Fullerene C60 and ascorbic acid protect cultured chromaffin cells against levodopa toxicity.

abstract：:Human P0 is the main myelin glycoprotein of the peripheral nervous system. It can bind six different glycans, all linked to Asn(93) , the unique glycosylation site. Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn(36) , MOG at Asn(31) ), bind only one glycan. The MAG has 10 glycosylation...

journal_title：Journal of neuroscience research

authors： Sedzik J,Jastrzebski JP,Grandis M

更新日期：2015-01-01 00:00:00

abstract：:The central nervous system (CNS) is considered a nonpermissive environment for axonal regeneration because of the presence of myelin and associated repulsive molecules. However, neural cells transplanted to the CNS preferably migrate and extend their fibers in white matter areas. We previously showed that white matter...

journal_title：Journal of neuroscience research

authors： Fang Z,Forslund N,Takenaga K,Lukanidin E,Kozlova EN

更新日期：2006-03-01 00:00:00

abstract：:The analysis of proteins in damaged myelin is crucial to clarify the mechanisms of dysmyelination and demyelination. In the present study, proteomic analysis of myelin using a modified two-dimensional electrophoresis (2-DE) method was carried out to obtain a better understanding of myelin biology. Although standard 2-...

journal_title：Journal of neuroscience research

authors： Yamaguchi Y,Miyagi Y,Baba H

更新日期：2008-03-01 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain. A deficiency of GABAergic inhibition mediated via the GABAA receptor complex has for a long time been suspected to be a central factor in epileptogenesis. Status epilepticus is a condition of sustained and prolonged excitation of...

journal_title：Journal of neuroscience research

authors： Karle J,Woldbye DP,Elster L,Diemer NH,Bolwig TG,Olsen RW,Nielsen M

更新日期：1998-12-15 00:00:00

abstract：:We suggest that a dysregulation of energy metabolism in the brain of genetic absence epilepsy rats from Strasbourg (GAERS) could create a specific cerebral environment that would favor the expression of spike-and-wave discharges (SWD) in the thalamocortical loop, largely dependent on glutamatergic and gamma-aminobutyr...

journal_title：Journal of neuroscience research

authors： Dufour F,Nalecz KA,Nalecz MJ,Nehlig A

更新日期：2001-12-01 00:00:00

abstract：:As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non-invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provides novel experimenta...

journal_title：Journal of neuroscience research

authors： Abellaneda-Pérez K,Vaqué-Alcázar L,Solé-Padullés C,Bartrés-Faz D

更新日期：2019-08-16 00:00:00

abstract：:Transection of the hindlimb dorsal column fibers leads to a partial deafferentation of the neurons of the nucleus gracilis, the first relay of the ascending dorsal column-medial lemniscal (DC-ML) neural network. In response to the deafferentation, a synaptic renewal cycle is initiated and the neurons of the nucleus gr...

journal_title：Journal of neuroscience research

authors： Riley LA,Bernstein JJ

更新日期：1995-03-01 00:00:00

abstract：:The neural cell adhesion molecule L1 is a multidomain protein that plays important roles in cell adhesion, migration, and neurite outgrowth. It can interact with itself by a self-binding, i.e., homophilic adhesion mechanism (Kadmon et al.: J Cell Biol 110: 193-208, 1990a). To determine the domains of L1 involved in ho...

journal_title：Journal of neuroscience research

authors： Holm J,Appel F,Schachner M

更新日期：1995-09-01 00:00:00

abstract：:Transferrin is the second most abundant plasma protein and functions to transport iron. It is an essential constituent in culture media for virtually all cells. In a recent study, we reported that transferrin (Tf) is specifically located in oligodendrocytes in the rat nervous system. This investigation examines immuno...

journal_title：Journal of neuroscience research

authors： Connor JR,Fine RE

更新日期：1987-01-01 00:00:00

abstract：:We investigated the role of kainate (KA) receptor activation and desensitization in inducing the increase in the intracellular free Ca(2+) concentration ([Ca(2+)](i)) in individual cultured rat hippocampal neurons. The rat hippocampal neurons in the cultures were shown to express kainate receptor subunits, KA2 and Glu...

