Music intervention improves spatial learning and memory and alters serum proteomics profiling in rats.

abstract：:Long-duration exposure to weightlessness results in bone demineralization, muscle atrophy, cardiovascular deconditioning, altered sensory-motor control, and central nervous system reorganizations. Exercise countermeasures and body loading methods so far employed have failed to prevent these changes. A human mission to...

journal_title：Journal of neuroscience research

authors： Lackner JR,DiZio P

更新日期：2000-10-15 00:00:00

abstract：:The effects of ischemia (removal of oxygen and glucose for 4 h) and anoxia (removal of oxygen alone) on astrocytes were studied in dissociated cultures of E14 spinal cord containing both neurons and astrocytes. In addition, a group of cultures was treated with a low Na+, low Ca2+, and high K+ medium during the 4-h isc...

journal_title：Journal of neuroscience research

authors： Goldberg WJ,Connor JR,Bernstein JJ

更新日期：1987-01-01 00:00:00

abstract：:We used a modified pial vessel disruption (PVD) protocol with adult male Wistar rats to mimic small-vessel stroke in the cerebral cortex. Within 3 weeks, this lesion develops into a single lacuna-like cavity, which is fluid-filled and encapsulated by reactive astrocytes. Minocycline treatment that commences 1 hr after...

journal_title：Journal of neuroscience research

authors： Cayabyab FS,Gowribai K,Walz W

更新日期：2013-07-01 00:00:00

abstract：:We describe here the presence of ubiquitin and its conjugation system in the rat retina. Retinal homogenates and supernatants conjugate [125I]human ubiquitin with either endogenous or exogenous proteins. The conjugating activity is relatively stable over time, requires ATP, and has a pH optimum of approximately 8. The...

journal_title：Journal of neuroscience research

authors： Naash M,Izbicka E,Anderson RE

更新日期：1991-10-01 00:00:00

abstract：:The production of collagen-degrading proteases by cultured neonatal rat microglia was examined using an immobilized fibronectin-gelatin matrix coupled to a fluorescent marker and by substrate gel analysis. When microglia were plated onto the surface of the matrix and incubated under resting (nonstimulated) conditions,...

journal_title：Journal of neuroscience research

authors： Colton CA,Keri JE,Chen WT,Monsky WL

更新日期：1993-06-15 00:00:00

abstract：:Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like...

journal_title：Journal of neuroscience research

authors： Krenzlin H,Lorenz V,Alessandri B

更新日期：2017-10-01 00:00:00

abstract：:Although gangliosides have been reported to enhance recovery from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of the substantia nigra, evidence as to whether the administered gangliosides actually reach this or any other site of lesion in the central nervous system (CNS) at which they putativel...

journal_title：Journal of neuroscience research

authors： Saulino MF,Schengrund CL

更新日期：1994-02-15 00:00:00

abstract：:To investigate the function of the dipeptide carnosine in the olfactory system, alterations of carnosine in the primary olfactory nerve after unilateral naris closure or olfactory bulb semilesion were studied by means of immunocytochemistry. After unilateral naris closure, carnosine staining showed no alteration, but ...

journal_title：Journal of neuroscience research

authors： Sakai M,Nagatsu I

更新日期：1993-04-15 00:00:00

abstract：:Membrane compaction and adhesion at the major dense line (cytoplasmic apposition) of myelin, particularly in the central nervous system (CNS), is typically attributed to myelin basic protein (MBP). To explore the role of MBP in myelin membrane adhesion, we attempted to reconstitute the major dense line of myelin from ...

journal_title：Journal of neuroscience research

authors： Riccio P,Fasano A,Borenshtein N,Bleve-Zacheo T,Kirschner DA

更新日期：2000-02-15 00:00:00

abstract：:A coordinated up-regulation in the expression of all three neurofilament (NF) proteins occurs during postnatal development in the rat (Schlaepfer and Bruce, J Neurosci Res [in press], 1990a). In the present study, sciatic nerves were transected in neonatal rats in order to determine the effects of axotomy on the postn...

journal_title：Journal of neuroscience research

authors： Schwartz ML,Shneidman PS,Bruce J,Schlaepfer WW

更新日期：1990-10-01 00:00:00

abstract：:We have developed tendon chitosan tubes having the ability to bind peptides covalently, and the effectiveness of laminin peptides coupled to these tubular wall on nerve regeneration was examined in vivo. Bridge graft implantation (15 mm) into the sciatic nerve of SD rats was carried out using chitosan tubes having a t...

