Abstract：
:Tauopathies, including Alzheimer's disease (AD), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally phosphorylated tau protein. In AD brains, it has been shown that the level of abnormally phosphorylated tau is higher than in age-matched control brains, suggesting that abnormally phosphorylated tau is resistant to degradation. By using a Drosophila model of tauopathy, we studied the relationship between tau phosphorylation and degradation. We showed that in vivo reduction of proteasome activity results in an accumulation of high-molecular-weight forms of hyperphosphorylated tau. We also found that glycogen synthase kinase (GSK)-3beta-mediated hyperphosphorylated forms of tau are degradable by the proteasomal machinery. Unexpectedly, GSK-3beta inactivation resulted in a very large accumulation of high-molecular-weight species consisting of hyperphosphorylated tau, suggesting that, depending on the kinase(s) involved, tau phosphorylation state affects its degradation differently. We thus propose a model for tauopathies in which, depending on toxic challenges (e.g., oxidative stress, exposure to amyloid peptide, etc.), abnormal phosphorylation of tau by kinases distinct from GSK-3beta leads to progressive accumulation of hyperphosphorylated tau oligomers that are resistant to degradation.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Blard O,Frébourg T,Campion D,Lecourtois Mdoi
10.1002/jnr.21006subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1107-15issue
5eissn
0360-4012issn
1097-4547journal_volume
84pub_type
杂志文章abstract：:Relationships among different intensities of electroshock treatment (EST), EEG-recordable primary after discharge (PAD), and beta-adrenergic binding in various brain regions were investigated in adult rats. Different intensities of EST (1-2, 6-8, 20-30 mamp) were applied through ear-clip electrodes for 7 consecutive d...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490070306
更新日期：1982-01-01 00:00:00
abstract：:Direct brain injections of the N-methyl-D-aspartate receptor agonist quinolinic acid (QA) trigger an excitotoxic cascade characterized by rapid neuronal death and glial/immune cell activation. The present study compared the timing of immediate early gene (IEG; c-fos, c-jun, jun-B, and zif/268) induction with the respo...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490360511
更新日期：1993-12-01 00:00:00
abstract：:The development of safe and effective treatments for age-associated neurodegenerative disorders is an on-going challenge faced by the scientific field. Key to the development of such therapies is the appropriate selection of modeling systems in which to investigate disease mechanisms and to test candidate intervention...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.24615
更新日期：2021-01-01 00:00:00
abstract：:Astroglial participation in the regional differences of vulnerability to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-induced neurodegeneration was investigated in the rat hippocampus and medial septum using L-alpha-aminoadipate (alpha-AA) as a specific astroglial toxin. alpha-AA was microinjected i...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20177
更新日期：2004-08-01 00:00:00
abstract：:Few diseases in clinical medicine cause as much diagnostic consternation as central nervous system (CNS) vasculitis because of its varying modes of presentation and frequently overlapping clinical and pathological features. There are no pathognomonic clinical or laboratory findings. The purpose of the present retrospe...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10180
更新日期：2002-03-15 00:00:00
abstract：:Localization of acetylcholine receptors (AChRs) to the postsynaptic region of muscle is mediated in part by transcriptional mechanisms, because the genes encoding AChR subunits are transcribed selectively in synaptic myofiber nuclei. Neuregulin-1 (NRG-1) is a synaptic signal and induces transcription of AChRs in muscl...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21563
更新日期：2008-04-01 00:00:00
abstract：:We reported previously that stem cell factor (SCF) is produced mainly by neurons and that its receptor (c-kitR), encoded by the protooncogene c-kit, is expressed in microglia, suggesting that SCF/c-kitR signaling may be involved in neuron-microglia interactions. We now report that SCF supports microglial survival in c...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980701)53:1<29::AID-JNR4
更新日期：1998-07-01 00:00:00
abstract：:Mitochondrial dysfunction has been implicated in cell death in many neurodegenerative diseases. Diminished activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a key and arguably rate-limiting enzyme of the Krebs cycle, occurs in these disorders and may underlie decreased brain metabolism. The present st...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10756
更新日期：2003-10-15 00:00:00
abstract：:The role of the plasmin-generating system, a serum component, in the development of dissociated embryonic chick spinal cord cells in culture was studied. Studies were performed in a defined system where the cells were maintained in a serum-free medium. Under these conditions the cells produce plasminogen activator. It...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490080237
更新日期：1982-01-01 00:00:00
abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21984
更新日期：2009-11-15 00:00:00
abstract：:Precursor cells of the adult mouse subventricular zone (SVZ) are mobilized and recruited by a lysolecithin (LPC)-induced demyelination of the corpus callosum. Because age decreases the proliferation of the SVZ neural precursors as well as the potential for myelin repair of the adult central nervous system, we have com...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10411
更新日期：2002-09-15 00:00:00
abstract：:The blood-brain barrier (BBB) refers to the network of microvessels that selectively restricts the passage of substances between the circulation and the central nervous system (CNS). This microvascular network is comprised of arterioles, capillaries and venules, yet the respective contribution of each of these to the ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22316