journal_title：Journal of neuroscience research

authors： Silva AP,Malva JO,Ambrósio AF,Salgado AJ,Carvalho AP,Carvalho CM

更新日期：2001-09-01 00:00:00

abstract：:Perceptually similar stimuli, despite not being consciously distinguishable, may result in distinct cortical brain activations. Hypothesizing that perceptually similar tastes are discriminable by electroencephalography (EEG), we recorded 22 human participants' response to equally intense sweet-tasting stimuli: caloric...

journal_title：Journal of neuroscience research

authors： Andersen CA,Kring ML,Andersen RH,Larsen ON,Kjaer TW,Kidmose U,Møller S,Kidmose P

更新日期：2019-03-01 00:00:00

abstract：:To study the influence of cell surface-associated molecules on intercellular communication, C6 glioma cells were cultured both on plastic and on substrata of paraformaldehyde-fixed B104 neuroblastoma cells. By then comparing the phenotypic expression of these "cocultured" C6 cells with cells cultured on tissue culture...

journal_title：Journal of neuroscience research

authors： Ciment G,de Vellis J

更新日期：1982-01-01 00:00:00

abstract：:Ca(2+) and synaptotagmin (a Ca(2+)-binding protein that regulates axolemmal fusion of synaptic vesicles) play essential roles in the repair of axolemmal damage in invertebrate giant axons. We now report that neurites of a rat pheochromocytoma (PC12) cell line transected and maintained in a serum medium form a dye barr...

journal_title：Journal of neuroscience research

authors： Detrait ER,Yoo S,Eddleman CS,Fukuda M,Bittner GD,Fishman HM

更新日期：2000-11-15 00:00:00

abstract：:The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway rema...

journal_title：Journal of neuroscience research

authors： Chinopoulos C

更新日期：2013-08-01 00:00:00

abstract：:Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H NMR experiments, originate undesired resonances i...

journal_title：Journal of neuroscience research

authors： Lei H,Duarte JM,Mlynarik V,Python A,Gruetter R

更新日期：2010-02-01 00:00:00

abstract：:Recent advances in human induced pluripotent stem cells (hiPSCs) offer new possibilities for biomedical research and clinical applications. Differentiated neurons from hiPSCs are expected to be useful for developing novel methods of treatment for various neurological diseases. However, the detailed process of function...

journal_title：Journal of neuroscience research

authors： Ohara Y,Koganezawa N,Yamazaki H,Roppongi RT,Sato K,Sekino Y,Shirao T

更新日期：2015-12-01 00:00:00

abstract：:In this study, we examined the neuroprotective effect of standardized Bacopa monniera extract (BME: BESEB CDRI-08) against the D-galactose (D-gal)-induced brain aging in rats. Experimental groups were subjected to contextual-associative learning task. We found that the administration of BME in the D-gal-treated group ...

journal_title：Journal of neuroscience research

authors： Prisila Dulcy C,Singh HK,Preethi J,Rajan KE

更新日期：2012-10-01 00:00:00

abstract：:Fast oscillations at approximately 200 Hz, termed ripples, occur in the hippocampus and cortex of several species, including humans, and are thought to play a role in physiological (e.g., sensory information processing or memory consolidation) and pathological (e.g., seizures) processes. Blocking gamma-aminobutyric ac...

journal_title：Journal of neuroscience research

authors： D'Antuono M,de Guzman P,Kano T,Avoli M

更新日期：2005-04-01 00:00:00

abstract：:In eukaryotes, mitochondria are critical for cellular bioenergetics and mediating apoptosis. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. However, the role of PGC-1alpha in neuronal a...

journal_title：Journal of neuroscience research

authors： Liang J,Yang Y,Zhu X,Wang X,Chen R

更新日期：2010-07-01 00:00:00

abstract：:Astrocytes are the most abundant glial cell in the central nervous system. They modulate synaptic function through a variety of mechanisms, and yet remain relatively understudied with respect to overall neuronal circuit function. Exploiting the tractability of the mouse olfactory system, we manipulated astrocyte activ...

journal_title：Journal of neuroscience research

authors： Ung K,Tepe B,Pekarek B,Arenkiel BR,Deneen B

更新日期：2020-08-01 00:00:00

abstract：:Multiple neurodegenerative disorders are associated with altered mitochondrial bioenergetics. Although mitochondrial O(2) consumption is frequently measured in isolated mitochondria, isolated synaptic nerve terminals (synaptosomes), or cultured cells, the absence of mature brain circuitry is a remaining limitation. He...