journal_title：Journal of neuroscience research

authors： Suzuki M,Itoh S,Yamaguchi I,Takakuda K,Kobayashi H,Shinomiya K,Tanaka J

更新日期：2003-06-01 00:00:00

abstract：:Protein zero (P0) glycoprotein is the major integral membrane protein of the peripheral nervous system myelin in higher vertebrates. Previous findings indicate the formation of tetrameric assemblies from studies on isolated P0. To determine whether in intact myelin the P0 exists as oligomers, we isolated myelin from s...

journal_title：Journal of neuroscience research

authors： Thompson AJ,Cronin MS,Kirschner DA

更新日期：2002-03-15 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) cause a wide spectrum of toxic effects in the brain through undefined mechanisms. Exposure to the PCB mixture Aroclor-1254 (A1254) increases the repressor element-1 silencing transcription factor (REST) expression, leading to neuronal death. This study sought to understand the sequence...

journal_title：Journal of neuroscience research

authors： Formisano L,Guida N,Laudati G,Boscia F,Esposito A,Secondo A,Di Renzo G,Canzoniero LM

更新日期：2015-01-01 00:00:00

abstract：:Neurofibromatosis type 2 is a hereditary cancer syndrome characterized by the development of bilateral vestibular schwannomas. Underlying the disease are inactivating mutations of the NF2 tumor suppressor gene, located on chromosome 22, encoding a 595-amino-acid protein. The NF2 protein, also known as merlin or schwan...

journal_title：Journal of neuroscience research

authors： den Bakker MA,Riegman PH,Suurmeijer AP,Vissers CJ,Sainio M,Carpen O,Zwarthoff EC

更新日期：2000-12-15 00:00:00

abstract：:Dihydropteridine reductase was purified approximately 1,700-fold from human outdated blood platelets. Two forms of the enzyme, A and B, were resolved. They have the same Km values for 2-amino-6,7,-dimethyl-4-hydroxydihydropteridine (46 microM vs 49 microM), but the A form has a Km for NADH that is two times higher tha...

journal_title：Journal of neuroscience research

authors： Shen R,Abell CW

更新日期：1981-01-01 00:00:00

abstract：:Microglia are prominently involved in neural degenerative diseases of the CNS and the retina. In this study, we determined the activation and phagocytotic function of different subtypes of retinal microglial cells at 1 week and 1 month following optic axotomy. Fluorescent DiI crystals were placed at the stumps of the ...

journal_title：Journal of neuroscience research

authors： Zhang C,Tso MO

更新日期：2003-09-15 00:00:00

abstract：:High levels of the proto-oncogene product, pp60c-src, have been found in developing and adult neural tissues as well as in certain fully mature cells of the hematopoietic lineage, e.g., platelets and myelomonocytes. Adrenal medullary chromaffin cells exhibit characteristics of both types of cells, i.e., they are deriv...

journal_title：Journal of neuroscience research

authors： Oddie KM,Litz JS,Balserak JC,Payne DM,Creutz CE,Parsons SJ

更新日期：1989-09-01 00:00:00

abstract：:Monoclonal 2C3 specific to β-amyloid (Aβ) oligomers (AβOs) enabled us to test our hypothesis that the alteration of lipoprotein-Aβ interaction in the central nervous system (CNS) initiates and/or accelerates the cascade favoring Aβ assembly. Immunoprecipitation of frontal cortex employing 2C3 unequivocally detected so...

journal_title：Journal of neuroscience research

authors： Takamura A,Kawarabayashi T,Yokoseki T,Shibata M,Morishima-Kawashima M,Saito Y,Murayama S,Ihara Y,Abe K,Shoji M,Michikawa M,Matsubara E

更新日期：2011-06-01 00:00:00

abstract：:Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disord...

journal_title：Journal of neuroscience research

authors： Hermanto Y,Maki T,Takagi Y,Miyamoto S,Takahashi J

更新日期：2019-07-01 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) such as intellectual disability and autism spectrum disorder consistently show a male bias in prevalence, but it remains unclear why males and females are affected with different frequency. While many behavioral studies of transgenic NDD models have focused only on males, the requir...

journal_title：Journal of neuroscience research

authors： Mossa A,Manzini MC

更新日期：2021-01-01 00:00:00

abstract：:Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because of neurofunctional and anatomic differences between rodents and primates. In the present study, the development of histopathologic changes ...

