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Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes.

Abstract：

:The cellular constituents of the blood-brain barrier (BBB) must make finely tuned, regulatory responses to maintain microvascular homeostasis. The mechanisms by which this task is accomplished are largely unknown. However, it is thought they involve a series of cross-talk mechanisms among endothelial cells (EC), pericytes (PC), and astrocytes. During inflammation, the BBB is exposed to a number of biological response modifiers including cytokines released by infiltrating leukocytes. The response to inflammatory cytokines may alter the normal regulatory function of EC and PC. These changes may account for some of the pathological findings in central nervous system (CNS) inflammatory disease. Previous studies have shown that PC and EC may have immune potential. We have investigated the response of the PC to a variety of inflammatory cytokines. Primary rat PC constitutively express low levels of intercellular adhesion molecule-1 (ICAM-1) and major histocompatibility complex (MHC) class I molecule, which can be upregulated in response to the cytokine interferon-gamma (IFNgamma). IFNgamma also induced the expression of MHC class II molecule. After induction of MHC class II molecule, CNS PC acquired the capacity to present antigen to primed syngeneic rat T-lymphocytes. Antigen presentation by PC was comparable to that seen with classic antigen-presenting cells. A small number of primary PC constitutively express low levels of vascular cell adhesion molecule-1 (VCAM-1), which was increased on exposure to tumor necrosis factor-alpha (TNFalpha). Results suggest that CNS PC respond to inflammatory cytokines, are involved in T-lymphocyte activation, and express cell surface adhesion molecules (VCAM-1, ICAM-1) that may provide costimulatory activity. It is likely that CNS PC are important in neuroimmune networks at the BBB.

journal_name

J Neurosci Res

journal_title

Journal of neuroscience research

authors

Balabanov R,Beaumont T,Dore-Duffy P

doi

10.1002/(SICI)1097-4547(19990301)55:5<578::AID-JNR

keywords:

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

578-87

issue

eissn

0360-4012

issn

1097-4547

pii

10.1002/(SICI)1097-4547(19990301)55:5<578::AID-JNR

journal_volume

pub_type

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Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes.