Abstract：
:High-affinity uptake, potassium-stimulated release and receptor binding of gamma-aminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetate-malate (IAM). Such treatments produce a selective damage of the inner retinal layers (MSG) or of the photoreceptor layer (IAM). MSG treatment decreased GABA uptake by more than 60%. Also, the potassium-stimulated release of this amino acid was markedly diminished (90%) in retinas lesioned by MSG. MSG treatment decreased 3H-GABA binding by 45%. Uptake, release or binding of GABA were unaffected by IAM-treatment. Taurine uptake was reduced by a similar degree by both MSG and IAM treatment, 57% and 38% respectively. Potassium-stimulated release of taurine was unchanged by MSG and 50% reduced by IAM. Both treatments reduced the spontaneous release of endogenous taurine. Binding of taurine to receptors in retinal membranes was practically unaffected by any of the treatments utilized. These results are consistent with a neurotransmitter action of GABA at the inner retinal layers, while they do not support a major role for taurine as a synaptic transmitter in retina.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Salceda R,Pasantes-Morales Hdoi
10.1002/jnr.490080407subject
Has Abstractpub_date
1982-01-01 00:00:00pages
631-42issue
4eissn
0360-4012issn
1097-4547journal_volume
8pub_type
杂志文章abstract：:Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21784
更新日期：2008-11-15 00:00:00
abstract：:Trophic factors, such as the neurotrophins, CNTF, and GDNF, represent unique families of proteins that are essential for the development of the vertebrate nervous system. Surprisingly, there is little evidence to date that these proteins exist in Drosophila melanogaster and Caenorhabditis elegans, even though other po...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：
更新日期：2000-02-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490170410
更新日期：1987-01-01 00:00:00
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journal_title：Journal of neuroscience research
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doi：10.1002/jnr.490290409
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19971201)50:5<829::AID-JNR
更新日期：1997-12-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19971001)50:1<23::AID-JNR3
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21005
更新日期：2006-10-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490310121
更新日期：1992-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10716
更新日期：2003-09-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(sici)1097-4547(19970101)47:1<77::aid-jnr8
更新日期：1997-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23385
更新日期：2014-07-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490340602
更新日期：1993-04-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490060505
更新日期：1981-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23426
更新日期：2014-11-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22241
更新日期：2010-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22547
更新日期：2011-02-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.24049
更新日期：2017-10-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(20000401)60:1<73::AID-JNR8
更新日期：2000-04-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490200411
更新日期：1988-08-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490220110
更新日期：1989-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/jnr.10320
更新日期：2002-08-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19981201)54:5<595::AID-JNR
更新日期：1998-12-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21900
更新日期：2009-03-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21152
更新日期：2007-02-15 00:00:00
abstract：:P0-glycoprotein, the major integral membrane protein of peripheral nerve myelin, is thought to mediate myelination and membrane interactions via its extracellular domain (P0-ED). Molecular modeling of P0-ED has suggested which of its amino acid side-chains may be involved in heterophilic and homophilic adhesions. We p...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19961115)46:4<502::AID-JNR
更新日期：1996-11-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21281
更新日期：2007-05-15 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490200303
更新日期：1988-07-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20645
更新日期：2005-11-15 00:00:00
abstract：:We review three principally different forms of injury-induced synaptic alterations. (1) Displacement of presynaptic terminals from perikarya and dendrites of axotomized neurons, (2) central changes in primary afferent terminals of peripherally axotomized sensory ganglion cells, and (3) anterograde Wallerian-type degen...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
abstract：:BACE1 initiates processing of the amyloid precursor protein (APP) in the production of amyloid beta (Abeta) peptide. After beta-cleavage by BACE1, the C-terminal stub of the APP fragment is further processed by the gamma-secretase complex to produce Abeta. Because APP, Abeta, the gamma-secretase complex, and BACE1 are...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21858
更新日期：2009-02-01 00:00:00
