Brain-derived neurotrophic factor and post-stroke depression.

Abstract:

:Brain-derived neurotrophic factor (BDNF) is well known to play a critical role in cognition. Its role in mood disorders, including post stroke depression (PSD), is also recognized with more evidence surfacing. In patients with PSD, their serum BNDF level is lower than in those without depression. Furthermore, antidepressants could enhance BDNF expression in the brain, resulting in an alleviation of depression symptoms. Such therapeutic effect can be abolished in animals with the BDNF gene deleted. In PSD patients, the presence of stroke may contribute to the development of depression, including affecting the expression of BDNF. However, the mechanisms of BDNF in the development of PSD remain largely unknown. Lower BDNF levels may have existed in some patients before stroke onset, making them vulnerable to develop depressive symptoms. Meanwhile, the hypoxic environment induced by stroke could possibly downregulate BDNF expression in the brain. Current antidepressant treatments are not specific for PSD and there is a lack of treatments to address the linkage between stroke and PSD. This review summarizes the current knowledge of BDNF in PSD. By regulating BDNF expression, a synergistic effect may be achieved when such treatments are applied together with existing antidepressants.

journal_name

J Neurosci Res

authors

Zhang E,Liao P

doi

10.1002/jnr.24510

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

537-548

issue

3

eissn

0360-4012

issn

1097-4547

journal_volume

98

pub_type

杂志文章,评审
  • Hypoglycemia reduces the blood-oxygenation level dependent signal in primary auditory and visual cortex: a functional magnetic resonance imaging study.

    abstract::Studies of the effects of hypoglycemia on the brain using neurocognitive testing have suggested that mainly complex functions subserved by secondary and tertiary cortex are affected by mild to moderate hypoglycemia and that intensively treated patients with Type I diabetes mellitus (T1DM) may have altered sensitivity ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21146

    authors: Driesen NR,Goldberg PA,Anderson AW,Tang L,Flanagan DE,Sherwin RS,Gore JC

    更新日期:2007-02-15 00:00:00

  • Innervation of cutaneous structures in the mouse hind paw: a confocal microscopy immunohistochemical study.

    abstract::The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-relat...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490410113

    authors: Navarro X,Verdú E,Wendelscafer-Crabb G,Kennedy WR

    更新日期:1995-05-01 00:00:00

  • 5-hydroxyoxindole, an indole metabolite, is present at high concentrations in brain.

    abstract::5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria. We have demonstrated recently that 5-hydroxyoxindole is an endogenous compound in blood and tissues of mammals, including humans. To date, 5-hydroxyoxindole's role...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21475

    authors: Crumeyrolle-Arias M,Tournaire MC,Rabot S,Malpaux B,Thiéry JC

    更新日期:2008-01-01 00:00:00

  • Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain.

    abstract::Soluble amyloid beta protein (Abeta) oligomers have been considered recently to be responsible for the cognitive dysfunction that sets in prior to senile plaque formation in the Alzheimer's disease (AD) brain. By using the newly prepared antibody against oligomer Abeta, rather than fibrillar or monomer Abeta, we obser...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20952

    authors: Ishibashi K,Tomiyama T,Nishitsuji K,Hara M,Mori H

    更新日期:2006-08-15 00:00:00

  • Separation of radiolabelled protein from brain and spinal cord of spinal hemisected rats on SDS polyacrylamide slab gels.

    abstract::After hemisection of the spinal cord in rats, alterations in amino acid incorporation into protein have been observed in brain and spinal cord. Proteins mediating these changes have been studied in the present experiment. Male, Long-Evans hooded rats were given either a laminectomy and dura incision (sham) at spinal s...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490050108

    authors: Wells MR

    更新日期:1980-01-01 00:00:00

  • Luteolin protects against reactive oxygen species-mediated cell death induced by zinc toxicity via the PI3K-Akt-NF-κB-ERK-dependent pathway.

