Abstract：
:Understanding the pathway for amyloid percursor protein (APP) catabolism has become an important line of investigation. APP is a ubiquitous membrane bound protein that is rapidly cleaved at the membrane, yielding a secreted protein identical to protease nexin II and an internalized 11.5 kDa 100 residue C terminal derivative (CTD). The levels of CTDs in a variety of cell lines have been examined and were found to differ. Cell types associated with the pathology of Alzheimer's disease (AD), such as olfactory neuroblasts (ON) and cortical vascular endothelial cells, have higher levels of CTDs than lymphoblasts and melanoma cells. The mechanism of CTD catabolism appears to involve the lysosome because blockade of lysosomal but not endosomal or mitochondrial function results in increased levels of CTDs. Under these conditions, production of larger, amyloidogenic CTDs is also seen. In cells possessing higher levels of CTDs we find that the mechanism for production of amyloidogenic CTDs may involve the internalization of intact full-length APP. Thus, inhibition of the lysosomal system appears capable of generating amyloidogenic peptides. The amount of amyloidogenic peptides appears to vary among cell lines. Such variation may shed light on why amyloid accumulates around specific cell types such as vascular endothelial cells, neurons, and glia. Finally, disfunction of the lysosomal system may play a role in the pathogenesis of Alzheimer's disease.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Wolozin B,Bacic M,Merrill MJ,Lesch KP,Chen C,Lebovics RS,Sunderland Tdoi
10.1002/jnr.490330121keywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
163-9issue
1eissn
0360-4012issn
1097-4547journal_volume
33pub_type
杂志文章abstract：:Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than ma...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23784
更新日期：2017-01-02 00:00:00
abstract：:The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10285
更新日期：2002-07-15 00:00:00
abstract：:Despite a large body of literature on the nociceptin (NC) opioid system in pain modulation, the mechanism of action of NC remains largely unexplored. Here, we investigated the role and mode of action of the spinal NC system in inflammatory pain. Preemptive intrathecal administration of NC attenuated thermal hyperalges...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21272
更新日期：2007-05-15 00:00:00
abstract：:P-glycoprotein (P-gp), a drug efflux pump, is known to alter the bioavailability of antiretroviral drugs at several sites, including the brain. We have previously shown that human immunodeficiency virus-1 (HIV-1) glycoprotein 120 (gp120) induces proinflammatory cytokine secretion and decreases P-gp functional expressi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22720
更新日期：2011-11-01 00:00:00
abstract：:Restless Legs Syndrome (RLS) is a disorder of sensation with a prevalence of around 2-5% of the population. Relevant to understanding the possible pathophysiological mechanism is the fact that RLS is extremely responsive to dopaminergic agents. A second issue is that iron deficiency states may precipitate RLS in as mu...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/1097-4547(20001201)62:5<623::AID-JNR1>3.0.
更新日期：2000-12-01 00:00:00
abstract：:Neuropathic pain is a debilitating chronic pain and represents a major clinical challenge. The molecular and cellular mechanisms underlying its development and maintenance are not fully understood but involve abnormal excitability in the dorsal horn of the spinal cord. A growing body of evidence has shown that this ab...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23816
更新日期：2017-06-01 00:00:00
abstract：:Germinal matrix (GM) vasculature is selectively vulnerable to hemorrhage in premature infants during the first 48 hr of life. This is attributed to rapid angiogenesis of this brain region, resulting in formation of nascent vessels that show a paucity of pericytes and immaturity of extracellular matrix. Integrins are k...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22301
更新日期：2010-05-01 00:00:00
abstract：:Parkinson's disease (PD) is a movement disorder characterized by a progressive loss of nigrostriatal dopaminergic neurons. Microglia activation and neuroinflammation have been associated with the pathogenesis of PD. Indeed, cytokines have been proposed as candidates that mediate the apoptotic cell death of dopaminergi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21503
更新日期：2008-02-01 00:00:00
abstract：:This investigation explores the central nervous system protein-synthetic responses to hemisection of the spinal cord. Adult male rats hemisected at mid T2 were given intravenous injections of 14C-leucine at 0.7, 30, or 70 days postoperative. Four hours later the T1, T2, T3, and C6 segments of the spinal cord and right...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490010107
更新日期：1975-01-01 00:00:00
abstract：:Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein ex...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24275
更新日期：2018-10-01 00:00:00
abstract：:In the present work, we analyzed whether endogenous and/or transplanted bone marrow mononuclear cells (BMMC) migrate spontaneously to the crushed sciatic nerve and whether they transdifferentiate into Schwann cells (SC) in order to help repair the damaged tissue. We also studied both the immunohistochemical evolution ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22645
更新日期：2011-08-01 00:00:00
abstract：:Astrocytes purified from the neonatal rat brain were cultured for up to 3 weeks prior to being treated with agents that can induce reactive changes in astrocytes. These agents included dibutyryl cAMP, interleukin-1 beta, and macrophage conditioned media. After treating astrocytes for 3 days, the agents were removed an...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490380108
更新日期：1994-05-01 00:00:00
abstract：:The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490190311
更新日期：1988-03-01 00:00:00
abstract：:Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond to any kind of damage or pathophysiological changes. These cells sense and rapidly respond to danger and inflammatory signals by changing their cell morphology; by release of cytokines, chemok...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21875
更新日期：2009-02-15 00:00:00
