Quercetin improves the activity of the ubiquitin-proteasomal system in 150Q mutated huntingtin-expressing cells but exerts detrimental effects on neuronal survivability.

abstract：:Changes in dopamine (DA) D(1), D(2), D(3), and D(4) receptors and serotonin 5-HT(1A) and 5-HT(2A) receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine fumarate] for 28 days with osmotic minipumps...

journal_title：Journal of neuroscience research

authors： Moran-Gates T,Massari C,Graulich A,Liégeois JF,Tarazi FI

更新日期：2006-08-15 00:00:00

abstract：:Epidural hematoma (EDH) is a type of life-threatening traumatic brain injury. Little is known about the extent to which EDH may cause neural damage and regenerative response in the cerebral cortex. Here we attempted to explore these issues by using guinea pigs as an experimental model. Unilateral EDH was induced by in...

journal_title：Journal of neuroscience research

authors： Pan A,Li M,Gao JY,Xue ZQ,Li Z,Yuan XY,Luo DW,Luo XG,Yan XX

更新日期：2013-02-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-exposed cats develop severe Parkinsonism that spontaneously resolves in 4-6 weeks. The present study examined the extent to which compensatory changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) gene and protein expression may underlie this behaviora...

journal_title：Journal of neuroscience research

authors： Rothblat DS,Schroeder JA,Schneider JS

更新日期：2001-08-01 00:00:00

abstract：:The minimal requirements for the regeneration of optic nerve fibers in vitro were established in a serum-free retinal explant preparation. This serum-free preparation was developed as a prerequisite for testing the growth-promoting activity of tissue extracts prepared from the primary target of regenerating fibers. Ex...

journal_title：Journal of neuroscience research

authors： Johnson JE,Turner JE

更新日期：1982-01-01 00:00:00

abstract：:Niemann-Pick C (NPC) disease is an autosomal recessive lipidosis characterized by lysosomal accumulations of unesterified cholesterol. Cultured NPC cells exhibit a defect in the intracellular trafficking of LDL-derived cholesterol that leads to lysosomal accumulations of unesterified cholesterol. We found in a prelimi...

journal_title：Journal of neuroscience research

authors： Goodrum JF,Pentchev PG

更新日期：1997-08-01 00:00:00

abstract：:Efficient functioning of maintenance and repair processes seem to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, under control of several genes termed vitagenes. These include members of the heat shock protein system,...

journal_title：Journal of neuroscience research

authors： Calabrese V,Ravagna A,Colombrita C,Scapagnini G,Guagliano E,Calvani M,Butterfield DA,Giuffrida Stella AM

更新日期：2005-02-15 00:00:00

abstract：:GM1 ganglioside has been shown to stimulate recovery of the damaged dopamine system under a number of different circumstances. In addition to rescue of damaged dopamine neurons, the present study assessed the ability of GM1 to enhance the synthesis of dopamine in remaining nigrostriatal neurons following 1-methyl-4-ph...

journal_title：Journal of neuroscience research

authors： Schneider JS,Kean A,DiStefano L

更新日期：1995-09-01 00:00:00

abstract：:The cholinergic neurons of the basal forebrain (CNBF) are the major source of cholinergic innervation of the cortex and hippocampus. In Alzheimer's disease and aged brain, there are severe losses of cholinergic neurons in the nucleus basalis of Meynert, leading to a reduction of cortical cholinergic activity which cor...

journal_title：Journal of neuroscience research

authors： Wörtwein G,Yu J,Toliver-Kinsky T,Perez-Polo JR

更新日期：1998-05-01 00:00:00

abstract：:Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond to any kind of damage or pathophysiological changes. These cells sense and rapidly respond to danger and inflammatory signals by changing their cell morphology; by release of cytokines, chemok...

journal_title：Journal of neuroscience research

authors： Färber K,Cheung G,Mitchell D,Wallis R,Weihe E,Schwaeble W,Kettenmann H

更新日期：2009-02-15 00:00:00

abstract：:Neural stem cells (NSCs) have great potential as a therapeutic tool for the repair of a number of CNS disorders. NSCs can either be isolated from embryonic and adult brain tissue or be induced from both mouse and human ES cells. These cells proliferate in vitro through many passages without losing their multipotential...

journal_title：Journal of neuroscience research

authors： Cao Q,Benton RL,Whittemore SR

更新日期：2002-06-01 00:00:00

abstract：:Muscle spindles are sensory receptors composed of specialized muscle fibers, known as intrafusal muscle fibers, along with the endings of sensory neuron axons that innervate these muscle fibers. Formation of muscle spindles requires neuregulin1 (NRG1), which is released by sensory axons, activating ErbB receptors in m...

