Abstract：
:Relationships among different intensities of electroshock treatment (EST), EEG-recordable primary after discharge (PAD), and beta-adrenergic binding in various brain regions were investigated in adult rats. Different intensities of EST (1-2, 6-8, 20-30 mamp) were applied through ear-clip electrodes for 7 consecutive days. A sigmoidal relationship was observed between the PAD and the applied current-intensity. 3H-dihydroalprenolol (DHA) was used as a ligand to evaluate beta-adrenergic receptor binding in membrane preparation of the following brain regions: Cerebral cortex, cerebellum, pons-medulla, and "midregion"-which consisted of the remainder tissue including thalamus, striatum, and midbrain. A significant decrease (28%) in binding was observed in cortex tissue after EST of 6-8 mamp but no changes were observed after either 1-2 mamp or 20-30 mamp. In "midregion," a significant increase (40%) in binding was observed after EST with the subconvulsive intensity (1-2 mamp) whereas no changes were seen at higher intensities. The results suggest that in cortex, the function relating beta-adrenergic binding to current intensities may not be monotonic. The increase in binding seen in the "midregion" after subconvulsive EST may not be associated with changes related to the clinical efficacy of EST.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Perumal AS,Barkai AIdoi
10.1002/jnr.490070306subject
Has Abstractpub_date
1982-01-01 00:00:00pages
289-96issue
3eissn
0360-4012issn
1097-4547journal_volume
7pub_type
杂志文章abstract：:The multifactorial nature of traumatic brain injury (TBI), especially the complex secondary tissue injury involving intertwined networks of molecular pathways that mediate cellular behavior, has confounded attempts to elucidate the pathology underlying the progression of TBI. Here, systems biology strategies are explo...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23503
更新日期：2015-02-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490050108
更新日期：1980-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990801)57:3<295::AID-JNR
更新日期：1999-08-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
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更新日期：1996-02-01 00:00:00
abstract：:Neurofibromatosis type 2 is a hereditary cancer syndrome characterized by the development of bilateral vestibular schwannomas. Underlying the disease are inactivating mutations of the NF2 tumor suppressor gene, located on chromosome 22, encoding a 595-amino-acid protein. The NF2 protein, also known as merlin or schwan...
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doi：10.1002/1097-4547(20001215)62:6<764::AID-JNR2>3.0.
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journal_title：Journal of neuroscience research
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doi：10.1002/jnr.23223
更新日期：2013-07-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20109
更新日期：2004-06-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490010205
更新日期：1975-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1159
更新日期：2001-08-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10123
更新日期：2002-02-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490280411
更新日期：1991-04-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490330121
更新日期：1992-09-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10155
更新日期：2002-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10482
更新日期：2003-02-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23383
更新日期：2014-08-01 00:00:00
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journal_title：Journal of neuroscience research
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doi：10.1002/jnr.23677
更新日期：2016-01-01 00:00:00
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journal_title：Journal of neuroscience research
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journal_title：Journal of neuroscience research
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journal_title：Journal of neuroscience research
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更新日期：2019-10-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490390506
更新日期：1994-12-01 00:00:00
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journal_title：Journal of neuroscience research
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doi：10.1002/jnr.20977
更新日期：2006-09-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19981101)54:3<353::AID-JNR
更新日期：1998-11-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20894
更新日期：2006-08-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490110405
更新日期：1984-01-01 00:00:00
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更新日期：2011-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23821
更新日期：2017-01-02 00:00:00
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更新日期：2003-09-15 00:00:00
