Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways.

abstract：:The influence of a concentrated extract of soluble substances from the sciatic nerve upon the acetylcholine receptor (AChR) content in the soleus muscle of adult rats was examined by in vivo infusions. Internal and membrane-inserted AChR were quantitated by the specific binding of 125I-alpha-bungarotoxin (a-BuTX). Int...

journal_title：Journal of neuroscience research

authors： Sayers ST,Yeoh HC,McLane JA,Held IR

更新日期：1986-01-01 00:00:00

abstract：:We investigated whether certain hydrophobic dipeptides, Leu-Ile, Leu-Pro, and Pro-Ile, which partially resemble the site on FK506 that binds to immunophilin, could stimulate glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) synthesis in cultured neurons and found only Leu-...

journal_title：Journal of neuroscience research

authors： Nitta A,Nishioka H,Fukumitsu H,Furukawa Y,Sugiura H,Shen L,Furukawa S

更新日期：2004-10-15 00:00:00

abstract：:The first synapse in the olfactory pathway mediates a significant transfer of information given the restricted association of specific olfactory receptor neurons with specific glomeruli in the olfactory bulb. To understand better how this connection is made and what the functional capacities of the participating cells...

journal_title：Journal of neuroscience research

authors： Josephson EM,Yilma S,Vodyanoy V,Morrison EE

更新日期：2004-03-01 00:00:00

abstract：:HEPES inhibited the taurine uptake in glial cells. A different kind of inhibition was observed when HEPES was present in the culture medium or in the incubation medium used for the taurine-uptake measurement. As an example of a possible interference of HEPES in pharmacological experiments, we have studied the effect o...

journal_title：Journal of neuroscience research

authors： Lleu PL,Rebel G

更新日期：1989-05-01 00:00:00

abstract：:Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of Parkinson's disease (PD). Neurogenesis, the generation of new neurons, persists throughout the mammalian life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of P...

journal_title：Journal of neuroscience research

authors： Schlachetzki JC,Grimm T,Schlachetzki Z,Ben Abdallah NM,Ettle B,Vöhringer P,Ferger B,Winner B,Nuber S,Winkler J

更新日期：2016-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that form a subfamily within the steroid hormone receptor group. Recent work has shown that one member of this group, PPARgamma, plays a central role in adipocyte differentiation. As oligodendrocytes are major lipid-producin...

journal_title：Journal of neuroscience research

authors： Granneman J,Skoff R,Yang X

更新日期：1998-03-01 00:00:00

abstract：:Recent studies have revealed a significant decrease in white matter volume, including loss of myelin, with age but minimal decrease in gray matter volume (Guttmann et al., [1998] Neurology 50:972-978). Myelin is necessary for the rapid conduction of impulses along axons. Myelinated nerve includes various domains, the ...

journal_title：Journal of neuroscience research

authors： Sugiyama I,Tanaka K,Akita M,Yoshida K,Kawase T,Asou H

更新日期：2002-11-01 00:00:00

abstract：:The blood-brain barrier (BBB) refers to the network of microvessels that selectively restricts the passage of substances between the circulation and the central nervous system (CNS). This microvascular network is comprised of arterioles, capillaries and venules, yet the respective contribution of each of these to the ...

journal_title：Journal of neuroscience research

authors： Macdonald JA,Murugesan N,Pachter JS

更新日期：2010-05-15 00:00:00

abstract：:The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...

journal_title：Journal of neuroscience research

authors： Yeh YY

更新日期：1988-03-01 00:00:00

abstract：:In a number of pathological states of the brain, the activation of the inducible nitric oxide synthase (iNOS) plays a major role. Interleukin (IL)-1beta is believed to be an essential factor in the induction of iNOS. However, little is known about the cascade of events culminating in iNOS expression in vivo. To identi...

journal_title：Journal of neuroscience research

authors： Hartlage-Rübsamen M,Lemke R,Schliebs R

更新日期：1999-08-01 00:00:00

abstract：:Cranial idiopathic acute peripheral facial nerve paralysis (Bell palsy) has been used as a model disease in the present study mainly to investigate trophic capacity of serum components. The ability to induce sprouting from chick embryo dorsal root ganglia was used as the bioassay for trophic activity. Sera from normal...

