Establishment of embryonic neuroepithelial cell lines exhibiting an epiplastic expression pattern of region specific markers.

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:Substance P (SP) acts as an immunoregulator by binding to specific functional cell surface receptors on a subpopulation of human T-helper lymphocytes. Receptors with similar properties have also been characterized on the human IM-9 B-lymphoblast cell line. Four distinct proteins of molecular weight (MW) 33,000, 58,000...

journal_title：Journal of neuroscience research

authors： McGillis JP,Organist ML,Scriven KH,Payan DG

更新日期：1987-01-01 00:00:00

abstract：:Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...

journal_title：Journal of neuroscience research

authors： Zeng Z,Yuan X,Liu G,Zeng X,Zeng X,Ng H,Chen H,Jiang T,Akasaki Y,Kessey K,Black KL,Yu JS

更新日期：2007-02-01 00:00:00

abstract：:A coordinated up-regulation in the expression of all three neurofilament (NF) proteins occurs during postnatal development in the rat (Schlaepfer and Bruce, J Neurosci Res [in press], 1990a). In the present study, sciatic nerves were transected in neonatal rats in order to determine the effects of axotomy on the postn...

journal_title：Journal of neuroscience research

authors： Schwartz ML,Shneidman PS,Bruce J,Schlaepfer WW

更新日期：1990-10-01 00:00:00

abstract：:Evidence indicates that the ubiquitin-proteasome system and the endoplasmic retculum (ER) quality-control system work in concert to ensure that proteins are correctly folded in the ER and that misfolded proteins are retrotransported to the cytosol for degradation by proteasomes. Dysfunction of either system results in...

journal_title：Journal of neuroscience research

authors： Kuang XL,Liu F,Chen H,Li Y,Liu Y,Xiao J,Shan G,Li M,Snider BJ,Qu J,Barger SW,Wu S

更新日期：2014-10-01 00:00:00

abstract：:Although reactive oxygen species (ROS) have been implicated in ischemic preconditioning (IPC)-induced neuronal protection, several key questions concerning ROS remain to be elucidated. The purpose of this study is to obtain direct evidence for the formation of specific ROS species generated by IPC, and to determine th...

journal_title：Journal of neuroscience research

authors： Furuichi T,Liu W,Shi H,Miyake M,Liu KJ

更新日期：2005-03-15 00:00:00

abstract：:The periglomerular cells (PG) of the olfactory bulb (OB) are involved in the primary processing and the refinement of sensory information from the olfactory epithelium. The neurochemical composition of these neurons has been studied in depth in many species, and over the last decades such studies have focused mainly o...

journal_title：Journal of neuroscience research

authors： Baltanás FC,Curto GG,Gómez C,Díaz D,Murias AR,Crespo C,Erdelyi F,Szabó G,Alonso JR,Weruaga E

更新日期：2011-01-01 00:00:00

abstract：:The incubation of murine thymocytes for 24 hr in the presence of cholinergic agonists induces selective proliferation of PNA- cells as measured by thymidine incorporation. The response of PNA- cells is mediated by the activation of nicotinic receptors. This conclusion is suggested by the inability of the muscarinic ag...

journal_title：Journal of neuroscience research

authors： Rossi A,Tria MA,Baschieri S,Doria G,Frasca D

更新日期：1989-11-01 00:00:00

abstract：:Here we show that rabbit Müller cell differentiation from radial glial progenitor cells is accompanied by a decreasing capability to respond to specific stimuli (depolarization and extracellular adenosine 5'-triphosphate [ATP]) with an elevation of intracellular calcium. Intracellular free calcium was recorded in reti...

journal_title：Journal of neuroscience research

authors： Uckermann O,Grosche J,Reichenbach A,Bringmann A

更新日期：2002-10-15 00:00:00

abstract：:F5 was identified originally as an interleukin-2-regulated gene in L2 cells, a murine helper T-lymphocyte clone. In adult mouse, F5 mRNA was expressed at a modest level in lymphoid tissues, at a high level in mature neurons in the nervous system, but not in other tissues. Although the F5 sequence is highly conserved o...

journal_title：Journal of neuroscience research

authors： Arai M,Cohen JA

更新日期：1993-10-15 00:00:00

abstract：:Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the...

