Cloning and characterization of MVP17: a developmentally regulated myelin protein in oligodendrocytes.


:The remarkable quantities of myelin membrane produced by oligodendrocytes has led us to examine the mechanisms involved in the sorting and transport of proteins and lipids during myelinogenesis. Noting that it has been proposed that proteins destined for the apical surface of polarized epithelial cells co-cluster with glycolipid-rich microdomains during sorting and transport from the trans-Golgi network (Simons and van Meer: Biochemistry 27:6197-6202, 1988; Simons and Wandinger-Ness: Cell 62:207-210, 1990), we hypothesized that the glycolipid-rich oligodendrocytes may adopt this mechanism for myelinogenesis. Protein-lipid complexes from oligodendrocytes and myelin were isolated utilizing detergent insolubility and two-dimensional gel electrophoresis. A developmentally regulated protein, MVP17 (myelin vesicular protein of 17 kDa), was identified. Microsequencing of the N-terminal peptide revealed a high homology to human T-cell MAL protein (Alonso and Weissman: Proc Natl Acad Sci USA 84:1997-2001, 1987). The corresponding MVP17 cDNA was isolated from an oligodendrocyte cDNA library. The predicted protein sequence showed 88.9% identity with MAL, and the hydrophobicity profile suggested four transmembrane domains. In vitro translation demonstrated a signal at the deduced Mr of approximately 17 kDa. Northern analyses indicated that MVP17 mRNA expression is restricted to brain and kidney and that this expression is up-regulated in oligodendrocytes and brain during the period of active myelination. These data suggest that MVP17 is involved in myelin biogenesis and/or myelin function.


J Neurosci Res


Kim T,Fiedler K,Madison DL,Krueger WH,Pfeiffer SE




Has Abstract


1995-10-15 00:00:00












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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Aguirre A,López-Bayghen E,Ortega A

    更新日期:2002-10-01 00:00:00

  • Effects of alcohol on brain-derived neurotrophic factor mRNA expression in discrete regions of the rat hippocampus and hypothalamus.

    abstract::Chronic alcohol consumption has adverse effects on the central nervous system, affecting some hippocampal and hypothalamic functions. In this study we tempted to demonstrate that some of these modifications could involve impairment of neurotrophic factors. Three experimental groups of male Sprague Dawley rats were stu...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Tapia-Arancibia L,Rage F,Givalois L,Dingeon P,Arancibia S,Beaugé F

    更新日期:2001-01-15 00:00:00

  • Isatin binding proteins in rat brain: in situ imaging, quantitative characterization of specific [3H]isatin binding, and proteomic profiling.

    abstract::Isatin (indole-2,3-dione) is an endogenous indole that has a distinct and discontinuous distribution in the brain and in other mammalian tissues and body fluids. Its output is increased under conditions of stress and anxiety. Its biological targets remain poorly characterized, although [(3)H]isatin binding sites have ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Crumeyrolle-Arias M,Buneeva O,Zgoda V,Kopylov A,Cardona A,Tournaire MC,Pozdnev V,Glover V,Medvedev A

    更新日期:2009-09-01 00:00:00

  • Plasminogen activator inhibitor 1, the primary regulator of fibrinolysis, in normal human cerebrospinal fluid.

    abstract::The occurrence of type-1 plasminogen activator inhibitor (PAI-1) in human cerebrospinal fluid (CSF) has not previously been reported. As a member of the serpin superfamily of serine protease inhibitors and an acute phase response component, PAI-1 has powerful potential roles in nervous system homeostasis. We have dete...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Rao JS,Chen M,Festoff BW

    更新日期:1993-02-15 00:00:00

  • Specificity protein 1 regulates topoisomerase IIβ expression in SH-SY5Y cells during neuronal differentiation.

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    journal_title:Journal of neuroscience research

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    authors: Guo H,Cao C,Chi X,Zhao J,Liu X,Zhou N,Han S,Yan Y,Wang Y,Xu Y,Yan Y,Cui H,Sun H

    更新日期:2014-10-01 00:00:00

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Kopper TJ,Gensel JC

    更新日期:2018-06-01 00:00:00

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    journal_title:Journal of neuroscience research

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    authors: Imamura K,Takeshima T,Kashiwaya Y,Nakaso K,Nakashima K

    更新日期:2006-11-01 00:00:00

  • Cell lines expressing an acetylcholine release mechanism; correction of a release-deficient cell by mediatophore transfection.

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    authors: Falk-Vairant J,Meunier FM,Lesbats B,Corrèges P,Eder-Colli L,Salem N,Synguelakis M,Dunant Y,Israël M

    更新日期:1996-08-01 00:00:00

  • Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Takada-Takatori Y,Kume T,Ohgi Y,Izumi Y,Niidome T,Fujii T,Sugimoto H,Akaike A

    更新日期:2008-12-01 00:00:00

  • Cloning and expression of the rat BACE1 promoter.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Lange-Dohna C,Zeitschel U,Gaunitz F,Perez-Polo JR,Bigl V,Rossner S

    更新日期:2003-07-01 00:00:00

  • Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Declèves X,Regina A,Laplanche JL,Roux F,Boval B,Launay JM,Scherrmann JM

    更新日期:2000-06-01 00:00:00

  • Early apoptotic and late necrotic components associated with altered Ca2+ homeostasis in a peptide-delivery model of polyglutamine-induced neuronal death.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Suzuki M,Koike T

