Abstract:
:Seventeen white patients from the Stanford Sleep Disorders Clinic complaining of excessive daytime somnolence (EDS) were selected for restriction-fragment-length polymorphism (RFLP) studies. Fourteen of the patients with clinically diagnosed narcolepsy were seropositive for DR2. RFLP analysis of these patients compared with a homozygous DR2-Dw2 cell line failed to reveal any polymorphism when digested with six restriction endonucleases and hybridized with three different cDNA probes. None of the three patients with central nervous system hypersomnia, a syndrome similar to narcolepsy, were DR2-positive. We conclude that any polymorphism of the DR beta, DQ alpha, or DQ beta genes of DR2 narcoleptics that might distinguish them from DR2 normals cannot be resolved through RFLP analysis.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Holloman JD,Bell JI,Kilduff TS,Dement WC,Guilleminault C,McDevitt HOdoi
10.1002/jnr.490180134subject
Has Abstractpub_date
1987-01-01 00:00:00pages
239-44issue
1eissn
0360-4012issn
1097-4547journal_volume
18pub_type
杂志文章abstract::Direct brain injections of the N-methyl-D-aspartate receptor agonist quinolinic acid (QA) trigger an excitotoxic cascade characterized by rapid neuronal death and glial/immune cell activation. The present study compared the timing of immediate early gene (IEG; c-fos, c-jun, jun-B, and zif/268) induction with the respo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360511
更新日期:1993-12-01 00:00:00
abstract::The close homologue of L1 (CHL1) is a member of the L1 family of cell recognition molecules. The protein is expressed by a variety of nerve cell types and subpopulations of glial cells in vivo and promotes elongation of neurites and survival of nerve cells in vitro. Here we demonstrate that glial cells up-regulate exp...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10533
更新日期:2003-03-15 00:00:00
abstract::Monoclonal antibody J1-31 (MAb J1-31, isotype IgG 2b) was raised against crude homogenate of brain tissue from a multiple sclerosis (MS) patient (autopsy sample; Malhotra et al.: Microbios Letters 26:151-157, 1984). In human brain, MAb J1-31 recognizes an intracellular protein antigen (J1-31 antigen), which bands at a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220106
更新日期:1989-01-01 00:00:00
abstract::We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. The study has now been extended to examine the processes that underlie this transcriptional stimulation an...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320219
更新日期:1992-06-01 00:00:00
abstract::Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be a critical step leading to axonal degeneration. Kinesin and microtubules (MT) were evaluated as molecular sites of action using...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19961001)46:1<7::AID-JNR2>
更新日期:1996-10-01 00:00:00
abstract::Recent advances in human induced pluripotent stem cells (hiPSCs) offer new possibilities for biomedical research and clinical applications. Differentiated neurons from hiPSCs are expected to be useful for developing novel methods of treatment for various neurological diseases. However, the detailed process of function...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23666
更新日期:2015-12-01 00:00:00
abstract::We have studied the effect of induced glial fibrillary acidic protein (GFAP) on motility, cell morphology, and proliferation of two originally GFAP-negative human glioma cell lines. Glioma cell lines U-1242 MG and U-251 MG sp subclone 3A were transfected with a vector system that allows for an inducible GFAP expressio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000415)60:2<245::AID-JNR
更新日期:2000-04-15 00:00:00
abstract::The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cell...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20090
更新日期:2004-06-15 00:00:00
abstract::HEPES inhibited the taurine uptake in glial cells. A different kind of inhibition was observed when HEPES was present in the culture medium or in the incubation medium used for the taurine-uptake measurement. As an example of a possible interference of HEPES in pharmacological experiments, we have studied the effect o...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490230111
更新日期:1989-05-01 00:00:00
abstract::Although upregulation of ryanodine receptor (RyR)-1 and -2 is mediated through the activation of dopamine D1 receptors (D1DRs) in the development of psychostimulant-induced place preference, little is known about how such increased expressions of RyRs are negatively regulated. This study investigated negative regulato...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23058
更新日期:2012-08-01 00:00:00
abstract::Chronic lead exposure during development is known to produce learning deficits. In the present study, we investigated the effects of developmental exposure to lead on spatial memory, as shown in the Morris water maze, and on expression of inducible cyclooxygenase-2 protein in the hippocampi of male rats. Rats were sep...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21423
更新日期:2007-11-01 00:00:00
abstract::The recent recognition that the p75 neurotrophin receptor, p75((NTR)), can induce apoptotic signals has contributed to the perception that it acts primarily as a death receptor. Although the molecular mechanisms of p75(NTR) signaling remain to be fully characterized, many of the currently identified pathways activated...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/1097-4547(20000801)61:3<237::AID-JNR1>3.0.
