Abstract:
:The role of the plasmin-generating system, a serum component, in the development of dissociated embryonic chick spinal cord cells in culture was studied. Studies were performed in a defined system where the cells were maintained in a serum-free medium. Under these conditions the cells produce plasminogen activator. It was found that plasminogen, when added to the chemically defined culture medium at concentrations of 0.2-0.75 microgram/ml, stimulates [3H]thymidine uptake (as expressed per total DNA) in a dose-response manner. This mitogenic effect is abolished by the protease inhibitors leupeptin and aprotinin. Trypsin, but not chymotrypsin, can produce similar effects. It is concluded that plasmin, which is produced as a result of the activation of plasminogen, is a component that serves as a proliferation factor in developing spinal cords in culture.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Kalderon Ndoi
10.1002/jnr.490080237subject
Has Abstractpub_date
1982-01-01 00:00:00pages
509-19issue
2-3eissn
0360-4012issn
1097-4547journal_volume
8pub_type
杂志文章abstract::In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...
journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490080221
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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journal_title:Journal of neuroscience research
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更新日期:2016-11-01 00:00:00
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journal_title:Journal of neuroscience research
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更新日期:2009-11-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/1097-4547(20001201)62:5<623::AID-JNR1>3.0.
更新日期:2000-12-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23080
更新日期:2012-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21146
更新日期:2007-02-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:1999-01-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20007
更新日期:2004-03-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23223
更新日期:2013-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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更新日期:1999-05-15 00:00:00
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更新日期:2011-08-01 00:00:00
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