journal_title：Journal of neuroscience research

authors： Herndon CA,Ankenbruck N,Fromm L

更新日期：2014-02-01 00:00:00

abstract：:Previously, we showed that in rat cortical neurons, chronic donepezil treatment (10 microM, 4 days) up-regulates nicotinic receptors (nAChR) and makes neurons more sensitive to the neuroprotective effect of donepezil. Here we examined the mechanism of donepezil-induced neuroprotection in neurons chronically treated wi...

journal_title：Journal of neuroscience research

authors： Takada-Takatori Y,Kume T,Ohgi Y,Izumi Y,Niidome T,Fujii T,Sugimoto H,Akaike A

更新日期：2008-12-01 00:00:00

abstract：:There is evidence that zinc may be involved in the pathogenesis of Parkinson's disease by an apoptotic pathway. However, the mechanisms underlying zinc-induced apoptosis are unknown. Previous studies showed that 6-hydroxydopamine (6-OHDA)-enhanced potassium channels are involved in apoptosis of dopaminergic neurons. O...

journal_title：Journal of neuroscience research

authors： Shi L,Song N,Jiang H,Wang J,Ma Z,Xie J

更新日期：2009-02-01 00:00:00

abstract：:Fast-scan cyclic voltammetry (FSCV) is an established method for measuring dopamine (DA) levels in the brain in real time. However, it is difficult to discriminate DA from other monoamines such as serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). We report a novel DA-specific biosensor consisting of a car...

journal_title：Journal of neuroscience research

authors： Ishida A,Imamura A,Ueda Y,Shimizu T,Marumoto R,Jung CG,Hida H

更新日期：2018-05-01 00:00:00

abstract：:Given the ubiquitous nature of opioids in the treatment of pain, it is an interesting paradox that this class of medications also represents one of the least understood components of clinical pain medicine. For many years, there has been intense interest in the mechanisms of opioid activity, but this has not resulted ...

journal_title：Journal of neuroscience research

authors： Montgomery LS

更新日期：2020-08-07 00:00:00

abstract：:Regulatory factor X4 variant 3 (RFX4_v3) is a recently identified transcription factor specifically expressed in the brain. Gene disruption in mice demonstrated that interruption of a single allele (heterozygous, +/-) prevented formation of the subcommissural organ (SCO), resulting in congenital hydrocephalus, whereas...

journal_title：Journal of neuroscience research

authors： Zhang D,Zeldin DC,Blackshear PJ

更新日期：2007-12-01 00:00:00

abstract：:A growing body of evidence suggests that neurotrophins (NTs) play a critical role in synaptic plasticity and other activity dependent processes in the CNS. Release of these growth factors by neurons and neuroendocrine cells was recently shown to occur via the regulated secretory pathway, representing a possible mechan...

journal_title：Journal of neuroscience research

authors： Möller JC,Krüttgen A,Heymach JV Jr,Ghori N,Shooter EM

更新日期：1998-02-15 00:00:00

abstract：:Multiple unit activity (MUA) was obtained from gonadotropic areas of the hypothalamus in quail. Pellets of radioluminous paint (RLP) were implanted unilaterally either in the nucleus tuberis or in the n. posterior medialis hypothalami. Control data were obtained from birds receiving nonluminous material (RP). Spontane...

journal_title：Journal of neuroscience research

authors： Oliver J,Baylé JD

更新日期：1976-01-01 00:00:00

abstract：:Mutations in the beta-amyloid precursor protein (APP) gene cause familial Alzheimer's disease (AD). Although amyloid beta peptide (Abeta) is the principal constituent of senile plaques in AD, other cleavage products of APP are also implicated in playing a role in the pathogenesis of AD. C-terminal fragments of APP (AP...

journal_title：Journal of neuroscience research

authors： Lee JP,Chang KA,Kim HS,Kim SS,Jeong SJ,Suh YH

更新日期：2000-05-15 00:00:00

abstract：:The secretory capabilities of the serotonergic neuron C1 of cerebral ganglion of Helix pomatia were markedly reduced when it was cultured in contact with the wrong target neuron, C3. When the neuron B2, one of its physiological targets, was micromanipulated within the network made of intermingled neurites originating ...