    abstract::Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22714

    authors: Zhou F,Qu L,Lv K,Chen H,Liu J,Liu X,Li Y,Sun X

    更新日期:2011-11-01 00:00:00

  • Genetic and functional analysis of a Pacific hagfish opioid system.

    abstract::The actions of endogenous opioids and nociceptin/orphanin FQ are mediated by four homologous G protein-coupled receptors that constitute the opioid receptor family. However, little is known about opioid systems in cyclostomes (living jawless fish) and how opioid systems might have evolved from invertebrates. Here, we ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24682

    authors: Huang AY,Taylor AMW,Ghogha A,Pribadi M,Wang Q,Kim TSJ,Cahill CM,Coppola G,Evans CJ

    更新日期:2020-08-23 00:00:00

  • Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.

    abstract::Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon 1 H...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24493

    authors: Franich NR,Hickey MA,Zhu C,Osborne GF,Ali N,Chu T,Bove NH,Lemesre V,Lerner RP,Zeitlin SO,Howland D,Neueder A,Landles C,Bates GP,Chesselet MF

    更新日期:2019-12-01 00:00:00

  • High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways.

    abstract::In culture, cerebellar granule neurons die of apoptosis in serum-free media containing a physiologic level of K(+) but survive in a depolarizing concentration of K(+) or when insulin-like growth factor 1 (IGF-1) is added. Both Akt/PKB activation and caspase-3 inhibition were implicated as the underlying neuroprotectiv...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20024

    authors: Zhong J,Deng J,Huang S,Yang X,Lee WH

    更新日期:2004-03-15 00:00:00

  • Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.

    abstract::The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR-alpha agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE), the animal model ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20518

    authors: Xu J,Storer PD,Chavis JA,Racke MK,Drew PD

    更新日期:2005-08-01 00:00:00

  • Maternal stress affects postnatal growth and the pituitary expression of prolactin in mouse offspring.

    abstract::Maternal stress exerts long-lasting psychiatric and somatic on offspring, which persist into adulthood. However, the effect of maternal stress on the postnatal growth of pups has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in low body weight of m...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22550

    authors: Gao P,Ishige A,Murakami Y,Nakata H,Oka J,Munakata K,Yamamoto M,Nishimura K,Watanabe K

    更新日期:2011-03-01 00:00:00

  • Neurotrophin-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons.

    abstract::Low density dissociated cultures of embryonic rat hippocampal cells were used to study the effects of neurotrophin-3 (NT-3) on neuronal morphogenesis. The results obtained indicate that NT-3 enhances neurite outgrowth and branching; this is a dose-dependent effect, detected in approximately 50% of the neurons, and pre...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490390212

    authors: Morfini G,DiTella MC,Feiguin F,Carri N,Cáceres A

    更新日期:1994-10-01 00:00:00

  • Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase.

    abstract::Dopamine has been implicated as a potential mediating factor in a variety of neurodegenerative disorders. Dopamine can be oxidized to form a reactive dopamine quinone that can covalently modify cellular macromolecules including protein and DNA. This oxidation can be enhanced through various enzymes including tyrosinas...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19981201)54:5<691::AID-JNR

    authors: Xu Y,Stokes AH,Roskoski R Jr,Vrana KE

    更新日期:1998-12-01 00:00:00

  • Modulating astrogliosis after neurotrauma.

    abstract::Traumatic injury to the adult central nervous system (CNS) results in a rapid response from resident astrocytes, a process often referred to as reactive astrogliosis or glial scarring. The robust formation of the glial scar and its associated extracellular matrix (ECM) molecules have been suggested to interfere with a...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/1097-4547(20010115)63:2<109::AID-JNR1002>3

    authors: McGraw J,Hiebert GW,Steeves JD

    更新日期:2001-01-15 00:00:00

  • Electrical stimulation promotes the survival of oligodendrocytes in mixed cortical cultures.