journal_title：Journal of neuroscience research

authors： Iwanami A,Yamane J,Katoh H,Nakamura M,Momoshima S,Ishii H,Tanioka Y,Tamaoki N,Nomura T,Toyama Y,Okano H

更新日期：2005-04-15 00:00:00

abstract：:Clusterin (apolipoprotein J) is a highly conserved, multifunctional, vertebrate glycoprotein. Several isoforms of clusterin have been described including the predominant secreted isoform (sCLU) and several nuclear isoforms (nCLU) associated with cell death. sCLU has been shown to bind a variety of partly unfolded, str...

journal_title：Journal of neuroscience research

authors： Carreras I,Garrett-Young R,Ullman MD,Eisenhauer PB,Fine RE,Wells JM,Conn KJ

更新日期：2005-02-15 00:00:00

abstract：:Mice heterozygously deficient in the major myelin component P0 are an established model of an inherited neuropathy and show signs of myelin degeneration in motor nerves. Unlike the case in patients, the sensory nerves are only mildly affected in the mouse mutants and do not show features indicative of myelin degenerat...

journal_title：Journal of neuroscience research

authors： Samsam M,Frei R,Marziniak M,Martini R,Sommer C

更新日期：2002-01-15 00:00:00

abstract：:Neuroanatomical studies suggest that neuronal atrophy and destruction occur over the course of many years in neurodegenerative conditions such as schizophrenia and Alzheimer's disease. In schizophrenia, early intervention with atypical neuroleptics such as olanzapine has been shown to prevent development of some of th...

journal_title：Journal of neuroscience research

authors： Wei Z,Bai O,Richardson JS,Mousseau DD,Li XM

更新日期：2003-08-01 00:00:00

abstract：:Functional MRI (fMRI) on spinal cord-injured rodents at 4 and 8 weeks post injury (PI) is described. The paradigm for fMRI, based on electrical stimulation of rat paws, was automated using an in-house designed microprocessor-based controller that was interfaced to a stimulator. The MR images were spatially normalized ...

journal_title：Journal of neuroscience research

authors： Ramu J,Bockhorst KH,Mogatadakala KV,Narayana PA

更新日期：2006-11-01 00:00:00

abstract：:The role of the plasmin-generating system, a serum component, in the development of dissociated embryonic chick spinal cord cells in culture was studied. Studies were performed in a defined system where the cells were maintained in a serum-free medium. Under these conditions the cells produce plasminogen activator. It...

journal_title：Journal of neuroscience research

authors： Kalderon N

更新日期：1982-01-01 00:00:00

abstract：:Traumatic brain injuries (TBIs) pose a massive burden of disease and continue to be a leading cause of morbidity and mortality throughout the world. A major obstacle in developing effective treatments is the lack of comprehensive understanding of the underlying mechanisms that mediate tissue damage and recovery after ...

journal_title：Journal of neuroscience research

authors： Bogoslovsky T,Bernstock JD,Bull G,Gouty S,Cox BM,Hallenbeck JM,Maric D

更新日期：2018-04-01 00:00:00

abstract：:Light microscopic anterograde tracing studies indicate that neurons in the central nucleus of the amygdala (CNA) project to a region of the dorsal pontine tegmentum ventral to the superior cerebellar peduncle which contains noradrenergic dendrites of the nucleus locus coeruleus (LC). However, it has not been establish...

journal_title：Journal of neuroscience research

authors： Van Bockstaele EJ,Chan J,Pickel VM

更新日期：1996-08-01 00:00:00

abstract：:The hypoxia-responsive cytokine erythropoietin (EPO) provides neuroprotective effects in the damaged brain during ischemic events and neurodegenerative diseases. The purpose of the present study is to evaluate the EPO/EPO receptor (EPOR) endogenous system between astrocyte and oligodendrocyte precursor cell (OPC) unde...

journal_title：Journal of neuroscience research

authors： Kato S,Aoyama M,Kakita H,Hida H,Kato I,Ito T,Goto T,Hussein MH,Sawamoto K,Togari H,Asai K

更新日期：2011-10-01 00:00:00

abstract：:Destruction of the ventromedial hypothalamic nuclei (VMN) in the weanling rat without injury to the median eminence results in a series of somatic, endocrine, and metabolic changes that are characterized by normal food and water intake but decreased linear growth, normal body weight but increased carcass fat and reduc...

journal_title：Journal of neuroscience research

authors： Bernardis LL,Goldman JK

更新日期：1976-01-01 00:00:00