Dissociation of β-amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates β-amyloid-42 assembly.

abstract：:In an effort to identify genes involved in neuronal differentiation, we have used representational difference analysis (RDA) to clone cDNAs that are preferentially induced by nerve growth factor (NGF) vs. epidermal growth factor (EGF) in PC12 pheochromocytoma cells. We now report the cloning of a previously unknown pr...

journal_title：Journal of neuroscience research

authors： Vician L,Silver AL,Farias-Eisner R,Herschman HR

更新日期：2001-04-15 00:00:00

abstract：:We describe here the presence of ubiquitin and its conjugation system in the rat retina. Retinal homogenates and supernatants conjugate [125I]human ubiquitin with either endogenous or exogenous proteins. The conjugating activity is relatively stable over time, requires ATP, and has a pH optimum of approximately 8. The...

journal_title：Journal of neuroscience research

authors： Naash M,Izbicka E,Anderson RE

更新日期：1991-10-01 00:00:00

abstract：:This study examined the effect of chronic exposure to ethanol and brain-derived neurotrophic factor (BDNF) on the responsiveness of cerebellar granule cells to gamma-aminobutyric acid (GABA). Cerebellar granule cell cultures were chronically exposed to ethanol (100 mM), BDNF (20 ng/ml), or the combination of ethanol a...

journal_title：Journal of neuroscience research

authors： Ericson M,Haythornthwaite AR,Yeh PW,Yeh HH

更新日期：2003-09-01 00:00:00

abstract：:Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...

journal_title：Journal of neuroscience research

authors： Kuo TY,Hong CJ,Chien HL,Hsueh YP

更新日期：2010-08-15 00:00:00

abstract：:The Dale's law postulates that a neuron releases the same neurotransmitter from all its branches. In the case of multiple neurotransmitters it would require all transmitters to be released from all branches. The retinal cholinergic amacrine cells contain and release gamma-aminobutyric (GABA) and, therefore, if GABA an...

journal_title：Journal of neuroscience research

authors： Duarte CB,Santos PF,Carvalho AP

更新日期：1999-11-15 00:00:00

abstract：:Alpha2-adrenergic receptors control norepinephrine (NE) release and tumor necrosis factor-alpha (TNF) production from neurons. TNF regulates NE release, depending on alpha2-adrenergic receptor functioning. The relationship between TNF production in the brain and alpha2-adrenergic receptor activation could have profoun...

journal_title：Journal of neuroscience research

authors： Reynolds JL,Ignatowski TA,Spengler RN

更新日期：2005-03-15 00:00:00

abstract：:Changes in executive function are at the root of most cognitive problems associated with Parkinson's disease. Because dopaminergic treatment does not necessarily alleviate deficits in executive function, it has been hypothesized that dysfunction of neurotransmitters/systems other than dopamine (DA) may be associated w...

journal_title：Journal of neuroscience research

authors： Pflibsen L,Stang KA,Sconce MD,Wilson VB,Hood RL,Meshul CK,Mitchell SH

更新日期：2015-12-01 00:00:00

abstract：:Male and female rodents respond differently to acute stress. We tested our hypothesis that this sex difference is based on differences in stress sensitivity of forebrain areas, by determining possible effects of a single acute psychogenic stressor (1-hr restraint stress) on neuronal gene expression (c-Fos and FosB imm...

journal_title：Journal of neuroscience research

authors： Sterrenburg L,Gaszner B,Boerrigter J,Santbergen L,Bramini M,Roubos EW,Peeters BW,Kozicz T

更新日期：2012-01-01 00:00:00

abstract：:The C57BL/6 mice strain is known to be reputedly resistant to induction of experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome in human by bovine peripheral myelin (BPM), and P2 protein or the P2 protein peptide 57-81. The P0 peptide 180-199 is a stronger neuritogenic antigen than the P2...

journal_title：Journal of neuroscience research

authors： Zou LP,Ljunggren HG,Levi M,Nennesmo I,Wahren B,Mix E,Winblad B,Schalling M,Zhu J

