Abstract:
:The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA binding proteins (RBPs). RBPs are a broad class of proteins involved in gene transcription and translation, and interaction with RBPs is considered an important part of circRNA function, which can serve as an essential element underlying the functions of circRNAs, including genesis, translation, transcriptional regulation of target genes, and extracellular transport. In this mini-review, we attempt to explore in detail the relationship between circRNAs and RBPs, and the interactions between the two factors. The goal of this review is to investigate the emerging studies of RBPs and circRNAs to better understand how their interaction alters cellular function.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Zang J,Lu D,Xu Adoi
10.1002/jnr.24356subject
Has Abstractpub_date
2020-01-01 00:00:00pages
87-97issue
1eissn
0360-4012issn
1097-4547journal_volume
98pub_type
杂志文章,评审abstract::Seventeen white patients from the Stanford Sleep Disorders Clinic complaining of excessive daytime somnolence (EDS) were selected for restriction-fragment-length polymorphism (RFLP) studies. Fourteen of the patients with clinically diagnosed narcolepsy were seropositive for DR2. RFLP analysis of these patients compare...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180134
更新日期:1987-01-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960601)44:5<490::AID-JNR
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22803
更新日期:2012-04-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2004-11-15 00:00:00
abstract::Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration of leptin, at 10 days after stroke onset, on neurogenesis and angiogenesis after stroke....
journal_title:Journal of neuroscience research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960715)45:2<129::AID-JNR
更新日期:1996-07-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270115
更新日期:1990-09-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990601)56:5<539::AID-JNR
更新日期:1999-06-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1217
更新日期:2001-10-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22104
更新日期:2009-09-01 00:00:00
abstract::In contrast to its known anti-apoptotic activity in sympathetic neurons, immortal neuronal cell lines, and primary cultured immature neurons of the central nervous system (CNS), the role of Bcl-2 in CNS neurons in the adult brain is poorly understood. In the present study, we examined effects of overexpression of Bcl-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990701)57:1<1::AID-JNR1>
更新日期:1999-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10571
更新日期:2003-04-15 00:00:00
abstract::Rho-GTPase has been implicated in the apoptosis of many cell types, including neurons, but the mechanism by which it acts is not fully understood. Here, we investigate the roles of Rho and ROCK in apoptosis during transplantation of embryonic stem cell-derived neural precursor cells. We find that dissociation of neura...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21502
更新日期:2008-02-01 00:00:00
abstract::Preterm birth results in significant cognitive and motor disabilities, but recent evidence suggests that there is variable recovery over time. One possibility that may explain this variable recovery entails variable neurogenic responses in the subventricular zone (SVZ) following the period of chronic hypoxia experienc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21597
更新日期:2008-05-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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更新日期:2020-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960301)43:5<554::AID-JNR
更新日期:1996-03-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/1097-4547(20001201)62:5<623::AID-JNR1>3.0.
更新日期:2000-12-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20613
更新日期:2005-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21902
更新日期:2009-03-01 00:00:00
abstract::The companion study showed that acoustic overstimulation of adult chinchillas, with a noise level sufficient to damage the cochlea, led to cytological changes and degeneration of synaptic endings in the cochlear nucleus within 1-16 weeks. In the present study, the same stimulus was used to study the long-term effects ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20212
更新日期:2004-09-15 00:00:00
abstract::The Shaw subfamily of potassium channel genes, including Kv3.1, are highly expressed within the auditory nuclei of the brainstem, where they have been implicated in the characteristic response properties of particular types of neurons. Potassium currents carried by Kv3.1 are voltage-dependent, have a high activation t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(sici)1097-4547(19991215)58:6<791::aid-jnr
更新日期:1999-12-15 00:00:00
abstract::We have studied the effect of induced glial fibrillary acidic protein (GFAP) on motility, cell morphology, and proliferation of two originally GFAP-negative human glioma cell lines. Glioma cell lines U-1242 MG and U-251 MG sp subclone 3A were transfected with a vector system that allows for an inducible GFAP expressio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000415)60:2<245::AID-JNR
更新日期:2000-04-15 00:00:00
abstract::Heat shock proteins (HSPs) are stress-responsive proteins that serve as important molecules contributing to cellular "protein triage." We and others have reported an increase of selected HSPs in multiple sclerosis (MS) lesions. However, the exact expression pattern of HSP family genes in MS is not known. The aim of ou...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23480
更新日期:2015-03-01 00:00:00
abstract::Alpha2-adrenergic receptors control norepinephrine (NE) release and tumor necrosis factor-alpha (TNF) production from neurons. TNF regulates NE release, depending on alpha2-adrenergic receptor functioning. The relationship between TNF production in the brain and alpha2-adrenergic receptor activation could have profoun...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20407
更新日期:2005-03-15 00:00:00
abstract::Cell death in outer hair cells of the mammalian inner ear induced by aminoglycoside antibiotics is mediated by reactive oxygen species (ROS) and can be prevented by antioxidants. The current study investigates the role of the nuclear factor (NF)-kappaB pathway in cell death or survival in adult CBA mice. Kanamycin (70...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20392
更新日期:2005-03-01 00:00:00