journal_title：Journal of neuroscience research

authors： Aviel A,Schwartz M

更新日期：1983-01-01 00:00:00

abstract：:Astrocytes are excitable neural cells that contribute to brain information processing via bidirectional communication with neurons. This involves the release of gliosignaling molecules that affect synapses patterning and activity. Mechanisms mediating the release of these molecules likely consist of non-vesicular and ...

journal_title：Journal of neuroscience research

authors： Jorgačevski J,Potokar M,Kreft M,Guček A,Mothet JP,Zorec R

更新日期：2017-11-01 00:00:00

abstract：:Biology of GnRH neurons is critically dependent on extracellular Ca(2+) (Ca(2+) (o)). We evaluated differences in gene expression patterns with low and high Ca(2+) (o) in an immortalized GnRH neuron line, GT1-7 cells. Mouse global oligonucleotide microarray was used to evaluate transcriptional differences among the ge...

journal_title：Journal of neuroscience research

authors： Bandyopadhyay S,Jeong KH,Hansen JT,Vassilev PM,Brown EM,Chattopadhyay N

更新日期：2007-03-01 00:00:00

abstract：:Phencyclidine (PCP) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Several studies have demonstrated that chronic NMDA receptor antagonist treatment in humans and animals can cause long-term behavioral changes that are reminiscent of negative and cognitive schizophrenia-like symptoms. The muscari...

journal_title：Journal of neuroscience research

authors： Newell KA,Zavitsanou K,Huang XF

更新日期：2007-05-01 00:00:00

abstract：:Pyruvate dehydrogenase complex (PDH) is a brain mitochondrial matrix enzyme. PDH impairment after stroke is particularly devastating given PDH's critical role in the link between anaerobic and aerobic metabolism. This study evaluates the restoration of oxidative metabolism and energy regulation with a therapeutic comb...

journal_title：Journal of neuroscience research

authors： Cai L,Thibodeau A,Peng C,Ji X,Rastogi R,Xin R,Singh S,Geng X,Rafols JA,Ding Y

更新日期：2016-08-01 00:00:00

abstract：:Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...

journal_title：Journal of neuroscience research

authors： Barajas M,Andrade A,Hernandez-Hernandez O,Felix R,Arias-Montaño JA

更新日期：2008-11-15 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) regulates the proliferation and migration of olfactory bulb (OB) interneuron progenitors derived from the subventricular zone (SVZ), but the role of GABA in the differentiation of these progenitors has been largely unexplored. This study examines the role of GABA in the differentiation o...

journal_title：Journal of neuroscience research

authors： Akiba Y,Sasaki H,Huerta PT,Estevez AG,Baker H,Cave JW

更新日期：2009-08-01 00:00:00

abstract：:Male gerbils (Meriones unguiculatus) were bred and reared either grouped under enriched environmental conditions or isolated under impoverished environmental conditions. The objective of the present study was to examine the influence of social environment on structural and functional ontogeny of the medial prefrontal ...

journal_title：Journal of neuroscience research

authors： Winterfeld KT,Teuchert-Noodt G,Dawirs RR

更新日期：1998-04-15 00:00:00

abstract：:Although they likely involve activation of N-methyl-D-aspartate (NMDA) receptors, the mechanisms giving rise to perinatal hypoxic-ischemic-induced damages remained unclear. The purpose of the present study was to investigate in vivo the mechanisms regulating the glutamate-induced release of toxic hydroxyl radicals (.O...

journal_title：Journal of neuroscience research

authors： Cambonie G,Laplanche L,Kamenka JM,Barbanel G

更新日期：2000-10-01 00:00:00

abstract：:Membrane compaction and adhesion at the major dense line (cytoplasmic apposition) of myelin, particularly in the central nervous system (CNS), is typically attributed to myelin basic protein (MBP). To explore the role of MBP in myelin membrane adhesion, we attempted to reconstitute the major dense line of myelin from ...

journal_title：Journal of neuroscience research

authors： Riccio P,Fasano A,Borenshtein N,Bleve-Zacheo T,Kirschner DA

更新日期：2000-02-15 00:00:00

abstract：:Living organotypic cocultures of rat thalamic and cortical explants were used to examine the effects of blocking action potential activity on the morphological development of axons in the mammalian neocortex. Studies in vivo have suggested that blocking sodium channel-dependent activity influences the growth character...