更新日期：2010-05-15 00:00:00
abstract：:The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. Here, the effects of BASP1 overexpression were investigated in PC12E2 cells and pr...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21678
更新日期：2008-08-01 00:00:00
abstract：:Glycolysis was blocked in the hippocampus of the otherwise unaffected rabbit by perfusion of a previously implanted thin dialysis tube with a medium containing 0.1 mM iodoacetate. The perfusate from the dialysis tube was analyzed for free amino acids with liquid chromatographic separation of ortophthaldialdehyde deriv...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490130403
更新日期：1985-01-01 00:00:00
abstract：:Transforming growth factor-β1 (TGF-β1) is an important member of multifunctional growth factor superfamily. It has been implicated in pain signaling, but little is known about the underlying mechanisms. Herein, we report that TGF-β1 can exert a sustained enhancing effect on the functional activity of acid-sensing ion ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24481
更新日期：2019-10-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490410310
更新日期：1995-06-15 00:00:00
abstract：:We investigated the role of kainate (KA) receptor activation and desensitization in inducing the increase in the intracellular free Ca(2+) concentration ([Ca(2+)](i)) in individual cultured rat hippocampal neurons. The rat hippocampal neurons in the cultures were shown to express kainate receptor subunits, KA2 and Glu...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1164
更新日期：2001-09-01 00:00:00
abstract：:Spinocerebellar ataxia type 1 (SCA1) is a devastating neurodegenerative disorder in which an abnormally expanded polyglutamine tract is inserted into causative ataxin-1 proteins. We have previously shown that SCA1 knockin (SCA1-KI) mice over 6 months of age exhibit a degeneration of motor neuron axons and their encasi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23698
更新日期：2016-03-01 00:00:00
abstract：:Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and it has multi-functional effects in a variety of cells in various organs. HGF stimulates DNA synthesis and promotes cell migration and morphogenesis in several cell types including the olfactory system. To characterize the potential mitogeni...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10009
更新日期：2001-11-15 00:00:00
abstract：:In searching for possible differences in the composition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) forms in dystrophic brain, the distribution of various enzyme molecules in normal (NB) and dystrophic (DB) 129B6F1/J mouse brain has been investigated. The tissue was sequentially extracted with sa...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19960115)43:2<224::AID-JNR
更新日期：1996-01-15 00:00:00
abstract：:The influence of a concentrated extract of soluble substances from the sciatic nerve upon the acetylcholine receptor (AChR) content in the soleus muscle of adult rats was examined by in vivo infusions. Internal and membrane-inserted AChR were quantitated by the specific binding of 125I-alpha-bungarotoxin (a-BuTX). Int...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490160307
更新日期：1986-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1159
更新日期：2001-08-15 00:00:00
abstract：:The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain c...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490220212
更新日期：1989-02-01 00:00:00
abstract：:We used the Plp1-overexpressing transgenic mouse model to investigate whether progressive demyelination of axons results in adaptive changes involving mitochondria within the axons. These models have myelinated axons from birth but gradually lose myelin and develop axonal loss associated with progressive neurological ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21867
更新日期：2009-02-01 00:00:00
abstract：:Organotypic slices are used frequently in studies of central nervous system development and function because they provide excellent experimental access with significant preservation of cellular context and relationships. Within a slice, however, a variety of factors may cause individual classes of neurons to respond d...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1174
更新日期：2001-09-01 00:00:00
abstract：:Lead is putatively regarded as an environmental neurotoxicant. Long-term low-level lead exposure causes cognitive deficits, but the mechanism remains to be elucidated. In the present study, the excitatory effects of low-level lead exposure on action potential (AP) firing of pyramidal neurons in CA1 region of rat hippo...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21804
更新日期：2008-12-01 00:00:00
abstract：:Adrenal chromaffin cell (ACC) transplants, alone or combined with levodopa treatment, were used in attempted therapy for Parkinson's disease (PD). In a previous study, we demonstrated that levodopa caused chromaffin cell death either by necrosis or by apoptosis in cell culture. Here we report the beneficial effect of ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10456
更新日期：2003-01-01 00:00:00
abstract：:During late postnatal development, mice with the autosomal recessive wobbler mutation (wr/wr) develop motoneuron degeneration associated with astrogliosis in the spinal cord. In vitro, primary wobbler astrocytes are also affected, exhibiting abnormal cell-cell contacts. To characterize further the wobbler disease, we ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Currently antidepressants take several weeks to be effective, which is one of the main reasons why patients with depression quit therapy. In the present study, we examine the acute and subacute effects of soluble epoxide hydolase (sEH) inhibitor (sEHI), a compound shown to have antidepressant effects, on mice. We foun...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24080
更新日期：2017-12-01 00:00:00
abstract：:The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA bindi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.24356
更新日期：2020-01-01 00:00:00
