Effects of dopamine on photopic L-type S-potentials in the catfish retina.

abstract：:It was previously reported that a monoclonal antibody to beta-amyloid precursor protein (mab22C11; Boehringer Mannheim, Indianapolis, IN) labels an intermediate filament-associated protein (beta APP-IFAP) in cultured human skin fibroblasts (Dooley et al.: J Neurosci Res 33:60-67, 1992). The time course of its expressi...

journal_title：Journal of neuroscience research

authors： Durham HD,Minotti S,Dooley NP,Nalbantoglu J

更新日期：1994-08-15 00:00:00

abstract：:An experimental model based on kainic acid (KA) injections replicates many phenomenological features of human temporal lobe epilepsy, the most common type of epilepsy in adults. Taurine, 2-aminoethanesulfonic acid, present in high concentrations in many invertebrate and vertebrate systems, is believed to serve several...

journal_title：Journal of neuroscience research

authors： Junyent F,Utrera J,Romero R,Pallàs M,Camins A,Duque D,Auladell C

更新日期：2009-05-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and it has multi-functional effects in a variety of cells in various organs. HGF stimulates DNA synthesis and promotes cell migration and morphogenesis in several cell types including the olfactory system. To characterize the potential mitogeni...

journal_title：Journal of neuroscience research

authors： Yan H,Nie X,Kocsis JD

更新日期：2001-11-15 00:00:00

abstract：:Although the thalamus is not considered primarily as a limbic structure, abundant evidence indicates the essential role of the thalamus as a modulator of limbic functions indirectly through the amygdala. The amygdala is a central component of the limbic system and serves an essential role in modulating the core proces...

journal_title：Journal of neuroscience research

authors： Kamali A,Riascos RF,Pillai JJ,Sair HI,Patel R,Nelson FM,Lincoln JA,Tandon N,Mirbagheri S,Rabiei P,Keser Z,Hasan KM

更新日期：2018-07-01 00:00:00

abstract：:A growing body of evidence suggests that neurotrophins (NTs) play a critical role in synaptic plasticity and other activity dependent processes in the CNS. Release of these growth factors by neurons and neuroendocrine cells was recently shown to occur via the regulated secretory pathway, representing a possible mechan...

journal_title：Journal of neuroscience research

authors： Möller JC,Krüttgen A,Heymach JV Jr,Ghori N,Shooter EM

更新日期：1998-02-15 00:00:00

abstract：:The role of intracellular proteases (e.g., calpains and caspases) in the pathophysiology of neuronal cell death has been extensively investigated. More recently, accumulating data have suggested that extracellular proteolysis also plays a critical role. The two major systems that modify the extracellular matrix in bra...

journal_title：Journal of neuroscience research

authors： Lo EH,Wang X,Cuzner ML

更新日期：2002-07-01 00:00:00

abstract：:After left unilateral cochlear ablation (UCA) in young adult guinea pigs, the appearance of plasticities in auditory pathways suggested altered gene expression and modified phenotypic behaviors of auditory neurons. Because phosphorylated cyclic-AMP response element-binding protein (CREB-P) is a transcription factor th...

journal_title：Journal of neuroscience research

authors： Mo Z,Suneja SK,Potashner SJ

更新日期：2006-05-15 00:00:00

abstract：:Both the adenosine analogue 2-chloro-adenosine (2-CA) and the reducing sugar deoxy-D-ribose (dRib) induce apoptosis of astroglial cells in rat brain primary cultures (Abbracchio et al.: Biochem Biophys Res Commun 213:908-915, 1995). The present study was undertaken to elucidate by both morphological and cytofluorimetr...

journal_title：Journal of neuroscience research

authors： Ceruti S,Barbieri D,Veronese E,Cattabeni F,Cossarizza A,Giammarioli AM,Malorni W,Franceschi C,Abbracchio MP

更新日期：1997-02-15 00:00:00

abstract：:Dopamine has been implicated as a potential mediating factor in a variety of neurodegenerative disorders. Dopamine can be oxidized to form a reactive dopamine quinone that can covalently modify cellular macromolecules including protein and DNA. This oxidation can be enhanced through various enzymes including tyrosinas...

journal_title：Journal of neuroscience research

authors： Xu Y,Stokes AH,Roskoski R Jr,Vrana KE

更新日期：1998-12-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) plays an important role in the differentiation, development, and survival of neural stem cells. In this study, we analyzed its effects on the stimulation of human umbilical cord blood-derived mesenchymal stem cells in terms of their potential to differentiate into neuron-like c...

