Abstract:
:The five major antioxidant enzymes, glutathione, and in vivo or in vitro stimulated (Fe(++)-ascorbate) peroxidation were similar in old and young Rana perezi frogs. Long-term (2.5 months) treatment with aminotriazole strongly decreased cerebral catalase (CAT) activity and increased in vivo but not in vitro peroxidation in the brain. This suggests that the increase in endogenous brain peroxidation after CAT inhibition is due to an increased free-radical attack on cerebral membranes, and not to a possible increase in their sensitivity to peroxidative damage. The increase of in vivo peroxidation is especially remarkable taking into account the low levels of CAT present in the vertebrate brain. On the other hand, these changes were not accompanied by any effect on the survival of the animals. Comparison of these results with those obtained in other species suggests the possibility that O2-free radicals be of minor importance in relation to brain aging in animals with low rates of oxygen consumption.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Barja de Quiroga G,Pérez-Campo R,López-Torres Mdoi
10.1002/jnr.490260314subject
Has Abstractpub_date
1990-07-01 00:00:00pages
370-6issue
3eissn
0360-4012issn
1097-4547journal_volume
26pub_type
杂志文章abstract::Two fundamental questions about neuron cell culture were addressed. Can one serum-free medium that was developed for optimum growth of hippocampal neurons support the growth of neurons from other regions of the brain? Is the region specific state of differentiation maintained in culture? To answer these questions, we ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420510
更新日期:1995-12-01 00:00:00
abstract::The vesicular acetylcholine transporter (VAChT) is a transmembrane protein required, in cholinergic neurons, for selective storage of acetylcholine into synaptic vesicles. Although dorsal root ganglion (DRG) neurons utilize neuropeptides and amino acids for neurotransmission, we have previously demonstrated the presen...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10855
更新日期:2004-01-15 00:00:00
abstract::High levels of the proto-oncogene product, pp60c-src, have been found in developing and adult neural tissues as well as in certain fully mature cells of the hematopoietic lineage, e.g., platelets and myelomonocytes. Adrenal medullary chromaffin cells exhibit characteristics of both types of cells, i.e., they are deriv...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490240107
更新日期:1989-09-01 00:00:00
abstract::The presence of oligodendrocyte precursor cells which cannot be removed from primary cultures by antibody-dependent techniques complicates the interpretation of transplantation experiments designed to examine the potential of astrocytes to influence remyelination (Blakemore et al.; Glia 13:79-91, 1995). In the present...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cell...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20090
更新日期:2004-06-15 00:00:00
abstract::A sensitive and convenient method of endopeptidase assay using as substrate globin modified with pyridoxal-5-phosphate was used for determination of acid proteinases in bovine hypothalamus separated by isoelectric focusing. The soluble protein fraction of hypothalamus upon elution from Sephadex gave five peaks of prot...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490040505
更新日期:1979-01-01 00:00:00
abstract::Comparisons were made of whole cell voltage clamp recordings from cultures of normal Schwann cells (SC) from three human subjects and from three neurofibrosarcoma cell lines. The whole cell K+ (K) currents of normal and tumor cells could be divided into three types based on voltage activation range, pharmacology, and ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19981115)54:4<495::AID-JNR
更新日期:1998-11-15 00:00:00
abstract::The first synapse in the olfactory pathway mediates a significant transfer of information given the restricted association of specific olfactory receptor neurons with specific glomeruli in the olfactory bulb. To understand better how this connection is made and what the functional capacities of the participating cells...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20007
更新日期:2004-03-01 00:00:00
abstract::Acute intoxication with large ammonia doses leads to activation of NMDA receptors in the brain, resulting in oxidative stress and disturbance of mitochondrial function. Altered mitochondrial function is a crucial step in some mechanisms of cellular apoptosis. This study assesses whether ammonia intoxication in vivo le...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21385
更新日期:2007-08-15 00:00:00
abstract::The mechanisms underlying brain seizure tolerance, a phenomenon in which brief periods of seizures protect brain against the lethal effects of subsequent sustained seizures, are poorly understood. Because brain seizure tolerance and brain ischemia tolerance likely share certain common mechanisms, the recent evidence t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20566
更新日期:2005-08-15 00:00:00
abstract::Hippocalcin is a Ca2+-binding protein that is expressed mainly in pyramidal nerve cells of the hippocampus. However, its functions and mechanism in the brain remain unclear. To elucidate the role of hippocalcin, we used a conditionally immortalized hippocampal cell line (H19-7) and showed that bFGF treatment increased...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21602
更新日期:2008-05-15 00:00:00
abstract::A previous study demonstrated the release of newly loaded radiolabelled taurine (Tau) from cultured rabbit Müller glia not only following typical cell volume-increasing treatments with high (65 mM) potassium ions or hypotonic media, but also with ammonium chloride (further referred to as ammonia), in a dose-dependent ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19961015)46:2<231::AID-JNR
更新日期:1996-10-15 00:00:00
abstract::The neural cell adhesion molecule (NCAM) plays a key role in neural development, regeneration, and synaptic plasticity. The crystal structure of a fragment of NCAM comprising the three N-terminal immunoglobulin (Ig)-like modules indicates that the first and second Ig modules bind to each other, thereby presumably medi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22380
更新日期:2010-08-01 00:00:00
