Abstract:
:Functional MRI (fMRI) on spinal cord-injured rodents at 4 and 8 weeks post injury (PI) is described. The paradigm for fMRI, based on electrical stimulation of rat paws, was automated using an in-house designed microprocessor-based controller that was interfaced to a stimulator. The MR images were spatially normalized to the Paxinos and Watson atlas using publicly available digital images of the cryosections. In normal uninjured animals, the activation was confined to the contralateral somatosensory cortex. In contrast, in injured animals, extensive activation, which included structures such as ipsilateral cortex, thalamus, hippocampus, and the caudate putamen, was observed at 4 and 8 weeks PI. Quantitative cluster analysis was carried out to calculate the volumes and centers of activation in individual brain structures. Based on this analysis, significant increase in activation between 4 and 8 weeks was observed only in the ipsilateral caudate putamen and thalamus. These studies suggest extensive and ongoing brain reorganization in spinal cord-injured animals.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Ramu J,Bockhorst KH,Mogatadakala KV,Narayana PAdoi
10.1002/jnr.21030subject
Has Abstractpub_date
2006-11-01 00:00:00pages
1235-44issue
6eissn
0360-4012issn
1097-4547journal_volume
84pub_type
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