Abstract:
:Damage to the lateral nucleus of the septum in the rat resulted in atypical learning to a previously meaningless stimulus. Nonreinforced preexposure to a stimulus normally makes more difficult subsequent use of that stimulus for learning. The effect of this preexposure on learning is termed latent inhibition and was demonstrated in sham operated animals. Rats in which the lateral septum was damaged demonstrated a paradoxically smaller learning deficit in the presence of a conditioned stimulus that was previously presented without reinforcement, when compared to the performance of both septal lesioned rats no receiving nonreinforced preexposure and sham operates receiving preexposure. The interaction of nonreinforced preexposure and lateral septal lesions can be explained using a proposed sensitization hypothesis.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Toga AW,Burton HAdoi
10.1002/jnr.490040309subject
Has Abstractpub_date
1979-01-01 00:00:00pages
215-24issue
3eissn
0360-4012issn
1097-4547journal_volume
4pub_type
杂志文章abstract::The iron transport protein, transferrin, and the iron storage protein ferritin were examined immunohistochemically along with iron in a number of brain regions from normal and aged humans. Two age groups were examined: a middle-aged group (28-49 years), and an older group (60-90 years). Transferrin, ferritin, and iron...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270421
更新日期:1990-12-01 00:00:00
abstract::Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of Parkinson's disease (PD). Neurogenesis, the generation of new neurons, persists throughout the mammalian life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of P...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23677
更新日期:2016-01-01 00:00:00
abstract::Neuronal development and differentiation is modulated by activity-dependent mechanisms that stimulate endogenous neurogenesis and differentiation to promote adaptive survival of the organism. Studies on bird odor imprinting have shown how sensory stimuli or environmental influences can affect neonatal behavior, presum...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23966
更新日期:2017-05-01 00:00:00
abstract::The Rho GTPases are important regulators of neurite outgrowth and pathfinding. We have recently reported that a Rho-family guanine nucleotide exchange factor, GEFT, modulates dendrite spine morphology and basal neurite outgrowth in primary hippocampal neurons and Neuro2A cells, respectively. Here we demonstrate that G...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20814
更新日期:2006-05-15 00:00:00
abstract::TCP and its derivative gacyclidine (+/- GK11) are high-affinity non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors (NMDARs) and as such exhibit significant neuroprotective properties. These compounds also bind with a low affinity to binding sites whose pharmacological profiles are different from that...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10203
更新日期:2002-05-01 00:00:00
abstract::The tachykinin, substance P, has long been associated with transmission of noxious stimuli. However, relatively little is known about signal transduction pathways subserving peptidergic regulation in sensory neurons. To investigate whether cyclic AMP (cAMP) could be a potential second messenger subserving substance P ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000301)59:5<624::AID-JNR
更新日期:2000-03-01 00:00:00
abstract::We have developed a silicone nerve regeneration chamber that is partitioned into two compartments by a strip of nitrocellulose paper. The modified two-compartment chamber allows the investigation of the effects on rat sciatic nerve regeneration of trophic or growth factors that are initially bound to the nitrocellulos...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200306
更新日期:1988-07-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) plays an important role in the differentiation, development, and survival of neural stem cells. In this study, we analyzed its effects on the stimulation of human umbilical cord blood-derived mesenchymal stem cells in terms of their potential to differentiate into neuron-like c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21669
更新日期:2008-08-01 00:00:00
abstract::GM1 ganglioside has been shown to stimulate recovery of the damaged dopamine system under a number of different circumstances. In addition to rescue of damaged dopamine neurons, the present study assessed the ability of GM1 to enhance the synthesis of dopamine in remaining nigrostriatal neurons following 1-methyl-4-ph...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420113
更新日期:1995-09-01 00:00:00
abstract::Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a chemically defined (...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490140202
更新日期:1985-01-01 00:00:00
abstract::Using subtype-specific Ca-channel blockers, we have characterised the voltage-sensitive Ca2+ currents as well as neurotransmitter release from cultured mouse cerebellar granule cells. The whole cell version of the patch clamp technique was adapted to monitor the isolated Ca-channel currents. The currents were activate...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(sici)1097-4547(19970401)48:1<43::aid-jnr4
更新日期:1997-04-01 00:00:00
abstract::Calcium-activated neutral proteinase (CANP) activity was determined in cytosolic and membranous subcellular fractions of transformed Schwann cells (tSc). The muM and mM Ca(2+)-sensitive (mu- and mCANP) forms of CANP were separated by DEAE and phenyl Sepharose column chromatography, the latter step enabling removal of ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490290310
更新日期:1991-07-01 00:00:00
abstract::Pathological processes affecting presynaptic terminals may contribute to morbidity following traumatic brain injury (TBI). Posttraumatic widespread neuronal depolarization and elevated extracellular potassium and glutamate are predicted to alter the transduction of action potentials in terminals into reliable synaptic...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000501)60:3<370::AID-JNR
更新日期:2000-05-01 00:00:00
abstract::Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21131
更新日期:2007-02-01 00:00:00
