Trophic factors: An evolutionary cul-de-sac or door into higher neuronal function?

abstract：:Biology of GnRH neurons is critically dependent on extracellular Ca(2+) (Ca(2+) (o)). We evaluated differences in gene expression patterns with low and high Ca(2+) (o) in an immortalized GnRH neuron line, GT1-7 cells. Mouse global oligonucleotide microarray was used to evaluate transcriptional differences among the ge...

journal_title：Journal of neuroscience research

authors： Bandyopadhyay S,Jeong KH,Hansen JT,Vassilev PM,Brown EM,Chattopadhyay N

更新日期：2007-03-01 00:00:00

abstract：:Nerve growth factor (NGF)-specific signal transduction leads to changes in protein methylation during neuronal differentiation of PC12 cells (Cimato et al. [1997] J. Cell Biol. 138:1089-1103). In the present work, we demonstrate that, among NGF-regulated proteins, arginine methylation is more prevalent than carboxylme...

journal_title：Journal of neuroscience research

authors： Cimato TR,Tang J,Xu Y,Guarnaccia C,Herschman HR,Pongor S,Aletta JM

更新日期：2002-02-15 00:00:00

abstract：:Increasing evidence has shown that β-amyloid (Aβ) induces hyperphosphorylation of tau and contributes to Aβ toxicity. Recently, tau hyperphosphorylation by glycogen synthase kinase-3β (GSK-3β) activation has been emphasized as one of the pathogenic mechanisms of Alzheimer's disease (AD). The phosphoinositide 3 kinase ...

journal_title：Journal of neuroscience research

authors： Zhang Z,Zhao R,Qi J,Wen S,Tang Y,Wang D

更新日期：2011-03-01 00:00:00

abstract：:The olfactory ensheathing cell (OEC) is a unique glial cell able to support neurite outgrowth in the CNS throughout life. The OEC has been described as having both Schwann cell-like and astrocyte-like characteristics. The purpose of this study was to compare gap junctional communication and connexin (Cx) expression in...

journal_title：Journal of neuroscience research

authors： Barnett SC,Thompson RJ,Lakatos A,Pitts J

更新日期：2001-09-15 00:00:00

abstract：:Apolipoprotein E (ApoE) is the major brain lipoprotein and plays an important role in lipid transport. ApoE-deficient mice whose apoE gene has been knocked out have distinct cognitive and neurochemical deficits, and their recovery from brain injury is impaired. In the present study we examined the possibility that the...

journal_title：Journal of neuroscience research

authors： Lomnitski L,Oron L,Sklan D,Michaelson DM

更新日期：1999-11-15 00:00:00

abstract：:A new subdivision with distinctive morphological and functional attributes has been identified at the caudomedial margin of the neostriatum and surrounding the rostrolateral border of the globus pallidus in the brains of the rat, cat, monkey, and human. The subdivision is termed marginal division (MrD) based on its lo...

journal_title：Journal of neuroscience research

authors： Shu SY,Bao X,Li S,Niu D,Xu Z,Li Y

更新日期：1999-10-15 00:00:00

abstract：:The tachykinin, substance P, has long been associated with transmission of noxious stimuli. However, relatively little is known about signal transduction pathways subserving peptidergic regulation in sensory neurons. To investigate whether cyclic AMP (cAMP) could be a potential second messenger subserving substance P ...

journal_title：Journal of neuroscience research

authors： Adler JE,Walker PD

更新日期：2000-03-01 00:00:00

abstract：:Perinatal hypoxia is a major cause of neurodevelopmental deficits. Neuronal migration patterns are particularly sensitive to perinatal hypoxia/ischemia and are associated with the clinical deficits. The rat model of hypoxia/ischemia at P7 mimics that of perinatal injury in humans. Before assessing the effects of postn...

journal_title：Journal of neuroscience research

authors： Bockhorst KH,Narayana PA,Liu R,Ahobila-Vijjula P,Ramu J,Kamel M,Wosik J,Bockhorst T,Hahn K,Hasan KM,Perez-Polo JR

更新日期：2008-05-15 00:00:00

abstract：:Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerability. Treatment of TBI is lacking due to its multimechanistic etiology, including derailed mitochondrial and cellular energy metabolism. Previous studies from our laboratory show that an endogenous nitric oxide (NO) metabolit...

journal_title：Journal of neuroscience research

authors： Khan M,Shunmugavel A,Dhammu TS,Khan H,Singh I,Singh AK

更新日期：2018-12-01 00:00:00

abstract：:Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the fronto-lateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of...

