Standardized extract of Bacopa monniera (BESEB CDRI-08) attenuates contextual associative learning deficits in the aging rat's brain induced by D-galactose.

abstract：:Ex vivo gene therapy is emerging as a promising approach for the treatment of neurodegenerative diseases and central nervous system (CNS) trauma. We have shown previously that human adult astrocytes can be expanded in vitro and can express various therapeutic transgenes (Ridet et al. [1999] Hum. Gene Ther. 10:271-280;...

journal_title：Journal of neuroscience research

authors： Ridet JL,Sarkis C,Serguera C,Zennou V,Charneau P,Mallet J

更新日期：2003-06-15 00:00:00

abstract：:The role of intracellular proteases (e.g., calpains and caspases) in the pathophysiology of neuronal cell death has been extensively investigated. More recently, accumulating data have suggested that extracellular proteolysis also plays a critical role. The two major systems that modify the extracellular matrix in bra...

journal_title：Journal of neuroscience research

authors： Lo EH,Wang X,Cuzner ML

更新日期：2002-07-01 00:00:00

abstract：:Astrocytomas are the most common brain tumors arising in the CNS and account for 65% of all primary brain tumors. Astrocytes have been shown to have the highest predisposition to malignant transformation compared to any other CNS cell type. The majority of astrocytomas are histologically malignant neoplasm. Previous s...

journal_title：Journal of neuroscience research

authors： Lal PG,Ghirnikar RS,Eng LF

更新日期：1996-05-01 00:00:00

abstract：:Among the ion channels and pumps activated by growth factor stimulation, K+ channels have been implicated in the growth and proliferation of several cancer cell lines. The role of these channels in central nervous system tumors, however, has not been described. This study used the malignant astrocytoma cell lines U87 ...

journal_title：Journal of neuroscience research

authors： Chin LS,Park CC,Zitnay KM,Sinha M,DiPatri AJ Jr,Perillán P,Simard JM

更新日期：1997-04-15 00:00:00

abstract：:A coordinated up-regulation in the expression of all three neurofilament (NF) proteins occurs during postnatal development in the rat (Schlaepfer and Bruce, J Neurosci Res [in press], 1990a). In the present study, sciatic nerves were transected in neonatal rats in order to determine the effects of axotomy on the postn...

journal_title：Journal of neuroscience research

authors： Schwartz ML,Shneidman PS,Bruce J,Schlaepfer WW

更新日期：1990-10-01 00:00:00

abstract：:The inward-rectifier K(+) channel Kir4.1 is responsible for maintaining cochlear homeostasis and restoring neural excitability. The large-conductance calcium-activated K(+) channel (BK(Ca)) plays a key role in phase locking signals in the mammalian inner ear. To evaluate the influence of mitochondrial dysfunction on t...

journal_title：Journal of neuroscience research

authors： Zou J,Zhang Y,Yin S,Wu H,Pyykkö I

更新日期：2009-01-01 00:00:00

abstract：:Neuropathic pain is a debilitating chronic pain and represents a major clinical challenge. The molecular and cellular mechanisms underlying its development and maintenance are not fully understood but involve abnormal excitability in the dorsal horn of the spinal cord. A growing body of evidence has shown that this ab...

journal_title：Journal of neuroscience research

authors： Tsuda M

更新日期：2017-06-01 00:00:00

abstract：:Finding inhibitors of the first step of the amyloid cascade, A beta (42) generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, beta-and gamma-secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes were not identified. U...

journal_title：Journal of neuroscience research

authors： Citron M

更新日期：2002-11-01 00:00:00

abstract：:Microglia are prominently involved in neural degenerative diseases of the CNS and the retina. In this study, we determined the activation and phagocytotic function of different subtypes of retinal microglial cells at 1 week and 1 month following optic axotomy. Fluorescent DiI crystals were placed at the stumps of the ...

journal_title：Journal of neuroscience research

authors： Zhang C,Tso MO

更新日期：2003-09-15 00:00:00

abstract：:Neuronal degeneration has been shown to be involved in various neurological disorders. Growth/trophic factors and their receptors are known to be important for the regeneration and survival of neurons. We report here the molecular cloning of a receptor-like protein tyrosine kinase, bsk, (for brain specific kinase). Bs...

