Abstract:
:HEPES inhibited the taurine uptake in glial cells. A different kind of inhibition was observed when HEPES was present in the culture medium or in the incubation medium used for the taurine-uptake measurement. As an example of a possible interference of HEPES in pharmacological experiments, we have studied the effect of this buffer on the modulation of taurine uptake by beta agonists or ionic concentration.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Lleu PL,Rebel Gdoi
10.1002/jnr.490230111subject
Has Abstractpub_date
1989-05-01 00:00:00pages
78-86issue
1eissn
0360-4012issn
1097-4547journal_volume
23pub_type
杂志文章abstract::Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400216
更新日期:1995-02-01 00:00:00
abstract::The mitochondrial permeability transition (mPT) has been implicated in both excitotoxic and apoptotic neuronal cell death, despite the fact that it has not been previously identified in neurons. To study the mPT in hippocampal neurons, cultures were loaded with the mitochondrial dye JC-1 and observed with confocal and...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980915)53:6<728::AID-JNR
更新日期:1998-09-15 00:00:00
abstract::Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180404
更新日期:1987-01-01 00:00:00
abstract::α-Synuclein (α-syn) is the major component of pathological inclusions characteristic of several neurodegenerative disorders, such as Parkinson's disease. The major posttranslational modification of α-syn is phosphorylation at S129, and previous studies estimate that approximately 90% of α-syn in proteinaceous, patholo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22537
更新日期:2011-02-01 00:00:00
abstract::Destruction of the ventromedial hypothalamic nuclei (VMN) in the weanling rat without injury to the median eminence results in a series of somatic, endocrine, and metabolic changes that are characterized by normal food and water intake but decreased linear growth, normal body weight but increased carcass fat and reduc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490020202
更新日期:1976-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease caused by the selective death of motor neurons. Between 5% and 10% of ALS patients have a genetically inherited form of the disease known as familial ALS (FALS), and approximately 20% of FALS patients have mutations in the SOD1 gene. Although the m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21902
更新日期:2009-03-01 00:00:00
abstract::Microglia are prominently involved in neural degenerative diseases of the CNS and the retina. In this study, we determined the activation and phagocytotic function of different subtypes of retinal microglial cells at 1 week and 1 month following optic axotomy. Fluorescent DiI crystals were placed at the stumps of the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10713
更新日期:2003-09-15 00:00:00
abstract::Hippocalcin is a Ca2+-binding protein that is expressed mainly in pyramidal nerve cells of the hippocampus. However, its functions and mechanism in the brain remain unclear. To elucidate the role of hippocalcin, we used a conditionally immortalized hippocampal cell line (H19-7) and showed that bFGF treatment increased...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21602
更新日期:2008-05-15 00:00:00
abstract::Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that form a subfamily within the steroid hormone receptor group. Recent work has shown that one member of this group, PPARgamma, plays a central role in adipocyte differentiation. As oligodendrocytes are major lipid-producin...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980301)51:5<563::AID-JNR
更新日期:1998-03-01 00:00:00
abstract::Parallel corticostriatonigral circuits have been proposed that separately process motor, cognitive, and emotional-motivational information. Functional integration requires that interactions exist between neurons participating in these circuits. This makes it imperative to study the complex anatomical substrate underly...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24242
更新日期:2018-09-01 00:00:00
abstract::Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond to any kind of damage or pathophysiological changes. These cells sense and rapidly respond to danger and inflammatory signals by changing their cell morphology; by release of cytokines, chemok...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21875
更新日期:2009-02-15 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is well known to play a critical role in cognition. Its role in mood disorders, including post stroke depression (PSD), is also recognized with more evidence surfacing. In patients with PSD, their serum BNDF level is lower than in those without depression. Furthermore, antidepr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24510
更新日期:2020-03-01 00:00:00
abstract::Recent findings suggest that exogenous gangliosides improve recovery of a learned behavior (alternation in a T-maze) which is thought to be related to sprouting after lesions of the entorhinal cortex. In the present investigation, we studied an unlearned behavior (the open-field hyperactivity resulting from bilateral ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490120228
更新日期:1984-01-01 00:00:00
abstract::Mutations in the beta-amyloid precursor protein (APP) gene cause familial Alzheimer's disease (AD). Although amyloid beta peptide (Abeta) is the principal constituent of senile plaques in AD, other cleavage products of APP are also implicated in playing a role in the pathogenesis of AD. C-terminal fragments of APP (AP...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000515)60:4<565::AID-JNR
更新日期:2000-05-15 00:00:00
abstract::We have developed a silicone nerve regeneration chamber that is partitioned into two compartments by a strip of nitrocellulose paper. The modified two-compartment chamber allows the investigation of the effects on rat sciatic nerve regeneration of trophic or growth factors that are initially bound to the nitrocellulos...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200306
更新日期:1988-07-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) infection in its human host often results in progressive dementia and encephalopathy in adults and children, respectively. The mechanisms underlying virus-induced neurocognitive dysfunction are not fully understood. However, several studies strongly suggest that secretory vi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20745
更新日期:2006-02-15 00:00:00
abstract::The cellular constituents of the blood-brain barrier (BBB) must make finely tuned, regulatory responses to maintain microvascular homeostasis. The mechanisms by which this task is accomplished are largely unknown. However, it is thought they involve a series of cross-talk mechanisms among endothelial cells (EC), peric...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990301)55:5<578::AID-JNR
更新日期:1999-03-01 00:00:00
abstract::Noradrenalin (NA) regulates the expression of arginine-vasopressin (AVP) and oxytocin (OT) by magnocellular neurons in the supraoptic nucleus (SON) of the hypothamalus. Nitric oxide (NO) may be one of the factors involved in the NA signaling pathway regulating AVP and OT expression. To test this possibility, we used a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21394
更新日期:2007-10-01 00:00:00
abstract::Contrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is expressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as a probe....
