The application of in vitro-derived human neurons in neurodegenerative disease modeling.

abstract：:The multifactorial nature of traumatic brain injury (TBI), especially the complex secondary tissue injury involving intertwined networks of molecular pathways that mediate cellular behavior, has confounded attempts to elucidate the pathology underlying the progression of TBI. Here, systems biology strategies are explo...

journal_title：Journal of neuroscience research

authors： Yu C,Boutté A,Yu X,Dutta B,Feala JD,Schmid K,Dave J,Tawa GJ,Wallqvist A,Reifman J

更新日期：2015-02-01 00:00:00

abstract：:The role of the NT-3 has been implicated in the survival of progenitor oligodendrocytes in culture. The object of this study was to investigate the expression of the TrkC receptor and its responsiveness in glial cells. We report the expression of two TrkC receptor isoforms in rat primary oligodendrocyte cultures, a gl...

journal_title：Journal of neuroscience research

authors： Kumar S,de Vellis J

更新日期：1996-06-01 00:00:00

abstract：:In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the ...

journal_title：Journal of neuroscience research

authors： Giménez y Ribotta M,Rajaofetra N,Morin-Richaud C,Alonso G,Bochelen D,Sandillon F,Legrand A,Mersel M,Privat A

更新日期：1995-05-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has attracted the greatest attention as a major factor in experimental autoimmune encephalomyelitis (EAE) pathogenesis. We compared rats undergoing EAE with manipulated but healthy animals by examining TNF-alpha gene expression in cells recovered from the brain. We used reverse ...

journal_title：Journal of neuroscience research

authors： Sun D,Hu X,Shah R,Zhang L,Coleclough C

更新日期：1996-08-15 00:00:00

abstract：:Apoptosis and neuronal atrophy are commonly seen in patients infected with the human immunodeficiency virus type 1 (HIV-1) in the late phase of infection. The HIV-1 envelope glycoprotein gp120 has been suggested to be a causal agent of neuronal loss. Therefore, blocking gp120 neurotoxicity may be an effective way to r...

journal_title：Journal of neuroscience research

authors： Bachis A,Mocchetti I

更新日期：2006-04-01 00:00:00

abstract：:Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the fronto-lateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of...

journal_title：Journal of neuroscience research

authors： Mahadik SP,Vilim F,Korenovsky A,Karpiak SE

更新日期：1988-08-01 00:00:00

abstract：:Diabetes and obesity are characterized by hyperlipidemia and represent risk factors for premature neurological disorders. Diabetic/obese animals have impaired adult neurogenesis. We hypothesize that lipotoxicity leading to neurogenesis impairment plays a role in the development of neurological complications. If so, no...

journal_title：Journal of neuroscience research

authors： Mansouri S,Ortsäter H,Pintor Gallego O,Darsalia V,Sjöholm A,Patrone C

更新日期：2012-04-01 00:00:00

abstract：:The incidence of dementia and obstructive sleep apnea (OSA) increases with age. Late-onset Alzheimer's disease (AD) is an irreversible neurodegenerative disease of the elderly characterized by amyloid β (Aβ) plaques and neurofibrillary tangles. The disease involves widespread synaptic loss in the neocortex and the hip...

journal_title：Journal of neuroscience research

authors： Daulatzai MA

更新日期：2015-12-01 00:00:00

abstract：:Gangliosides, sialic acid-containing glycosphingolipids, are ubiquitously expressed in all eukaryotic cells and are localized primarily in the plasma membrane. For a rat pheochromocytoma cell line, PC12, which has been used frequently as a model for investigating events leading to neuronal differentiation, it is gener...

journal_title：Journal of neuroscience research

authors： Yanagisawa M,Ariga T,Yu RK

更新日期：2006-11-01 00:00:00

abstract：:Male and female rodents respond differently to acute stress. We tested our hypothesis that this sex difference is based on differences in stress sensitivity of forebrain areas, by determining possible effects of a single acute psychogenic stressor (1-hr restraint stress) on neuronal gene expression (c-Fos and FosB imm...

journal_title：Journal of neuroscience research

authors： Sterrenburg L,Gaszner B,Boerrigter J,Santbergen L,Bramini M,Roubos EW,Peeters BW,Kozicz T