journal_title：Journal of neuroscience research

authors： Lim JY,Park SI,Oh JH,Kim SM,Jeong CH,Jun JA,Lee KS,Oh W,Lee JK,Jeun SS

更新日期：2008-08-01 00:00:00

abstract：:Primary cultures of cerebral glia derived from neonatal rat brain were utilized to determine 1) the developmental changes of dolichol-linked oligosaccharide and N-linked glycoprotein biosyntheses, 2) the enzymatic correlates of these developmental changes, and 3) the temporal relations between the biosyntheses of doli...

journal_title：Journal of neuroscience research

authors： Ishii S,Volpe JJ

更新日期：1988-08-01 00:00:00

abstract：:An angiotensin 2 type 1 receptor blocker, olmesartan, and a calcium channel blocker, azelnidipine, possess not only an antihypertensive effect but also an antioxidative effect and other beneficial effects. In the present study, we examined the efficacy of olmesartan and azelnidipine monotherapy (2 mg/kg or 10 mg/kg ea...

journal_title：Journal of neuroscience research

authors： Omote Y,Deguchi K,Kono S,Liu W,Kurata T,Hishikawa N,Yamashita T,Ikeda Y,Abe K

更新日期：2014-10-01 00:00:00

abstract：:Autonomic neuropathy in several neurodegenerative disorders results from disturbance in physiological functions of different cell types in the central and peripheral nervous systems. For a clearer understanding of the etiology and pathogenesis of the autonomic disorders it is necessary to create animal models in which...

journal_title：Journal of neuroscience research

authors： Sawada H,Nishii K,Suzuki T,Hasegawa K,Hata T,Nagatsu I,Kreitman RJ,Pastan I,Nagatsu T,Kobayashi K

更新日期：1998-01-15 00:00:00

abstract：:Sphingolipidoses are a class of inherited diseases that result from the toxic accumulation of undigested sphingolipids in lysosomes and other cellular membranes. Sphingolipids are particularly enriched in cells of the nervous system, and their excessive accumulation during disease has a significant impact on the nervo...

journal_title：Journal of neuroscience research

authors： Sural-Fehr T,Bongarzone ER

更新日期：2016-11-01 00:00:00

abstract：:The effects of exogenous GM1 and GD1a on S20Y murine neuroblastoma cells were assessed by monitoring morphology, tumorigenicity, mitotic index, and plating efficiency. S20Y cells were seeded at a density equivalent to 5 X 10(4) cells per 35-mm tissue culture dish; 38-42 hr after seeding (preconfluent stage) the cells ...

journal_title：Journal of neuroscience research

authors： Carine K,Schengrund CL

更新日期：1984-01-01 00:00:00

abstract：:The growth and differentiation of neural precursor cells in the central nervous system (CNS) are regulated by their response to polypeptide growth factors which interact with specific transmembrane receptor tyrosine kinases (RTKs). We demonstrate that rat oligodendrocyte-type 2 astrocyte (O-2A) glial progenitor cells,...

journal_title：Journal of neuroscience research

authors： Ida JA Jr,Dubois-Dalcq M,McKinnon RD

更新日期：1993-12-01 00:00:00

abstract：:Plexiform layer synaptic and photoreceptor cell components were investigated in retinas of Royal College of Surgeons (RCS) dystrophic rats transplanted with normal retinal pigment epithelial (RPE) cells by immunocytochemistry using previously characterized monoclonal antibodies. In retinas of normal adult rats and RPE...

journal_title：Journal of neuroscience research

authors： Sheedlo HJ,Li L,Barnstable CJ,Turner JE

更新日期：1993-11-01 00:00:00

abstract：:Using [3H]-dopamine (DA) as the ligand of choice, we have shown that rat lymphocytes possess DA binding sites. The binding of [3H]-DA was specific, saturable, and of high affinity. The specific binding in membranes obtained from Con A-activated lymphoblasts was greater than the binding in respective unactivated lympho...

journal_title：Journal of neuroscience research

authors： Ovadia H,Abramsky O

更新日期：1987-01-01 00:00:00

abstract：:The potassium-induced stimulation of oxygen consumption in brain slices has a threshold value of 15-20 mM potassium, and it reaches its maximum at 35-50 mM. Although this phenomenon now has been known for almost 50 years, its physiological role remains undetermined. One reason for this may be that the high concentrati...

journal_title：Journal of neuroscience research

authors： Hertz L,Kjeldsen CS

更新日期：1985-01-01 00:00:00

abstract：:As a neurotransmitter and neuromodulator, serotonin (5-HT) influences neuronal outgrowth in the nervous systems of several species. In PC12 cells, 5-HT is known to have neuritogenic effects, although the signal transduction pathway responsible for these effects is not understood. In this study, we hypothesized that a ...

