Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice.

abstract：:The existence of endogenous neural progenitor cells (NPCs) in the adult spinal cord (sc) provides the potential for tailored repair therapies after spinal cord injury (SCI). This study investigates the impact of inflammatory mediators on properties of NPC cultures derived from adult rats after SCI. The Infinite Horizo...

journal_title：Journal of neuroscience research

authors： Knerlich-Lukoschus F,Krossa S,Krause J,Mehdorn HM,Scheidig A,Held-Feindt J

更新日期：2015-04-01 00:00:00

abstract：:The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cell...

journal_title：Journal of neuroscience research

authors： Mandyam CD,Norris RD,Eisch AJ

更新日期：2004-06-15 00:00:00

abstract：:The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. Here, the effects of BASP1 overexpression were investigated in PC12E2 cells and pr...

journal_title：Journal of neuroscience research

authors： Korshunova I,Caroni P,Kolkova K,Berezin V,Bock E,Walmod PS

更新日期：2008-08-01 00:00:00

abstract：:Given the ubiquitous nature of opioids in the treatment of pain, it is an interesting paradox that this class of medications also represents one of the least understood components of clinical pain medicine. For many years, there has been intense interest in the mechanisms of opioid activity, but this has not resulted ...

journal_title：Journal of neuroscience research

authors： Montgomery LS

更新日期：2020-08-07 00:00:00

abstract：:The effect of the potent soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) on neurite outgrowth and retraction was investigated in PC12 cells and SH-SY5Y human neuroblastoma cells. ODQ inhibited neurite outgrowth and triggered neurite retraction in the cells stimulated with ner...

journal_title：Journal of neuroscience research

authors： Lee HG,Kim SY,Kim du S,Seo SR,Lee SI,Shin DM,De Smet P,Seo JT

更新日期：2009-01-01 00:00:00

abstract：:Thymocyte differentiation antigen-1 (Thy-1) is a cell surface glycoprotein found on T cells and neurons and is involved in cell-to-cell interactions. In addition, Thy-1 knockouts (KO) are a potential mouse model of restless legs syndrome (RLS) based on clinical observations and the role of dopamine in the disease. In ...

journal_title：Journal of neuroscience research

authors： Carkaci-Salli N,Battula S,Wang X,Connor JR,Vrana KE

更新日期：2012-08-01 00:00:00

abstract：:We investigated the role of kainate (KA) receptor activation and desensitization in inducing the increase in the intracellular free Ca(2+) concentration ([Ca(2+)](i)) in individual cultured rat hippocampal neurons. The rat hippocampal neurons in the cultures were shown to express kainate receptor subunits, KA2 and Glu...

journal_title：Journal of neuroscience research

authors： Silva AP,Malva JO,Ambrósio AF,Salgado AJ,Carvalho AP,Carvalho CM

更新日期：2001-09-01 00:00:00

abstract：:P-glycoprotein (P-gp), a drug efflux pump, is known to alter the bioavailability of antiretroviral drugs at several sites, including the brain. We have previously shown that human immunodeficiency virus-1 (HIV-1) glycoprotein 120 (gp120) induces proinflammatory cytokine secretion and decreases P-gp functional expressi...

journal_title：Journal of neuroscience research

authors： Ashraf T,Ronaldson PT,Persidsky Y,Bendayan R

更新日期：2011-11-01 00:00:00

abstract：:Noradrenalin (NA) regulates the expression of arginine-vasopressin (AVP) and oxytocin (OT) by magnocellular neurons in the supraoptic nucleus (SON) of the hypothamalus. Nitric oxide (NO) may be one of the factors involved in the NA signaling pathway regulating AVP and OT expression. To test this possibility, we used a...

journal_title：Journal of neuroscience research

authors： Maolood N,Grange-Messent V,Raison D,Hardin-Pouzet H

更新日期：2007-10-01 00:00:00

abstract：:Adult neurogenesis is influenced by blood-borne factors. In this context, greater or lesser vascular permeability along neurogenic niches would expose differentially neural stem cells (NSCs), transit amplifying cells (TACs), and neuroblasts to such factors. Here we evaluate endothelial cell morphology and vascular per...