更新日期：2012-01-01 00:00:00

abstract：:We have studied the interaction between several growth factors to promote parasympathetic neuronal survival. Neither insulin nor insulin-like growth factor-I (IGF-I) had any effect on the survival of embryonic day 8 chick ciliary neurons in culture. Similarly, the protein kinase C activator phorbol dibutyrate (PdBu) h...

journal_title：Journal of neuroscience research

authors： Crouch MF,Hendry IA

更新日期：1991-01-01 00:00:00

abstract：:We present here a fast protocol that could be used to obtain highly purified cultures of maximal proliferating adult rat Schwann cells. These adult rat Schwann cells can be transfected in a nonbiological way using the physical transfection method of electroporation. Schwann cells are decisive in recovery of peripheral...

journal_title：Journal of neuroscience research

authors： Mauritz C,Grothe C,Haastert K

更新日期：2004-08-01 00:00:00

abstract：:Despite a large body of literature on the nociceptin (NC) opioid system in pain modulation, the mechanism of action of NC remains largely unexplored. Here, we investigated the role and mode of action of the spinal NC system in inflammatory pain. Preemptive intrathecal administration of NC attenuated thermal hyperalges...

journal_title：Journal of neuroscience research

authors： Chen Y,Sommer C

更新日期：2007-05-15 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter of CNS, has been consistently implicated in the pathophysiology of schizophrenia. GABA is synthesized from glutamate by the enzyme glutamic acid decarboxylase (GAD). Two isoforms of GAD have been identified and have been named GAD65 and GAD67 ba...

journal_title：Journal of neuroscience research

authors： Dracheva S,Elhakem SL,McGurk SR,Davis KL,Haroutunian V

更新日期：2004-05-15 00:00:00

abstract：:An increased level of myelin basic protein (MBP) degradation peptide 80-89, representative of myelin breakdown, is detected in myelinating foetal rat brain aggregate cultures supplemented with peritoneal macrophages at a time coinciding with the onset of myelination. During the period of myelination, the proportion of...

journal_title：Journal of neuroscience research

authors： Copelman CA,Diemel LT,Gveric D,Gregson NA,Cuzner ML

更新日期：2001-12-15 00:00:00

abstract：:Brain edema accounts for significant morbidity and mortality in many neurologic conditions such as head trauma, stroke, meningitis, and brain tumor. The water channel aquaporin-4 (AQP4) has been found to be an important determinant of brain water accumulation and clearance of excess brain water. We report the developm...

journal_title：Journal of neuroscience research

authors： Thiagarajah JR,Papadopoulos MC,Verkman AS

更新日期：2005-04-15 00:00:00

abstract：:Cyclin-dependent kinase 5 (cdk5), in contrast to other members of the cyclin-dependent kinase family, is not activated by cyclins but instead is activated by complexing with neuron-specific activator molecules (p35, p39, and p67). The most effective activator of cdk5 both in vitro and in vivo is p35. We have taken a k...

journal_title：Journal of neuroscience research

authors： Amin ND,Albers W,Pant HC

更新日期：2002-02-01 00:00:00

abstract：:Nicotine has been reported to be neuroprotective in experimental and epidemiological studies. In addition to nicotine, tobacco and cigarette smoke contain cembranoids, which are antagonists of neuronal nicotinic receptors (nAChR). Exposure of hippocampal slices to N-methyl-D-aspartate (NMDA) decreases the population s...

journal_title：Journal of neuroscience research

authors： Ferchmin PA,Hao J,Perez D,Penzo M,Maldonado HM,Gonzalez MT,Rodriguez AD,de Vellis J

更新日期：2005-12-01 00:00:00

abstract：:Several recently discovered lines of evidence support the involvement of myelin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested for reactivity to cl...

journal_title：Journal of neuroscience research

authors： Chou YK,Henderikx P,Vainiene M,Whitham R,Bourdette D,Chou CH,Hashim G,Offner H,Vandenbark AA

更新日期：1991-02-01 00:00:00

abstract：:A-type K+ channels (IA channels) contribute to learning and memory mechanisms by regulating neuronal excitabilities in the CNS, and their expression level is targeted by Ca2+ influx via synaptic NMDA receptors (NMDARs) during long-term potentiation (LTP). However, it is not clear how local synaptic Ca2+ changes induce...

