Abstract:
:Recent findings suggest that exogenous gangliosides improve recovery of a learned behavior (alternation in a T-maze) which is thought to be related to sprouting after lesions of the entorhinal cortex. In the present investigation, we studied an unlearned behavior (the open-field hyperactivity resulting from bilateral entorhinal lesions) to evaluate whether ganglioside treatments reduce the severity of initial postlesion impairments or improve recovery. We also examined whether the treatments enhance the sprouting of septodenate fibers which parallels the recovery of open-field activity. The typical behavioral changes induced by bilateral entorhinal lesions include hyperactivity, reduced habituation of activity, and a gradual time-dependent return toward control levels. We found that rats treated with total brain gangliosides (30 mg/kg) showed a smaller lesion-induced increase, consistently lower levels, and greater within-session habituation of activity than did saline-treated counterparts. Control rats treated with gangliosides did not exhibit a reduction in activity, suggesting that the effect was on lesion-induced hyperactivity rather than on activity, per se. Ganglioside-treated rats showed a slight, but consistently smaller lesion-induced sprouting response by the septodentate pathway than did untreated counterparts at all postlesion intervals examined (3, 5, 7, and 10 days). The present findings indicate that ganglioside treatments reduce the severity of the initial behavioral effects after entorhinal lesions without enhancing the sprouting by septodentate fibers.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Fass B,Ramirez JJdoi
10.1002/jnr.490120228subject
Has Abstractpub_date
1984-01-01 00:00:00pages
445-58issue
2-3eissn
0360-4012issn
1097-4547journal_volume
12pub_type
杂志文章abstract::Little is known about the structural neural substrates that may contribute to sex differences in risk-taking propensity (RTP). A close association between risk-seeking behavior and the emotional-regulation network led us to hypothesize that the sex differences in RTP would be associated with sex differences in brain m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24504
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400111
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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abstract::This paper describes a novel technique to identify and study neurons that express specific mRNAs. The method is called Live FISH because it is like fluorescent in situ hybridization (FISH) but can be applied to living tissues. In Live FISH, molecular beacons, which fluoresce only in the presence of the complementary m...
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