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180402
更新日期:1987-01-01 00:00:00
abstract::Although alterations in adenylate cyclase (AC) activity and somatostatin (SRIF) receptor density have been reported in Alzheimer's disease, the effects of amyloid beta-peptide (Abeta) on these parameters in the hippocampus are unknown. Our aim was to investigate whether the peptide fragment Abeta(25-35) can affect the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21115
更新日期:2007-02-01 00:00:00
abstract::Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate-induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53(-/-), n = 9) and their wild-type ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22491
更新日期:2010-11-15 00:00:00
abstract::The five major antioxidant enzymes, glutathione, and in vivo or in vitro stimulated (Fe(++)-ascorbate) peroxidation were similar in old and young Rana perezi frogs. Long-term (2.5 months) treatment with aminotriazole strongly decreased cerebral catalase (CAT) activity and increased in vivo but not in vitro peroxidatio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490260314
更新日期:1990-07-01 00:00:00
abstract::Green fluorescent protein (GFP) transgenic zebrafish technology has been employed to directly visualize and analyze dynamic developmental processes, such as cell migration and morphogenesis. Stable transgenic zebrafish that express GFP in oligodendrocytes can be a valuable tool to visualize complex myelination process...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20516
更新日期:2005-07-01 00:00:00
abstract::This essay discusses the directional movements of metazoan tissue cells generally, with special emphasis on neurons, in an attempt to show that the directional movements of all share fundamental similarities. ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490130102
更新日期:1985-01-01 00:00:00
abstract::The large, medium-sized, and small neurons of the dorsal root ganglion (DRG) have different functions in the processing of various senses. Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN) contribute greatly to neuronal excitability. In the present study, which used whole-cell patch clamp techniques ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20109
更新日期:2004-06-01 00:00:00
abstract::The presence of glycosaminoglycans (GAG) has been histochemically demonstrated in the CNS of various mammalian species. They have been related with some nerve functions as neurotransmitters storage and synaptic transmission. In the present paper, the histochemical properties of nerve cell cytoplasmic GAG were studied ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490110103
更新日期:1984-01-01 00:00:00
abstract::A rodent model of Parkinson's disease, the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine treated mouse, was used to determine whether striatal dopamine levels recover following grafting adrenal medulla into the striatum. Four types of grafts were performed: 1) adult mouse adrenal medulla, 2) adult adrenal me...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250303
更新日期:1990-03-01 00:00:00
abstract::The inner ear of humans and experimental animals demonstrate an abundance of glucocorticoid receptors (GR). Glucocorticoids (GC) are widely used to treat different hearing disorders; yet the mechanisms of GC action on the inner ear are unknown. We demonstrate how GR can directly modulate hearing sensitivity in respons...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20795
更新日期:2006-05-01 00:00:00
abstract::Efficient functioning of maintenance and repair processes seem to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, under control of several genes termed vitagenes. These include members of the heat shock protein system,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20386
更新日期:2005-02-15 00:00:00
abstract::To scale up human neural stem/progenitor cell (NSPC) cultures for clinical use, we need to know how long these cells can live ex vivo without losing their ability to proliferate and differentiate; thus, a convenient method is needed to estimate the proliferative activity of human NSPCs grown in neurosphere cultures, a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10377
更新日期:2002-09-15 00:00:00