更新日期:2000-08-01 00:00:00
abstract::Hippocalcin is a Ca2+-binding protein that is expressed mainly in pyramidal nerve cells of the hippocampus. However, its functions and mechanism in the brain remain unclear. To elucidate the role of hippocalcin, we used a conditionally immortalized hippocampal cell line (H19-7) and showed that bFGF treatment increased...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21602
更新日期:2008-05-15 00:00:00
abstract::The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1084
更新日期:2001-05-15 00:00:00
abstract::This essay discusses the directional movements of metazoan tissue cells generally, with special emphasis on neurons, in an attempt to show that the directional movements of all share fundamental similarities. ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490130102
更新日期:1985-01-01 00:00:00
abstract::Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330305
更新日期:1992-11-01 00:00:00
abstract::Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and receptors have been studied in these areas, but amino acid transmitters, e.g....
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21225
更新日期:2007-05-01 00:00:00
abstract::Previously, we have demonstrated a novel interaction between Galpha(o) protein and Purkinje cell protein-2 (Pcp2, also known as L7) in vitro and in transfected cells (Luo and Denker [1999] J. Biol. Chem. 274:10685-10688). Pcp2 is uniquely expressed in cerebellar Purkinje cells and in retinal bipolar neurons, and it ma...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10460
更新日期:2002-12-01 00:00:00
abstract::Recent studies suggest that heterotypic cell-cell interactions influence gliogenesis in the developing rat central nervous system. CNS neuron-derived factors have been hypothesized to exist, and several have been identified and partially characterized which affect the number of oligodendrocytes in vitro. In order to s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200303
更新日期:1988-07-01 00:00:00
abstract::The C57BL/6 mice strain is known to be reputedly resistant to induction of experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome in human by bovine peripheral myelin (BPM), and P2 protein or the P2 protein peptide 57-81. The P0 peptide 180-199 is a stronger neuritogenic antigen than the P2...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20001201)62:5<717::AID-JNR11>3.0
更新日期:2000-12-01 00:00:00
abstract::A series of AMPA [(R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid] analogues were evaluated for activity at homomeric, heteromeric, and chimeric rat GluR1(o) and GluR3(o) receptors expressed in Xenopus oocytes, using the two-electrode voltage clamp technique. The formation of heteromeric receptor compl...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(sici)1097-4547(19970715)49:2<176::aid-jnr
更新日期:1997-07-15 00:00:00
abstract::We have previously shown in rat primary cultured mesencephalic cells that cyanide induces a high level of oxidative stress and necrotic death. To evaluate the mechanism of the cytotoxicity, the effects of cyanide on intracellular glutathione (GSH) pools and inducible nitric oxide synthase (iNOS)-mediated reactive nitr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20998
更新日期:2006-10-01 00:00:00
abstract::Quercetin, a strong free radical scavenger, is investigated for neuroprotective effects in a Neuro 2a cell line conditionally transfected with 16Q huntingtin (Htt) and 150Q Htt, which express the protein upon stimulation. Cells were protected from death by a 20-µM dose of quercetin on the second day of Htt induction, ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23618
更新日期:2015-10-01 00:00:00
abstract::The remarkable quantities of myelin membrane produced by oligodendrocytes has led us to examine the mechanisms involved in the sorting and transport of proteins and lipids during myelinogenesis. Noting that it has been proposed that proteins destined for the apical surface of polarized epithelial cells co-cluster with...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420316
更新日期:1995-10-15 00:00:00
abstract::The two inbred strains of mice C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) mice have been shown to differ significantly in their preference for alcohol (EtOH). We have previously demonstrated the differences in the density and the affinity of cannabinoid (CB1) receptors in the brains of the two inbred C5...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1094
更新日期:2001-05-15 00:00:00
abstract::The effect of neonatal hyperthyroidism produced by injection of tri-iodothyronine (T3) on myelination and on the microperoxisomal population of the brain was studied in young rats. Data on the lipid composition of myelin show that myelinogenesis starts earlier in treated animals. In coincidence with the early appearan...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250312
更新日期:1990-03-01 00:00:00
abstract::Corticosteroids, released from the adrenal gland in response to stress, bind to receptors that act as transcription factors to alter gene expression and, subsequently, protein synthesis. Using [(35)S]-methionine-cysteine incorporation to measure protein synthesis in hippocampal slices incubated under ischemic conditio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1159
更新日期:2001-08-15 00:00:00
abstract::The Brn-3a transcription factor is critical for survival and differentiation of sensory neurons derived from neural crest cells (NCC). Interaction of Brn-3a with p53 results in differential effects on target gene expression, which profoundly affects fate of neuronal cells. Here we demonstrate colocalization of p53 in ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20299
更新日期:2004-12-15 00:00:00
abstract::Myelin-associated glycoprotein (MAG) is expressed on the innermost myelin membrane wrap, directly apposed to the axon surface. Although it is not required for myelination, MAG enhances long-term axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. In addition to its role in ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21992
更新日期:2009-11-15 00:00:00
abstract::GM1, GD1a, and GT1b inhibit both PDGF-stimulated and serum-stimulated DNA synthesis in Swiss 3T3 cells and the human glioma cell line U-1242 MG in a dose-dependent manner. The ganglioside inhibitory effect is counteracted in a dose-responsive fashion by serum such that ganglioside-induced inhibition is essentially abo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410408
更新日期:1995-07-01 00:00:00