) associated with cell death. sCLU has been shown to bind a variety of partly unfolded, str...

journal_title：Journal of neuroscience research

authors： Carreras I,Garrett-Young R,Ullman MD,Eisenhauer PB,Fine RE,Wells JM,Conn KJ

更新日期：2005-02-15 00:00:00

abstract：:We investigated by (13)C nuclear magnetic resonance (NMR) the mechanisms underlying Li(+) effects on glutamatergic and GABAergic neurotransmission systems in the adult rat brain and in primary cultures of cortical neurons and astrocytes during the metabolism of (1-(13)C) glucose or (2-(13)C) acetate. Adult male rats r...

journal_title：Journal of neuroscience research

authors： Fonseca CP,Sierra A,Geraldes CF,Cerdán S,Castro MM

更新日期：2009-03-01 00:00:00

abstract：:Larval acetylcholinesterase (acetylcholine acetylhydrolase) EC 3.1.3.7 of the trematode Schistosoma mansoni was characterized and purified by affinity chromatography. The enzyme was solubilized from sonicated cercarial tissue and showed a Km value of 1.83 mM and a Vmax value of 102 U/mg protein. It was characterized a...

journal_title：Journal of neuroscience research

authors： Goldlust A,Arnon R,Silman I,Tarrab-Hazdai R

更新日期：1986-01-01 00:00:00

abstract：:Recent studies have indicated that embryonic stem cells (ESCs) can be a source for the replacement of spiral ganglion neurons (SGNs), auditory primary neurons, and neurite projections from ESC-derived neurons to auditory sensory epithelia. However, the potential of ESC-derived neurons for synapse formation with audito...

journal_title：Journal of neuroscience research

authors： Matsumoto M,Nakagawa T,Kojima K,Sakamoto T,Fujiyama F,Ito J

更新日期：2008-11-01 00:00:00

abstract：:The N-methyl-D-aspartate receptor (NMDAR) is a major neurotransmitter receptor in the central nervous system (CNS), with functional roles in learning, memory, and sensation. Several mechanisms potentiate NMDARs, and NMDAR hyperexcitability plays pathophysiological roles in many conditions, such as neurodegenerative di...

journal_title：Journal of neuroscience research

authors： Mattar PA,Holmes KD,Dekaban GA

更新日期：2003-12-01 00:00:00

abstract：:Understanding the pathway for amyloid percursor protein (APP) catabolism has become an important line of investigation. APP is a ubiquitous membrane bound protein that is rapidly cleaved at the membrane, yielding a secreted protein identical to protease nexin II and an internalized 11.5 kDa 100 residue C terminal deri...

journal_title：Journal of neuroscience research

authors： Wolozin B,Bacic M,Merrill MJ,Lesch KP,Chen C,Lebovics RS,Sunderland T

更新日期：1992-09-01 00:00:00