更新日期：2000-12-01 00:00:00

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:Axotomy of peripheral nerves in neonatal rats induces motoneuron death that can be delayed but not arrested by the application of several neurotrophic factors (NFs) or adenoviral vectors carrying genes for NFs. We tested whether an adenoviral vector carrying the gene for glial cell-line-derived neurotrophic factor (Ad...

journal_title：Journal of neuroscience research

authors： Baumgartner BJ,Shine HD

更新日期：1998-12-15 00:00:00

abstract：:Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...

journal_title：Journal of neuroscience research

authors： Dringen R,Pawlowski PG,Hirrlinger J

更新日期：2005-01-01 00:00:00

abstract：:By using two different approaches, ubiquitin C-terminal hydrolase 1 (UCHL1) was identified as a potential cerebrospinal fluid (CSF) biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage (ASAH) and presumably other CNS damage and disease states. Appropriate antibodies and a sensitive ELISA were generated, an...

journal_title：Journal of neuroscience research

authors： Lewis SB,Wolper R,Chi YY,Miralia L,Wang Y,Yang C,Shaw G

更新日期：2010-05-15 00:00:00

abstract：:It has been postulated that cellular glutamate is released into the extracellular fluid when the energy supply of the brain is compromised (i.e., anoxia or oxygen/glucose deprivation), and there the amino acid triggers the so-called excitotoxic cascade, causing neuronal death. Several mechanisms for this release have ...

journal_title：Journal of neuroscience research

authors： Martín ME,Muñoz FM,Dickinson DA,Forman HJ,Martín del Río R,Salinas M,Fando JL

更新日期：2005-10-01 00:00:00

abstract：:Amyloid beta-peptide (A beta) likely causes functional alterations in neurons well prior to their death. Nuclear factor-kappaB (NF-kappaB), a transcription factor that is known to play important roles in cell survival and apoptosis, has been shown to be modulated by A beta in neurons and glia, but the mechanism is unk...

journal_title：Journal of neuroscience research

authors： Kawamoto EM,Lepsch LB,Boaventura MF,Munhoz CD,Lima LS,Yshii LM,Avellar MC,Curi R,Mattson MP,Scavone C

更新日期：2008-03-01 00:00:00

abstract：:Toll-like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)-mediated innate immunity against viral infections. We examined whether human neuronal cells (primary human neurons, NT2-N and CHP-212 cells) express TLRs and mount type I IFN-mediated innate immunity against herpes si...

journal_title：Journal of neuroscience research

authors： Zhou Y,Ye L,Wan Q,Zhou L,Wang X,Li J,Hu S,Zhou D,Ho W

更新日期：2009-10-01 00:00:00

abstract：:Sphingolipidoses are a class of inherited diseases that result from the toxic accumulation of undigested sphingolipids in lysosomes and other cellular membranes. Sphingolipids are particularly enriched in cells of the nervous system, and their excessive accumulation during disease has a significant impact on the nervo...

journal_title：Journal of neuroscience research

authors： Sural-Fehr T,Bongarzone ER

更新日期：2016-11-01 00:00:00

abstract：:We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)-induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this study investigated th...

journal_title：Journal of neuroscience research

authors： Matsushita H,Hijioka M,Ishibashi H,Anan J,Kurauchi Y,Hisatsune A,Seki T,Shudo K,Katsuki H

更新日期：2014-08-01 00:00:00

abstract：:Tauopathies, including Alzheimer's disease (AD), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally phosphorylated tau protein. In AD brains, it has been shown that the level of abnormally phosphorylated tau is higher than in age-matched contr...

journal_title：Journal of neuroscience research

authors： Blard O,Frébourg T,Campion D,Lecourtois M

更新日期：2006-10-01 00:00:00

abstract：:Previous studies have shown that the mechanical wounding of 3-week-old cultured rat astrocytes results in cell proliferation and hypertrophy resembling astrocyte responses to a brain injury in vivo. We now report the effects of basic fibroblast growth factor (bFGF) and an anti-bFGF antibody on astrocyte morphology, pr...

journal_title：Journal of neuroscience research

authors： Hou YJ,Yu AC,Garcia JM,Aotaki-Keen A,Lee YL,Eng LF,Hjelmeland LJ,Menon VK