abstract：:Human T-cell lymphotropic virus type I (HTLV-I) may infect up to 10% of peripheral blood T cells in patients with HTLV-I myelopathy. To examine the impact of HTLV-I infection on the abilities of T cells to present and respond to peptide antigen, we HTLV-I infected and subcloned a myelin basic protein peptide 84-102 (M...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19960915)45:6<786::AID-JNR
更新日期：1996-09-15 00:00:00
abstract：:In the following review, we address difficulties that have arisen when attempting to convert the myelin multilayers into vesicles. The emphasis is on CNS myelin of adult mammals although both central nervous system (CNS) and peripheral nervous system (PNS) myelin are considered. The ability to prepare vesicle of myeli...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.490410202
更新日期：1995-06-01 00:00:00
abstract：:Mice heterozygously deficient in the major myelin component P0 are an established model of an inherited neuropathy and show signs of myelin degeneration in motor nerves. Unlike the case in patients, the sensory nerves are only mildly affected in the mouse mutants and do not show features indicative of myelin degenerat...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10115
更新日期：2002-01-15 00:00:00
abstract：:The engrailed gene has been identified in Drosophila as an important developmental gene involved in the control of segmentation. Here we describe the embryonic expression of a chicken gene, ChickEn (Darnell et al.: J Cell Biol 103(5):311a, 1986), which contains homology to the Drosophila engrailed gene. Northern blots...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490210234
更新日期：1988-10-01 00:00:00
abstract：:The phosphorylative neuromodulation of the regulatory subunit of protein kinase type II (R-II) in cytosolic fractions from denervated and sham-operated, contralateral soleus muscles of the rat was evaluated. The denervation-induced increase in the 32P-phosphorylation of R-II is not related to an increased dephosphoryl...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490140208
更新日期：1985-01-01 00:00:00
abstract：:We have developed an animal model of learning and memory impairment associated with activation of microglia in the mouse brain. Injection of lipopolysaccharide into the CA1 region of the mouse hippocampus resulted in an increased production of inflammatory cytokines, such as interleukin-1β. Immunostaining for interleu...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22582
更新日期：2011-04-01 00:00:00
abstract：:An aminopeptidase purified to homogeneity from cytosol of rat brain cleaved dynorphins having 5-17 residues and selected proenkephalins at the Tyr-Gly bond only to release Tyr and the desTyr fragments. The enzyme protein consisted of a single polypeptide chain of Mr 103,000 and was inhibited by puromycin, bestatin, an...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490110311
更新日期：1984-01-01 00:00:00
abstract：:Autonomic neuropathy in several neurodegenerative disorders results from disturbance in physiological functions of different cell types in the central and peripheral nervous systems. For a clearer understanding of the etiology and pathogenesis of the autonomic disorders it is necessary to create animal models in which...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980115)51:2<162::AID-JNR
更新日期：1998-01-15 00:00:00
abstract：:Cell death in outer hair cells of the mammalian inner ear induced by aminoglycoside antibiotics is mediated by reactive oxygen species (ROS) and can be prevented by antioxidants. The current study investigates the role of the nuclear factor (NF)-kappaB pathway in cell death or survival in adult CBA mice. Kanamycin (70...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20392
更新日期：2005-03-01 00:00:00
abstract：:This study was undertaken in order to establish the presence of pluripotential neuroblasts in the developing chick CNS. This has been suggested by our previous observations that expression of emerging neuronal phenotypes in the chick embryo CNS is affected by exposure to neurotrophic substances (i.e., GHRH, SRIF, NGF,...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490410516
更新日期：1995-08-01 00:00:00
abstract：:In 2000, a landmark case report described the concurrent restoration of consciousness and thalamo-frontal connectivity after severe brain injury (Laureys et al., ). Being a single case however, this study could not disambiguate whether the result was specific to the restoration of consciousness per se as opposed to th...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24115
更新日期：2018-04-01 00:00:00
abstract：:As the main input structure of the basal ganglia (BG), the striatum collects and integrates information from several brain areas and funnels them forward to other BG nuclei. The striatal projection neurons are medium-sized spiny neurons classified in two main subpopulations, based on their neurochemical characterizati...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.24479
更新日期：2019-10-01 00:00:00
abstract：:Neurogenesis of heterotopic gray matter in the brain of the microcephalic mouse prenatally exposed to X-rays at embryonic day 13 (E13) was studied immunohistochemically. Bromodeoxyuridine (BrdU) as a marker to label the migrating position of neuroblasts generated at various embryonic stages showed that no "inside-out"...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10018
更新日期：2001-12-15 00:00:00
abstract：:Neuronal progenitors in the adult hippocampus continually proliferate and differentiate to the neuronal lineage, and ischemic insult promotes hippocampal neurogenesis. However, newborn neurons show a progressive reduction in numbers during the initial few weeks, therefore, enhanced survival of newborn neurons seems to...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21036
更新日期：2006-11-01 00:00:00
abstract：:The cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) signal through a receptor complex formed between two transmembrane proteins, gp130 and LIFRbeta. In addition, CNTF also uses a ligand-binding component which is anchored to the cell membrane. In the case of cardiotrophin-1 (CT-1), LI...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990101)55:1<119::AID-JNR
更新日期：1999-01-01 00:00:00
abstract：:Accumulating evidence points to roles for oxidative stress, amyloid beta (Aβ), and mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the base excision repair pathway is the predominant DNA repair (BER) pathway for repairing oxidized base lesions. Apurinic/apyrimidinic endonuclease ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23565
更新日期：2015-06-01 00:00:00