journal_title：Journal of neuroscience research

authors： Mahadik SP,Vilim F,Korenovsky A,Karpiak SE

更新日期：1988-08-01 00:00:00

abstract：:Studies have shown that individuals with both a history of traumatic brain injury and inheritance of apolipoprotein E-4 (ApoE4) allele are associated with a poor neurologic outcome and an increased risk for Alzheimer's disease. We assessed the hypothesis that thrombin released during brain injury causes an increase in...

journal_title：Journal of neuroscience research

authors： Mhatre M,Hensley K,Nguyen A,Grammas P

更新日期：2006-08-01 00:00:00

abstract：:Neurotransmitter transporters are involved in termination of the synaptic neurotransmission and they also play a key role in neuroregulation and brain development. In this report, we describe the developmental distribution of the y-aminobutyric acid transporter GAT3 which transports gamma-aminobutyric acid (GABA) and ...

journal_title：Journal of neuroscience research

authors： Jursky F,Nelson N

更新日期：1999-02-01 00:00:00

abstract：:Raf kinases are downstream effectors of Ras and upstream activators of the MEK-ERK cascade. Ras and MEK-ERK signaling play roles in learning and memory (L&M) and neural plasticity, but the roles of Raf kinases in L&M and plasticity are unclear. Among Raf isoforms, B-raf is preferentially expressed in the brain. To det...

journal_title：Journal of neuroscience research

authors： Chen AP,Ohno M,Giese KP,Kühn R,Chen RL,Silva AJ

更新日期：2006-01-01 00:00:00

abstract：:Although proteins belonging to the sHSP superfamily are diverse in sequence and size, most share characteristic features, including 1) a small molecular mass of 12-43 kDa, 2) a conserved alpha-crystallin domain of 80-100 residues, 3) formation of large oligomers, 4) a dynamic quaternary structure, and 5) induction by ...

journal_title：Journal of neuroscience research

authors： Hu Z,Yang B,Lu W,Zhou W,Zeng L,Li T,Wang X

更新日期：2008-08-01 00:00:00

abstract：:Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be a critical step leading to axonal degeneration. Kinesin and microtubules (MT) were evaluated as molecular sites of action using...

journal_title：Journal of neuroscience research

authors： Sickles DW,Brady ST,Testino A,Friedman MA,Wrenn RW

更新日期：1996-10-01 00:00:00

abstract：:The p53 tumor suppressor gene, which is considered the guardian of the genome, encodes a phosphoprotein, which is a sequence-specific transcriptional activator or repressor of target genes. The role of p53 in developmental processes has not been studied extensively, although its expression appears to undergo temporal ...

journal_title：Journal of neuroscience research

authors： Poulaki V,Benekou A,Bozas E,Bolaris S,Stylianopoulou F

更新日期：1999-05-15 00:00:00

abstract：:Understanding the pathway for amyloid percursor protein (APP) catabolism has become an important line of investigation. APP is a ubiquitous membrane bound protein that is rapidly cleaved at the membrane, yielding a secreted protein identical to protease nexin II and an internalized 11.5 kDa 100 residue C terminal deri...

journal_title：Journal of neuroscience research

authors： Wolozin B,Bacic M,Merrill MJ,Lesch KP,Chen C,Lebovics RS,Sunderland T

更新日期：1992-09-01 00:00:00

abstract：:An elevated expression of c-fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long-term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c-fos expression as well. On the basis of biolo...

journal_title：Journal of neuroscience research

authors： Kaczmarek L

更新日期：1993-03-01 00:00:00

abstract：:Damage to the lateral nucleus of the septum in the rat resulted in atypical learning to a previously meaningless stimulus. Nonreinforced preexposure to a stimulus normally makes more difficult subsequent use of that stimulus for learning. The effect of this preexposure on learning is termed latent inhibition and was d...

journal_title：Journal of neuroscience research

authors： Toga AW,Burton HA

更新日期：1979-01-01 00:00:00

abstract：:Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...

journal_title：Journal of neuroscience research

authors： Mioduszewska B,Jaworski J,Szklarczyk AW,Klejman A,Kaczmarek L

更新日期：2008-01-01 00:00:00

abstract：:The analysis of proteins in damaged myelin is crucial to clarify the mechanisms of dysmyelination and demyelination. In the present study, proteomic analysis of myelin using a modified two-dimensional electrophoresis (2-DE) method was carried out to obtain a better understanding of myelin biology. Although standard 2-...