abstract::We describe here the presence of ubiquitin and its conjugation system in the rat retina. Retinal homogenates and supernatants conjugate [125I]human ubiquitin with either endogenous or exogenous proteins. The conjugating activity is relatively stable over time, requires ATP, and has a pH optimum of approximately 8. The...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300220
更新日期:1991-10-01 00:00:00
abstract::Relationships among different intensities of electroshock treatment (EST), EEG-recordable primary after discharge (PAD), and beta-adrenergic binding in various brain regions were investigated in adult rats. Different intensities of EST (1-2, 6-8, 20-30 mamp) were applied through ear-clip electrodes for 7 consecutive d...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490070306
更新日期:1982-01-01 00:00:00
abstract::In recent years, several novel types of disorders have been characterized, including what have been termed polyalanine diseases, in which patients have expanded triplet repeats in specific genes, resulting in the translation of aberrantly elongated polyalanine stretches. In this study, we showed that yellow fluorescen...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21619
更新日期:2008-05-15 00:00:00
abstract::The amino acid glutamate plays a key role in brain function. One of the major roles of glutamate is to mediate fast excitatory neurotransmission via activation of ionotropic glutamate receptors (iGluRs). More recently, however, it has become clear that glutamate also serves a regulatory function through activation of ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-4547(19961015)46:2<131::AID-JNR
更新日期:1996-10-15 00:00:00
abstract::Soluble oligomeric aggregates of the amyloid-beta (A beta) peptide are believed to be the most neurotoxic A beta species affecting the brain in Alzheimer disease (AD), a terminal neurodegenerative disorder involving severe cognitive decline underscored by initial synaptic dysfunction and later extensive neuronal death...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22445
更新日期:2010-10-01 00:00:00
abstract::The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 causes neuronal cell death; however, the molecular mechanisms of the neurotoxic effect remain largely unresolved. It has been suggested that gp120 evokes cell death by inducing the release of neurotoxins, including glutamate. The objective of this work...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10826
更新日期:2004-01-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to multiple sclerosis that requires the activation of auto reactive T cells that infiltrate the central nervous system. In previous studies we have shown that intraperitoneal administration of synaptosomal antige...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22048
更新日期:2009-08-01 00:00:00
abstract::Sympathetic noradrenergic nerve fibers, stained with antiserum for tyrosine hydroxylase (TH), richly innervate the splenic white pulp. These fibers distribute with the vascular and trabecular systems, and associate mainly with the central artery and its branches, the periarteriolar lymphatic sheath (PALS), the margina...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180107
更新日期:1987-01-01 00:00:00
abstract::Superior cervical ganglion (SCG) cells from neonatal rats underwent apoptosis upon treatment with colchicine, a microtubule-disrupting agent. Western blotting and activity measurements showed that caspase-3 was indeed activated, but its peptide inhibitor (Ac-DEVD-CHO) neither suppressed nuclear fragmentation nor rescu...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10008
更新日期:2001-11-15 00:00:00
abstract::Little is known about the structural neural substrates that may contribute to sex differences in risk-taking propensity (RTP). A close association between risk-seeking behavior and the emotional-regulation network led us to hypothesize that the sex differences in RTP would be associated with sex differences in brain m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24504
更新日期:2020-02-01 00:00:00
abstract::Diabetes and obesity are characterized by hyperlipidemia and represent risk factors for premature neurological disorders. Diabetic/obese animals have impaired adult neurogenesis. We hypothesize that lipotoxicity leading to neurogenesis impairment plays a role in the development of neurological complications. If so, no...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22803
更新日期:2012-04-01 00:00:00
abstract::The amygdala contributes to the generation and propagation of epileptiform activity in temporal lobe epilepsy (TLE). Ictal symptoms such as fear, dreamy states (déjà vu, memory flashbacks, experiential hallucinations), epigastric auras, or sympathetic outflow with cardiovascular changes are often linked to a seizure f...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23689
更新日期:2016-06-01 00:00:00
abstract::A study was conducted on the adsorption of 14C-ATP to a surface film of a hydrophobic protein derived from synaptic membranes isolated from bovine cerebellum. The adsorption of ATP to the protein film followed a rate law based on diffusion and an energy barrier to adsorption, the rate law being generally applicable to...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490020109
更新日期:1976-01-01 00:00:00
abstract::The mast cell, an immunocompetent cell that contributes to neurogenic inflammation in a variety of tissues, including synovium, is found in close proximity to peripheral terminals of unmyelinated primary afferents and sympathetic postganglionic nerve terminals. In this study we evaluated the hypothesis that the densit...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490260306
更新日期:1990-07-01 00:00:00
abstract::We have developed an animal model of learning and memory impairment associated with activation of microglia in the mouse brain. Injection of lipopolysaccharide into the CA1 region of the mouse hippocampus resulted in an increased production of inflammatory cytokines, such as interleukin-1β. Immunostaining for interleu...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22582
更新日期:2011-04-01 00:00:00
abstract::Taurine, 2-aminoethanesulfonic acid, is present at high concentrations in many invertebrate and vertebrate systems and has several biological functions. In addition, it has been related to a neuroprotective role against several diseases such as epilepsy. In the present work, we treated mice with taurine and examined i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22192
更新日期:2010-01-01 00:00:00