journal_title：Journal of neuroscience research

authors： Garcia-Rill E

更新日期：2019-12-01 00:00:00

abstract：:Mice heterozygously deficient in the major myelin component P0 are an established model of an inherited neuropathy and show signs of myelin degeneration in motor nerves. Unlike the case in patients, the sensory nerves are only mildly affected in the mouse mutants and do not show features indicative of myelin degenerat...

journal_title：Journal of neuroscience research

authors： Samsam M,Frei R,Marziniak M,Martini R,Sommer C

更新日期：2002-01-15 00:00:00

abstract：:In 2000, a landmark case report described the concurrent restoration of consciousness and thalamo-frontal connectivity after severe brain injury (Laureys et al., ). Being a single case however, this study could not disambiguate whether the result was specific to the restoration of consciousness per se as opposed to th...

journal_title：Journal of neuroscience research

authors： Crone JS,Bio BJ,Vespa PM,Lutkenhoff ES,Monti MM

更新日期：2018-04-01 00:00:00

abstract：:HEPES inhibited the taurine uptake in glial cells. A different kind of inhibition was observed when HEPES was present in the culture medium or in the incubation medium used for the taurine-uptake measurement. As an example of a possible interference of HEPES in pharmacological experiments, we have studied the effect o...

journal_title：Journal of neuroscience research

authors： Lleu PL,Rebel G

更新日期：1989-05-01 00:00:00

abstract：:Although gangliosides have been reported to enhance recovery from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of the substantia nigra, evidence as to whether the administered gangliosides actually reach this or any other site of lesion in the central nervous system (CNS) at which they putativel...

journal_title：Journal of neuroscience research

authors： Saulino MF,Schengrund CL

更新日期：1994-02-15 00:00:00

abstract：:Neural precursor cells, including neural stem and progenitor cells, in the subventricular zone (SVZ) are the main targets for cytomegalovirus (CMV) infection in developing brains. The neural precursor cells in the SVZ of the adult brain have been reported to respond by proliferating after infusion with epidermal growt...

journal_title：Journal of neuroscience research

authors： Han GP,Li L,Kosugi I,Kawasaki H,Tsuchida T,Miura K,Tsutsui Y

更新日期：2007-10-01 00:00:00

abstract：:The inner ear of humans and experimental animals demonstrate an abundance of glucocorticoid receptors (GR). Glucocorticoids (GC) are widely used to treat different hearing disorders; yet the mechanisms of GC action on the inner ear are unknown. We demonstrate how GR can directly modulate hearing sensitivity in respons...

journal_title：Journal of neuroscience research

authors： Tahera Y,Meltser I,Johansson P,Bian Z,Stierna P,Hansson AC,Canlon B

更新日期：2006-05-01 00:00:00

abstract：:Previous studies have suggested that sensory mechanisms may be important components of addiction to, and withdrawal from, cigarette smoking. The sensory and respiratory responses to nicotine are mediated, in part, by bronchopulmonary C-fiber afferents. Nicotine has a direct stimulatory effect on pulmonary sensory neur...

journal_title：Journal of neuroscience research

authors： Dehkordi O,Rose JE,Balan KV,Kc P,Millis RM,Jayam-Trouth A

更新日期：2009-05-15 00:00:00

abstract：:The role of the plasmin-generating system, a serum component, in the development of dissociated embryonic chick spinal cord cells in culture was studied. Studies were performed in a defined system where the cells were maintained in a serum-free medium. Under these conditions the cells produce plasminogen activator. It...

journal_title：Journal of neuroscience research

authors： Kalderon N

更新日期：1982-01-01 00:00:00

abstract：:To promote neurite elongation, nerve growth cones must adhere to other surfaces. A complex of integral membrane glycoproteins mediates cell binding to the extracellular glycoproteins fibronectin and laminin (Horwitz et al., J Cell Biol 101:2134-2144, 1985). The receptor complex, named integrin, binds to fibronectin by...

journal_title：Journal of neuroscience research

authors： Letourneau PC,Pech IV,Rogers SL,Palm SL,McCarthy JB,Furcht LT

更新日期：1988-10-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a chemically defined (...