    abstract::Oligodendrocyte (OLG) death plays a major role in white matter dysfunction and demyelination following injury to the CNS. Axonal contact, communication, and neuronal activity appear to promote OLG survival and function in cell culture and during development. The application of electrical stimulation to mixed neural cu...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22717

    authors: Gary DS,Malone M,Capestany P,Houdayer T,McDonald JW

    更新日期:2012-01-01 00:00:00

  • Parallel astrocyte calcium signaling modulates olfactory bulb responses.

    abstract::Astrocytes are the most abundant glial cell in the central nervous system. They modulate synaptic function through a variety of mechanisms, and yet remain relatively understudied with respect to overall neuronal circuit function. Exploiting the tractability of the mouse olfactory system, we manipulated astrocyte activ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24634

    authors: Ung K,Tepe B,Pekarek B,Arenkiel BR,Deneen B

    更新日期:2020-08-01 00:00:00

  • Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus.

    abstract::Two fundamental questions about neuron cell culture were addressed. Can one serum-free medium that was developed for optimum growth of hippocampal neurons support the growth of neurons from other regions of the brain? Is the region specific state of differentiation maintained in culture? To answer these questions, we ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490420510

    authors: Brewer GJ

    更新日期:1995-12-01 00:00:00

  • Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro.

    abstract::To determine whether one or more opioid receptor types might be preferentially involved in gliogenesis, primary mixed glial cultures derived from mouse cerebra were continuously treated with varying concentrations of opioid agonists selective for mu (mu), i.e., DAGO ([D-Ala2, MePhe4, Gly(ol)5]enkephalin), delta (delta...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490290415

    authors: Stiene-Martin A,Hauser KF

    更新日期:1991-08-01 00:00:00

  • Cobalt-dependent potentiation of net inward current density in Helix aspersa neurons.

    abstract::A low concentration of transition metal ions Co2+ and Ni2+ increases the inward current density in neurons from the land snail Helix aspersa. The currents were measured using a single electrode voltage-clamp/internal perfusion method under conditions in which the external Na+ was replaced by Tris+, the predominant ext...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490280411

    authors: Kim YK,Woodruff ML

    更新日期:1991-04-01 00:00:00

  • Purinergic modulation of neuronal gap junction circuits in the CNS of the leech.

    abstract::Gap junctions (GJs) are widely distributed in brains across the animal kingdom. To visualize the GJ- coupled networks of two major mechanosensory neurons in the ganglia of medicinal leeches, we injected these cells with the GJ-permeable tracer Neurobiotin. When diffusion time was limited to only 30 min, tracer couplin...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24599

    authors: Segura OM,Abdulnoor L,Hua VV,Solano MJ,Macagno ER,Baker MW

    更新日期:2020-06-01 00:00:00

  • Influence of laminin on the responsiveness of early chick embryo neural tube neurons to nerve growth factor.

    abstract::Dissociated neurons from the neural tube containing the trigeminal motor nucleus from early chick embryos were cultured on laminin or collagen-polyornithine substrates, with and without nerve growth factor (NGF). Control cultures were grown in similar conditions with cytochrome-C. It was found that neuronal survival w...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490220404

    authors: Heaton MB

    更新日期:1989-04-01 00:00:00

  • The role of maternal diet on offspring gut microbiota development: A review.

    abstract::In offspring, an adequate maternal diet is important for neurodevelopment. One mechanism by which maternal diet impacts neurodevelopment is through its dynamic role in the development of the gut microbiota. Communication between the gut, and its associated microbiota, and the brain is facilitated by the vagus nerve, i...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24605

    authors: Al Rubaye H,Adamson CC,Jadavji NM

    更新日期:2021-01-01 00:00:00

  • Altered localization of Cav1.2 (L-type) calcium channels in nerve fibers, Schwann cells, odontoblasts, and fibroblasts of tooth pulp after tooth injury.

    abstract::We have determined the localization of Cav1.2 (L-Type) Ca2+ channels in the cells and nerve fibers in molars of normal or injured rats. We observed high levels of immunostaining of L-type Ca2+ channels in odontoblast cell bodies and their processes, in fibroblast cell bodies and in Schwann cells. Many Cav1.2-containin...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10863

    authors: Westenbroek RE,Anderson NL,Byers MR

    更新日期:2004-02-01 00:00:00

  • Inflammation-regulatory microRNAs: Valuable targets for intracranial atherosclerosis.