journal_title：Journal of neuroscience research

authors： Wilkemeyer MF,Angelides KJ

更新日期：1996-03-15 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of unknown etiology. Both genetic-susceptibility and environment exposures, including vitamin D deficiency, Epstein-Barr viral and Herpesvirus (HHV-6) infections are strongly implicated in the activation of T cells and MS-pathogenesis. Despite precis...

journal_title：Journal of neuroscience research

authors： Tiwari S,Lapierre J,Ojha CR,Martins K,Parira T,Dutta RK,Caobi A,Garbinski L,Ceyhan Y,Esteban-Lopez M,El-Hage N

更新日期：2018-12-01 00:00:00

abstract：:The Brn-3a transcription factor is critical for survival and differentiation of sensory neurons derived from neural crest cells (NCC). Interaction of Brn-3a with p53 results in differential effects on target gene expression, which profoundly affects fate of neuronal cells. Here we demonstrate colocalization of p53 in ...

journal_title：Journal of neuroscience research

authors： Hudson CD,Podesta J,Henderson D,Latchman DS,Budhram-Mahadeo V

更新日期：2004-12-15 00:00:00

abstract：:Previously we reported results of an incubation experiment with neurofilaments that supported the existence of a mu-type of Ca2+-activated neutral protease in the rat peripheral nerve; it was active with microM order Ca2+ (mu-CANP). This time, we partially purified the mu-CANP from a crude CANP fraction of rat periphe...

journal_title：Journal of neuroscience research

authors： Kamakura K,Ishiura S,Sugita H

更新日期：1986-01-01 00:00:00

abstract：:This study demonstrates the ability of proteasome inhibitors (lactacystin, MG 115, MG 132) adenosine diphosphate to induce a time- and dose-dependent increase in poly-ADP-ribosylation (PAR) in the neural PC6 cell line, a subclone of PC12 cells. Elevated levels of PAR contribute to the toxicity associated with impaired...

journal_title：Journal of neuroscience research

authors： Keller JN,Markesbery WR

更新日期：2000-08-15 00:00:00

abstract：:Electrical activity shapes development of the nervous system, presumably in part by regulating gene expression. A set of regulatory genes, immediate early genes (IEGs), which are responsive to a number of extrinsic cellular stimuli have been proposed to play a role in coupling such activity to gene expression. Using a...

journal_title：Journal of neuroscience research

authors： Sheng HZ,Fields RD,Nelson PG

更新日期：1993-08-01 00:00:00

abstract：:In 2000, a landmark case report described the concurrent restoration of consciousness and thalamo-frontal connectivity after severe brain injury (Laureys et al., ). Being a single case however, this study could not disambiguate whether the result was specific to the restoration of consciousness per se as opposed to th...

journal_title：Journal of neuroscience research

authors： Crone JS,Bio BJ,Vespa PM,Lutkenhoff ES,Monti MM

更新日期：2018-04-01 00:00:00

abstract：:Brain edema accounts for significant morbidity and mortality in many neurologic conditions such as head trauma, stroke, meningitis, and brain tumor. The water channel aquaporin-4 (AQP4) has been found to be an important determinant of brain water accumulation and clearance of excess brain water. We report the developm...

journal_title：Journal of neuroscience research

authors： Thiagarajah JR,Papadopoulos MC,Verkman AS

更新日期：2005-04-15 00:00:00

abstract：:Oligodendrocyte responses in vitro to platelet-derived growth factor (PDGF) include proliferation, survival, migration, and changes in cell morphology and molecular expression. Studies of mixed glial cultures established that astrocytes secrete PDGF; thus astrocytes are considered to be key regulators of oligodendrocy...

journal_title：Journal of neuroscience research

authors： Ellison JA,Scully SA,de Vellis J

更新日期：1996-07-01 00:00:00

abstract：:Adhesion responses triggered by integrin-class matrix receptors have been implicated in the synaptic reorganization events necessary for certain types of neuronal plasticity. Hippocampal slice cultures were used to test whether the related structural transformations elicited by NMDA receptor stimulation are regulated ...

journal_title：Journal of neuroscience research

authors： Bahr BA

更新日期：2000-03-15 00:00:00