Abstract:
:The recent recognition that the p75 neurotrophin receptor, p75((NTR)), can induce apoptotic signals has contributed to the perception that it acts primarily as a death receptor. Although the molecular mechanisms of p75(NTR) signaling remain to be fully characterized, many of the currently identified pathways activated by p75(NTR) may be generally characterized as stress response signals. This review describes recent advances in identifying the molecular components involved in p75(NTR) signal transduction and suggests that p75(NTR) signaling may more aptly serve as a general mechanism for the transduction and modulation of stress signals.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Dobrowsky RT,Carter BDdoi
10.1002/1097-4547(20000801)61:3<237::AID-JNR1>3.0.keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
237-43issue
3eissn
0360-4012issn
1097-4547pii
10.1002/1097-4547(20000801)61:3<237::AID-JNR1>3.0.journal_volume
61pub_type
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abstract::HEPES inhibited the taurine uptake in glial cells. A different kind of inhibition was observed when HEPES was present in the culture medium or in the incubation medium used for the taurine-uptake measurement. As an example of a possible interference of HEPES in pharmacological experiments, we have studied the effect o...
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