journal_title：Journal of neuroscience research

authors： Schuh RA,Clerc P,Hwang H,Mehrabian Z,Bittman K,Chen H,Polster BM

更新日期：2011-12-01 00:00:00

abstract：:Microtubule-associated protein (MAP)1B-heterozygous (MAP1B+/-) mice are deficient in the expression of MAP1B in the hippocampus, cerebellum, and olfactory cortex. Although MAP1B+/- mice showed half the normal levels of MAP1B protein, they had no measurable amounts of phosphorylated MAP1B. High-frequency theta burst st...

journal_title：Journal of neuroscience research

authors： Zervas M,Opitz T,Edelmann W,Wainer B,Kucherlapati R,Stanton PK

更新日期：2005-10-01 00:00:00

abstract：:The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. Here, the effects of BASP1 overexpression were investigated in PC12E2 cells and pr...

journal_title：Journal of neuroscience research

authors： Korshunova I,Caroni P,Kolkova K,Berezin V,Bock E,Walmod PS

更新日期：2008-08-01 00:00:00

abstract：:We studied the effects of electrical stimulation of the inferior alveolar nerve (IAN) on cardiovascular responses in cats. There was statistical correlation between cardiovascular response and prestimulus mean arterial blood pressure (MABP) and heart rate (HR). A trigeminal depressor response (TDR) was induced when th...

journal_title：Journal of neuroscience research

authors： Ohshita N,Nakajo N,Takemura M

更新日期：2004-06-15 00:00:00

abstract：:Using morphological, immunocytochemical, and functional parameters we have previously shown that highly purified adult rat microglial cells undergo a process of "activation" when cultured in a serum-containing medium in the absence of added proinflammatory substances or other factors (Slepko and Levi: Glia 16:241-246,...

journal_title：Journal of neuroscience research

authors： Slepko N,Minghetti L,Polazzi E,Nicolini A,Levi G

更新日期：1997-08-01 00:00:00

abstract：:Larval acetylcholinesterase (acetylcholine acetylhydrolase) EC 3.1.3.7 of the trematode Schistosoma mansoni was characterized and purified by affinity chromatography. The enzyme was solubilized from sonicated cercarial tissue and showed a Km value of 1.83 mM and a Vmax value of 102 U/mg protein. It was characterized a...

journal_title：Journal of neuroscience research

authors： Goldlust A,Arnon R,Silman I,Tarrab-Hazdai R

更新日期：1986-01-01 00:00:00

abstract：:Although reactive oxygen species (ROS) have been implicated in ischemic preconditioning (IPC)-induced neuronal protection, several key questions concerning ROS remain to be elucidated. The purpose of this study is to obtain direct evidence for the formation of specific ROS species generated by IPC, and to determine th...

journal_title：Journal of neuroscience research

authors： Furuichi T,Liu W,Shi H,Miyake M,Liu KJ

更新日期：2005-03-15 00:00:00

abstract：:Structure and dimension of the dendritic arbor are important determinants of information processing by the nerve cell, but mechanisms and molecules involved in dendritic growth are essentially unknown. We investigated early mechanisms of dendritic growth using mouse fetal hippocampal neurons in primary culture, which ...

journal_title：Journal of neuroscience research

authors： Grosse G,Grosse J,Tapp R,Kuchinke J,Gorsleben M,Fetter I,Höhne-Zell B,Gratzl M,Bergmann M

更新日期：1999-06-01 00:00:00

abstract：:Preterm birth results in significant cognitive and motor disabilities, but recent evidence suggests that there is variable recovery over time. One possibility that may explain this variable recovery entails variable neurogenic responses in the subventricular zone (SVZ) following the period of chronic hypoxia experienc...

journal_title：Journal of neuroscience research

authors： Li Q,Michaud M,Stewart W,Schwartz M,Madri JA

更新日期：2008-05-01 00:00:00

abstract：:Oligodendrocytes have a high rate of synthetic activity and produce vast amounts of myelin. The membrane production requires specific sorting and transport processes and structural support. In culture, oligodendrocytes extend flat membranous sheets containing an extensive cytoskeletal network of microtubules (MTs) and...

journal_title：Journal of neuroscience research

authors： Richter-Landsberg C

更新日期：2000-01-01 00:00:00