    abstract::Intracranial atherosclerosis (ICAS) is the most common etiology of ischemic stroke with the highest rate of stroke recurrence. Little is currently known of the association of circulating inflammation-regulatory microRNAs (miRNAs) with ICAS. In this review, we briefly discuss that ICAS is characterized as a dynamic and...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.24487

    authors: Li J,Li K,Chen X

    更新日期:2019-10-01 00:00:00

  • Loss of Purkinje cell-associated benzodiazepine receptors spares a high affinity subpopulation: a study with pcd mutant mice.

    abstract::In order to identify the relative number of benzodiazepine (BZ) receptors in Purkinje and granule cells, the Purkinje cell degeneration (pcd) mutant mouse was used at different ages. In these mice, Purkinje cells have degenerated almost completely by 45-50 days of age. Granule cell loss occurs only later, and is most ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490090308

    authors: Vaccarino FM,Ghetti B,Wade SE,Rea MA,Aprison MH

    更新日期:1983-01-01 00:00:00

  • Gap junctional communication and connexin expression in cultured olfactory ensheathing cells.

    abstract::The olfactory ensheathing cell (OEC) is a unique glial cell able to support neurite outgrowth in the CNS throughout life. The OEC has been described as having both Schwann cell-like and astrocyte-like characteristics. The purpose of this study was to compare gap junctional communication and connexin (Cx) expression in...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.1182

    authors: Barnett SC,Thompson RJ,Lakatos A,Pitts J

    更新日期:2001-09-15 00:00:00

  • Chronic inhibition of brain glycolysis initiates epileptogenesis.

    abstract::Metabolic abnormalities found in epileptogenic tissue provide considerable evidence of brain hypometabolism, while major risk factors for acquired epilepsy all share brain hypometabolism as one common outcome, suggesting that a breakdown of brain energy homeostasis may actually precede epileptogenesis. However, a caus...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24019

    authors: Samokhina E,Popova I,Malkov A,Ivanov AI,Papadia D,Osypov A,Molchanov M,Paskevich S,Fisahn A,Zilberter M,Zilberter Y

    更新日期:2017-11-01 00:00:00

  • Tumor necrosis factor expressed by primary hippocampal neurons and SH-SY5Y cells is regulated by alpha(2)-adrenergic receptor activation.

    abstract::Neuron expression of the cytokine tumor necrosis factor-alpha (TNF), and the regulation of the levels of TNF by alpha(2)-adrenergic receptor activation were investigated. Adult rat hippocampal neurons and phorbol ester (PMA)-differentiated SH-SY5Y cells were examined. Intracellular levels of TNF mRNA accumulation, as ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10101

    authors: Renauld AE,Spengler RN

    更新日期:2002-01-15 00:00:00

  • Tissue kallikrein alleviates glutamate-induced neurotoxicity by activating ERK1.

    abstract::Glutamate-induced neurotoxicity consequent to N-methyl-D-aspartic acid (NMDA) and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propionic acid (AMPA) receptor activation underlies the pathogenesis of a wide range of central nervous system disorders, including brain ischemia. Prevention of ischemia/reperfusion (I/R)-ind...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22151

    authors: Liu L,Zhang R,Liu K,Zhou H,Tang Y,Su J,Yu X,Yang X,Tang M,Dong Q

    更新日期:2009-12-01 00:00:00

  • Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia.

    abstract::Transient global ischemia causes delayed white matter injury to the brain with oligodendrocyte (OLG) death and myelin breakdown. There is increasing evidence that hypoxia may be involved in several diseases of the white matter, including multiple sclerosis, vascular dementia, and ischemia. Matrix metalloproteinases (M...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22257

    authors: Walker EJ,Rosenberg GA

    更新日期:2010-03-01 00:00:00