journal_title：Journal of neuroscience research

authors： Zhou R,Copeland TD,Kromer LF,Schulz NT

更新日期：1994-01-01 00:00:00

abstract：:A number of cytokines and growth factors may affect astrocyte proliferation and functions. Transforming growth factor-beta 1 (TGF-beta 1) is a pleiotropic cytokine which exerts multiple effects on growth and differentiation of different cell types. TGF-beta 1 is present in low amounts in the normal brain. TGF-beta 1 g...

journal_title：Journal of neuroscience research

authors： Vergeli M,mazzanti B,Ballerini C,Gran B,Amaducci L,Massacesi L

更新日期：1995-01-01 00:00:00

abstract：:Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...

journal_title：Journal of neuroscience research

authors： Barajas M,Andrade A,Hernandez-Hernandez O,Felix R,Arias-Montaño JA

更新日期：2008-11-15 00:00:00

abstract：:Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Glioma cells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be i...

journal_title：Journal of neuroscience research

authors： Widmer M,Hanemann CO,Zajicek J

更新日期：2008-11-01 00:00:00

abstract：:Cell transplantation offers a potential new treatment for stroke. Animal studies using models that produce ischemic damage in both the striatum and the frontal cortex have shown beneficial effects when hNT cells (postmitotic immature neurons) were transplanted into the ischemic striatum. In this study, we investigated...

journal_title：Journal of neuroscience research

authors： Bliss TM,Kelly S,Shah AK,Foo WC,Kohli P,Stokes C,Sun GH,Ma M,Masel J,Kleppner SR,Schallert T,Palmer T,Steinberg GK

更新日期：2006-05-01 00:00:00

abstract：:The 14-3-3 proteins exist predominantly in the brain and may play regulatory roles in cellular processes of growth, differentiation, survival, and apoptosis. The biological functions, however, of the various 14-3-3 isoforms (beta, epsilon, eta, gamma, and zeta) in the brain remain unclear. We have reported previously ...

journal_title：Journal of neuroscience research

authors： Chen XQ,Liu S,Qin LY,Wang CR,Fung YW,Yu AC

更新日期：2005-01-01 00:00:00

abstract：:Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the...

journal_title：Journal of neuroscience research

authors： Garcia-Rill E

更新日期：2019-12-01 00:00:00

abstract：:The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-1 beta, induce an intense fever in the rat when they are injected directly into the anterior hypothalamic, pre-optic area (AH/POA), a region containing thermosensitive neurons. The purpose of this study was to compare the central action on b...

journal_title：Journal of neuroscience research

authors： Myers RD,Lopez-Valpuesta FJ,Miñano FJ,Wooten MH,Barwick VS,Wolpe SD

更新日期：1994-09-01 00:00:00

abstract：:Although proteins belonging to the sHSP superfamily are diverse in sequence and size, most share characteristic features, including 1) a small molecular mass of 12-43 kDa, 2) a conserved alpha-crystallin domain of 80-100 residues, 3) formation of large oligomers, 4) a dynamic quaternary structure, and 5) induction by ...

journal_title：Journal of neuroscience research

authors： Hu Z,Yang B,Lu W,Zhou W,Zeng L,Li T,Wang X

更新日期：2008-08-01 00:00:00

abstract：:The Shaw subfamily of potassium channel genes, including Kv3.1, are highly expressed within the auditory nuclei of the brainstem, where they have been implicated in the characteristic response properties of particular types of neurons. Potassium currents carried by Kv3.1 are voltage-dependent, have a high activation t...

journal_title：Journal of neuroscience research

authors： Hendriks R,Morest DK,Kaczmarek LK

更新日期：1999-12-15 00:00:00

abstract：:Previously, we showed that in rat cortical neurons, chronic donepezil treatment (10 microM, 4 days) up-regulates nicotinic receptors (nAChR) and makes neurons more sensitive to the neuroprotective effect of donepezil. Here we examined the mechanism of donepezil-induced neuroprotection in neurons chronically treated wi...

journal_title：Journal of neuroscience research

authors： Takada-Takatori Y,Kume T,Ohgi Y,Izumi Y,Niidome T,Fujii T,Sugimoto H,Akaike A

更新日期：2008-12-01 00:00:00

abstract：:Apolipoprotein E (ApoE) is the major brain lipoprotein and plays an important role in lipid transport. ApoE-deficient mice whose apoE gene has been knocked out have distinct cognitive and neurochemical deficits, and their recovery from brain injury is impaired. In the present study we examined the possibility that the...