journal_title：Journal of neuroscience research

authors： Yamaguchi Y,Miyagi Y,Baba H

更新日期：2008-03-01 00:00:00

abstract：:The G protein-coupled muscarinic acetylcholine receptor (mAChR) isoforms have been identified in neural stem/progenitor (or precursor) cells. In previous studies, activation of these receptors induced elevations in intracellular Ca(2+) signals and mitogen-activated protein (MAP) kinase activity that led to enhanced DN...

journal_title：Journal of neuroscience research

authors： Zhao WQ,Alkon DL,Ma W

更新日期：2003-05-01 00:00:00

abstract：:Pyruvate dehydrogenase complex (PDH) is a brain mitochondrial matrix enzyme. PDH impairment after stroke is particularly devastating given PDH's critical role in the link between anaerobic and aerobic metabolism. This study evaluates the restoration of oxidative metabolism and energy regulation with a therapeutic comb...

journal_title：Journal of neuroscience research

authors： Cai L,Thibodeau A,Peng C,Ji X,Rastogi R,Xin R,Singh S,Geng X,Rafols JA,Ding Y

更新日期：2016-08-01 00:00:00

abstract：:Previous studies on the NG2 chondroitin sulfate proteoglycan have shown that NG2 is expressed on A2B5-positive O2A progenitor cells, which are known to respond to platelet-derived growth factor (PDGF). In the accompanying paper (Nishiyama et al.; J Neurosci Res 43:299-314, 1996) we show that on O2A progenitors in the ...

journal_title：Journal of neuroscience research

authors： Nishiyama A,Lin XH,Giese N,Heldin CH,Stallcup WB

更新日期：1996-02-01 00:00:00

abstract：:It is generally recognized that lipid peroxides play an important role in the pathogenesis of several diseases and that sulfhydryl groups are critically involved in cellular defense against endogenous or exogenous oxidants. Recent evidence indicates that lipid peroxides directly participate in induction of cytoprotect...

journal_title：Journal of neuroscience research

authors： Calabrese V,Scapagnini G,Ravagna A,Fariello RG,Giuffrida Stella AM,Abraham NG

更新日期：2002-04-01 00:00:00

abstract：:Recent studies suggest that heterotypic cell-cell interactions influence gliogenesis in the developing rat central nervous system. CNS neuron-derived factors have been hypothesized to exist, and several have been identified and partially characterized which affect the number of oligodendrocytes in vitro. In order to s...

journal_title：Journal of neuroscience research

authors： Bottenstein JE,Hunter SF,Seidel M

更新日期：1988-07-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has attracted the greatest attention as a major factor in experimental autoimmune encephalomyelitis (EAE) pathogenesis. We compared rats undergoing EAE with manipulated but healthy animals by examining TNF-alpha gene expression in cells recovered from the brain. We used reverse ...

journal_title：Journal of neuroscience research

authors： Sun D,Hu X,Shah R,Zhang L,Coleclough C

更新日期：1996-08-15 00:00:00

abstract：:Estradiol attenuates the ATP-induced increase of intracellular calcium concentration ([Ca(2+)](i)) in rat dorsal root ganglion (DRG) neurons by blocking the L-type voltage gated calcium channel (VGCC). Because ATP is a putative nociceptive signal, this action may indicate a site of estradiol regulation of pain. In oth...

journal_title：Journal of neuroscience research

authors： Chaban V,Li J,McDonald JS,Rapkin A,Micevych P

更新日期：2011-11-01 00:00:00

abstract：:Few diseases in clinical medicine cause as much diagnostic consternation as central nervous system (CNS) vasculitis because of its varying modes of presentation and frequently overlapping clinical and pathological features. There are no pathognomonic clinical or laboratory findings. The purpose of the present retrospe...

journal_title：Journal of neuroscience research

authors： Nylén K,Karlsson JE,Blomstrand C,Tarkowski A,Trysberg E,Rosengren LE

更新日期：2002-03-15 00:00:00

abstract：:In the following review, we address difficulties that have arisen when attempting to convert the myelin multilayers into vesicles. The emphasis is on CNS myelin of adult mammals although both central nervous system (CNS) and peripheral nervous system (PNS) myelin are considered. The ability to prepare vesicle of myeli...

journal_title：Journal of neuroscience research

authors： Sedzik J,Blaurock AE

更新日期：1995-06-01 00:00:00