更新日期：1995-02-15 00:00:00

abstract：:Spinal cord injury (SCI) triggers chronic intraspinal inflammation consisting of activated resident and infiltrating immune cells (especially microglia/macrophages). The environmental factors contributing to this protracted inflammation are not well understood; however, myelin lipid debris is a hallmark of SCI. Myelin...

journal_title：Journal of neuroscience research

authors： Kopper TJ,Gensel JC

更新日期：2018-06-01 00:00:00

abstract：:Macrophages play critical roles in both degenerative and regenerative processes following peripheral nerve injury. These include phagocytosis of debris, stimulation of Schwann cell dedifferentiation and proliferation, and salvage of myelin lipids for reutilization during regeneration. To better define the role of macr...

journal_title：Journal of neuroscience research

authors： Venezie RD,Toews AD,Morell P

更新日期：1995-01-01 00:00:00

abstract：:Two fundamental questions about neuron cell culture were addressed. Can one serum-free medium that was developed for optimum growth of hippocampal neurons support the growth of neurons from other regions of the brain? Is the region specific state of differentiation maintained in culture? To answer these questions, we ...

journal_title：Journal of neuroscience research

authors： Brewer GJ

更新日期：1995-12-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon 1 H...

journal_title：Journal of neuroscience research

authors： Franich NR,Hickey MA,Zhu C,Osborne GF,Ali N,Chu T,Bove NH,Lemesre V,Lerner RP,Zeitlin SO,Howland D,Neueder A,Landles C,Bates GP,Chesselet MF

更新日期：2019-12-01 00:00:00

abstract：:Fast-scan cyclic voltammetry (FSCV) is an established method for measuring dopamine (DA) levels in the brain in real time. However, it is difficult to discriminate DA from other monoamines such as serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). We report a novel DA-specific biosensor consisting of a car...

journal_title：Journal of neuroscience research

authors： Ishida A,Imamura A,Ueda Y,Shimizu T,Marumoto R,Jung CG,Hida H

更新日期：2018-05-01 00:00:00

abstract：:Activation of proteolytic enzymes, including the caspase family of proteinases, is a feature characteristic of the apoptotic program. In the present study, we examined a potential role of intracellular proteinases in the death of neuronal PC12 and primary cultured rat microglial cells induced by 6-hydroxydopamine (6-O...

journal_title：Journal of neuroscience research

authors： Takai N,Nakanishi H,Tanabe K,Nishioku T,Sugiyama T,Fujiwara M,Yamamoto K

更新日期：1998-10-15 00:00:00

abstract：:Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Glioma cells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be i...

journal_title：Journal of neuroscience research

authors： Widmer M,Hanemann CO,Zajicek J

更新日期：2008-11-01 00:00:00

abstract：:Numerical synaptic density and synaptic vesicle density in rat frontal cortex were examined by electron microscopy as a function of age. The density of axospinous synapses, a major population of synapses, was found to peak at age 1 month, and to gradually decrease with aging. The synaptic vesicle density in axospinous...

journal_title：Journal of neuroscience research

authors： Nakamura H,Kobayashi S,Ohashi Y,Ando S

更新日期：1999-05-01 00:00:00

abstract：:Epilepsy is one of the leading causes of chronic neurological morbidity worldwide. Acquired epilepsy may result from a number of conditions, such as brain injury, anoxia, tumors, stroke, neurotoxicity, and prolonged seizures. Sex differences have been observed in many seizure types; however, some sex-specific seizure ...

journal_title：Journal of neuroscience research

authors： Samba Reddy D

更新日期：2017-01-02 00:00:00

abstract：:Nerve growth factor (NGF) is a protein essential for the survival and normal function of sympathetic neurons. Two-site immunoassays have been developed over the past decade in several laboratories and used to estimate its endogenous concentrations in a variety of effector tissues. However, levels appear restricted to ...

journal_title：Journal of neuroscience research

authors： Zettler C,Bridges DC,Zhou XF,Rush RA

更新日期：1996-12-01 00:00:00