journal_title：Journal of neuroscience research

authors： Lomnitski L,Oron L,Sklan D,Michaelson DM

更新日期：1999-11-15 00:00:00

abstract：:Increasing evidence has shown that β-amyloid (Aβ) induces hyperphosphorylation of tau and contributes to Aβ toxicity. Recently, tau hyperphosphorylation by glycogen synthase kinase-3β (GSK-3β) activation has been emphasized as one of the pathogenic mechanisms of Alzheimer's disease (AD). The phosphoinositide 3 kinase ...

journal_title：Journal of neuroscience research

authors： Zhang Z,Zhao R,Qi J,Wen S,Tang Y,Wang D

更新日期：2011-03-01 00:00:00

abstract：:The effects of exogenous GM1 and GD1a on S20Y murine neuroblastoma cells were assessed by monitoring morphology, tumorigenicity, mitotic index, and plating efficiency. S20Y cells were seeded at a density equivalent to 5 X 10(4) cells per 35-mm tissue culture dish; 38-42 hr after seeding (preconfluent stage) the cells ...

journal_title：Journal of neuroscience research

authors： Carine K,Schengrund CL

更新日期：1984-01-01 00:00:00

abstract：:Recent studies have indicated that embryonic stem cells (ESCs) can be a source for the replacement of spiral ganglion neurons (SGNs), auditory primary neurons, and neurite projections from ESC-derived neurons to auditory sensory epithelia. However, the potential of ESC-derived neurons for synapse formation with audito...

journal_title：Journal of neuroscience research

authors： Matsumoto M,Nakagawa T,Kojima K,Sakamoto T,Fujiyama F,Ito J

更新日期：2008-11-01 00:00:00

abstract：:Iron deficiency and chronic mild carbon monoxide (CO) exposure are nutritional and environmental problems that can be experienced simultaneously. We examined the effects of chronic mild CO exposure and iron availability on auditory development in the rat. We propose that chronic mild CO exposure creates an oxidative s...

journal_title：Journal of neuroscience research

authors： Webber DS,Lopez I,Korsak RA,Hirota S,Acuna D,Edmond J

更新日期：2005-06-01 00:00:00

abstract：:Acute intoxication with large ammonia doses leads to activation of NMDA receptors in the brain, resulting in oxidative stress and disturbance of mitochondrial function. Altered mitochondrial function is a crucial step in some mechanisms of cellular apoptosis. This study assesses whether ammonia intoxication in vivo le...

journal_title：Journal of neuroscience research

authors： Kosenko E,Kaminsky Y,Solomadin I,Marov N,Venediktova N,Felipo V,Montoliu C

更新日期：2007-08-15 00:00:00

abstract：:Traumatic injury to the adult central nervous system (CNS) results in a rapid response from resident astrocytes, a process often referred to as reactive astrogliosis or glial scarring. The robust formation of the glial scar and its associated extracellular matrix (ECM) molecules have been suggested to interfere with a...

journal_title：Journal of neuroscience research

authors： McGraw J,Hiebert GW,Steeves JD

更新日期：2001-01-15 00:00:00

abstract：:Localization of acetylcholine receptors (AChRs) to the postsynaptic region of muscle is mediated in part by transcriptional mechanisms, because the genes encoding AChR subunits are transcribed selectively in synaptic myofiber nuclei. Neuregulin-1 (NRG-1) is a synaptic signal and induces transcription of AChRs in muscl...

journal_title：Journal of neuroscience research

authors： Herndon CA,Fromm L

更新日期：2008-04-01 00:00:00

abstract：:The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA bindi...

journal_title：Journal of neuroscience research

authors： Zang J,Lu D,Xu A

更新日期：2020-01-01 00:00:00

abstract：:The existence of endogenous neural progenitor cells (NPCs) in the adult spinal cord (sc) provides the potential for tailored repair therapies after spinal cord injury (SCI). This study investigates the impact of inflammatory mediators on properties of NPC cultures derived from adult rats after SCI. The Infinite Horizo...

journal_title：Journal of neuroscience research

authors： Knerlich-Lukoschus F,Krossa S,Krause J,Mehdorn HM,Scheidig A,Held-Feindt J

更新日期：2015-04-01 00:00:00