journal_title：Journal of neuroscience research

authors： Yang YS,Jeon SC,Kang MS,Kim SH,Eun SY,Jin SH,Jung SC

更新日期：2017-12-01 00:00:00

abstract：:Dissociated embryonic rat ventral mesencephalon containing the developing A8-A10 dopamine (DA) neurons was cultured alone or in the presence of a 10 mm segment of adult rat sciatic nerve that had been explanted and maintained in separate culture for 72 hours prior to introduction to mesencephalic cultures. Nerve segme...

journal_title：Journal of neuroscience research

authors： Collier TJ,Sladek CD,Gallagher MJ,Gereau RW 4th,Springer JE

更新日期：1990-11-01 00:00:00

abstract：:Transplanting neural stem cells (NSC) to the damaged brain has been regarded as a potential treatment for neurodegenerative diseases such as Alzheimer's disease (AD), a condition characterized by memory loss. We hypothesized that transplantation of NSC into the hippocampal regions of APP + PS1 transgenic (Tg) mice, a ...

journal_title：Journal of neuroscience research

authors： Zhang W,Wang GM,Wang PJ,Zhang Q,Sha SH

更新日期：2014-02-01 00:00:00

abstract：:The expression of GABAB receptors in cultured mouse cerebellar granule cells was investigated in binding experiments using [3H](S,R)-baclofen as well as in functional assessment of the ability of (R)-baclofen to interact with depolarization (15-40 mM KCl) coupled changes in intracellular Ca2+ homeostasis and neurotran...

journal_title：Journal of neuroscience research

authors： Kardos J,Elster L,Damgaard I,Krogsgaard-Larsen P,Schousboe A

更新日期：1994-12-15 00:00:00

abstract：:Recent data indicate that molecular mimicry may play a role in the pathogenesis of human-T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an immune-mediated disease of the central nervous system (CNS). Specifically, HAM/TSP patients developed antibodies that cross-reac...

journal_title：Journal of neuroscience research

authors： Kalume F,Lee SM,Morcos Y,Callaway JC,Levin MC

更新日期：2004-07-01 00:00:00

abstract：:Epidural hematoma (EDH) is a type of life-threatening traumatic brain injury. Little is known about the extent to which EDH may cause neural damage and regenerative response in the cerebral cortex. Here we attempted to explore these issues by using guinea pigs as an experimental model. Unilateral EDH was induced by in...

journal_title：Journal of neuroscience research

authors： Pan A,Li M,Gao JY,Xue ZQ,Li Z,Yuan XY,Luo DW,Luo XG,Yan XX

更新日期：2013-02-01 00:00:00

abstract：:Pathological processes affecting presynaptic terminals may contribute to morbidity following traumatic brain injury (TBI). Posttraumatic widespread neuronal depolarization and elevated extracellular potassium and glutamate are predicted to alter the transduction of action potentials in terminals into reliable synaptic...

journal_title：Journal of neuroscience research

authors： Reeves TM,Kao CQ,Phillips LL,Bullock MR,Povlishock JT

更新日期：2000-05-01 00:00:00

abstract：:Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis...

journal_title：Journal of neuroscience research

authors： Kane DJ,Ord T,Anton R,Bredesen DE

更新日期：1995-02-01 00:00:00

abstract：:In this study, the responses of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) activities were quantitatively analyzed at different times in both ipsilateral and contralateral sides of trigeminal nuclei, after unilateral trigeminal muscle nerve transection, i...

journal_title：Journal of neuroscience research

authors： Varathan V,Shigenaga Y,Takemura M

更新日期：2001-11-01 00:00:00

abstract：:As the main input structure of the basal ganglia (BG), the striatum collects and integrates information from several brain areas and funnels them forward to other BG nuclei. The striatal projection neurons are medium-sized spiny neurons classified in two main subpopulations, based on their neurochemical characterizati...

journal_title：Journal of neuroscience research

authors： Ciriachi C,Svane-Petersen D,Rickhag M

更新日期：2019-10-01 00:00:00

abstract：:Although proteins belonging to the sHSP superfamily are diverse in sequence and size, most share characteristic features, including 1) a small molecular mass of 12-43 kDa, 2) a conserved alpha-crystallin domain of 80-100 residues, 3) formation of large oligomers, 4) a dynamic quaternary structure, and 5) induction by ...

journal_title：Journal of neuroscience research

authors： Hu Z,Yang B,Lu W,Zhou W,Zeng L,Li T,Wang X

更新日期：2008-08-01 00:00:00