journal_title：Journal of neuroscience research

authors： Colín-Castelán D,Ramírez-Santos J,Gutiérrez-Ospina G

更新日期：2016-02-01 00:00:00

abstract：:The effects of blinding with or without pineal ablation on brain monoamine levels were studied in male rats. Brain dopamine (DA), norepinephrine (NE), epinephrine (E), and serotonin (5-HT) were measured by radioenzymatic assays. Four weeks following pinealectomy, E levels were significantly enhanced in the frontal cor...

journal_title：Journal of neuroscience research

authors： Niles LP,Brown GM,Mishra RK

更新日期：1983-01-01 00:00:00

abstract：:Electrical activity shapes development of the nervous system, presumably in part by regulating gene expression. A set of regulatory genes, immediate early genes (IEGs), which are responsive to a number of extrinsic cellular stimuli have been proposed to play a role in coupling such activity to gene expression. Using a...

journal_title：Journal of neuroscience research

authors： Sheng HZ,Fields RD,Nelson PG

更新日期：1993-08-01 00:00:00

abstract：:Growth hormone (GH) appears to play a major role in a reciprocal axis that has been postulated between the thymus and pituitary glands. Our previous studies showed that thymic structure, as well as T-cell proliferation and IL-2 synthesis, could be restored in aged female Wistar-Furth rats by the implantation of GH3 pi...

journal_title：Journal of neuroscience research

authors： Davila DR,Brief S,Simon J,Hammer RE,Brinster RL,Kelley KW

更新日期：1987-01-01 00:00:00

abstract：:The ligand-activated transcription factor peroxisome proliferator-activated receptor beta (PPARbeta) is present in the brain and is implicated in the regulation of genes with potential roles in neurotoxicity. We sought to examine the role of PPARbeta in neuronal cell death by using the PPARbeta ligand GW0742. Primary ...

journal_title：Journal of neuroscience research

authors： Smith SA,Monteith GR,Robinson JA,Venkata NG,May FJ,Roberts-Thomson SJ

更新日期：2004-07-15 00:00:00

abstract：:Cross-linking of alpha-synuclein and Lewy body formation have been implicated in the dopaminergic neuronal cell death observed in Parkinson's disease (PD); the mechanisms responsible, however, are not clear. Reactive oxygen species and advanced glycation end products (AGEs) have been found in the intracellular, alpha-...

journal_title：Journal of neuroscience research

authors： Shaikh S,Nicholson LF

更新日期：2008-07-01 00:00:00

abstract：:Metabolism of amyloid-beta peptide (A beta) is closely associated with the pathology and etiology of Alzheimer's disease (AD). Neprilysin is the only rate-limiting catabolic peptidase proven by means of reverse genetics to participate in A beta metabolism in vivo. The aim of the present study is to assess whether poss...

journal_title：Journal of neuroscience research

authors： Iwata N,Takaki Y,Fukami S,Tsubuki S,Saido TC

更新日期：2002-11-01 00:00:00

abstract：:Our previous results support the idea that CREB (cyclic AMP-response element binding protein) may be a mediator of neuroligand and growth factor signals that, coupled to different signal transduction pathways, play different roles at specific stages of oligodendrocyte development. In the early stages, when cells are i...

journal_title：Journal of neuroscience research

authors： Afshari FS,Chu AK,Sato-Bigbee C

更新日期：2001-10-01 00:00:00

abstract：:The distribution of phosphofructokinase (PFK) in gray and white matter regions of the rat nervous system was evaluated. Determinations of PFK activity revealed that cell body enriched regions (sensorimotor cortex) had a significantly higher level of activity than axonal regions (sciatic nerve, dorsal roots, and optic ...

journal_title：Journal of neuroscience research

authors： Oblinger MM,Foe LG,Kwiatkowska D,Kemp RG

更新日期：1988-09-01 00:00:00

abstract：:Scatchard analysis of saturation isotherms of [125I]-iodopindolol was used to characterize beta-adrenoceptor density (Bmax) and affinity constant (Kd) in female and male hamster Harderian glands. Single-point experiments were also completed in intact females, intact males, and castrated or superior cervical ganglionec...

journal_title：Journal of neuroscience research

authors： Pangerl A,Pangerl B,Buzzell GR,Jones DJ,Reiter RJ

更新日期：1989-04-01 00:00:00

abstract：:The mitochondrial permeability transition (mPT) has been implicated in both excitotoxic and apoptotic neuronal cell death, despite the fact that it has not been previously identified in neurons. To study the mPT in hippocampal neurons, cultures were loaded with the mitochondrial dye JC-1 and observed with confocal and...