abstract::A link between aluminum (Al) exposure and age-related neurological disorders has long been proposed. Although the exact mechanism by which the metal may influence disease processes is unknown, there is evidence that exposure to Al causes an increase in both oxidative stress and inflammatory events. These processes hav...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10877
更新日期:2004-02-15 00:00:00
abstract::Neuronal pathology of the brain with Alzheimer's disease (AD) is characterized by numerous depositions of amyloid-beta peptides (Abeta). Abeta binding to the 75-kDa neurotrophin receptor (p75NTR) causes neuronal cell death. Here we report that Abeta causes cell death in neuronal hybrid cells transfected with p75NTR, b...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10703
更新日期:2003-09-01 00:00:00
abstract::The cellular constituents of the blood-brain barrier (BBB) must make finely tuned, regulatory responses to maintain microvascular homeostasis. The mechanisms by which this task is accomplished are largely unknown. However, it is thought they involve a series of cross-talk mechanisms among endothelial cells (EC), peric...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990301)55:5<578::AID-JNR
更新日期:1999-03-01 00:00:00
abstract::Although serotonin regulates synthesis of the neurotrophic factor S-100 beta by astrocytes, its ability to affect nerve growth factor (NGF) synthesis has never been examined. We report here that there is a correlation between the effect of serotonin on cyclic adenosine monophosphate (cAMP) content and on NGF content i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1074
更新日期:2001-05-01 00:00:00
abstract::An aminopeptidase purified to homogeneity from cytosol of rat brain cleaved dynorphins having 5-17 residues and selected proenkephalins at the Tyr-Gly bond only to release Tyr and the desTyr fragments. The enzyme protein consisted of a single polypeptide chain of Mr 103,000 and was inhibited by puromycin, bestatin, an...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490110311
更新日期:1984-01-01 00:00:00
abstract::Few diseases in clinical medicine cause as much diagnostic consternation as central nervous system (CNS) vasculitis because of its varying modes of presentation and frequently overlapping clinical and pathological features. There are no pathognomonic clinical or laboratory findings. The purpose of the present retrospe...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10180
更新日期:2002-03-15 00:00:00
abstract::Enriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10253
更新日期:2002-07-01 00:00:00
abstract::Differentiated human NT2-N neurons were shown to express CCR5 and CXCR4 chemokine receptor mRNA and protein, and to be responsive to the chemokines CCL5 and CXCL12. Using cDNA microarray technology, CCL5 was found to induce a distinct transcriptional program, with reproducible induction of 46 and 9 genes after 2 and 8...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20250
更新日期:2004-11-01 00:00:00
abstract::Factor Xa (FXa) plays a critical role in the coagulation cascade by generation of thrombin. During focal ischemia thrombin levels increase in the brain tissue and cause neural damage. This study examined the hypothesis that administration of the FXa inhibitor, apixaban, following focal ischemic stroke may have therape...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24253
更新日期:2018-08-01 00:00:00
abstract::Chondroitinase ABC (Ch'ase ABC) is a bacterial lyase that degrades chondroitin sulfate (CS), dermatan sulfate, and hyaluronan glycosaminoglycans (GAGs). This enzyme has received significant attention as a potential therapy for promoting central nervous system and peripheral nervous system repair based on its degradati...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21199
更新日期:2007-04-01 00:00:00
abstract::In this study, we tested the hypothesis that chronic administration of phencyclidine (PCP), an N-methyl-D-aspartate (NMDA) receptor antagonist, would cause a long-lasting behavioral sensitization associated with neuronal toxicity. Female Sprague-Dawley rats were administered PCP (20 mg/kg, i.p.) once a day for 5 days,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980615)52:6<709::AID-JNR
更新日期:1998-06-15 00:00:00
abstract::Intact synaptosomes prepared from 28-day-old rat brains were incubated with CMP-N-acetyl-(14C) neuraminic acid in Krebs-Henseleit buffer in an atmosphere of 95% O2: 5% CO2, at 37 degrees C. The activity of CMP-NANA:ganglioside sialosyltransferase using endogenous acceptors was 0.84 pmoles NANA transferred/mg synaptoso...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180312
更新日期:1987-01-01 00:00:00
abstract::Astrocyte activation is an important feature in many disorders of the central nervous system, including chronic pain conditions. Activation of astrocytes is characterized by a change in morphology, including hypertrophy and increased size of processes, proliferation, and an increased production of proinflammatory medi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23144
更新日期:2013-02-01 00:00:00
abstract::The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220212
更新日期:1989-02-01 00:00:00
abstract::Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because of neurofunctional and anatomic differences between rodents and primates. In the present study, the development of histopathologic changes ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20435
更新日期:2005-04-15 00:00:00
abstract::In searching for possible differences in the composition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) forms in dystrophic brain, the distribution of various enzyme molecules in normal (NB) and dystrophic (DB) 129B6F1/J mouse brain has been investigated. The tissue was sequentially extracted with sa...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960115)43:2<224::AID-JNR
更新日期:1996-01-15 00:00:00
abstract::Time-to-contact (TTC) perception refers to the ability of an observer to estimate the remaining time before an object reaches a point in the environment, and is of crucial importance in daily life. Noninvasive correlational approaches have identified several brain areas sensitive to TTC information. Here we report the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24740
更新日期:2021-02-01 00:00:00