journal_title：Journal of neuroscience research

authors： Morrison RS,De Vellis J,Lee YL,Bradshaw RA,Eng LF

更新日期：1985-01-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and it has multi-functional effects in a variety of cells in various organs. HGF stimulates DNA synthesis and promotes cell migration and morphogenesis in several cell types including the olfactory system. To characterize the potential mitogeni...

journal_title：Journal of neuroscience research

authors： Yan H,Nie X,Kocsis JD

更新日期：2001-11-15 00:00:00

abstract：:Human T-cell lymphotropic virus type I (HTLV-I) may infect up to 10% of peripheral blood T cells in patients with HTLV-I myelopathy. To examine the impact of HTLV-I infection on the abilities of T cells to present and respond to peptide antigen, we HTLV-I infected and subcloned a myelin basic protein peptide 84-102 (M...

journal_title：Journal of neuroscience research

authors： Scholz C,Hafler DA,Höllsberg P

更新日期：1996-09-15 00:00:00

abstract：:TCP and its derivative gacyclidine (+/- GK11) are high-affinity non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors (NMDARs) and as such exhibit significant neuroprotective properties. These compounds also bind with a low affinity to binding sites whose pharmacological profiles are different from that...

journal_title：Journal of neuroscience research

authors： Hirbec H,Mausset AL,Kamenka JM,Privat A,Vignon J

更新日期：2002-05-01 00:00:00

abstract：:The objective of the present investigation was to answer the following question: Does the visual cortex affect the neuronal firing of retinal ganglion cells in the rat? To test this hypothesis, the visual cortex was inactivated by a reversible cryoblockade. Action potentials of a ganglion cell were recorded from its a...

journal_title：Journal of neuroscience research

authors： Molotchnikoff S,Tremblay F

更新日期：1983-01-01 00:00:00

abstract：:Activation of proteolytic enzymes, including the caspase family of proteinases, is a feature characteristic of the apoptotic program. In the present study, we examined a potential role of intracellular proteinases in the death of neuronal PC12 and primary cultured rat microglial cells induced by 6-hydroxydopamine (6-O...

journal_title：Journal of neuroscience research

authors： Takai N,Nakanishi H,Tanabe K,Nishioku T,Sugiyama T,Fujiwara M,Yamamoto K

更新日期：1998-10-15 00:00:00

abstract：:The hippocampus is an important brain region involved in memory and learning. Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B (TrkB), and phospho-p44/p42 mitogen-activated protein kinase (MAPK) are known to contribute to hippocampal memory/learning. The present study aimed to clarify the effects o...

journal_title：Journal of neuroscience research

authors： Ogawa T,Okihara H,Kokai S,Abe Y,Karin Harumi UK,Makiguchi M,Kato C,Yabushita T,Michikawa M,Ono T

更新日期：2018-06-01 00:00:00

abstract：:To study the influence of cell surface-associated molecules on intercellular communication, C6 glioma cells were cultured both on plastic and on substrata of paraformaldehyde-fixed B104 neuroblastoma cells. By then comparing the phenotypic expression of these "cocultured" C6 cells with cells cultured on tissue culture...

journal_title：Journal of neuroscience research

authors： Ciment G,de Vellis J

更新日期：1982-01-01 00:00:00

abstract：:The twitcher mouse is well known as a naturally occurring authentic mouse model of human globoid cell leukodystrophy (GLD; Krabbe disease) due to genetic deficiency of lysosomal galactosylceramidase. The twitcher mice used most commonly are on the C57BL/6J background. We generated twitcher mice that were on the mixed ...

journal_title：Journal of neuroscience research

authors： Tominaga K,Matsuda J,Kido M,Naito E,Yokota I,Toida K,Ishimura K,Suzuki K,Kuroda Y

更新日期：2004-08-15 00:00:00

abstract：:Restless Legs Syndrome (RLS) is a disorder of sensation with a prevalence of around 2-5% of the population. Relevant to understanding the possible pathophysiological mechanism is the fact that RLS is extremely responsive to dopaminergic agents. A second issue is that iron deficiency states may precipitate RLS in as mu...

journal_title：Journal of neuroscience research

authors： Earley CJ,Allen RP,Beard JL,Connor JR

更新日期：2000-12-01 00:00:00