journal_title：Journal of neuroscience research

authors： Dubinsky JM,Levi Y

更新日期：1998-09-15 00:00:00

abstract：:We used the Plp1-overexpressing transgenic mouse model to investigate whether progressive demyelination of axons results in adaptive changes involving mitochondria within the axons. These models have myelinated axons from birth but gradually lose myelin and develop axonal loss associated with progressive neurological ...

journal_title：Journal of neuroscience research

authors： Hogan V,White K,Edgar J,McGill A,Karim S,McLaughlin M,Griffiths I,Turnbull D,Nichols P

更新日期：2009-02-01 00:00:00

abstract：:Mitotic activity persists in various regions of the adult mammal CNS. While evidences of neurogenesis appeared, many studies focused on the features of the adult stem cells from germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus, the cortex, the fourth ven...

journal_title：Journal of neuroscience research

authors： Picard-Riera N,Nait-Oumesmar B,Baron-Van Evercooren A

更新日期：2004-04-15 00:00:00

abstract：:Cultures of rat C6 rat glioma cells exhibit a diminished response to isoproterenol and forskolin after being treated with phorbol 12,13-dibutyrate (PDbU). An IC50 for PDbU of 38 +/- 5 nM and 62 +/- 8 nM was observed in the isoproterenol and forskolin response, respectively. Similarly, C6 cultures exhibited a diminishe...

journal_title：Journal of neuroscience research

authors： Bressler JP,Tinsely P

更新日期：1990-01-01 00:00:00

abstract：:Enriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis...

journal_title：Journal of neuroscience research

authors： Lee YB,Nagai A,Kim SU

更新日期：2002-07-01 00:00:00

abstract：:Glutamate, the major excitatory neurotransmitter, induces a signal from the membrane to the nucleus that regulates gene expression. The gene encoding the chick kainate binding protein undergoes a glutamate-dependent transcriptional regulation via an activator protein-1 site within its promoter region. To characterize ...

journal_title：Journal of neuroscience research

authors： Aguirre A,López-Bayghen E,Ortega A

更新日期：2002-10-01 00:00:00

abstract：:Despite a large body of literature on the nociceptin (NC) opioid system in pain modulation, the mechanism of action of NC remains largely unexplored. Here, we investigated the role and mode of action of the spinal NC system in inflammatory pain. Preemptive intrathecal administration of NC attenuated thermal hyperalges...

journal_title：Journal of neuroscience research

authors： Chen Y,Sommer C

更新日期：2007-05-15 00:00:00

abstract：:Adrenal chromaffin cell (ACC) transplants, alone or combined with levodopa treatment, were used in attempted therapy for Parkinson's disease (PD). In a previous study, we demonstrated that levodopa caused chromaffin cell death either by necrosis or by apoptosis in cell culture. Here we report the beneficial effect of ...

journal_title：Journal of neuroscience research

authors： Corona-Morales AA,Castell A,Escobar A,Drucker-Colín R,Zhang L

更新日期：2003-01-01 00:00:00

abstract：:This study demonstrates the ability of proteasome inhibitors (lactacystin, MG 115, MG 132) adenosine diphosphate to induce a time- and dose-dependent increase in poly-ADP-ribosylation (PAR) in the neural PC6 cell line, a subclone of PC12 cells. Elevated levels of PAR contribute to the toxicity associated with impaired...

journal_title：Journal of neuroscience research

authors： Keller JN,Markesbery WR

更新日期：2000-08-15 00:00:00

abstract：:Contrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is expressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as a probe....

journal_title：Journal of neuroscience research

authors： Puckett C,Hudson L,Ono K,Friedrich V,Benecke J,Dubois-Dalcq M,Lazzarini RA

更新日期：1987-01-01 00:00:00

abstract：:Nerve growth factor (NGF) is a protein essential for the survival and normal function of sympathetic neurons. Two-site immunoassays have been developed over the past decade in several laboratories and used to estimate its endogenous concentrations in a variety of effector tissues. However, levels appear restricted to ...

journal_title：Journal of neuroscience research

authors： Zettler C,Bridges DC,Zhou XF,Rush RA

更新日期：1996-12-01 00:00:00