    更新日期:2005-05-15 00:00:00

  • Sendai virus vector-mediated brain-derived neurotrophic factor expression ameliorates memory deficits and synaptic degeneration in a transgenic mouse model of Alzheimer's disease.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Iwasaki Y,Negishi T,Inoue M,Tashiro T,Tabira T,Kimura N

    更新日期:2012-05-01 00:00:00

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Shih YY,Chen YY,Chen CC,Chen JC,Chang C,Jaw FS

    更新日期:2008-06-01 00:00:00

  • Role for myelin-associated glycoprotein as a functional tenascin-R receptor.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Yang H,Xiao ZC,Becker B,Hillenbrand R,Rougon G,Schachner M

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  • Regulation of pp60(c-src) synthesis in rat hippocampal slices by in vitro ischemia and glucocorticoid administration.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Barr CS,Dokas LA

    更新日期:2001-08-15 00:00:00

  • K+ channel properties in cultured mouse Schwann cells: dependence on extracellular K+.

    abstract::In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the t...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Verkhratsky A,Hoppe D,Kettenmann H

    更新日期:1991-02-01 00:00:00

  • In vitro studies of primary explosive blast loading on neurons.

    abstract::In a military setting, traumatic brain injury (TBI) is frequently caused by blast waves that can trigger a series of neuronal biochemical changes. Although many animal models have been used to study the effects of primary blast waves, elucidating the mechanisms of damage in a whole-animal model is extremely complex. I...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Zander NE,Piehler T,Boggs ME,Banton R,Benjamin R

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  • Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Guo A,Wang T,Ng EL,Aulia S,Chong KH,Teng FY,Wang Y,Tang BL

    更新日期:2006-05-01 00:00:00

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Karle J,Woldbye DP,Elster L,Diemer NH,Bolwig TG,Olsen RW,Nielsen M

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  • Acidic fibroblast growth factor (aFGF) is expressed in the neuronal and glial spinal cord cells of adult mice.

    abstract::Fibroblast growth factors (FGFs) are known to be synthesized in the central nervous system (CNS) and to act on CNS cells in vitro, but less is known about their synthesis, expression, and role in vivo. In this work, using specific anti-acidic fibroblast growth factor (aFGF) antibodies, we have shown for the first time...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Tourbah A,Oliver L,Jeanny JC,Gumpel M

    更新日期:1991-08-01 00:00:00

  • Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits.

    abstract::We have developed an animal model of learning and memory impairment associated with activation of microglia in the mouse brain. Injection of lipopolysaccharide into the CA1 region of the mouse hippocampus resulted in an increased production of inflammatory cytokines, such as interleukin-1β. Immunostaining for interleu...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Tanaka S,Kondo H,Kanda K,Ashino T,Nakamachi T,Sekikawa K,Iwakura Y,Shioda S,Numazawa S,Yoshida T

    更新日期:2011-04-01 00:00:00

  • Steady growth cone currents revealed by a novel circularly vibrating probe: a possible mechanism underlying neurite growth.

    abstract::The rate and direction of neurite growth have been shown in a number of studies to be determined by the distribution of adhesive sites on the growth cone. Recent evidence showing that the application of extrinsic electric fields can redistribute membrane molecules and alter both the rate and direction of neurite growt...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Freeman JA,Manis PB,Snipes GJ,Mayes BN,Samson PC,Wikswo JP Jr,Freeman DB

    更新日期:1985-01-01 00:00:00

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Slepko N,Minghetti L,Polazzi E,Nicolini A,Levi G

    更新日期:1997-08-01 00:00:00

  • Interactions among memory-related centers in the brain.

    abstract::The structures associated with learning and memory have been widely studied for over 100 years. The idea of the famous neuropsychologist K.S. Lashley, that learning and memory are stored diffusely in the brain, dominated neuroscience in the early half of Twentieth Century. Since Scoville reported in 1957 a persistent ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Shu SY,Wu YM,Bao XM,Leonard B

    更新日期:2003-03-01 00:00:00

  • Pentylenetetrazol seizures increase pro-nerve growth factor-like immunoreactivity in the reticular thalamic nucleus and nerve growth factor mRNA in the dentate gyrus.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Humpel C,Ebendal T,Cao Y,Olson L

    更新日期:1993-07-01 00:00:00

  • Neurons rely on glucose rather than astrocytic lactate during stimulation.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Díaz-García CM,Yellen G

    更新日期:2019-08-01 00:00:00

  • Sprouting inducing activity of human sera: low capacity in sera from patients with cranial polyneuropathy.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Aviel A,Schwartz M

    更新日期:1983-01-01 00:00:00

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    abstract::Despite the large number of growth factors shown to affect dopaminergic cell survival and differentiation in vitro, presently little is known about the role these growth factors play during normal in vivo development of dopaminergic neurons. To address this issue, glia and neurons of both the mesencephalic home region...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Engele J

    更新日期:1998-08-15 00:00:00

  • Differentiation of PC12 cells with K-ras: comparison with nerve growth factor.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Simpson DL,Dickens G,Doll S,Koizumi S,Tocco M,Okuda O,Oshima M,Rudkin BB,Brightman M,Guroff G

    更新日期:1991-04-01 00:00:00