journal_title：Journal of neuroscience research

authors： Ghirardi M,Naretto G,Fiumara F,Vitiello F,Montarolo PG

更新日期：2001-07-15 00:00:00

abstract：:The possibility that neuron-astrocyte communication may be responsible for glutamate (Glu)-stimulated cGMP formation even in relatively homogeneous primary cultures of mouse cerebellar granule cells (7 days in vitro) was investigated. Pharmacological analysis using selective excitatory amino acid (EAA) receptor antago...

journal_title：Journal of neuroscience research

authors： Malcolm C,Grieve A,Ritchie L,Schousboe A,Griffiths R

更新日期：1996-07-15 00:00:00

abstract：:High-affinity uptake, potassium-stimulated release and receptor binding of gamma-aminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetate-malate (IAM). Such treatments produce a selective damage of the inner retinal layers (MSG) or of the photoreceptor...

journal_title：Journal of neuroscience research

authors： Salceda R,Pasantes-Morales H

更新日期：1982-01-01 00:00:00

abstract：:Unilateral eye removal results in an increased delivery of blood-borne glucose, norepinephrine, choline, and tyrosine, but not of proline, to the denervated optic lobes. Administration of reserpine to chicks increases penetrance of norepinephrine into the brain but not of tyrosine, choline, or proline. Selective alter...

journal_title：Journal of neuroscience research

authors： Walker JB,Walker JP,Bondy SC,Purdy J

更新日期：1975-01-01 00:00:00

abstract：:After hemisection of the spinal cord in rats, alterations in amino acid incorporation into protein have been observed in brain and spinal cord. Proteins mediating these changes have been studied in the present experiment. Male, Long-Evans hooded rats were given either a laminectomy and dura incision (sham) at spinal s...

journal_title：Journal of neuroscience research

authors： Wells MR

更新日期：1980-01-01 00:00:00

abstract：:In order to quantify the changes that occur in the cholinergic central nervous system with aging, we have compared acetylcholine (Ach) formation in brain cortex slice preparations from 2-year-old aged CBF-1 mouse brains and compared the findings with those in 2-4-month-old young adult mouse brain slices. Incorporation...

journal_title：Journal of neuroscience research

authors： Saito M,Kindel G,Karczmar AG,Rosenberg A

更新日期：1986-01-01 00:00:00

abstract：:NG2 chondroitin sulfate proteoglycan is a surface marker of oligodendroglial progenitor cells (OPCs) in various species. In contrast to well-studied rat OPCs, however, we found that purified mouse NG2 surface positive cells (NG2(+) cells) require additional activation of cyclic AMP (cAMP) signaling for survival in a m...

journal_title：Journal of neuroscience research

authors： Horiuchi M,Lindsten T,Pleasure D,Itoh T

更新日期：2010-04-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 causes neuronal cell death; however, the molecular mechanisms of the neurotoxic effect remain largely unresolved. It has been suggested that gp120 evokes cell death by inducing the release of neurotoxins, including glutamate. The objective of this work...

journal_title：Journal of neuroscience research

authors： Bachis A,Mocchetti I

更新日期：2004-01-01 00:00:00

abstract：:Utilizing a specific polyclonal antibody against a peptide unique for brain-derived neurotrophic factor (BDNF), we investigated the regional and temporal profiles of immunoreactivity of the BDNF protein in the rat hippocampus after transient forebrain ischemia. The pattern of immunoreactivity for the BDNF receptor (Tr...

journal_title：Journal of neuroscience research

authors： Yamasaki Y,Shigeno T,Furukawa Y,Furukawa S

更新日期：1998-08-01 00:00:00

abstract：:The molecular pathways underlying the neuroprotective effects of preconditioning are promising, potentially drugable targets to promote cell survival. However, these pathways are complex and are not yet fully understood. In this study we have established a paradigm of hypoxic preconditioning based on a chick embryo mo...

journal_title：Journal of neuroscience research

authors： Giusti S,Fiszer de Plazas S

更新日期：2012-02-01 00:00:00

abstract：:The tissue- and cell-specific expression of three neutral glycosphingolipids, gangliotetraosylceramide (GA1), gangliopentaosylceramide (GalNAc-GA1), and the novel 3-O-acetyl-sphingosine-series glycolipid (FMC-5), were examined with monospecific polyclonal antibodies. Immunohistochemical studies of rodent brain cross-s...

journal_title：Journal of neuroscience research

authors： Dasgupta S,Bhat NR,Spicer SS,Hogan EL,Furuya S,Hirabayashi Y

更新日期：2007-10-01 00:00:00