journal_title：Journal of neuroscience research

authors： Homma K,Kitamura Y,Ogawa H,Oka K

更新日期：2006-08-01 00:00:00

abstract：:Alcohol consumption is largely associated with alterations in the extracellular glutamate concentrations in several brain reward regions. We recently showed that glutamate transporter 1 (GLT-1) is downregulated following chronic exposure to ethanol for 5 weeks in alcohol-preferring (P) rats and that upregulation of th...

journal_title：Journal of neuroscience research

authors： Aal-Aaboda M,Alhaddad H,Osowik F,Nauli SM,Sari Y

更新日期：2015-06-01 00:00:00

abstract：:Although alterations in adenylate cyclase (AC) activity and somatostatin (SRIF) receptor density have been reported in Alzheimer's disease, the effects of amyloid beta-peptide (Abeta) on these parameters in the hippocampus are unknown. Our aim was to investigate whether the peptide fragment Abeta(25-35) can affect the...

journal_title：Journal of neuroscience research

authors： Burgos-Ramos E,Hervás-Aguilar A,Puebla-Jiménez L,Boyano-Adánez MC,Arilla-Ferreiro E

更新日期：2007-02-01 00:00:00

abstract：:Neuroadaptations in the nucleus accumbens (NAc) are associated with the development of drug addiction. Plasticity in synaptic strength and intrinsic excitability of NAc medium spiny neurons (MSNs) play critical roles in addiction induced by different classes of abused drugs. However, it is unknown whether morphine exp...

journal_title：Journal of neuroscience research

authors： Wu X,Shi M,Wei C,Yang M,Liu Y,Liu Z,Zhang X,Ren W

更新日期：2012-06-01 00:00:00

abstract：:Lentiviral vectors are used widely to direct efficient gene transfer in vivo. We examined cell-specific expression in adult murine white matter after stereotaxic microinjection of four lentiviral constructs. We synthesized vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped lentiviruses with combinations of tw...

journal_title：Journal of neuroscience research

authors： McIver SR,Lee CS,Lee JM,Green SH,Sands MS,Snider BJ,Goldberg MP

更新日期：2005-11-01 00:00:00

abstract：:Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the fronto-lateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of...

journal_title：Journal of neuroscience research

authors： Mahadik SP,Vilim F,Korenovsky A,Karpiak SE

更新日期：1988-08-01 00:00:00

abstract：:We describe here a novel monoclonal antibody (mab H6) which recognizes CD9, an integral cell surface constituent previously described in cells of the hematopoietic lineage and involved in the aggregation of platelets. Mab H6 was raised against membranes of immature mouse astrocytes and reacted with a protein of 25-27 ...

journal_title：Journal of neuroscience research

authors： Schmidt C,Künemund V,Wintergerst ES,Schmitz B,Schachner M

更新日期：1996-01-01 00:00:00

abstract：:It has been postulated that cellular glutamate is released into the extracellular fluid when the energy supply of the brain is compromised (i.e., anoxia or oxygen/glucose deprivation), and there the amino acid triggers the so-called excitotoxic cascade, causing neuronal death. Several mechanisms for this release have ...

journal_title：Journal of neuroscience research

authors： Martín ME,Muñoz FM,Dickinson DA,Forman HJ,Martín del Río R,Salinas M,Fando JL

更新日期：2005-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)-mediated innate immunity against viral infections. We examined whether human neuronal cells (primary human neurons, NT2-N and CHP-212 cells) express TLRs and mount type I IFN-mediated innate immunity against herpes si...

journal_title：Journal of neuroscience research

authors： Zhou Y,Ye L,Wan Q,Zhou L,Wang X,Li J,Hu S,Zhou D,Ho W

更新日期：2009-10-01 00:00:00

abstract：:The demyelinative potential of the cytokines interleukin-1 alpha (IL-1 alpha), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) has been investigated in myelinating aggregate brain cell cultures. Treatment of myelinated cultures with these cytokines resulted in a reduction in myelin basic prot...

journal_title：Journal of neuroscience research

authors： Loughlin AJ,Honegger P,Woodroofe MN,Comte V,Matthieu JM,Cuzner ML

更新日期：1994-04-01 00:00:00

abstract：:Apoptosis and neuronal atrophy are commonly seen in patients infected with the human immunodeficiency virus type 1 (HIV-1) in the late phase of infection. The HIV-1 envelope glycoprotein gp120 has been suggested to be a causal agent of neuronal loss. Therefore, blocking gp120 neurotoxicity may be an effective way to r...

journal_title：Journal of neuroscience research

authors： Bachis A,Mocchetti I

更新日期：2006-04-01 00:00:00